当前位置： SCI文献检索 > Genes期刊下所有文献 > Proteomics Reveals Distinct Changes Associated with Increased Gamma Radiation Resistance in the Black Yeast Exophiala dermatitidis.

Proteomics Reveals Distinct Changes Associated with Increased Gamma Radiation Resistance in the Black Yeast Exophiala dermatitidis.

Abstract：

:The yeast Exophiala dermatitidis exhibits high resistance to γ-radiation in comparison to many other fungi. Several aspects of this phenotype have been characterized, including its dependence on homologous recombination for the repair of radiation-induced DNA damage, and the transcriptomic response invoked by acute γ-radiation exposure in this organism. However, these findings have yet to identify unique γ-radiation exposure survival strategies-many genes that are induced by γ-radiation exposure do not appear to be important for recovery, and the homologous recombination machinery of this organism is not unique compared to more sensitive species. To identify features associated with γ-radiation resistance, here we characterized the proteomes of two E. dermatitidis strains-the wild type and a hyper-resistant strain developed through adaptive laboratory evolution-before and after γ-radiation exposure. The results demonstrate that protein intensities do not change substantially in response to this stress. Rather, the increased resistance exhibited by the evolved strain may be due in part to increased basal levels of single-stranded binding proteins and a large increase in ribosomal content, possibly allowing for a more robust, induced response during recovery. This experiment provides evidence enabling us to focus on DNA replication, protein production, and ribosome levels for further studies into the mechanism of γ-radiation resistance in E. dermatitidis and other fungi.

journal_name

Genes (Basel)

journal_title

Genes

authors

Schultzhaus ZS,Schultzhaus JN,Romsdahl J,Chen A,Hervey Iv WJ,Leary DH,Wang Z

doi

10.3390/genes11101128

subject

Has Abstract

pub_date

2020-09-25 00:00:00

issue

10

issn

2073-4425

pii

genes11101128

journal_volume

11

pub_type

杂志文章

相关文献

Genes文献大全
  • Detection of Microaneurysms in Fundus Images Based on an Attention Mechanism.

    abstract：:Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes10100817

    authors： Zhang L,Feng S,Duan G,Li Y,Liu G

    更新日期：2019-10-17 00:00:00

  • Association of XPC Gene Polymorphisms with Colorectal Cancer Risk in a Southern Chinese Population: A Case-Control Study and Meta-Analysis.

    abstract：:Xeroderma pigmentosum group C (XPC) is a key component of the nucleotide excision repair (NER) pathway. Dysfunctional XPC protein may impair NER-mediated DNA repair capacity and further lead to genomic instability and carcinogenesis. Two common nonsynonymous polymorphisms in the XPC gene, Lys939Gln (rs2228001 A > C) a...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes7100073

    authors： Hua RX,Zhu J,Jiang DH,Zhang SD,Zhang JB,Xue WQ,Li XZ,Zhang PF,He J,Jia WH

    更新日期：2016-09-24 00:00:00

  • From Chromosomes to Genome: Insights into the Evolutionary Relationships and Biogeography of Old World Knifefishes (Notopteridae; Osteoglossiformes).

    abstract：:In addition to its wide geographical distribution, osteoglossiform fishes represent one of the most ancient freshwater teleost lineages; making it an important group for systematic and evolutionary studies. These fishes had a Gondwanan origin and their past distribution may have contributed to the diversity present in...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9060306

    authors： Barby FF,Ráb P,Lavoué S,Ezaz T,Bertollo LAC,Kilian A,Maruyama SR,Aguiar de Oliveira E,Artoni RF,Santos MH,Ilesanmi Jegede O,Hatanaka T,Tanomtong A,Liehr T,Cioffi MB

    更新日期：2018-06-19 00:00:00

  • New Insights into the Melanophilin (MLPH) Gene Affecting Coat Color Dilution in Rabbits.

    abstract：:Coat color dilution corresponds to a specific pigmentation phenotype that leads to a dilution of wild type pigments. It affects both eumelanin and pheomelanin containing melanosomes. The mode of inheritance of the dilution phenotype is autosomal recessive. Candidate gene approaches focused on the melanophilin (MLPH) g...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9090430

    authors： Demars J,Iannuccelli N,Utzeri VJ,Auvinet G,Riquet J,Fontanesi L,Allain D

