Characterization of DNA Methylation in Circulating Tumor Cells.


:Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant for metastasis by providing direct access to systemic cancer. CTCs can be used as prognostic markers in cancer patients and are regarded as potential metastatic precursor cells. However, despite substantial technical progress, the detection and molecular characterization of CTCs remain challenging, in particular the analysis of DNA methylation. As recent studies have started to address the epigenetic state of CTCs, we discuss here the potential of such investigations to elucidate mechanisms of metastasis and to develop tumor biomarkers.


Genes (Basel)




Pixberg CF,Schulz WA,Stoecklein NH,Neves RP




Has Abstract


2015-10-21 00:00:00














  • mRNA Expression and DNA Methylation Analysis of Serotonin Receptor 2A (HTR2A) in the Human Schizophrenic Brain.

    abstract::Serotonin receptor 2A (HTR2A) is an important signalling factor implicated in cognitive functions and known to be associated with schizophrenia. The biological significance of HTR2A in schizophrenia remains unclear as molecular analyses including genetic association, mRNA expression and methylation studies have report...


    pub_type: 杂志文章


    authors: Cheah SY,Lawford BR,Young RM,Morris CP,Voisey J

    更新日期:2017-01-04 00:00:00

  • Extracellular Vesicles-Mediated Transfer of miRNA Let-7b from PC3 Cells to Macrophages.

    abstract::Prostate-derived extracellular vesicles (pEVs) may represent a way to selectively transport cargo molecules from the producing cells to the target cells to allow biological events, both in physiological and pathological circumstances. pEVs cargo participates in the modulation of the inflammatory responses in physiolog...


    pub_type: 杂志文章


    authors: Costanzi E,Romani R,Scarpelli P,Bellezza I

    更新日期:2020-12-12 00:00:00

  • Graph Algorithms for Mixture Interpretation.

    abstract::The scale of genetic methods are presently being expanded: forensic genetic assays previously were limited to tens of loci, but now technologies allow for a transition to forensic genomic approaches that assess thousands to millions of loci. However, there are subtle distinctions between genetic assays and their genom...


    pub_type: 杂志文章


    authors: Crysup B,Woerner AE,King JL,Budowle B

    更新日期:2021-01-27 00:00:00

  • Fitness Costs of the Glutathione S-Transferase Epsilon 2 (L119F-GSTe2) Mediated Metabolic Resistance to Insecticides in the Major African Malaria Vector Anopheles Funestus.

    abstract::Metabolic resistance to insecticides threatens malaria control. However, little is known about its fitness cost in field populations of malaria vectors, thus limiting the design of suitable resistance management strategies. Here, we assessed the association between the glutathione S-transferase GSTe2-mediated metaboli...


    pub_type: 杂志文章


    authors: Tchouakui M,Riveron JM,Djonabaye D,Tchapga W,Irving H,Soh Takam P,Njiokou F,Wondji CS

    更新日期:2018-12-19 00:00:00

  • Development of Tissue-Specific Age Predictors Using DNA Methylation Data.

    abstract::DNA methylation patterns have been shown to change throughout the normal aging process. Several studies have found epigenetic aging markers using age predictors, but these studies only focused on blood-specific or tissue-common methylation patterns. Here, we constructed nine tissue-specific age prediction models using...


    pub_type: 杂志文章


    authors: Choi H,Joe S,Nam H

    更新日期:2019-11-04 00:00:00

  • Beyond junk-variable tandem repeats as facilitators of rapid evolution of regulatory and coding sequences.

    abstract::Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type of genetic variation, namely changes in tandem repeat number. Historically, tandem repeats have been designated as...


    pub_type: 杂志文章


    authors: Gemayel R,Cho J,Boeynaems S,Verstrepen KJ

    更新日期:2012-07-26 00:00:00

  • Constructing the Microbial Association Network from Large-Scale Time Series Data Using Granger Causality.

    abstract::The increasing availability of large-scale time series data allows the inference of microbial community dynamics by association network analysis. However, correlation-based association network analyses are noninformative of causal, mediating and time-dependent relationships between microbial community functional facto...


    pub_type: 杂志文章


    authors: Ai D,Li X,Liu G,Liang X,Xia LC

    更新日期:2019-03-14 00:00:00

  • AMH: Could It Be Used as A Biomarker for Fertility and Superovulation in Domestic Animals?

