Abstract：
:Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant for metastasis by providing direct access to systemic cancer. CTCs can be used as prognostic markers in cancer patients and are regarded as potential metastatic precursor cells. However, despite substantial technical progress, the detection and molecular characterization of CTCs remain challenging, in particular the analysis of DNA methylation. As recent studies have started to address the epigenetic state of CTCs, we discuss here the potential of such investigations to elucidate mechanisms of metastasis and to develop tumor biomarkers.
journal_name
Genes (Basel)journal_title
Genesauthors
Pixberg CF,Schulz WA,Stoecklein NH,Neves RPdoi
10.3390/genes6041053subject
Has Abstractpub_date
2015-10-21 00:00:00pages
1053-75issue
4issn
2073-4425pii
genes6041053journal_volume
6pub_type
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