The Complete Genome of an Endogenous Nimavirus (Nimav-1_LVa) From the Pacific Whiteleg Shrimp Penaeus (Litopenaeus) Vannamei.

abstract：:Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational...

journal_title：Genes

authors： Edwards AM,Addo MA,Dos Santos PC

更新日期：2020-08-07 00:00:00

abstract：:Olfaction, which is mediated by olfactory receptor (OR) genes, is essential in the daily life of fish, especially in foraging. However, Chinese perch (Siniperca chuatsi) is believed to prey with reliance on vision and lateral sensation, but not on olfaction. Therefore, understanding the evolutionary dynamics of the Ch...

journal_title：Genes

authors： Lv LY,Liang XF,He S

更新日期：2019-02-25 00:00:00

abstract：:The performance of genomic prediction (GP) on genetically correlated traits can be improved through an interdependence multi-trait model under a multi-environment context. In this study, a panel of 237 soft facultative wheat (Triticumaestivum L.) lines was evaluated to compare single- and multi-trait models for predic...

journal_title：Genes

authors： Guo J,Khan J,Pradhan S,Shahi D,Khan N,Avci M,Mcbreen J,Harrison S,Brown-Guedira G,Murphy JP,Johnson J,Mergoum M,Esten Mason R,Ibrahim AMH,Sutton R,Griffey C,Babar MA

更新日期：2020-10-28 00:00:00

abstract：:Gruiformes is a group with phylogenetic issues. Recent studies based on mitochondrial and genomic DNA have proposed the existence of a core Gruiformes, consisting of five families: Heliornithidae, Aramidae, Gruidae, Psophiidae and Rallidae. Karyotype studies on these species are still scarce, either by conventional st...

journal_title：Genes

authors： Furo IO,Kretschmer R,O'Brien PCM,Pereira JC,Ferguson-Smith MA,de Oliveira EHC

更新日期：2020-03-13 00:00:00

abstract：:Network medicine relies on different types of networks: from the molecular level of protein⁻protein interactions to gene regulatory network and correlation studies of gene expression. Among network approaches based on the analysis of the topological properties of protein⁻protein interaction (PPI) networks, we discuss ...

journal_title：Genes

authors： Fiscon G,Conte F,Farina L,Paci P

更新日期：2018-08-31 00:00:00

abstract：:Monogenic forms of beta cell diabetes account for approximately 1%-2% of all cases of diabetes, yet remain underdiagnosed. Overlapping clinical features with common forms of diabetes, make diagnosis challenging. A genetic diagnosis of monogenic diabetes in many cases alters therapy, affects prognosis, enables genetic ...

journal_title：Genes

authors： Carroll RW,Murphy R

更新日期：2013-09-26 00:00:00

abstract：:Loss of seed shattering is a key trait in crop domestication, particularly for grain crops. For wild plants, seed shattering is a crucial mechanism to achieve greater fitness, although in the agricultural context, this mechanism reduces harvesting efficiency, especially under dry conditions. Loss of seed shattering wa...

journal_title：Genes

authors： Di Vittori V,Gioia T,Rodriguez M,Bellucci E,Bitocchi E,Nanni L,Attene G,Rau D,Papa R

更新日期：2019-01-19 00:00:00

abstract：:Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This revi...

journal_title：Genes

authors： Porazinski S,Ladomery M

更新日期：2018-03-13 00:00:00

abstract：:Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...

journal_title：Genes

authors： Moura J,Børsheim E,Carvalho E

更新日期：2014-09-29 00:00:00

abstract：:microRNA (miRNA) activity and regulation are of increasing interest as new therapeutic targets. Traditional approaches to assess miRNA levels in cells rely on RNA sequencing or quantitative PCR. While useful, these approaches are based on RNA extraction and cannot be applied in real-time to observe miRNA activity with...

journal_title：Genes

authors： Turk MA,Chung CZ,Manni E,Zukowski SA,Engineer A,Badakhshi Y,Bi Y,Heinemann IU

