Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies.

abstract：:Photoperiod is one of the important factors leading to seasonal reproduction of sheep. However, the molecular mechanisms underlying the photoperiod regulation of seasonal reproduction remain poorly understood. In this study, we compared the expression profiles of mRNAs, lncRNAs, and circRNAs in uterine tissues from Su...

journal_title：Genes

authors： La Y,He X,Zhang L,Di R,Wang X,Gan S,Zhang X,Zhang J,Hu W,Chu M

更新日期：2020-03-12 00:00:00

abstract：:In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process. In rat, two splicing events produce several isoforms of ADAR2, called ADAR2a, ADAR2b, ADAR2e, and ADAR2f, but only ADAR2a and AD...

journal_title：Genes

authors： Filippini A,Bonini D,Giacopuzzi E,La Via L,Gangemi F,Colombi M,Barbon A

更新日期：2018-02-08 00:00:00

abstract：:There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of linc...

journal_title：Genes

authors： Zou C,Li S,Deng L,Guan Y,Chen D,Yuan X,Xia T,He X,Shan Y,Li C

更新日期：2017-08-18 00:00:00

abstract：:Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...

journal_title：Genes

authors： Liu H,Li Q,Xing Y

更新日期：2018-10-10 00:00:00

abstract：:Crested wheatgrass (Agropyron cristatum L.) breeding programs aim to develop later maturing cultivars for extending early spring grazing in Western Canada. Plant maturity is a complex genetic trait, and little is known about genes associated with late maturity in this species. An attempt was made using RNA-Seq to prof...

journal_title：Genes

authors： Zeng F,Biligetu B,Coulman B,Schellenberg MP,Fu YB

更新日期：2017-10-25 00:00:00

abstract：:Ferns are a representative clade in plant evolution although underestimated in the genomic era. Ceratopteris richardii is an emergent model for developmental processes in ferns, yet a complete scheme of the different growth stages is necessary. Here, we present a developmental analysis, at the tissue and cellular leve...

journal_title：Genes

authors： Aragón-Raygoza A,Vasco A,Blilou I,Herrera-Estrella L,Cruz-Ramírez A

更新日期：2020-12-04 00:00:00

abstract：:Network medicine relies on different types of networks: from the molecular level of protein⁻protein interactions to gene regulatory network and correlation studies of gene expression. Among network approaches based on the analysis of the topological properties of protein⁻protein interaction (PPI) networks, we discuss ...

journal_title：Genes

authors： Fiscon G,Conte F,Farina L,Paci P

更新日期：2018-08-31 00:00:00

abstract：:Architectural proteins play key roles in genome construction and regulate the expression of many genes, albeit the modulation of genome plasticity by these proteins is largely unknown. A critical screening of the architectural proteins in five crop species, viz., Oryza sativa, Zea mays, Sorghum bicolor, Cicer arietinu...

journal_title：Genes

authors： Verma JK,Wardhan V,Singh D,Chakraborty S,Chakraborty N

更新日期：2018-03-28 00:00:00

abstract：:Heat stress (HS) is challenging in humans and animals as it is a complicated regulatory mechanism. This prompted us to characterize the physiological and molecular responses of a HS-animal model. In this study, a rat model system was developed by using three temperature treatments (40 ℃, 42 ℃, and 43 ℃) and sixteen bi...

journal_title：Genes

authors： Dou J,Khan A,Khan MZ,Mi S,Wang Y,Yu Y,Wang Y

更新日期：2020-03-13 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a complex multisystemic condition caused by a lack of paternal expression of imprinted genes from the 15q11.2-q13 region. Limited literature exists on the association between molecular classes, growth hormone use, and the prevalence of psychiatric phenotypes in PWS. In this study, we ana...

journal_title：Genes

authors： Montes AS,Osann KE,Gold JA,Tamura RN,Driscoll DJ,Butler MG,Kimonis VE

更新日期：2020-10-23 00:00:00

abstract：:Transfer RNA (tRNA) is a dynamic molecule used by all forms of life as a key component of the translation apparatus. Each tRNA is highly processed, structured, and modified, to accurately deliver amino acids to the ribosome for protein synthesis. The tRNA molecule is a critical component in synthetic biology methods f...

