Pathogenicity Islands Distribution in Non-O157 Shiga Toxin-Producing Escherichia coli (STEC).

abstract：:The histone-like nucleoid structuring protein (H-NS) has played a key role in shaping the evolution of Shigella spp., and provides the backdrop to the regulatory cascade that controls virulence by silencing many genes found on the large virulence plasmid. H-NS and its paralogue StpA are present in all four Shigella sp...

journal_title：Genes

authors： Picker MA,Wing HJ

更新日期：2016-12-01 00:00:00

abstract：:Wnt is a complex signaling pathway involved in the regulation of crucial biological functions such as development, proliferation, differentiation and migration of cells, mainly stem cells, which are virtually present in all embryonic and adult tissues. Conversely, dysregulation of Wnt signal is implicated in developme...

journal_title：Genes

authors： Zuccarini M,Giuliani P,Ziberi S,Carluccio M,Iorio PD,Caciagli F,Ciccarelli R

更新日期：2018-02-17 00:00:00

abstract：:Blumeria graminis f. sp. hordei (Bgh), the causal agent of barley powdery mildew (PM), is one of the most important barley leaf diseases and is prevalent in most barley growing regions. Infection decreases grain quality and yields on average by 30%. Multi-parent advanced generation inter-cross (MAGIC) populations comb...

journal_title：Genes

authors： Novakazi F,Krusell L,Jensen JD,Orabi J,Jahoor A,Bengtsson T,On Behalf Of The Ppp Barley Consortium

更新日期：2020-12-18 00:00:00

abstract：:Our current knowledge of B chromosome biology has been augmented by an increase in the number and diversity of species observed to carry B chromosomes as well as the use of next-generation sequencing for B chromosome genomic analysis. Within the genus Drosophila, B chromosomes have been observed in a handful of specie...

journal_title：Genes

authors： Hanlon SL,Hawley RS

更新日期：2018-09-27 00:00:00

abstract：:Several transcription factors (TFs) coordinate to regulate expression of specific genes at the transcriptional level. In Arabidopsis thaliana it is estimated that approximately 10% of all genes encode TFs or TF-like proteins. It is important to identify target genes that are directly regulated by TFs in order to under...

journal_title：Genes

authors： Kurihara Y,Makita Y,Kawashima M,Hamasaki H,Yamamoto YY,Matsui M

更新日期：2014-12-19 00:00:00

abstract：:The grizzly bear (Ursus arctos ssp. horribilis) represents the largest population of brown bears in North America. Its genome was sequenced using a microfluidic partitioning library construction technique, and these data were supplemented with sequencing from a nanopore-based long read platform. The final assembly was...

journal_title：Genes

authors： Taylor GA,Kirk H,Coombe L,Jackman SD,Chu J,Tse K,Cheng D,Chuah E,Pandoh P,Carlsen R,Zhao Y,Mungall AJ,Moore R,Birol I,Franke M,Marra MA,Dutton C,Jones SJM

更新日期：2018-11-30 00:00:00

abstract：:DNA damage leads to genome instability by interfering with DNA replication. Cells possess several damage bypass pathways that mitigate the effects of DNA damage during replication. These pathways include translesion synthesis and template switching. These pathways are regulated largely through post-translational modif...

journal_title：Genes

authors： Ripley BM,Gildenberg MS,Washington MT

更新日期：2020-01-29 00:00:00

abstract：:At each round of cell division, the DNA must be correctly duplicated and distributed between the two daughter cells to maintain genome identity. In order to achieve proper chromosome replication and segregation, sister chromatids must be recognized as such and kept together until their separation. This process of cohe...

journal_title：Genes

authors： Finardi A,Massari LF,Visintin R

更新日期：2020-08-07 00:00:00

abstract：:The SLC6A4 gene has been implicated in psychiatric disorder susceptibility and antidepressant response variability. The SLC6A4 promoter is defined by a variable number of homologous 20-24 bp repeats (5-HTTLPR), and long (L) and short (S) alleles are associated with higher and lower expression, respectively. However, t...