    abstract::Anti-Müllerian hormone (AMH) is a reliable and easily detectable reproductive marker for the fertility competence of many farm animal species. AMH is also a good predictor of superovulation in cattle, sheep, and mares. In this review, we have summarized the recent findings related to AMH and its predictive reliability...


    pub_type: 杂志文章,评审


    authors: Umer S,Zhao SJ,Sammad A,Weldegebriall Sahlu B,Yunwei P,Zhu H

    更新日期:2019-12-04 00:00:00

  • A Pan-Genome Guided Metabolic Network Reconstruction of Five Propionibacterium Species Reveals Extensive Metabolic Diversity.

    abstract::Propionibacteria have been studied extensively since the early 1930s due to their relevance to industry and importance as human pathogens. Still, their unique metabolism is far from fully understood. This is partly due to their signature high GC content, which has previously hampered the acquisition of quality sequenc...


    pub_type: 杂志文章


    authors: McCubbin T,Gonzalez-Garcia RA,Palfreyman RW,Stowers C,Nielsen LK,Marcellin E

    更新日期:2020-09-23 00:00:00

  • Targeting MDM4 Splicing in Cancers.

    abstract::MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...


    pub_type: 杂志文章,评审


    authors: Bardot B,Toledo F

    更新日期:2017-02-20 00:00:00

  • DNA Barcoding Reveals High Levels of Divergence among Mitochondrial Lineages of Brycon (Characiformes, Bryconidae).

    abstract::Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...


    pub_type: 杂志文章


    authors: Arruda PSS,Ferreira DC,Oliveira C,Venere PC

    更新日期:2019-08-23 00:00:00

  • Sparsity-Penalized Stacked Denoising Autoencoders for Imputing Single-Cell RNA-Seq Data.

    abstract::Single-cell RNA-seq (scRNA-seq) is quite prevalent in studying transcriptomes, but it suffers from excessive zeros, some of which are true, but others are false. False zeros, which can be seen as missing data, obstruct the downstream analysis of single-cell RNA-seq data. How to distinguish true zeros from false ones i...


    pub_type: 杂志文章


    authors: Chi W,Deng M

    更新日期:2020-05-11 00:00:00

  • Genes Contributing to Domestication of Rice Seed Traits and Its Global Expansion.

    abstract::Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...


    pub_type: 杂志文章,评审


    authors: Liu H,Li Q,Xing Y

    更新日期:2018-10-10 00:00:00

  • Transcriptome Analysis of Landrace Pig Subcutaneous Preadipocytes during Adipogenic Differentiation.

    abstract::Fat deposition in pigs, which significantly contributes to meat quality, fattening efficiency, reproductive performance, and immunity, is critically affected by preadipocyte adipogenic differentiation. We elucidated adipogenesis in pigs using transcriptome analysis. Preadipocytes from subcutaneous adipose tissue (SAT)...


    pub_type: 杂志文章


    authors: Zhao X,Chen S,Tan Z,Wang Y,Zhang F,Yang T,Liu Y,Ao H,Xing K,Wang C

    更新日期:2019-07-19 00:00:00

  • Genetic Differentiation in Hatchery and Stocked Populations of Sea Trout in the Southern Baltic: Selection Evidence at SNP Loci.

    abstract::The impacts and interactions between hatchery-bred fish and wild fish populations has been a topic of active investigation in recent decades. In some instances, the benefits of stocking can be overshadowed by negative effects such as genetic introgression with natural populations, loss of genetic diversity, and diluti...


    pub_type: 杂志文章


    authors: Bernaś R,Poćwierz-Kotus A,Árnyasi M,Kent MP,Lien S,Wenne R

    更新日期:2020-02-10 00:00:00

  • Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish.

    abstract::DNA methylation plays several roles in regulating neuronal proliferation, differentiation, and physiological functions. The major de novo methyltransferase, DNMT3, controls the DNA methylation pattern in neurons according to environmental stimulations and behavioral regulations. Previous studies demonstrated that knoc...


    pub_type: 杂志文章


    authors: Lai YH,Audira G,Liang ST,Siregar P,Suryanto ME,Lin HC,Villalobos O,Villaflores OB,Hao E,Lim KH,Hsiao CD

