Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.

abstract：:The grizzly bear (Ursus arctos ssp. horribilis) represents the largest population of brown bears in North America. Its genome was sequenced using a microfluidic partitioning library construction technique, and these data were supplemented with sequencing from a nanopore-based long read platform. The final assembly was...

journal_title：Genes

authors： Taylor GA,Kirk H,Coombe L,Jackman SD,Chu J,Tse K,Cheng D,Chuah E,Pandoh P,Carlsen R,Zhao Y,Mungall AJ,Moore R,Birol I,Franke M,Marra MA,Dutton C,Jones SJM

更新日期：2018-11-30 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen and an important cause of livestock infections. More than 20 staphylococcal enterotoxins with emetic activity can be produced by specific strains responsible for staphylococcal food poisoning, one of the most common food-borne diseases. Whole genome sequencing provides a...

journal_title：Genes

authors： Macori G,Bellio A,Bianchi DM,Chiesa F,Gallina S,Romano A,Zuccon F,Cabrera-Rubio R,Cauquil A,Merda D,Auvray F,Decastelli L

更新日期：2019-12-27 00:00:00

abstract：:Propionibacteria have been studied extensively since the early 1930s due to their relevance to industry and importance as human pathogens. Still, their unique metabolism is far from fully understood. This is partly due to their signature high GC content, which has previously hampered the acquisition of quality sequenc...

journal_title：Genes

authors： McCubbin T,Gonzalez-Garcia RA,Palfreyman RW,Stowers C,Nielsen LK,Marcellin E

更新日期：2020-09-23 00:00:00

abstract：:Hepatic lipase (encoded by LIPC) is a glycoprotein in the triacylglycerol lipase family and mainly synthesized in and secreted from the liver. Previous studies demonstrated that hepatic lipase is crucial for reverse cholesterol transport and modulating metabolism and the plasma levels of several lipoproteins. This stu...

journal_title：Genes

authors： Liao YH,Er LK,Wu S,Ko YL,Teng MS

更新日期：2021-01-22 00:00:00

abstract：:Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extreme...

journal_title：Genes

authors： Wang X,Liu J,Wang P,deMello A,Feng L,Zhu X,Wen W,Kodzius R,Gong X

更新日期：2018-06-05 00:00:00

abstract：:There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of linc...

journal_title：Genes

authors： Zou C,Li S,Deng L,Guan Y,Chen D,Yuan X,Xia T,He X,Shan Y,Li C

更新日期：2017-08-18 00:00:00

abstract：:The Himalayas are one of earth's hotspots of biodiversity. Among its many cryptic and undiscovered organisms, including vertebrates, this complex high-mountain ecosystem is expected to harbour many species with adaptations to life in high altitudes. However, modern evolutionary genomic studies in Himalayan vertebrates...

journal_title：Genes

authors： Hofmann S,Kuhl H,Baniya CB,Stöck M

更新日期：2019-10-31 00:00:00

abstract：:Oral vaccination is a practical method for the active immunization of farmed fish in the matter of animal welfare and handling costs. However, it always shows insufficient protective immunity, mainly due to antigen degradation in the gastrointestinal tract (GIT). Bacillus subtilis spores have been shown to be able to ...

journal_title：Genes

authors： Sun R,Zhang M,Chen H,Wei Y,Ning D

更新日期：2020-11-14 00:00:00

abstract：:Genomic imprinting in domestic animals contributes to the variance of performance traits. However, research remains to be done on large-scale detection of epigenetic landscape of porcine imprinted loci including the GNAS complex locus. The purpose of this study was to generate porcine parthenogenetic fetuses and compr...

journal_title：Genes

authors： Ahn J,Wu H,Lee J,Hwang IS,Yu D,Ahn JS,Lee JW,Hwang S,Lee K

更新日期：2020-01-14 00:00:00

abstract：:It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and t...

journal_title：Genes

authors： Pickard MR,Williams GT

更新日期：2015-07-07 00:00:00

abstract：:Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyzed the right-ventricular systolic pressure (RVSP), right-ventricular hypertrophy (RVH), lung histology, and transcriptomes of six-week-old male rats with PH induced by (1) hypoxia (HO), (2) administration of monocrotalin...