更新日期：2018-06-19 00:00:00

abstract：:Preimplantation genetic testing (PGT) has evolved into a well-established alternative to invasive prenatal diagnosis, even though genetic testing of single or few cells is quite challenging. PGT-M is in theory available for any monogenic disorder for which the disease-causing locus has been unequivocally identified. I...

journal_title：Genes

authors： De Rycke M,Berckmoes V

更新日期：2020-07-31 00:00:00

abstract：:The Sichuan partridge (Arborophila rufipectus, Phasianidae, Galliformes) is distributed in south-west China, and classified as endangered grade. To examine the evolution and genomic features of Sichuan partridge, we de novo assembled the Sichuan partridge reference genome. The final draft assembly consisted of approxi...

journal_title：Genes

authors： Zhou C,Tu H,Yu H,Zheng S,Dai B,Price M,Wu Y,Yang N,Yue B,Meng Y

更新日期：2019-09-05 00:00:00

abstract：:The P-type plasma membrane (PM) H+-ATPase plays a major role during the growth and development of a plant. It is also involved in plant resistance to a variety of biotic and abiotic factors, including salt stress. The PM H+-ATPase gene family has been well characterized in Arabidopsis and other crop plants such as ric...

journal_title：Genes

authors： Xu Z,Marowa P,Liu H,Du H,Zhang C,Li Y

更新日期：2020-03-27 00:00:00

abstract：:N6-methyladenosine (m6A) is the most abundant RNA modification. It has been involved in the regulation of RNA metabolism, including degradation and translation, in both physiological and disease conditions. A recent study showed that m6A-mediated degradation of key transcripts also plays a role in the control of T cel...

journal_title：Genes

authors： Furlan M,Galeota E,de Pretis S,Caselle M,Pelizzola M

更新日期：2019-01-08 00:00:00

abstract：:Bacterial fruit blotch (BFB) causes losses in melon marketable yield. However, until now, there has been no information about the genetic loci responsible for resistance to the disease or their pattern of inheritance. We determined the inheritance pattern of BFB resistance from a segregating population of 491 F2 indiv...

journal_title：Genes

authors： Islam MR,Hossain MR,Jesse DMI,Jung HJ,Kim HT,Park JI,Nou IS

更新日期：2020-02-19 00:00:00

abstract：:In forensics, mitochondrial DNA (mtDNA) analysis is foremost applied to rootless hairs often lacking detectable nuclear DNA. Sanger sequencing is the routine mtDNA method in most forensic laboratories, even though interpretation of mixed samples and heteroplasmic sites can be challenging. Individuals may hold cells wi...

journal_title：Genes

authors： Gaag KJV,Desmyter S,Smit S,Prieto L,Sijen T

更新日期：2020-11-16 00:00:00

abstract：:Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...

journal_title：Genes

authors： Yin Z,Han X,Li Y,Wang J,Wang D,Wang S,Fu X,Ye W

更新日期：2017-12-05 00:00:00

abstract：:Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fert...

journal_title：Genes

authors： Somers M,Olde Loohuis LM,Aukes MF,Pasaniuc B,de Visser KCL,Kahn RS,Sommer IE,Ophoff RA

更新日期：2017-05-04 00:00:00

abstract：:Gene doping, an activity which abuses and misuses gene therapy, is a major concern in sports and horseracing industries. Effective methods capable of detecting and monitoring gene doping are urgently needed. Although several PCR-based methods that detect transgenes have been developed, many of them focus only on a sin...

journal_title：Genes

authors： Tozaki T,Ohnuma A,Kikuchi M,Ishige T,Kakoi H,Hirota KI,Kusano K,Nagata SI

更新日期：2020-04-23 00:00:00

abstract：:Golgi reassembly and stacking protein (GRASP) is required for polysaccharide secretion and virulence in Cryptococcus neoformans. In fungal species, extracellular vesicles (EVs) participate in the export of polysaccharides, proteins and RNA. In the present work, we investigated if EV-mediated RNA export is functionally...