    更新日期：2018-08-23 00:00:00

  • The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia.

    abstract：:Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease. About 2900 variants of LDLR, APOB, and PCSK9 genes potentially associated with FH have been described earlier. Nev...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes12010066

    authors： Meshkov A,Ershova A,Kiseleva A,Zotova E,Sotnikova E,Petukhova A,Zharikova A,Malyshev P,Rozhkova T,Blokhina A,Limonova A,Ramensky V,Divashuk M,Khasanova Z,Bukaeva A,Kurilova O,Skirko O,Pokrovskaya M,Mikova V,Snigir E

    更新日期：2021-01-06 00:00:00

  • Novel Aspects on The Interaction Between Grapevine and Plasmopara viticola: Dual-RNA-Seq Analysis Highlights Gene Expression Dynamics in The Pathogen and The Plant During The Battle For Infection.

    abstract：:Mgaloblishvili, a Vitis vinifera cultivar, exhibits unique resistance traits against Plasmopara viticola, the downy mildew agent. This offers the unique opportunity of exploring the molecular responses in compatible and incompatible plant-pathogen interaction. In this study, whole transcriptomes of Mgaloblishvili, Pin...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11030261

    authors： Toffolatti SL,De Lorenzis G,Brilli M,Moser M,Shariati V,Tavakol E,Maddalena G,Passera A,Casati P,Pindo M,Cestaro A,Maghradze D,Failla O,Bianco PA,Quaglino F

    更新日期：2020-02-28 00:00:00

  • MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway.

    abstract：:The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11091052

    authors： Cui J,Liu X,Yang L,Che S,Guo H,Han J,Zhu Z,Cao B,An X,Zhang L,Song Y

    更新日期：2020-09-07 00:00:00

  • The Role of Wnt Signal in Glioblastoma Development and Progression: A Possible New Pharmacological Target for the Therapy of This Tumor.

    abstract：:Wnt is a complex signaling pathway involved in the regulation of crucial biological functions such as development, proliferation, differentiation and migration of cells, mainly stem cells, which are virtually present in all embryonic and adult tissues. Conversely, dysregulation of Wnt signal is implicated in developme...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes9020105

    authors： Zuccarini M,Giuliani P,Ziberi S,Carluccio M,Iorio PD,Caciagli F,Ciccarelli R

    更新日期：2018-02-17 00:00:00

  • Characterization of the IS200/IS605 Insertion Sequence Family in Halanaerobium Hydrogeniformans.

    abstract：:Mobile DNA elements play a significant evolutionary role by promoting genome plasticity. Insertion sequences are the smallest prokaryotic transposable elements. They are highly diverse elements, and the ability to accurately identify, annotate, and infer the full genomic impact of insertion sequences is lacking. Halan...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11050484

    authors： Sadler M,R Mormile M,L Frank R

    更新日期：2020-04-29 00:00:00

  • Extracellular Vesicles-Mediated Transfer of miRNA Let-7b from PC3 Cells to Macrophages.

    abstract：:Prostate-derived extracellular vesicles (pEVs) may represent a way to selectively transport cargo molecules from the producing cells to the target cells to allow biological events, both in physiological and pathological circumstances. pEVs cargo participates in the modulation of the inflammatory responses in physiolog...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11121495

    authors： Costanzi E,Romani R,Scarpelli P,Bellezza I

    更新日期：2020-12-12 00:00:00

  • Transmission and Drive Involving Parasitic B Chromosomes.

    abstract：:B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes9080388

    authors： Jones RN

    更新日期：2018-07-31 00:00:00

  • Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies.

    abstract：:Pancreatic ductal adenocarcinoma is an extremely aggressive disease with a high metastatic potential. Most patients are diagnosed with metastatic disease, at which the five-year survival rate is only 3%. A better understanding of the mechanisms that drive metastasis is imperative for the development of better therapeu...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes11010006

    authors： Ayres Pereira M,Chio IIC

    更新日期：2019-12-19 00:00:00

  • The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing.