journal_title：Genes

authors： Mathew R,Huang J,Iacobas S,Iacobas DA

更新日期：2020-01-23 00:00:00

abstract：:Cisplatin is a chemotherapeutic agent widely used for multiple indications. Unfortunately, in a substantial set of patients treated with cisplatin, dose-limiting acute kidney injury (AKI) occurs. Here, we assessed the association of 3 catechol-O-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) with incr...

journal_title：Genes

authors： Agema BC,Koolen SLW,With M,Doorn NV,Heersche N,Hoop EO,Visser S,Aerts JGJV,Bins S,Schaik RHNV,Mathijssen RHJ

更新日期：2020-03-27 00:00:00

abstract：:This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1-42-transduced hippocampal neurons. Aβ1-42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1-42. MTT assay and flow cytometry were used to detect the viability and apoptosis of hippocampal...

journal_title：Genes

authors： Wang T,Cheng Y,Han H,Liu J,Tian B,Liu X

更新日期：2019-04-21 00:00:00

abstract：:Plant genomes generated by Sanger and Next Generation Sequencing (NGS) have provided insight into species diversity and evolution. However, Sanger sequencing is limited in its applications due to high cost, labor intensity, and low throughput, while NGS reads are too short to resolve abundant repeats and polyploidy, l...

journal_title：Genes

authors： Li C,Lin F,An D,Wang W,Huang R

更新日期：2017-12-28 00:00:00

abstract：:The actin depolymerizing factor (ADF) proteins have growth, development, defense-related and growth regulatory functions in plants. The present study used genome-wide analysis to investigate ADF family genes in tomato. Eleven tomato ADF genes were identified and differential expression patterns were found in different...

journal_title：Genes

authors： Khatun K,Robin AH,Park JI,Kim CK,Lim KB,Kim MB,Lee DJ,Nou IS,Chung MY

更新日期：2016-09-29 00:00:00

abstract：:Satellite DNAs are tandemly repeated sequences preferentially assembled into large arrays within constitutive heterochromatin and their transcription is often activated by stress conditions, particularly by heat stress. Bioinformatic analyses of sequenced genomes however reveal single repeats or short arrays of satell...

journal_title：Genes

authors： Feliciello I,Sermek A,Pezer Ž,Matulić M,Ugarković Đ

更新日期：2020-06-18 00:00:00

abstract：:The development of the udder and the milk yield are closely related to the number and vitality of mammary epithelial cells. Many previous studies have proved that non-coding RNAs (ncRNAs) are widely involved in mammary gland development and the physiological activities of lactation. Our laboratory previous sequencing ...

journal_title：Genes

authors： Zhang M,Ma L,Liu Y,He Y,Li G,An X,Cao B

更新日期：2020-06-28 00:00:00

abstract：:Hypersialylation caused by the overexpression of sialyltransferases (STs) is a common feature in cancer that is associated with several characteristics of tumorigenesis. Thus, identifying cancer-associated STs is critical for cancer therapy. However, ST screening has been frequently conducted in cell line models. In t...

journal_title：Genes

authors： Kan JY,Moi SH,Hung WC,Hou MF,Chen FM,Shih SL,Shiau JP,Li CL,Chiang CP

更新日期：2020-11-28 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a complex multisystemic condition caused by a lack of paternal expression of imprinted genes from the 15q11.2-q13 region. Limited literature exists on the association between molecular classes, growth hormone use, and the prevalence of psychiatric phenotypes in PWS. In this study, we ana...

journal_title：Genes

authors： Montes AS,Osann KE,Gold JA,Tamura RN,Driscoll DJ,Butler MG,Kimonis VE

更新日期：2020-10-23 00:00:00

abstract：:Oral clefts are composed of cleft of the lip, cleft of the lip and palate, or cleft of the palate, and they are associated with a wide range of expression and severity. When cleft of the palate is associated with cleft of the lip with preservation of the primary palate, it defines an atypical phenotype called disconti...

