Genome-Wide Identification and Characterization of Xyloglucan Endotransglycosylase/Hydrolase in Ananas comosus during Development.

abstract：:Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...

journal_title：Genes

authors： Moon CI,Tompkins W,Wang Y,Godec A,Zhang X,Pipkorn P,Miller CA,Dehner C,Dahiya S,Hirbe AC

更新日期：2020-05-01 00:00:00

abstract：:There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of linc...

journal_title：Genes

authors： Zou C,Li S,Deng L,Guan Y,Chen D,Yuan X,Xia T,He X,Shan Y,Li C

更新日期：2017-08-18 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:Gene expression in the brain is dramatically regulated by a variety of stimuli. While the role of neural activity has been extensively studied, less is known about the effects of metabolism and nutrition on transcriptional control mechanisms in the brain. Extracellular signals are integrated at the chromatin level thr...

journal_title：Genes

authors： Pizzorusso T,Tognini P

更新日期：2020-07-03 00:00:00

abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...

journal_title：Genes

authors： Rick K,Ottewell K,Lohr C,Thavornkanlapachai R,Byrne M,Kennington WJ

更新日期：2019-10-28 00:00:00

abstract：:Divergent selection between ecologically dissimilar habitats promotes local adaptation, which can lead to reproductive isolation (RI). Populations in the Poecilia mexicana species complex have independently adapted to toxic hydrogen sulfide and show varying degrees of RI. Here, we examined the variation in the mate ch...

journal_title：Genes

authors： Zimmer C,Riesch R,Jourdan J,Bierbach D,Arias-Rodriguez L,Plath M

更新日期：2018-05-02 00:00:00

abstract：:Acquisition of mobile elements by horizontal gene transfer can play a major role in bacterial adaptation and genome evolution by providing traits that contribute to bacterial fitness. However, gaining foreign DNA can also impose significant fitness costs to the host bacteria and can even produce detrimental effects. T...

journal_title：Genes

authors： Piña-Iturbe A,Suazo ID,Hoppe-Elsholz G,Ulloa-Allendes D,González PA,Kalergis AM,Bueno SM

更新日期：2020-01-29 00:00:00

abstract：:Maize kernel development is a complex biological process that involves the temporal and spatial expression of many genes and fine gene regulation at a transcriptional and post-transcriptional level, and microRNAs (miRNAs) play vital roles during this process. To gain insight into miRNA-mediated regulation of maize ker...

journal_title：Genes

authors： Xing L,Zhu M,Zhang M,Li W,Jiang H,Zou J,Wang L,Xu M

更新日期：2017-12-14 00:00:00

abstract：:Transcriptional regulation of the genome arguably provides the basis for the anatomical elaboration and dynamic operation of the human brain. It logically follows that genetic variations affecting gene transcription contribute to mental health disorders, including autism spectrum disorder (ASD). A number of recent stu...

journal_title：Genes

authors： Kim Y,An JY

更新日期：2020-05-11 00:00:00

abstract：:The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a maj...

journal_title：Genes

authors： Nagpal S,Gibson G,Marigorta UM

更新日期：2018-08-14 00:00:00

abstract：:The superior performance of hybrids to parents, termed heterosis, has been widely utilized in animal and plant breeding programs, but the molecular mechanism underlying heterosis remains an enigma. RNA-Seq provides a novel way to investigate heterosis at the transcriptome-wide level, because gene expression functions ...

journal_title：Genes

authors： Zhuo Z,Lamont SJ,Abasht B

更新日期：2019-01-07 00:00:00

abstract：:Genome wide association studies (GWAS) are a well established methodology to identify genomic variants and genes that are responsible for traits of interest in all branches of the life sciences. Despite the long time this methodology has had to mature the reliable detection of genotype-phenotype associations is still ...

journal_title：Genes

authors： Ramzan F,Gültas M,Bertram H,Cavero D,Schmitt AO

更新日期：2020-08-05 00:00:00

abstract：:Oral vaccination is a practical method for the active immunization of farmed fish in the matter of animal welfare and handling costs. However, it always shows insufficient protective immunity, mainly due to antigen degradation in the gastrointestinal tract (GIT). Bacillus subtilis spores have been shown to be able to ...

journal_title：Genes

authors： Sun R,Zhang M,Chen H,Wei Y,Ning D

更新日期：2020-11-14 00:00:00

abstract：:During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...

journal_title：Genes

authors： Argyridou E,Parsch J

更新日期：2018-05-04 00:00:00

abstract：:Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-gr...

journal_title：Genes

authors： Tan Z,Dong W,Ding Y,Ding X,Zhang Q,Jiang L

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...

