Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors.

abstract：:Vavilovia formosa is a relict leguminous plant growing in hard-to-reach habitats in the rocky highlands of the Caucasus and Middle East, and it is considered as the putative closest living relative of the last common ancestor (LCA) of the Fabeae tribe. Symbionts of Vavilovia belonging to Rhizobium leguminosarum bv. vi...

journal_title：Genes

authors： Chirak ER,Kimeklis AK,Karasev ES,Kopat VV,Safronova VI,Belimov AA,Aksenova TS,Kabilov MR,Provorov NA,Andronov EE

更新日期：2019-12-01 00:00:00

abstract：:Lysosomal storage disorders (LSDs) represent a group of more than 50 severe metabolic diseases caused by the deficiency of specific lysosomal hydrolases, activators, carriers, or lysosomal integral membrane proteins, leading to the abnormal accumulation of substrates within the lysosomes. Numerous mutations have been ...

journal_title：Genes

authors： Dardis A,Buratti E

更新日期：2018-02-06 00:00:00

abstract：:The southern elephant seal Mirounga leonina is the largest phocid seal and one of the two species of elephant seals. They are listed as 'least concern' by the International Union for Conservation of Nature (IUCN) Red List of Threatened Species 2015. Here, we have assembled the reference genome for M. leonina using the...

journal_title：Genes

authors： Kim BM,Lee YJ,Kim JH,Kim JH,Kang S,Jo E,Lee SJ,Lee JH,Chi YM,Park H

更新日期：2020-02-03 00:00:00

abstract：:White mold (WM) is a devastating fungal disease affecting common bean (Phaseolus vulgaris L.). In this research, a genome-wide association study (GWAS) for WM resistance was conducted using 294 lines of the Spanish diversity panel. One single-locus method and six multi-locus methods were used in the GWAS. Response to ...

journal_title：Genes

authors： Campa A,García-Fernández C,Ferreira JJ

更新日期：2020-12-12 00:00:00

abstract：:Elite athlete status is a partially heritable trait, as are many of the underpinning physiological, anthropometrical, and psychological traits that contribute to elite performance. In recent years, our understanding of the specific genetic variants that contribute to these traits has grown, such that there is consider...

journal_title：Genes

authors： Pickering C,Kiely J,Grgic J,Lucia A,Del Coso J

更新日期：2019-11-26 00:00:00

abstract：:In genome analysis, k-mer-based comparison methods have become standard tools. However, even though they are able to deliver reliable results, other algorithms seem to work better in some cases. To improve k-mer-based DNA sequence analysis and comparison, we successfully checked whether adding positional resolution is...

journal_title：Genes

authors： Sievers A,Bosiek K,Bisch M,Dreessen C,Riedel J,Froß P,Hausmann M,Hildenbrand G

更新日期：2017-04-19 00:00:00

abstract：:DNA double-strand breaks (DSBs) jeopardize genome integrity and can-when repaired unfaithfully-give rise to structural rearrangements associated with cancer. Exogenous agents such as ionizing radiation or chemotherapy can invoke DSBs, but a vast amount of breakage arises during vital endogenous DNA transactions, such ...

journal_title：Genes

authors： Bouwman BAM,Crosetto N

更新日期：2018-12-14 00:00:00

abstract：:The woody Sonchus alliance consists primarily of woody species of the genus Sonchus (subgenus Dendrosonchus; family Asteraceae). Most members of the alliance are endemic to the oceanic archipelagos in the phytogeographic region of Macaronesia. They display extensive morphological, ecological, and anatomical diversity,...

journal_title：Genes

authors： Cho MS,Yang JY,Yang TJ,Kim SC

更新日期：2019-03-14 00:00:00

abstract：:Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...

journal_title：Genes

authors： Arruda PSS,Ferreira DC,Oliveira C,Venere PC

更新日期：2019-08-23 00:00:00

abstract：:At each round of cell division, the DNA must be correctly duplicated and distributed between the two daughter cells to maintain genome identity. In order to achieve proper chromosome replication and segregation, sister chromatids must be recognized as such and kept together until their separation. This process of cohe...