    abstract：:Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes5040926

    authors： Moura J,Børsheim E,Carvalho E

    更新日期：2014-09-29 00:00:00

  • Identification of Differentially Expressed Genes between Original Breast Cancer and Xenograft Using Machine Learning Algorithms.

    abstract：:Breast cancer is one of the most common malignancies in women. Patient-derived tumor xenograft (PDX) model is a cutting-edge approach for drug research on breast cancer. However, PDX still exhibits differences from original human tumors, thereby challenging the molecular understanding of tumorigenesis. In particular, ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9030155

    authors： Wang D,Li JR,Zhang YH,Chen L,Huang T,Cai YD

    更新日期：2018-03-12 00:00:00

  • Transcriptomic Analysis Reveals Involvement of the Macrophage Migration Inhibitory Factor Gene Network in Duchenne Muscular Dystrophy.

    abstract：:Duchenne muscular dystrophy (DMD) is a progressive hereditary muscular disease with X-linked recessive inheritance, that leads patients to premature death. The loss of dystrophin determines membrane instability, causing cell damage and inflammatory response. Macrophage migration inhibitory factor (MIF) is a cytokine t...

    journal_title：Genes

    pub_type： 杂志文章,meta分析

    doi：10.3390/genes10110939

    authors： Lombardo SD,Mazzon E,Mangano K,Basile MS,Cavalli E,Mammana S,Fagone P,Nicoletti F,Petralia MC

    更新日期：2019-11-18 00:00:00

  • Transcriptional Basis for Differential Thermosensitivity of Seedlings of Various Tomato Genotypes.

    abstract：:Transcriptional reprograming after the exposure of plants to elevated temperatures is a hallmark of stress response which is required for the manifestation of thermotolerance. Central transcription factors regulate the stress survival and recovery mechanisms and many of the core responses controlled by these factors a...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11060655

    authors： Hu Y,Fragkostefanakis S,Schleiff E,Simm S

    更新日期：2020-06-16 00:00:00

  • Development of Molecular Marker Linked with Bacterial Fruit Blotch Resistance in Melon (Cucumis melo L.).

    abstract：:Bacterial fruit blotch (BFB) causes losses in melon marketable yield. However, until now, there has been no information about the genetic loci responsible for resistance to the disease or their pattern of inheritance. We determined the inheritance pattern of BFB resistance from a segregating population of 491 F2 indiv...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11020220

    authors： Islam MR,Hossain MR,Jesse DMI,Jung HJ,Kim HT,Park JI,Nou IS

    更新日期：2020-02-19 00:00:00

  • Monogenic diabetes: a diagnostic algorithm for clinicians.

    abstract：:Monogenic forms of beta cell diabetes account for approximately 1%-2% of all cases of diabetes, yet remain underdiagnosed. Overlapping clinical features with common forms of diabetes, make diagnosis challenging. A genetic diagnosis of monogenic diabetes in many cases alters therapy, affects prognosis, enables genetic ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes4040522

    authors： Carroll RW,Murphy R

    更新日期：2013-09-26 00:00:00

  • The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function.

    abstract：:Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can seq...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes10040318

    authors： Doksani Y

    更新日期：2019-04-24 00:00:00

  • Female Choice Undermines the Emergence of Strong Sexual Isolation between Locally Adapted Populations of Atlantic Mollies (Poecilia mexicana).

    abstract：:Divergent selection between ecologically dissimilar habitats promotes local adaptation, which can lead to reproductive isolation (RI). Populations in the Poecilia mexicana species complex have independently adapted to toxic hydrogen sulfide and show varying degrees of RI. Here, we examined the variation in the mate ch...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes9050232

    authors： Zimmer C,Riesch R,Jourdan J,Bierbach D,Arias-Rodriguez L,Plath M

    更新日期：2018-05-02 00:00:00

  • TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes.

    abstract：:Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85-90% reactivate telomerase, while 10-15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between b...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11070834

    authors： Armendáriz-Castillo I,López-Cortés A,García-Cárdenas J,Guevara-Ramírez P,Leone PE,Pérez-Villa A,Yumiceba V,Zambrano AK,Guerrero S,Paz-Y-Miño C

