Golgi Reassembly and Stacking Protein (GRASP) Participates in Vesicle-Mediated RNA Export in Cryptococcus Neoformans.

abstract：:The telomerase RNA in yeasts is large, usually >1000 nt, and contains functional elements that have been extensively studied experimentally in several disparate species. Nevertheless, they are very difficult to detect by homology-based methods and so far have escaped annotation in the majority of the genomes of Saccha...

journal_title：Genes

authors： Waldl M,Thiel BC,Ochsenreiter R,Holzenleiter A,de Araujo Oliveira JV,Walter MEMT,Wolfinger MT,Stadler PF

更新日期：2018-07-26 00:00:00

abstract：:Xeroderma pigmentosum group C (XPC) is a key component of the nucleotide excision repair (NER) pathway. Dysfunctional XPC protein may impair NER-mediated DNA repair capacity and further lead to genomic instability and carcinogenesis. Two common nonsynonymous polymorphisms in the XPC gene, Lys939Gln (rs2228001 A > C) a...

journal_title：Genes

authors： Hua RX,Zhu J,Jiang DH,Zhang SD,Zhang JB,Xue WQ,Li XZ,Zhang PF,He J,Jia WH

更新日期：2016-09-24 00:00:00

abstract：:In angiosperms, meiotic failure coupled with the formation of genetically unreduced gametophytes in ovules (apomeiosis) constitute major components of gametophytic apomixis. These aberrant developmental events are generally thought to be caused by mutation. However, efforts to locate the responsible mutations have fai...

journal_title：Genes

authors： Mateo de Arias M,Gao L,Sherwood DA,Dwivedi KK,Price BJ,Jamison M,Kowallis BM,Carman JG

更新日期：2020-12-02 00:00:00

abstract：:Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...

journal_title：Genes

authors： Gimenez E,Manzano-Agugliaro F

更新日期：2017-10-30 00:00:00

abstract：:Quorum sensing (QS) is a cell-to-cell communication system that uses autoinducers as signaling molecules to enable inter-species and intra-species interactions in response to external stimuli according to the population density. QS allows bacteria such as Acinetobacter baumannii to react rapidly in response to environ...

journal_title：Genes

authors： Ng CK,How KY,Tee KK,Chan KG

更新日期：2019-04-08 00:00:00

abstract：:The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding ...

journal_title：Genes

authors： Cui J,Liu X,Yang L,Che S,Guo H,Han J,Zhu Z,Cao B,An X,Zhang L,Song Y

更新日期：2020-09-07 00:00:00

abstract：:A large number of studies have focused on identifying molecular biomarkers, including microRNAs (miRNAs) to aid in the diagnosis and prognosis of the most common subtypes of non-Hodgkin lymphoma (NHL), Diffuse Large B-cell Lymphoma and Follicular Lymphoma. NHL is difficult to diagnose and treat with many cases becomin...

journal_title：Genes

authors： Bradshaw G,Sutherland HG,Haupt LM,Griffiths LR

更新日期：2016-12-17 00:00:00

abstract：:Variants of the LOXHD1 gene, which are expressed in hair cells of the cochlea and vestibule, have been reported to cause a progressive form of autosomal recessive non-syndromic hereditary hearing loss, DFNB77. In this study, genetic screening was conducted on 8074 Japanese hearing loss patients utilizing massively par...

journal_title：Genes

authors： Maekawa K,Nishio SY,Abe S,Goto SI,Honkura Y,Iwasaki S,Kanda Y,Kobayashi Y,Oka SI,Okami M,Oshikawa C,Sakuma N,Sano H,Shirakura M,Uehara N,Usami SI

更新日期：2019-09-23 00:00:00

abstract：:Smoltification and early seawater phase are critical developmental periods with physiological and biochemical changes in Atlantic salmon that facilitates survival in saltwater. MicroRNAs (miRNAs) are known to have important roles in development, but whether any miRNAs are involved in regulation of gene expression duri...

journal_title：Genes

authors： Shwe A,Østbye TK,Krasnov A,Ramberg S,Andreassen R

更新日期：2020-09-08 00:00:00

abstract：:Colorectal cancer is the fourth most common neoplasia in Europe, where it accounts for 28.2 new cases per 100,000 inhabitants. In an effort to decrease the incidence of this disease, various prevention measures are being studied, one of which are anthocyanin-rich foods. Anthocyanins are potent antioxidant flavonoids m...

journal_title：Genes

authors： Fernández J,García L,Monte J,Villar CJ,Lombó F

更新日期：2018-03-01 00:00:00

abstract：:DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that needs to be faithfully replicated during mitosis in order to maintain cell phenotype during successive cell divisions. This epigenetic mark is located on the 5'-carbon of the cytosine mainly within cytosine⁻phosphate⁻guanine (CpG)...

journal_title：Genes

authors： Bronner C,Alhosin M,Hamiche A,Mousli M

更新日期：2019-01-18 00:00:00

abstract：:Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa an...

journal_title：Genes

authors： Djuicy DD,Hearn J,Tchouakui M,Wondji MJ,Irving H,Okumu FO,Wondji CS

更新日期：2020-11-05 00:00:00

abstract：:Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alzheimer's disease ma...

journal_title：Genes

authors： Chakravarthy M,Veedu RN

更新日期：2019-09-12 00:00:00

abstract：:Scutellaria baicalensis Georgi (Lamiaceae) is the source of the well-known traditional Chinese medicine "HuangQin" (Radix Scutellariae). Natural sources of S. baicalensis are rapidly declining due to high market demand and overexploitation. Moreover, the commercial products of Radix Scutellariae have often been found ...

