Abstract:
:Neural stem cells (NSCs) are capable of producing a variety of neural cell types, and are indispensable for the development of the mammalian brain. NSCs can be induced in vitro from pluripotent stem cells, including embryonic stem cells and induced-pluripotent stem cells. Although the transplantation of these exogenous NSCs is a potential strategy for improving presently untreatable neurological conditions, there are several obstacles to its implementation, including tumorigenic, immunological, and ethical problems. Recent studies have revealed that NSCs also reside in the adult brain. The endogenous NSCs are activated in response to disease or trauma, and produce new neurons and glia, suggesting they have the potential to regenerate damaged brain tissue while avoiding the above-mentioned problems. Here we present an overview of the possibility and limitations of using endogenous NSCs in regenerative medicine.
journal_name
Genes (Basel)journal_title
Genesauthors
Kaneko N,Kako E,Sawamoto Kdoi
10.3390/genes2010107subject
Has Abstractpub_date
2011-01-14 00:00:00pages
107-30issue
1issn
2073-4425pii
genes2010107journal_volume
2pub_type
杂志文章相关文献
Genes文献大全abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100269
更新日期:2017-10-13 00:00:00
abstract::The mutation parameter θ is fundamental and ubiquitous in the analysis of population samples of DNA sequences. This paper presents a new highly efficient estimator of θ by utilizing the phylogenetic information among distinct alleles in a sample of DNA sequences. The new estimator, called Allelic BLUE, is derived from...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes5030561
更新日期:2014-07-22 00:00:00
abstract:BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10080568
更新日期:2019-07-26 00:00:00
abstract::Cell size affects almost all biosynthetic processes by controlling the size of organelles and disrupting the nutrient uptake process. Yeast cells must reach a critical size to be able to enter a new cell cycle stage. Abnormal changes in cell size are often observed under pathological conditions such as cancer disease....
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11040430
更新日期:2020-04-16 00:00:00
abstract::Rust caused by the fungus Puccinia helianthi and downy mildew (DM) caused by the obligate pathogen Plasmopara halstedii are two of the most globally important sunflower diseases. Resistance to rust and DM is controlled by race-specific single dominant genes. The present study aimed at pyramiding rust resistance genes ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010010
更新日期:2019-12-20 00:00:00
abstract::Plants grown under highly variable natural light regimes differ strongly from plants grown under constant light (CL) regimes. Plant phenotype and adaptation responses are important for plant biomass and fitness. However, the underlying regulatory mechanisms are still poorly understood, particularly from a transcriptio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090662
更新日期:2019-08-29 00:00:00
abstract::The efficient extraction of DNA from challenging samples, such as bones, is critical for the success of downstream genotyping analysis in molecular genetic disciplines. Even though the ancient DNA community has developed several protocols targeting small DNA fragments that are typically present in decomposed or old sp...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes12020146
更新日期:2021-01-22 00:00:00
abstract::In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, we employed BE and PE mRNAs in conjunction with chemically synthesized sgRNAs and pegRNAs for efficient editing of human i...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050511
更新日期:2020-05-06 00:00:00
abstract::One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by the activation of a telomere maintenance mechanism (TMM). The majority of cancers reactivate the reverse transcriptase, telomerase, to maintain their telomere length but a minority (10% to 15%) utilize an alternative lengt...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11020133
更新日期:2020-01-27 00:00:00
abstract::The superior performance of hybrids to parents, termed heterosis, has been widely utilized in animal and plant breeding programs, but the molecular mechanism underlying heterosis remains an enigma. RNA-Seq provides a novel way to investigate heterosis at the transcriptome-wide level, because gene expression functions ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010027
更新日期:2019-01-07 00:00:00
abstract::Prader-Willi Syndrome Association (USA) monitors the ongoing health and welfare of individuals with Prader-Willi syndrome (PWS) through active communication with members by membership surveys and data registries. Thromboembolism and blood clots have emerged in clinical studies as significant risk factors for injury an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10070550
更新日期:2019-07-19 00:00:00
abstract::The multiple organellar RNA editing factors (MORF) gene family plays a key role in organelle RNA editing in flowering plants. MORF genes expressions are also affected by abiotic stress. Although seven OsMORF genes have been identified in rice, few reports have been published on their expression patterns in different t...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090694
更新日期:2019-09-10 00:00:00
abstract::The SLC6A4 gene has been implicated in psychiatric disorder susceptibility and antidepressant response variability. The SLC6A4 promoter is defined by a variable number of homologous 20-24 bp repeats (5-HTTLPR), and long (L) and short (S) alleles are associated with higher and lower expression, respectively. However, t...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111333
