Characterization of DNA Methylation in Circulating Tumor Cells.

Abstract:

:Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant for metastasis by providing direct access to systemic cancer. CTCs can be used as prognostic markers in cancer patients and are regarded as potential metastatic precursor cells. However, despite substantial technical progress, the detection and molecular characterization of CTCs remain challenging, in particular the analysis of DNA methylation. As recent studies have started to address the epigenetic state of CTCs, we discuss here the potential of such investigations to elucidate mechanisms of metastasis and to develop tumor biomarkers.

journal_name

Genes (Basel)

journal_title

Genes

authors

Pixberg CF,Schulz WA,Stoecklein NH,Neves RP

doi

10.3390/genes6041053

subject

Has Abstract

pub_date

2015-10-21 00:00:00

pages

1053-75

issue

4

issn

2073-4425

pii

genes6041053

journal_volume

6

pub_type

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