当前位置： SCI文献检索 > Genes期刊下所有文献 > RNA-Seq Analyses Identify Additivity as the Predominant Gene Expression Pattern in F1 Chicken Embryonic Brain and Liver.

RNA-Seq Analyses Identify Additivity as the Predominant Gene Expression Pattern in F1 Chicken Embryonic Brain and Liver.

Abstract：

:The superior performance of hybrids to parents, termed heterosis, has been widely utilized in animal and plant breeding programs, but the molecular mechanism underlying heterosis remains an enigma. RNA-Seq provides a novel way to investigate heterosis at the transcriptome-wide level, because gene expression functions as an intermediate phenotype that contributes to observable traits. Here we compared embryonic gene expression between chicken hybrids and their inbred parental lines to identify inheritance patterns of gene expression. Inbred Fayoumi and Leghorn were crossed reciprocally to obtain F1 fertile eggs. RNA-Seq was carried out using 24 brain and liver samples taken from day 12 embryos, and the differentially expressed (DE) genes were identified by pairwise comparison among the hybrids, parental lines, and mid-parent expression values. Our results indicated the expression levels of the majority of the genes in the F1 cross are not significantly different from the mid-parental values, suggesting additivity as the predominant gene expression pattern in the F1. The second and third prevalent gene expression patterns are dominance and over-dominance. Additionally, we found only 7⁻20% of the DE genes exhibit allele-specific expression in the F1, suggesting that trans regulation is the main driver for differential gene expression and thus contributes to heterosis effect in the F1 crosses.

journal_name

Genes (Basel)

journal_title

Genes

authors

Zhuo Z,Lamont SJ,Abasht B

doi

10.3390/genes10010027

subject

Has Abstract

pub_date

2019-01-07 00:00:00

issue

1

issn

2073-4425

pii

genes10010027

journal_volume

10

pub_type

杂志文章

相关文献

Genes文献大全
  • Multi-Tissue Transcriptomes Yield Information on High-Altitude Adaptation and Sex-Determination in Scutiger cf. sikimmensis.

    abstract：:The Himalayas are one of earth's hotspots of biodiversity. Among its many cryptic and undiscovered organisms, including vertebrates, this complex high-mountain ecosystem is expected to harbour many species with adaptations to life in high altitudes. However, modern evolutionary genomic studies in Himalayan vertebrates...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10110873

    authors： Hofmann S,Kuhl H,Baniya CB,Stöck M

    更新日期：2019-10-31 00:00:00

  • Exposure to Formaldehyde Perturbs the Mouse Gut Microbiome.

    abstract：:Exposure to Formaldehyde (FA) results in many pathophysiological symptoms, however the underlying mechanisms are not well understood. Given the complicated modulatory role of intestinal microbiota on human health, we hypothesized that interactions between FA and the gut microbiome may account for FA's toxicity. Balb/c...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9040192

    authors： Guo J,Zhao Y,Jiang X,Li R,Xie H,Ge L,Xie B,Yang X,Zhang L

    更新日期：2018-04-03 00:00:00

  • Delineation of Novel Compound Heterozygous Variants in LTBP2 Associated with Juvenile Open Angle Glaucoma.

    abstract：:Juvenile open angle glaucoma (JOAG), which is an uncommon form of primary open angle glaucoma, is a clinically and genetically heterogeneous disorder. We report on a family with a recessively inherited form of JOAG. The proband has a superior and an inferior never fiber layer thinning in both the eyes and the nasal vi...

    journal_title：Genes

    pub_type：

    doi：10.3390/genes9110527

    authors： Saeedi O,Yousaf S,Tsai J,Palmer K,Riazuddin S,Ahmed ZM

    更新日期：2018-10-30 00:00:00

  • Characterization of DNA Methylation in Circulating Tumor Cells.

    abstract：:Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes6041053

    authors： Pixberg CF,Schulz WA,Stoecklein NH,Neves RP

    更新日期：2015-10-21 00:00:00

  • The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

    abstract：:Hepatitis B virus (HBV) is divided into nine genotypes, A to I. Currently, it remains unclear how the individual genotypes contribute to the estimated 250 million chronic HBV infections. We performed a literature search on HBV genotyping data throughout the world. Over 900 publications were assessed and data were extr...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9100495

    authors： Velkov S,Ott JJ,Protzer U,Michler T

    更新日期：2018-10-15 00:00:00

  • Genome Sequencing and Assembly by Long Reads in Plants.