journal_title：Genes

authors： Buiga P,Elson A,Tabernero L,Schwartz JM

更新日期：2019-07-26 00:00:00

abstract：:The transition from a dormant to a germinating seed represents a crucial developmental switch in the life cycle of a plant. Subsequent transition from a germinating seed to an autotrophic organism also requires a robust and multi-layered control. Seed germination and seedling growth are multistep processes, involving ...

journal_title：Genes

authors： Longo C,Holness S,De Angelis V,Lepri A,Occhigrossi S,Ruta V,Vittorioso P

更新日期：2020-12-31 00:00:00

abstract：:MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...

journal_title：Genes

authors： Bardot B,Toledo F

更新日期：2017-02-20 00:00:00

abstract：:Genetic variations introduced via introgression from Western to Chinese pigs have contributed to the performance of Chinese breeds in traits such as growth rate and feed conversion efficiency. However, little is known about the underlying genomic changes that occurred during introgression and the types of traits affec...

journal_title：Genes

authors： Wang J,Liu C,Chen J,Bai Y,Wang K,Wang Y,Fang M

更新日期：2020-03-04 00:00:00

abstract：:During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organ...

journal_title：Genes

authors： Reich S,Weinstein DC

更新日期：2019-11-06 00:00:00

abstract：:The plant circadian clock coordinates environmental signals with internal processes including secondary metabolism, growth, flowering, and volatile emission. Plant tissues are specialized in different functions, and petals conceal the sexual organs while attracting pollinators. Here we analyzed the transcriptional str...

journal_title：Genes

authors： Terry MI,Carrera-Alesina M,Weiss J,Egea-Cortines M

更新日期：2019-10-30 00:00:00

abstract：:Protein sequence, structure, and function are inherently linked through evolution and population genetics. Our knowledge of protein structure comes from solved structures in the Protein Data Bank (PDB), our knowledge of sequence through sequences found in the NCBI sequence databases (http://www.ncbi.nlm.nih.gov/), and...

journal_title：Genes

authors： Siltberg-Liberles J,Grahnen JA,Liberles DA

更新日期：2011-10-28 00:00:00

abstract：:Sorghum is one of the world's major crops, expresses traits for resilience to climate change, and can be used for several purposes including food and clean fuels. Multiple-trait genomic prediction and selection models were implemented using genotyping-by-sequencing single nucleotide polymorphism markers and phenotypic...

journal_title：Genes

authors： Habyarimana E,Lopez-Cruz M,Baloch FS

更新日期：2020-01-05 00:00:00

abstract：BACKGROUND:Atopic dermatitis is a common inflammatory skin disorder that affects up to 15-20% of the population and is characterized by recurrent eczematous lesions with intense itching. As a heterogeneous disease, multiple factors have been suggested to explain the nature of atopic dermatitis (AD), and its high preval...

journal_title：Genes

authors： Martin MJ,Estravís M,García-Sánchez A,Dávila I,Isidoro-García M,Sanz C

更新日期：2020-04-18 00:00:00

abstract：:The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFts...

journal_title：Genes

authors： Geng MT,Min Y,Yao Y,Chen X,Fan J,Yuan S,Wang L,Sun C,Zhang F,Shang L,Wang YL,Li RM,Fu SP,Duan RJ,Liu J,Hu XW,Guo JC

更新日期：2017-12-15 00:00:00

abstract：:In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This study aimed to identity candidate genes related to growth of duck skele...

journal_title：Genes

authors： Hu Z,Cao J,Liu G,Zhang H,Liu X

更新日期：2020-10-20 00:00:00

abstract：:Illumina and nanopore sequencing technologies are powerful tools that can be used to determine the bacterial composition of complex microbial communities. In this study, we compared nasal microbiota results at genus level using both Illumina and nanopore 16S rRNA gene sequencing. We also monitored the progression of n...

journal_title：Genes

authors： Heikema AP,Horst-Kreft D,Boers SA,Jansen R,Hiltemann SD,de Koning W,Kraaij R,de Ridder MAJ,van Houten CB,Bont LJ,Stubbs AP,Hays JP

更新日期：2020-09-21 00:00:00

abstract：:Yersinia enterocolitica is the causative agent of yersiniosis, a zoonotic disease of growing epidemiological importance with significant consequences for public health. This pathogenic species has been intensively studied for many years. Six biotypes (1A, 1B, 2, 3, 4, 5) and more than 70 serotypes of Y. enterocolitica...

journal_title：Genes

authors： Bancerz-Kisiel A,Pieczywek M,Łada P,Szweda W

更新日期：2018-05-03 00:00:00

abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

journal_title：Genes

authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

更新日期：2020-04-27 00:00:00

abstract：:Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...

journal_title：Genes

authors： Josling GA,Selvarajah SA,Petter M,Duffy MF

更新日期：2012-05-29 00:00:00