    更新日期：2020-07-21 00:00:00

  • Genome-Wide Identification of lncRNAs During Rice Seed Development.

    abstract：:Rice seed is a pivotal reproductive organ that directly determines yield and quality. Long non-coding RNAs (lncRNAs) have been recognized as key regulators in plant development, but the roles of lncRNAs in rice seed development remain unclear. In this study, we performed a paired-end RNA sequencing in samples of rice ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11030243

    authors： Zhao J,Ajadi AA,Wang Y,Tong X,Wang H,Tang L,Li Z,Shu Y,Liu X,Li S,Wang S,Liu W,Zhang J

    更新日期：2020-02-26 00:00:00

  • Host-Induced Gene Silencing of Rice Blast Fungus Magnaporthe oryzae Pathogenicity Genes Mediated by the Brome Mosaic Virus.

    abstract：:Magnaportheoryzae is a devastating plant pathogen, which has a detrimental impact on rice production worldwide. Despite its agronomical importance, some newly-emerging pathotypes often overcome race-specific disease resistance rapidly. It is thus desirable to develop a novel strategy for the long-lasting resistance of...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8100241

    authors： Zhu L,Zhu J,Liu Z,Wang Z,Zhou C,Wang H

    更新日期：2017-09-26 00:00:00

  • Dynamin-Related Protein 1 at the Crossroads of Cancer.

    abstract：:Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes9020115

    authors： Lima AR,Santos L,Correia M,Soares P,Sobrinho-Simões M,Melo M,Máximo V

    更新日期：2018-02-21 00:00:00

  • The POU Transcription Factor POU-M2 Regulates Vitellogenin Receptor Gene Expression in the Silkworm, Bombyx mori.

    abstract：:Vitellogenin receptors (VgRs) play critical roles in egg formation by transporting vitellogenin (Vg) into oocytes in insects. Although the function of VgR in insects is well studied, the transcriptional regulation of this gene is still unclear. Here, we cloned the promoter of the VgR gene from Bombyx mori (BmVgR), and...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11040394

    authors： Shen G,Chen E,Ji X,Liu L,Liu J,Hua X,Li D,Xiao Y,Xia Q

    更新日期：2020-04-06 00:00:00

  • The Complete Genome of an Endogenous Nimavirus (Nimav-1_LVa) From the Pacific Whiteleg Shrimp Penaeus (Litopenaeus) Vannamei.

    abstract：:White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other ...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes11010094

    authors： Bao W,Tang KFJ,Alcivar-Warren A

    更新日期：2020-01-14 00:00:00

  • Aberrant Single Exon Skipping is not Altered by Age in Exons of NF1, RABAC1, AATF or PCGF2 in Human Blood Cells and Fibroblasts.

    abstract：:In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatmen...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes2030562

    authors： Mellert K,Uhl M,Högel J,Lamla M,Kemkemer R,Kaufmann D

    更新日期：2011-08-02 00:00:00

  • Identification of the Ovine Keratin-Associated Protein 22-1 (KAP22-1) Gene and Its Effect on Wool Traits.

    abstract：:Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8010027

    authors： Li S,Zhou H,Gong H,Zhao F,Wang J,Liu X,Luo Y,Hickford JG

    更新日期：2017-01-11 00:00:00

  • Study of mcr-1 Gene-Mediated Colistin Resistance in Enterobacteriaceae Isolated from Humans and Animals in Different Countries.

    abstract：:In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...

    journal_title：Genes

    pub_type： 杂志文章

    doi：10.3390/genes8120394

    authors： Hadjadj L,Riziki T,Zhu Y,Li J,Diene SM,Rolain JM

    更新日期：2017-12-19 00:00:00

  • Epigenetic Control of Pancreatic Regeneration in Diabetes.

    abstract：:Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...

    journal_title：Genes

    pub_type： 杂志文章,评审

    doi：10.3390/genes9090448

    authors： Balaji S,Napolitano T,Silvano S,Friano ME,Garrido-Utrilla A,Atlija J,Collombat P

    更新日期：2018-09-07 00:00:00