    abstract：:Plant genomes generated by Sanger and Next Generation Sequencing (NGS) have provided insight into species diversity and evolution. However, Sanger sequencing is limited in its applications due to high cost, labor intensity, and low throughput, while NGS reads are too short to resolve abundant repeats and polyploidy, l...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes9010006

    authors： Li C,Lin F,An D,Wang W,Huang R

    更新日期：2017-12-28 00:00:00

  • Analysis of Gene Expression of miRNA-106b-5p and TRAIL in the Apoptosis Pathway in Gastric Cancer.

    abstract：:Helicobacter pylori (H. pylori) is one of the main causes of gastric gancer. TNF-related apoptosis-inducing ligand (TRAIL) is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via TRAIL. It is believed that MicroRNA-106b-5p might be involved in t...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11040393

    authors： Pereira J,Santos M,Delabio R,Barbosa M,Smith M,Payão S,Rasmussen L

    更新日期：2020-04-05 00:00:00

  • Genome-Wide Analysis of the Zn(II)₂Cys₆ Zinc Cluster-Encoding Gene Family in Tolypocladium guangdongense and Its Light-Induced Expression.

    abstract：:The Zn(II)₂Cys₆ zinc cluster gene family is a subclass of zinc-finger proteins, which are transcriptional regulators involved in a wide variety of biological processes in fungi. We performed genome-wide identification and characterization of Zn(II)₂Cys₆ zinc-cluster gene (C6 zinc gene) family in Tolypocladiumguangdong...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10030179

    authors： Zhang C,Huang H,Deng W,Li T

    更新日期：2019-02-26 00:00:00

  • Role of Homologous Recombination Genes in Repair of Alkylation Base Damage by Candida albicans.

    abstract：:Candida albicans mutants deficient in homologous recombination (HR) are extremely sensitive to the alkylating agent methyl-methane-sulfonate (MMS). Here, we have investigated the role of HR genes in the protection and repair of C. albicans chromosomes by taking advantage of the heat-labile property (55 °C) of MMS-indu...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9090447

    authors： Ciudad T,Bellido A,Andaluz E,Hermosa B,Larriba G

    更新日期：2018-09-07 00:00:00

  • Serendipitous In Situ Conservation of Faba Bean Landraces in Tunisia: A Case Study.

    abstract：:Cultivation of faba bean (Vicia faba L.) in Tunisia is largely based on improved varieties of the crop. However, a few farmers continue to produce local cultivars or landraces. The National Gene Bank of Tunisia (NGBT) recently launched a collection project for faba bean landraces, with special focus on the regions of ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11020236

    authors： Babay E,Khamassi K,Sabetta W,Miazzi MM,Montemurro C,Pignone D,Danzi D,Finetti-Sialer MM,Mangini G

    更新日期：2020-02-24 00:00:00

  • Genomic Prediction and Genome-Wide Association Studies of Flour Yield and Alveograph Quality Traits Using Advanced Winter Wheat Breeding Material.

    abstract：:Use of genetic markers and genomic prediction might improve genetic gain for quality traits in wheat breeding programs. Here, flour yield and Alveograph quality traits were inspected in 635 F6 winter wheat breeding lines from two breeding cycles. Genome-wide association studies revealed single nucleotide polymorphisms...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10090669

    authors： Kristensen PS,Jensen J,Andersen JR,Guzmán C,Orabi J,Jahoor A

    更新日期：2019-08-31 00:00:00

  • Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.

    abstract：:Cerebral ischaemia is the most common cause of impaired brain function. Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH(4-7)PGP (Semax), has been used successfully in the treatment of patients with severe impairment...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11060681

    authors： Filippenkov IB,Stavchansky VV,Denisova AE,Yuzhakov VV,Sevan'kaeva LE,Sudarkina OY,Dmitrieva VG,Gubsky LV,Myasoedov NF,Limborska SA,Dergunova LV

    更新日期：2020-06-22 00:00:00

  • Multigene Expression Assay for Assessment of the Immune Status of Atlantic Salmon.

    abstract：:We report the development of a multigene gene expression assay on the BioMark HD platform for the evaluation of immune competence (ImCom) in farmed Atlantic salmon. The first version of the assay included 92 genes selected on the basis of transcriptome analyses in 54 trials that challenged the immune system; annotatio...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11111236

    authors： Krasnov A,Afanasyev S,Nylund S,Rebl A

    更新日期：2020-10-22 00:00:00

  • Transcriptional Basis for Differential Thermosensitivity of Seedlings of Various Tomato Genotypes.