journal_title：Genes

authors： Botton MR,Yang Y,Scott ER,Desnick RJ,Scott SA

更新日期：2020-11-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. An ALS drug, Riluzole, has been shown to induce two different anticancer effects on hepatocellular carcinoma (HCC). In light of this finding, we explore the relationship between ALS and cancer, especially for HCC, from the molecular biological v...

journal_title：Genes

authors： Taguchi YH,Wang H

更新日期：2017-09-27 00:00:00

abstract：:Gene expression in the brain is dramatically regulated by a variety of stimuli. While the role of neural activity has been extensively studied, less is known about the effects of metabolism and nutrition on transcriptional control mechanisms in the brain. Extracellular signals are integrated at the chromatin level thr...

journal_title：Genes

authors： Pizzorusso T,Tognini P

更新日期：2020-07-03 00:00:00

abstract：:Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and autism spectrum disorder, and among those with fragile X syndrome, approximately 1/3rd meet a threshold for an autism spectrum disorder (ASD) diagnosis. Previous functional imaging studies of fragile X syndrome have typically fo...

journal_title：Genes

authors： McKechanie AG,Campbell S,Eley SEA,Stanfield AC

更新日期：2019-12-17 00:00:00

abstract：:Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minirevi...

journal_title：Genes

authors： Walker RSK,Pretorius IS

更新日期：2018-07-06 00:00:00

abstract：:Modulated electromagnetic fields (wEMFs), as generated by modern communication technologies, have raised concerns about adverse health effects. The International Agency for Research on Cancer (IARC) classifies them as "possibly carcinogenic to humans" (Group 2B), yet, the underlying molecular mechanisms initiating and...

journal_title：Genes

authors： Schuermann D,Ziemann C,Barekati Z,Capstick M,Oertel A,Focke F,Murbach M,Kuster N,Dasenbrock C,Schär P

更新日期：2020-03-25 00:00:00

abstract：:The microRNA (miR)-17 family is widely expressed in mammalian tissues and play important roles in various physiological and pathological processes. Here, the functions of miR-106a-5p, a member of miR-17 family, were explored during myogenic differentiation in C2C12 cell line. First, miR-106a-5p was found to be relativ...

journal_title：Genes

authors： Li X,Zhu Y,Zhang H,Ma G,Wu G,Xiang A,Shi X,Yang GS,Sun S

更新日期：2018-07-02 00:00:00

abstract：:Gene duplication is an important evolutionary mechanism allowing to provide new genetic material and thus opportunities to acquire new gene functions for an organism, with major implications such as speciation events. Various processes are known to allow a gene to be duplicated and different models explain how duplica...

journal_title：Genes

authors： Lallemand T,Leduc M,Landès C,Rizzon C,Lerat E

更新日期：2020-09-04 00:00:00

abstract：:Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of...

journal_title：Genes

authors： Ravaioli F,Bacalini MG,Franceschi C,Garagnani P

更新日期：2018-01-16 00:00:00

abstract：:Long non-coding (lnc) RNAs serve a multitude of functions in cells. NEAT1 RNA is a highly abundant 4 kb lncRNA in nuclei, and coincides with paraspeckles, nuclear domains that control sequestration of paraspeckle proteins. We examined NEAT1 RNA levels and its function in 3T3-L1 cells during differentiation to adipocyt...

journal_title：Genes

authors： Cooper DR,Carter G,Li P,Patel R,Watson JE,Patel NA

更新日期：2014-11-27 00:00:00

abstract：:The complete mutational spectrum of dystrophinopathies and limb-girdle muscular dystrophy (LGMD) remains unknown in Mexican population. Seventy-two unrelated Mexican male patients (73% of pediatric age) with clinical suspicion of muscular dystrophy and no evidence of DMD gene deletion on multiplex polymerase chain rea...

journal_title：Genes

authors： Alcántara-Ortigoza MA,Reyna-Fabián ME,González-Del Angel A,Estandia-Ortega B,Bermúdez-López C,Cruz-Miranda GM,Ruíz-García M

更新日期：2019-10-29 00:00:00

abstract：:Roan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-roan ratio of foals ...

