Abstract：
:Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, Reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated. Given that cell epigenetic profile changes with age, the study of cell-fate manipulation approaches on cells deriving from old donors or centenarians may provide new insights not only on regenerative features and physiology of these cells, but also on reprogramming-associated and age-related epigenetic derangement.
journal_name
Genes (Basel)journal_title
Genesauthors
Ravaioli F,Bacalini MG,Franceschi C,Garagnani Pdoi
10.3390/genes9010039subject
Has Abstractpub_date
2018-01-16 00:00:00issue
1issn
2073-4425pii
genes9010039journal_volume
9pub_type
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