journal_title：Genes

authors： Finardi A,Massari LF,Visintin R

更新日期：2020-08-07 00:00:00

abstract：:In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This study aimed to identity candidate genes related to growth of duck skele...

journal_title：Genes

authors： Hu Z,Cao J,Liu G,Zhang H,Liu X

更新日期：2020-10-20 00:00:00

abstract：:Circadian clocks in eukaryotes involve both transcriptional-translational feedback loops, post-translational regulation, and metabolic, non-transcriptional oscillations. We recently identified the involvement of circadian oscillations in the intracellular concentrations of magnesium ions (Mg2+i) that were conserved in...

journal_title：Genes

authors： Feord HK,Dear FEG,Obbard DJ,van Ooijen G

更新日期：2019-02-19 00:00:00

abstract：:One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by the activation of a telomere maintenance mechanism (TMM). The majority of cancers reactivate the reverse transcriptase, telomerase, to maintain their telomere length but a minority (10% to 15%) utilize an alternative lengt...

journal_title：Genes

authors： Sommer A,Royle NJ

更新日期：2020-01-27 00:00:00

abstract：:The telomerase RNA in yeasts is large, usually >1000 nt, and contains functional elements that have been extensively studied experimentally in several disparate species. Nevertheless, they are very difficult to detect by homology-based methods and so far have escaped annotation in the majority of the genomes of Saccha...

journal_title：Genes

authors： Waldl M,Thiel BC,Ochsenreiter R,Holzenleiter A,de Araujo Oliveira JV,Walter MEMT,Wolfinger MT,Stadler PF

更新日期：2018-07-26 00:00:00

abstract：:RabGTPase activating proteins (RabGAP) are responsible for directing the deactivation of vesicular trafficking master regulators associated to plant development, the RabGTPase proteins. Recently, RabGAPs were identified in Arabidopsis and rice, but studies were not yet reported in tomato. Herein, we identified 24 RabG...

journal_title：Genes

authors： Madrid-Espinoza J,Salinas-Cornejo J,Ruiz-Lara S

更新日期：2019-08-23 00:00:00

abstract：:GOLDEN2-LIKE (GLK) is a member of the myeloblastosis (MYB) family transcription factor and it plays an important role in the regulation of plastid development and stress tolerance. In this study, a gene named AhGLK1b was identified from a cultivated peanut showing down-regulation in response to low calcium with a comp...

journal_title：Genes

authors： Ali N,Chen H,Zhang C,Khan SA,Gandeka M,Xie D,Zhuang W

更新日期：2020-03-24 00:00:00

abstract：:Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated...

journal_title：Genes

authors： Agosto LM,Gagne M,Henderson AJ

更新日期：2015-09-30 00:00:00

abstract：:Gene doping, an activity which abuses and misuses gene therapy, is a major concern in sports and horseracing industries. Effective methods capable of detecting and monitoring gene doping are urgently needed. Although several PCR-based methods that detect transgenes have been developed, many of them focus only on a sin...

journal_title：Genes

authors： Tozaki T,Ohnuma A,Kikuchi M,Ishige T,Kakoi H,Hirota KI,Kusano K,Nagata SI

更新日期：2020-04-23 00:00:00

abstract：:Bone mineral density (BMD) is of concern in Prader-Willi syndrome (PWS). This study compared responses to a physical activity intervention in bone parameters and remodeling markers in youth with PWS (n = 45) and youth with non-syndromic obesity (NSO; n = 66). Measurements occurred at baseline (PRE) and after 24 weeks ...

journal_title：Genes

authors： Rubin DA,Wilson KS,Orsso CE,Gertz ER,Haqq AM,Castner DM,Dumont-Driscoll M