    更新日期:2020-11-07 00:00:00

  • Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling.

    abstract::DNA double-strand breaks (DSBs) jeopardize genome integrity and can-when repaired unfaithfully-give rise to structural rearrangements associated with cancer. Exogenous agents such as ionizing radiation or chemotherapy can invoke DSBs, but a vast amount of breakage arises during vital endogenous DNA transactions, such ...


    pub_type: 杂志文章,评审


    authors: Bouwman BAM,Crosetto N

    更新日期:2018-12-14 00:00:00

  • The Genome of the Northern Sea Otter (Enhydra lutris kenyoni).

    abstract::The northern sea otter inhabits coastal waters of the northern Pacific Ocean and is the largest member of the Mustelidae family. DNA sequencing methods that utilize microfluidic partitioned and non-partitioned library construction were used to establish the sea otter genome. The final assembly provided 2.426 Gbp of hi...


    pub_type: 杂志文章


    authors: Jones SJ,Haulena M,Taylor GA,Chan S,Bilobram S,Warren RL,Hammond SA,Mungall KL,Choo C,Kirk H,Pandoh P,Ally A,Dhalla N,Tam AKY,Troussard A,Paulino D,Coope RJN,Mungall AJ,Moore R,Zhao Y,Birol I,Ma Y,Marra M,Jo

    更新日期:2017-12-11 00:00:00

  • Cord Blood DNA Methylation Biomarkers for Predicting Neurodevelopmental Outcomes.

    abstract::Adverse environmental exposures in pregnancy can significantly alter the development of the fetus resulting in impaired child neurodevelopment. Such exposures can lead to epigenetic alterations like DNA methylation, which may be a marker of poor cognitive, motor and behavioral outcomes in the infant. Here we review st...


    pub_type: 杂志文章,评审


    authors: Hodyl NA,Roberts CT,Bianco-Miotto T

    更新日期:2016-12-03 00:00:00

  • Comparative Analysis of Cotton Small RNAs and Their Target Genes in Response to Salt Stress.

    abstract::Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...


    pub_type: 杂志文章


    authors: Yin Z,Han X,Li Y,Wang J,Wang D,Wang S,Fu X,Ye W

    更新日期:2017-12-05 00:00:00

  • Genome-Wide Profiling of Enterotoxigenic Staphylococcus aureus Strains Used for the Production of Naturally Contaminated Cheeses.

    abstract::Staphylococcus aureus is a major human pathogen and an important cause of livestock infections. More than 20 staphylococcal enterotoxins with emetic activity can be produced by specific strains responsible for staphylococcal food poisoning, one of the most common food-borne diseases. Whole genome sequencing provides a...


    pub_type: 杂志文章


    authors: Macori G,Bellio A,Bianchi DM,Chiesa F,Gallina S,Romano A,Zuccon F,Cabrera-Rubio R,Cauquil A,Merda D,Auvray F,Decastelli L

    更新日期:2019-12-27 00:00:00

  • Diverse Roles of MAX1 Homologues in Rice.

    abstract::Cytochrome P450 enzymes encoded by MORE AXILLARY GROWTH1 (MAX1)-like genes produce most of the structural diversity of strigolactones during the final steps of strigolactone biosynthesis. The diverse copies of MAX1 in Oryza sativa provide a resource to investigate why plants produce such a wide range of strigolactones...


    pub_type: 杂志文章


    authors: Marzec M,Situmorang A,Brewer PB,Brąszewska A

    更新日期:2020-11-13 00:00:00

  • Assessing Metagenomic Signals Recovered from Lyuba, a 42,000-Year-Old Permafrost-Preserved Woolly Mammoth Calf.

    abstract::The reconstruction of ancient metagenomes from archaeological material, and their implication in human health and evolution, is one of the most recent advances in paleomicrobiological studies. However, as for all ancient DNA (aDNA) studies, environmental and laboratory contamination need to be specifically addressed. ...


    pub_type: 杂志文章


    authors: Ferrari G,Lischer HEL,Neukamm J,Rayo E,Borel N,Pospischil A,Rühli F,Bouwman AS,Campana MG

    更新日期:2018-08-31 00:00:00

  • Patterns, Mechanisms and Genetics of Speciation in Reptiles and Amphibians.