journal_title：Genes

authors： Peres da Silva R,Martins ST,Rizzo J,Dos Reis FCG,Joffe LS,Vainstein M,Kmetzsch L,Oliveira DL,Puccia R,Goldenberg S,Rodrigues ML,Alves LR

更新日期：2018-08-08 00:00:00

abstract：:Juvenile open angle glaucoma (JOAG), which is an uncommon form of primary open angle glaucoma, is a clinically and genetically heterogeneous disorder. We report on a family with a recessively inherited form of JOAG. The proband has a superior and an inferior never fiber layer thinning in both the eyes and the nasal vi...

journal_title：Genes

authors： Saeedi O,Yousaf S,Tsai J,Palmer K,Riazuddin S,Ahmed ZM

更新日期：2018-10-30 00:00:00

abstract：:Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...

journal_title：Genes

authors： Arruda PSS,Ferreira DC,Oliveira C,Venere PC

更新日期：2019-08-23 00:00:00

abstract：:Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...

journal_title：Genes

authors： Josling GA,Selvarajah SA,Petter M,Duffy MF

更新日期：2012-05-29 00:00:00

abstract：:Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telomere dysfunction an...

journal_title：Genes

authors： M'kacher R,Colicchio B,Borie C,Junker S,Marquet V,Heidingsfelder L,Soehnlen K,Najar W,Hempel WM,Oudrhiri N,Wilhelm-Murer N,Miguet M,Arnoux M,Ferrapie C,Kerbrat W,Plesch A,Dieterlen A,Girinsky T,Voisin P,Deschenes G

更新日期：2020-04-27 00:00:00

abstract：:Helicobacter pylori (H. pylori) is one of the main causes of gastric gancer. TNF-related apoptosis-inducing ligand (TRAIL) is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via TRAIL. It is believed that MicroRNA-106b-5p might be involved in t...

journal_title：Genes

authors： Pereira J,Santos M,Delabio R,Barbosa M,Smith M,Payão S,Rasmussen L

更新日期：2020-04-05 00:00:00

abstract：:Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can seq...

journal_title：Genes

authors： Doksani Y

更新日期：2019-04-24 00:00:00

abstract：:In the years since the first complete human genome sequence was reported, there has been a rapid development of technologies to facilitate high-throughput sequence analysis of DNA (termed "next-generation" sequencing). These novel approaches to DNA sequencing offer the promise of complete genomic analysis at a cost fe...

journal_title：Genes

authors： Anderson MW,Schrijver I

更新日期：2010-05-25 00:00:00

abstract：:Several transcription factors (TFs) coordinate to regulate expression of specific genes at the transcriptional level. In Arabidopsis thaliana it is estimated that approximately 10% of all genes encode TFs or TF-like proteins. It is important to identify target genes that are directly regulated by TFs in order to under...

journal_title：Genes

authors： Kurihara Y,Makita Y,Kawashima M,Hamasaki H,Yamamoto YY,Matsui M

更新日期：2014-12-19 00:00:00

abstract：:Silver-Russell syndrome (SRS) is a rare growth-related genetic disorder that is mainly associated with prenatal and postnatal growth retardation. Molecular causes are not clear in all cases, the most common ones being loss of methylation on chromosome 11p15 (≈50%) and maternal uniparental disomy for chromosome 7 (upd(...

journal_title：Genes

authors： Vado Y,Pereda A,Llano-Rivas I,Gorria-Redondo N,Díez I,Perez de Nanclares G

更新日期：2020-12-05 00:00:00

abstract：:The p.R577X polymorphism (rs1815739) in the ACTN3 gene causes individuals with the ACTN3 XX genotype to be deficient in functional α-actinin-3. Previous investigations have found that XX athletes are more prone to suffer non-contact muscle injuries. This investigation aimed to determine the influence of the ACTN3 R577...

journal_title：Genes

authors： Gutiérrez-Hellín J,Baltazar-Martins G,Aguilar-Navarro M,Ruiz-Moreno C,Oliván J,Del Coso J

更新日期：2021-01-08 00:00:00