journal_title：Genes

authors： Voß K,Tetens J,Thaller G,Becker D

更新日期：2020-06-22 00:00:00

abstract：:Root nodule symbioses (nodulation) and whole genome duplication (WGD, polyploidy) are both important phenomena in the legume family (Leguminosae). Recently, it has been proposed that polyploidy may have played a critical role in the origin or refinement of nodulation. However, while nodulation and polyploidy have been...

journal_title：Genes

authors： Powell AF,Doyle JJ

更新日期：2017-11-30 00:00:00

abstract：:Hypersialylation caused by the overexpression of sialyltransferases (STs) is a common feature in cancer that is associated with several characteristics of tumorigenesis. Thus, identifying cancer-associated STs is critical for cancer therapy. However, ST screening has been frequently conducted in cell line models. In t...

journal_title：Genes

authors： Kan JY,Moi SH,Hung WC,Hou MF,Chen FM,Shih SL,Shiau JP,Li CL,Chiang CP

更新日期：2020-11-28 00:00:00

abstract：:Transfer RNA (tRNA) is a dynamic molecule used by all forms of life as a key component of the translation apparatus. Each tRNA is highly processed, structured, and modified, to accurately deliver amino acids to the ribosome for protein synthesis. The tRNA molecule is a critical component in synthetic biology methods f...

journal_title：Genes

authors： Hoffman KS,Crnković A,Söll D

更新日期：2018-11-07 00:00:00

abstract：:Cell Division Autoantigen 1 (CDA1) was discovered following screening a human expression library with serum from a patient with Discoid Lupus Erythematosus. CDA1, encoded by TSPYL2 on the X chromosome, shares anti-proliferative and pro‑fibrotic properties with TGF-b. It inhibits cell growth through p53, pERK1/2 and p2...

journal_title：Genes

authors： Toh BH,Tu Y,Cao Z,Cooper ME,Chai Z

更新日期：2010-09-30 00:00:00

abstract：:coalescence methods have emerged as a popular alternative for inferring species trees with large genomic datasets, because these methods explicitly account for incomplete lineage sorting. However, statistical consistency of summary coalescence methods is not guaranteed unless several model assumptions are true, includ...

journal_title：Genes

authors： Springer MS,Gatesy J

更新日期：2018-02-26 00:00:00

abstract：:As a major infectious disease in chickens, Newcastle disease virus (NDV) causes considerable economic losses in the poultry industry, especially in developing countries where there is limited access to effective vaccination. Therefore, enhancing resistance to the virus in commercial chickens through breeding is a prom...

journal_title：Genes

authors： Zhang J,Kaiser MG,Gallardo RA,Kelly TR,Dekkers JCM,Zhou H,Lamont SJ

更新日期：2020-08-26 00:00:00

abstract：:The P-type plasma membrane (PM) H+-ATPase plays a major role during the growth and development of a plant. It is also involved in plant resistance to a variety of biotic and abiotic factors, including salt stress. The PM H+-ATPase gene family has been well characterized in Arabidopsis and other crop plants such as ric...

journal_title：Genes

authors： Xu Z,Marowa P,Liu H,Du H,Zhang C,Li Y

更新日期：2020-03-27 00:00:00

abstract：:Neural stem cells (NSCs) are capable of producing a variety of neural cell types, and are indispensable for the development of the mammalian brain. NSCs can be induced in vitro from pluripotent stem cells, including embryonic stem cells and induced-pluripotent stem cells. Although the transplantation of these exogenou...

journal_title：Genes

authors： Kaneko N,Kako E,Sawamoto K

更新日期：2011-01-14 00:00:00

abstract：:The continuous development of new genotyping technologies requires awareness of their potential advantages and limitations concerning utility for pharmacogenomics (PGx). In this review, we provide an overview of technologies that can be applied in PGx research and clinical practice. Most commonly used are single nucle...

journal_title：Genes

authors： van der Lee M,Kriek M,Guchelaar HJ,Swen JJ

更新日期：2020-12-04 00:00:00

abstract：:Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...

journal_title：Genes

authors： Li S,Zhou H,Gong H,Zhao F,Wang J,Liu X,Luo Y,Hickford JG

更新日期：2017-01-11 00:00:00