journal_title：Genes

authors： Jiang D,Zhao Z,Zhang T,Zhong W,Liu C,Yuan Q,Huang L

更新日期：2017-09-13 00:00:00

abstract：:The P-type plasma membrane (PM) H+-ATPase plays a major role during the growth and development of a plant. It is also involved in plant resistance to a variety of biotic and abiotic factors, including salt stress. The PM H+-ATPase gene family has been well characterized in Arabidopsis and other crop plants such as ric...

journal_title：Genes

authors： Xu Z,Marowa P,Liu H,Du H,Zhang C,Li Y

更新日期：2020-03-27 00:00:00

abstract：:MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...

journal_title：Genes

authors： Bardot B,Toledo F

更新日期：2017-02-20 00:00:00

abstract：:Autoimmune blistering dermatoses (ABDs) are characterized by autoantibodies to keratinocyte surface antigens and molecules within the dermal-epidermal junction causing disruption of skin integrity. The affinity of Fc receptors (FcRs) causing an autoimmune response in ABDs may vary based on single-nucleotide polymorphi...

journal_title：Genes

authors： Gornowicz-Porowska J,Kowalczyk MJ,Seraszek-Jaros A,Bowszyc-Dmochowska M,Kaczmarek E,Żaba R,Dmochowski M

更新日期：2020-03-30 00:00:00

abstract：:White mold (WM) is a devastating fungal disease affecting common bean (Phaseolus vulgaris L.). In this research, a genome-wide association study (GWAS) for WM resistance was conducted using 294 lines of the Spanish diversity panel. One single-locus method and six multi-locus methods were used in the GWAS. Response to ...

journal_title：Genes

authors： Campa A,García-Fernández C,Ferreira JJ

更新日期：2020-12-12 00:00:00

abstract：:Novel coat colour phenotypes often emerge during domestication, and there is strong evidence of genetic selection for the two main genes that control base coat colour in horses-ASIP and MC1R. These genes direct the type of pigment produced, red pheomelanin (MC1R) or black eumelanin (ASIP), as well as the relative conc...

journal_title：Genes

authors： Corbin LJ,Pope J,Sanson J,Antczak DF,Miller D,Sadeghi R,Brooks SA

更新日期：2020-05-30 00:00:00

abstract：:Lysosomal storage disorders (LSDs) represent a group of more than 50 severe metabolic diseases caused by the deficiency of specific lysosomal hydrolases, activators, carriers, or lysosomal integral membrane proteins, leading to the abnormal accumulation of substrates within the lysosomes. Numerous mutations have been ...

journal_title：Genes

authors： Dardis A,Buratti E

更新日期：2018-02-06 00:00:00

abstract：:In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatmen...

journal_title：Genes

authors： Mellert K,Uhl M,Högel J,Lamla M,Kemkemer R,Kaufmann D

更新日期：2011-08-02 00:00:00

abstract：:In this review we present the developmental, histological, evolutionary and functional properties of insect chemosensory proteins (CSPs) in insect species. CSPs are small globular proteins folded like a prism and notoriously known for their complex and arguably obscure function(s), particularly in pheromone olfaction....

journal_title：Genes

authors： Liu G,Xuan N,Rajashekar B,Arnaud P,Offmann B,Picimbon JF

更新日期：2020-04-10 00:00:00

abstract：:Xyloglucan endotransglycosylase/hydrolase (XTH) is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. In this study, 48 XTH genes were identified from two pineapple (Ananas comosus) cultivars ('F153' and 'MD2') and designated Ac(F153)XTH1 to -24 and Ac(MD2)XTH1...

journal_title：Genes

authors： Li Q,Li H,Yin C,Wang X,Jiang Q,Zhang R,Ge F,Chen Y,Yang L

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...

journal_title：Genes

authors： Zhang Z,Conner J,Guo Y,Ozias-Akins P

更新日期：2020-09-12 00:00:00

abstract：:The plant circadian clock coordinates environmental signals with internal processes including secondary metabolism, growth, flowering, and volatile emission. Plant tissues are specialized in different functions, and petals conceal the sexual organs while attracting pollinators. Here we analyzed the transcriptional str...

journal_title：Genes

authors： Terry MI,Carrera-Alesina M,Weiss J,Egea-Cortines M

更新日期：2019-10-30 00:00:00

abstract：:Preimplantation genetic testing (PGT) has evolved into a well-established alternative to invasive prenatal diagnosis, even though genetic testing of single or few cells is quite challenging. PGT-M is in theory available for any monogenic disorder for which the disease-causing locus has been unequivocally identified. I...

journal_title：Genes

authors： De Rycke M,Berckmoes V

更新日期：2020-07-31 00:00:00

abstract：:The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for mo...

journal_title：Genes

authors： Esposito U,Das R,Syed S,Pirooznia M,Elhaik E

更新日期：2018-12-12 00:00:00

abstract：:DNA Helicase B (HELB) is a conserved helicase in higher eukaryotes with roles in the initiation of DNA replication and in the DNA damage and replication stress responses. HELB is a predominately nuclear protein in G1 phase where it is involved in initiation of DNA replication through interactions with DNA topoisomeras...

journal_title：Genes

authors： Hazeslip L,Zafar MK,Chauhan MZ,Byrd AK

更新日期：2020-05-21 00:00:00

abstract：:Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...

journal_title：Genes

authors： Balaji S,Napolitano T,Silvano S,Friano ME,Garrido-Utrilla A,Atlija J,Collombat P

更新日期：2018-09-07 00:00:00

abstract：:Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For ...

journal_title：Genes

authors： Klymenko SV,Smida J,Atkinson MJ,Bebeshko VG,Nathrath M,Rosemann M

更新日期：2011-05-31 00:00:00