    abstract::In this contribution, the aspects of reptile and amphibian speciation that emerged from research performed over the past decade are reviewed. First, this study assesses how patterns and processes of speciation depend on knowing the taxonomy of the group in question, and discuss how integrative taxonomy has contributed...


    pub_type: 杂志文章,评审


    authors: Wollenberg Valero KC,Marshall JC,Bastiaans E,Caccone A,Camargo A,Morando M,Niemiller ML,Pabijan M,Russello MA,Sinervo B,Werneck FP,Sites JW,Jr.,Wiens JJ,Steinfartz S

    更新日期:2019-08-26 00:00:00

  • The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

    abstract::Hepatitis B virus (HBV) is divided into nine genotypes, A to I. Currently, it remains unclear how the individual genotypes contribute to the estimated 250 million chronic HBV infections. We performed a literature search on HBV genotyping data throughout the world. Over 900 publications were assessed and data were extr...


    pub_type: 杂志文章


    authors: Velkov S,Ott JJ,Protzer U,Michler T

    更新日期:2018-10-15 00:00:00

  • Three New Integration Vectors and Fluorescent Proteins for Use in the Opportunistic Human Pathogen Streptococcus pneumoniae.

    abstract::Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed vectors, named PEP for Pneumococcal Engineering Platform (PEP), employ an IPTG-inducible promoter and BglBrick and BglFusion compatible multiple c...


    pub_type: 杂志文章


    authors: Keller LE,Rueff AS,Kurushima J,Veening JW

    更新日期:2019-05-22 00:00:00

  • The Role of Salmonella Genomic Island 4 in Metal Tolerance of Salmonella enterica Serovar I 4,[5],12:i:- Pork Outbreak Isolate USDA15WA-1.

    abstract::Multidrug-resistant (MDR; resistance to >3 antimicrobial classes) Salmonella enterica serovar I 4,[5],12:i:- strains were linked to a 2015 foodborne outbreak from pork. Strain USDA15WA-1, associated with the outbreak, harbors an MDR module and the metal tolerance element Salmonella Genomic Island 4 (SGI-4). Characteri...


    pub_type: 杂志文章


    authors: Bearson BL,Trachsel JM,Shippy DC,Sivasankaran SK,Kerr BJ,Loving CL,Brunelle BW,Curry SM,Gabler NK,Bearson SMD

    更新日期:2020-10-30 00:00:00

  • Convergent Evolution of the Seed Shattering Trait.

    abstract::Loss of seed shattering is a key trait in crop domestication, particularly for grain crops. For wild plants, seed shattering is a crucial mechanism to achieve greater fitness, although in the agricultural context, this mechanism reduces harvesting efficiency, especially under dry conditions. Loss of seed shattering wa...


    pub_type: 杂志文章,评审


    authors: Di Vittori V,Gioia T,Rodriguez M,Bellucci E,Bitocchi E,Nanni L,Attene G,Rau D,Papa R

    更新日期:2019-01-19 00:00:00

  • miR-101b Regulates Lipid Deposition and Metabolism of Primary Hepatocytes in Teleost Yellow Catfish Pelteobagrus fulvidraco.

    abstract::Excessive fat deposition in the hepatocytes, associated with excess dietary fat intake, was related to the occurrence of fatty livers in fish. miR-101b plays the important roles in controlling lipid metabolism, but the underlying mechanism at the post-transcriptional level remains unclear. The purpose of this study is...


    pub_type: 杂志文章


    authors: Chen GH,Zhao T,Wei XL,Zhang DG,Zhuo MQ,Luo Z

    更新日期:2020-07-29 00:00:00

  • Shedding the Light on Litopenaeus vannamei Differential Muscle and Hepatopancreas Immune Responses in White Spot Syndrome Virus (WSSV) Exposure.

    abstract::White Spot Syndrome Virus (WSSV) is one of the main threats to farming Litopenaeus vannamei, the most important crustacean commercialized in aquaculture worldwide. Here, we performed RNA-seq analyses in hepatopancreas and muscle from WSSV-negative (healthy) and WSSV-positive (unhealthy) L. vannamei, previously exposed...


    pub_type: 杂志文章


    authors: Santos CA,Andrade SCS,Fernandes JMO,Freitas PD

    更新日期:2020-07-16 00:00:00