更新日期:2020-11-12 00:00:00
abstract::RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing 11-cis retinal. To date, almost 200 loss-of-function mutations have ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11121420
更新日期:2020-11-27 00:00:00
abstract::Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6041053
更新日期:2015-10-21 00:00:00
abstract::One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8080195
更新日期:2017-08-03 00:00:00
abstract::Modulated electromagnetic fields (wEMFs), as generated by modern communication technologies, have raised concerns about adverse health effects. The International Agency for Research on Cancer (IARC) classifies them as "possibly carcinogenic to humans" (Group 2B), yet, the underlying molecular mechanisms initiating and...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11040347
更新日期:2020-03-25 00:00:00
abstract::Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11070777
更新日期:2020-07-11 00:00:00
abstract::Testis cords are the embryonic precursors of the seminiferous tubules. Development of testis cords is a key event during embryonic testicular morphogenesis and is regulated by multiple signaling molecules produced by Sertoli cells. However, the exact nature and the cascade of molecular events underlying testis cord de...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10120974
更新日期:2019-11-26 00:00:00
abstract::Exposure to Formaldehyde (FA) results in many pathophysiological symptoms, however the underlying mechanisms are not well understood. Given the complicated modulatory role of intestinal microbiota on human health, we hypothesized that interactions between FA and the gut microbiome may account for FA's toxicity. Balb/c...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9040192
更新日期:2018-04-03 00:00:00
abstract::As a major infectious disease in chickens, Newcastle disease virus (NDV) causes considerable economic losses in the poultry industry, especially in developing countries where there is limited access to effective vaccination. Therefore, enhancing resistance to the virus in commercial chickens through breeding is a prom...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091003
更新日期:2020-08-26 00:00:00
abstract::The southern elephant seal Mirounga leonina is the largest phocid seal and one of the two species of elephant seals. They are listed as 'least concern' by the International Union for Conservation of Nature (IUCN) Red List of Threatened Species 2015. Here, we have assembled the reference genome for M. leonina using the...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020160
更新日期:2020-02-03 00:00:00
abstract::Use of genetic markers and genomic prediction might improve genetic gain for quality traits in wheat breeding programs. Here, flour yield and Alveograph quality traits were inspected in 635 F6 winter wheat breeding lines from two breeding cycles. Genome-wide association studies revealed single nucleotide polymorphisms...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090669
更新日期:2019-08-31 00:00:00
abstract::Increasing evidence suggests that dysregulation of microRNAs (miRNAs) may lead to a variety of diseases. Therefore, identifying disease-related miRNAs is a crucial problem. Currently, many computational approaches have been proposed to predict binary miRNA-disease associations. In this study, in order to predict under...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9030139
更新日期:2018-03-02 00:00:00
abstract::Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9010039
更新日期:2018-01-16 00:00:00
abstract::The availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to understand the evolutionary dynamics of their tandem repeat sequences (satellites), as a result of ev...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120351
更新日期:2017-11-28 00:00:00
abstract::Since ancient times, the importance of physical activity (PA) and of a wholesome diet for human health has been clearly recognized. However, only recently, it has been acknowledged that PA can reverse at least some of the unwanted effects of a sedentary lifestyle, contributing to the treatment of pathologies such as h...
journal_title:Genes
pub_type: 社论
doi:10.3390/genes10121043
更新日期:2019-12-16 00:00:00
abstract::The development of high-throughput sequencing technologies and screening of big patient cohorts with familial and sporadic amyotrophic lateral sclerosis (ALS) led to the identification of a significant number of genetic variants, which are sometimes difficult to interpret. The American College of Medical Genetics and ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101123
更新日期:2020-09-24 00:00:00
abstract::Despite a considerable body of published research on hepatitis B in Bangladesh, researchers continue to lament the lack of reliable information about hepatitis B virus (HBV) infection epidemiology. The present review aims to provide a comprehensive survey of the literature with particular focus on a number of epidemio...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9110541
更新日期:2018-11-08 00:00:00
abstract::Bacterial fruit blotch (BFB) causes losses in melon marketable yield. However, until now, there has been no information about the genetic loci responsible for resistance to the disease or their pattern of inheritance. We determined the inheritance pattern of BFB resistance from a segregating population of 491 F2 indiv...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020220
更新日期:2020-02-19 00:00:00