    abstract：:Transcriptional reprograming after the exposure of plants to elevated temperatures is a hallmark of stress response which is required for the manifestation of thermotolerance. Central transcription factors regulate the stress survival and recovery mechanisms and many of the core responses controlled by these factors a...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11060655

    authors： Hu Y,Fragkostefanakis S,Schleiff E,Simm S

    更新日期：2020-06-16 00:00:00

  • Predominance of Dystrophinopathy Genotypes in Mexican Male Patients Presenting as Muscular Dystrophy with A Normal Multiplex Polymerase Chain Reaction DMD Gene Result: A Study Including Targeted Next-Generation Sequencing.

    abstract：:The complete mutational spectrum of dystrophinopathies and limb-girdle muscular dystrophy (LGMD) remains unknown in Mexican population. Seventy-two unrelated Mexican male patients (73% of pediatric age) with clinical suspicion of muscular dystrophy and no evidence of DMD gene deletion on multiplex polymerase chain rea...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10110856

    authors： Alcántara-Ortigoza MA,Reyna-Fabián ME,González-Del Angel A,Estandia-Ortega B,Bermúdez-López C,Cruz-Miranda GM,Ruíz-García M

    更新日期：2019-10-29 00:00:00

  • Identification of QTLs for Resistance to Fusarium Head Blight Using a Doubled Haploid Population Derived from Southeastern United States Soft Red Winter Wheat Varieties AGS 2060 and AGS 2035.

    abstract：:Fusarium head blight (FHB), caused primarily by the fungus Fusarium graminearum, is one of the most damaging diseases of wheat, causing significant loss of yield and quality worldwide. Warm and wet conditions during flowering, a lack of resistant wheat varieties, and high inoculum pressure from corn stubble contribute...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11060699

    authors： Castro Aviles A,Alan Harrison S,Joseph Arceneaux K,Brown-Guidera G,Esten Mason R,Baisakh N

    更新日期：2020-06-25 00:00:00

  • Impact, Characterization, and Rescue of Pre-mRNA Splicing Mutations in Lysosomal Storage Disorders.

    abstract：:Lysosomal storage disorders (LSDs) represent a group of more than 50 severe metabolic diseases caused by the deficiency of specific lysosomal hydrolases, activators, carriers, or lysosomal integral membrane proteins, leading to the abnormal accumulation of substrates within the lysosomes. Numerous mutations have been ...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes9020073

    authors： Dardis A,Buratti E

    更新日期：2018-02-06 00:00:00

  • Identification of Loci Controlling the Dwarfism Trait in the White Sailfin Molly (Poecilia latipinna) Using Genome-Wide Association Studies Based on Genotyping-By-Sequencing.

    abstract：:Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trai...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10060418

    authors： Shao F,Liu J,Ren M,Li J,Bao H,Wu C

    更新日期：2019-05-30 00:00:00

  • High-Throughput Genetic Testing in ALS: The Challenging Path of Variant Classification Considering the ACMG Guidelines.

    abstract：:The development of high-throughput sequencing technologies and screening of big patient cohorts with familial and sporadic amyotrophic lateral sclerosis (ALS) led to the identification of a significant number of genetic variants, which are sometimes difficult to interpret. The American College of Medical Genetics and ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11101123

    authors： Lattante S,Marangi G,Doronzio PN,Conte A,Bisogni G,Zollino M,Sabatelli M

    更新日期：2020-09-24 00:00:00

  • Canine Melanomas as Models for Human Melanomas: Clinical, Histological, and Genetic Comparison.

    abstract：:Despite recent genetic advances and numerous ongoing therapeutic trials, malignant melanoma remains fatal, and prognostic factors as well as more efficient treatments are needed. The development of such research strongly depends on the availability of appropriate models recapitulating all the features of human melanom...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes10070501

    authors： Prouteau A,André C

    更新日期：2019-06-30 00:00:00

  • Gene Expression Profile in Similar Tissues Using Transcriptome Sequencing Data of Whole-Body Horse Skeletal Muscle.

