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Repression of Inappropriate Gene Expression in the Vertebrate Embryonic Ectoderm.

Abstract：

:During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organism. An early critical step during vertebrate development is the formation of the three primary germ layers-ectoderm, mesoderm, and endoderm-which emerge during the process of gastrulation. While much attention has been focused on the induction of mesoderm and endoderm, it has become clear that differentiation of the ectoderm involves more than the simple absence of inductive cues; rather, it additionally requires the inhibition of mesendoderm-promoting genes. This review aims to summarize our current understanding of the various inhibitors of inappropriate gene expression in the presumptive ectoderm.

journal_name

Genes (Basel)

journal_title

Genes

authors

Reich S,Weinstein DC

doi

10.3390/genes10110895

subject

Has Abstract

pub_date

2019-11-06 00:00:00

issue

11

issn

2073-4425

pii

genes10110895

journal_volume

10

pub_type

杂志文章,评审

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