journal_title：Genes

authors： Demeer B,Revencu N,Helaers R,Gbaguidi C,Dakpe S,François G,Devauchelle B,Bayet B,Vikkula M

更新日期：2019-10-22 00:00:00

abstract：:Although genome-wide association studies (GWAS) have identified several hundred loci associated with autoimmune diseases, their mechanistic insights are still poorly understood. The human genome is more complex than single nucleotide polymorphisms (SNPs) that are interrogated by GWAS arrays. Apart from SNPs, it also c...

journal_title：Genes

authors： Ye J,Gillespie KM,Rodriguez S

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:Large-scale screening of drug sensitivity on cancer cell models can mimic in vivo cellular behavior providing wider scope for biological research on cancer. Since the therapeutic effect of a single drug or drug combination depends on the individual patient's genome characteristics and cancer cells integratio...

journal_title：Genes

authors： Cheng L,Majumdar A,Stover D,Wu S,Lu Y,Li L

更新日期：2020-02-28 00:00:00

abstract：:The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively investigate the association of DNA methylation levels with SSc in dermal ...

journal_title：Genes

authors： Baker Frost D,da Silveira W,Hazard ES,Atanelishvili I,Wilson RC,Flume J,Day KL,Oates JC,Bogatkevich GS,Feghali-Bostwick C,Hardiman G,Ramos PS

更新日期：2021-01-20 00:00:00

abstract：:Despite recent genetic advances and numerous ongoing therapeutic trials, malignant melanoma remains fatal, and prognostic factors as well as more efficient treatments are needed. The development of such research strongly depends on the availability of appropriate models recapitulating all the features of human melanom...

journal_title：Genes

authors： Prouteau A,André C

更新日期：2019-06-30 00:00:00

abstract：:MYO6 is known as a genetic cause of autosomal dominant and autosomal recessive inherited hearing loss. In this study, to clarify the frequency and clinical characteristics of hearing loss caused by MYO6 gene mutations, a large-scale genetic analysis of Japanese patients with hearing loss was performed. By means of mas...

journal_title：Genes

authors： Oka SI,Day TF,Nishio SY,Moteki H,Miyagawa M,Morita S,Izumi S,Ikezono T,Abe S,Nakayama J,Hyogo M,Okamoto N,Uehara N,Oshikawa C,Kitajiri SI,Usami SI

更新日期：2020-03-04 00:00:00

abstract：:DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the dynamic DNA methylation patterns of embryonic and adult cells. We summarize the current knowledge on the molecular mechanism of DNMTs' fun...

journal_title：Genes

authors： Loaeza-Loaeza J,Beltran AS,Hernández-Sotelo D

更新日期：2020-11-12 00:00:00

abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

journal_title：Genes

authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

更新日期：2020-04-27 00:00:00

abstract：:Rice seed is a pivotal reproductive organ that directly determines yield and quality. Long non-coding RNAs (lncRNAs) have been recognized as key regulators in plant development, but the roles of lncRNAs in rice seed development remain unclear. In this study, we performed a paired-end RNA sequencing in samples of rice ...

journal_title：Genes

authors： Zhao J,Ajadi AA,Wang Y,Tong X,Wang H,Tang L,Li Z,Shu Y,Liu X,Li S,Wang S,Liu W,Zhang J

更新日期：2020-02-26 00:00:00

abstract：:During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...

journal_title：Genes

authors： Argyridou E,Parsch J

更新日期：2018-05-04 00:00:00

abstract：:The yeast Exophiala dermatitidis exhibits high resistance to γ-radiation in comparison to many other fungi. Several aspects of this phenotype have been characterized, including its dependence on homologous recombination for the repair of radiation-induced DNA damage, and the transcriptomic response invoked by acute γ-...

journal_title：Genes

authors： Schultzhaus ZS,Schultzhaus JN,Romsdahl J,Chen A,Hervey Iv WJ,Leary DH,Wang Z

更新日期：2020-09-25 00:00:00