    abstract：:Horses have been studied for exercise function rather than food production, unlike most livestock. Therefore, the role and characteristics of tissue landscapes are critically understudied, except for certain muscles used in exercise-related studies. In the present study, we compared RNA-Seq data from 18 Jeju horse ske...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11111359

    authors： Lee HY,Kim JY,Kim KH,Jeong S,Cho Y,Kim N

    更新日期：2020-11-17 00:00:00

  • Slow Adaptive Response of Budding Yeast Cells to Stable Conditions of Continuous Culture Can Occur without Genome Modifications.

    abstract：:Continuous cultures assure the invariability of environmental conditions and the metabolic state of cultured microorganisms, whereas batch-cultured cells undergo constant changes in nutrients availability. For that reason, continuous culture is sometimes employed in the whole transcriptome, whole proteome, or whole me...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11121419

    authors： Klim J,Zielenkiewicz U,Kurlandzka A,Kaczanowski S,Skoneczny M

    更新日期：2020-11-27 00:00:00

  • Genome-Wide Identification and Characterization of Xyloglucan Endotransglycosylase/Hydrolase in Ananas comosus during Development.

    abstract：:Xyloglucan endotransglycosylase/hydrolase (XTH) is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. In this study, 48 XTH genes were identified from two pineapple (Ananas comosus) cultivars ('F153' and 'MD2') and designated Ac(F153)XTH1 to -24 and Ac(MD2)XTH1...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10070537

    authors： Li Q,Li H,Yin C,Wang X,Jiang Q,Zhang R,Ge F,Chen Y,Yang L

    更新日期：2019-07-16 00:00:00

  • Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits.

    abstract：:Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8010027

    authors： Li S,Zhou H,Gong H,Zhao F,Wang J,Liu X,Luo Y,Hickford JG

    更新日期：2017-01-11 00:00:00

  • Development of a DNA Barcoding-Like Approach to Detect Mustard Allergens in Wheat Flours.

    abstract：:The spread of food allergens is a topic of global importance due to its impact on public health. National and International regulations ask food producers and manufacturers to declare product compositions on the label, especially in case of processed raw materials. Wheat flour (Triticum aestivum) can be contaminated b...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10030234

    authors： Frigerio J,Pellesi R,Mezzasalma V,De Mattia F,Galimberti A,Lambertini F,Suman M,Zanardi S,Leporati A,Labra M

    更新日期：2019-03-19 00:00:00

  • Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain.

    abstract：:In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process. In rat, two splicing events produce several isoforms of ADAR2, called ADAR2a, ADAR2b, ADAR2e, and ADAR2f, but only ADAR2a and AD...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9020079

    authors： Filippini A,Bonini D,Giacopuzzi E,La Via L,Gangemi F,Colombi M,Barbon A

    更新日期：2018-02-08 00:00:00

  • Effects of Fat and Fatty Acids on the Formation of Autolysosomes in the Livers from Yellow Catfish Pelteobagrus Fulvidraco.

    abstract：:The autophagy-lysosome pathway, which involves many crucial genes and proteins, plays crucial roles in the maintenance of intracellular homeostasis by the degradation of damaged components. At present, some of these genes and proteins have been identified but their specific functions are largely unknown. This study wa...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10100751

    authors： Wu LX,Wei CC,Yang SB,Zhao T,Luo Z

    更新日期：2019-09-25 00:00:00

  • Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism.

    abstract：:More than fifteen genetic diseases, including Huntington's disease, myotonic dystrophy 1, fragile X syndrome and Friedreich ataxia, are caused by the aberrant expansion of a trinucleotide repeat. The mutation is unstable and further expands in specific cells or tissues with time, which can accelerate disease progressi...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes4030375

    authors： Goula AV,Merienne K

    更新日期：2013-07-25 00:00:00

  • Kinetic Modeling of DUSP Regulation in Herceptin-Resistant HER2-Positive Breast Cancer.

    abstract：BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10080568

    authors： Buiga P,Elson A,Tabernero L,Schwartz JM

    更新日期：2019-07-26 00:00:00

  • NetR and AttR, Two New Bioinformatic Tools to Integrate Diverse Datasets into Cytoscape Network and Attribute Files.

    abstract：:High-throughput technologies have allowed researchers to obtain genome-wide data from a wide array of experimental model systems. Unfortunately, however, new data generation tends to significantly outpace data re-utilization, and most high throughput datasets are only rarely used in subsequent studies or to generate n...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10060423

    authors： Halajyan A,Weingart N,Yeahia M,Loza-Coll M

    更新日期：2019-06-01 00:00:00