更新日期：2020-08-24 00:00:00

abstract：:Amazonian puffing snakes (Spilotes; Colubridae) are snakes widely distributed in the Neotropical region. However, chromosomal data are scarce in this group and, when available, are only limited to karyotype description using conventional staining. In this paper, we focused on the process of karyotype evolution and tre...

journal_title：Genes

authors： Viana PF,Ezaz T,de Bello Cioffi M,Jackson Almeida B,Feldberg E

更新日期：2019-04-09 00:00:00

abstract：:Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...

journal_title：Genes

authors： Boeger H,Shelansky R,Patel H,Brown CR

更新日期：2015-06-30 00:00:00

abstract：:Vitellogenin receptors (VgRs) play critical roles in egg formation by transporting vitellogenin (Vg) into oocytes in insects. Although the function of VgR in insects is well studied, the transcriptional regulation of this gene is still unclear. Here, we cloned the promoter of the VgR gene from Bombyx mori (BmVgR), and...

journal_title：Genes

authors： Shen G,Chen E,Ji X,Liu L,Liu J,Hua X,Li D,Xiao Y,Xia Q

更新日期：2020-04-06 00:00:00

abstract：:Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and...

journal_title：Genes

authors： Pewan SB,Otto JR,Huerlimann R,Budd AM,Mwangi FW,Edmunds RC,Holman BWB,Henry MLE,Kinobe RT,Adegboye OA,Malau-Aduli AEO

更新日期：2020-05-25 00:00:00

abstract：:Serotonin receptor 2A (HTR2A) is an important signalling factor implicated in cognitive functions and known to be associated with schizophrenia. The biological significance of HTR2A in schizophrenia remains unclear as molecular analyses including genetic association, mRNA expression and methylation studies have report...

journal_title：Genes

authors： Cheah SY,Lawford BR,Young RM,Morris CP,Voisey J

更新日期：2017-01-04 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. An ALS drug, Riluzole, has been shown to induce two different anticancer effects on hepatocellular carcinoma (HCC). In light of this finding, we explore the relationship between ALS and cancer, especially for HCC, from the molecular biological v...

journal_title：Genes

authors： Taguchi YH,Wang H

更新日期：2017-09-27 00:00:00

abstract：:Tetralin (1,2,3,4-tetrahydonaphthalene) is a recalcitrant compound that consists of an aromatic and an alicyclic ring. It is found in crude oils, produced industrially from naphthalene or anthracene, and widely used as an organic solvent. Its toxicity is due to the alteration of biological membranes by its hydrophobic...

journal_title：Genes

authors： Floriano B,Santero E,Reyes-Ramírez F

更新日期：2019-05-06 00:00:00

abstract：:The Zn(II)₂Cys₆ zinc cluster gene family is a subclass of zinc-finger proteins, which are transcriptional regulators involved in a wide variety of biological processes in fungi. We performed genome-wide identification and characterization of Zn(II)₂Cys₆ zinc-cluster gene (C6 zinc gene) family in Tolypocladiumguangdong...

journal_title：Genes

authors： Zhang C,Huang H,Deng W,Li T

更新日期：2019-02-26 00:00:00

abstract：:White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other ...

journal_title：Genes

authors： Bao W,Tang KFJ,Alcivar-Warren A

更新日期：2020-01-14 00:00:00

abstract：:Gene expression in the brain is dramatically regulated by a variety of stimuli. While the role of neural activity has been extensively studied, less is known about the effects of metabolism and nutrition on transcriptional control mechanisms in the brain. Extracellular signals are integrated at the chromatin level thr...

journal_title：Genes

authors： Pizzorusso T,Tognini P

更新日期：2020-07-03 00:00:00

abstract：:Trees and their seeds regulate their germination, growth, and reproduction in response to environmental stimuli. These stimuli, through signal transduction, trigger transcription factors that alter the expression of various genes leading to the unfolding of the genetic program. A regulon is conceptually defined as a s...

journal_title：Genes

authors： Xia X

更新日期：2020-08-25 00:00:00