journal_title：Genes

authors： Hoffman KS,Crnković A,Söll D

更新日期：2018-11-07 00:00:00

abstract：:Epigenetic alterations at imprinted genes on different chromosomes have been linked to several imprinting disorders (IDs) such as Beckwith-Wiedemann syndrome (BWS) and pseudohypoparathyroidism type 1b (PHP1b). Here, we present a male patient with these two distinct IDs caused by two independent mechanisms-loss of meth...

journal_title：Genes

authors： Choufani S,Ko JM,Lou Y,Shuman C,Fishman L,Weksberg R

更新日期：2021-01-27 00:00:00

abstract：:DNA damage leads to genome instability by interfering with DNA replication. Cells possess several damage bypass pathways that mitigate the effects of DNA damage during replication. These pathways include translesion synthesis and template switching. These pathways are regulated largely through post-translational modif...

journal_title：Genes

authors： Ripley BM,Gildenberg MS,Washington MT

更新日期：2020-01-29 00:00:00

abstract：:DNA methylation patterns have been shown to change throughout the normal aging process. Several studies have found epigenetic aging markers using age predictors, but these studies only focused on blood-specific or tissue-common methylation patterns. Here, we constructed nine tissue-specific age prediction models using...

journal_title：Genes

authors： Choi H,Joe S,Nam H

更新日期：2019-11-04 00:00:00

abstract：:Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...

journal_title：Genes

authors： Moon CI,Tompkins W,Wang Y,Godec A,Zhang X,Pipkorn P,Miller CA,Dehner C,Dahiya S,Hirbe AC

更新日期：2020-05-01 00:00:00

abstract：:Magnaportheoryzae is a devastating plant pathogen, which has a detrimental impact on rice production worldwide. Despite its agronomical importance, some newly-emerging pathotypes often overcome race-specific disease resistance rapidly. It is thus desirable to develop a novel strategy for the long-lasting resistance of...

journal_title：Genes

authors： Zhu L,Zhu J,Liu Z,Wang Z,Zhou C,Wang H

更新日期：2017-09-26 00:00:00

abstract：:Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...

journal_title：Genes

authors： Badji A,Kwemoi DB,Machida L,Okii D,Mwila N,Agbahoungba S,Kumi F,Ibanda A,Bararyenya A,Solemanegy M,Odong T,Wasswa P,Otim M,Asea G,Ochwo-Ssemakula M,Talwana H,Kyamanywa S,Rubaihayo P

更新日期：2020-06-24 00:00:00

abstract：:The homeodomain-leucine zipper (HD-Zip) gene family, as plant-specific transcription factors, plays an important role in plant development and growth as well as in the response to diverse stresses. Although HD-Zip genes have been extensively studied in many plants, they had not yet been studied in wheat, especially th...

journal_title：Genes

authors： Yue H,Shu D,Wang M,Xing G,Zhan H,Du X,Song W,Nie X

更新日期：2018-02-01 00:00:00

abstract：:Information on the biochemical pathways of carbon and energy metabolism in representatives of the deep lineage bacterial phylum Deferribacteres are scarce. Here, we report the results of the sequencing and analysis of the high-quality draft genome of the thermophilic chemolithoautotrophic anaerobe Deferribacter autotr...

journal_title：Genes

authors： Slobodkin A,Slobodkina G,Allioux M,Alain K,Jebbar M,Shadrin V,Kublanov I,Toshchakov S,Bonch-Osmolovskaya E

更新日期：2019-10-26 00:00:00

abstract：:One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affe...

journal_title：Genes

authors： Villarino GH,Hu Q,Scanlon MJ,Mueller L,Bombarely A,Mattson NS

更新日期：2017-08-03 00:00:00

abstract：:Epigenetic modifications are a mechanism conveying environmental information to subsequent generations via parental germ lines. Research on epigenetic responses to environmental changes in wild mammals has been widely neglected, as well as studies that compare responses to changes in different environmental factors. H...

journal_title：Genes

authors： Weyrich A,Lenz D,Fickel J

更新日期：2018-12-21 00:00:00

abstract：:Croatian viticulture was most extensive at the beginning of the 20th century, when about 400 varieties were in use. Autochthonous varieties are the result of spontaneous hybridization from the pre-phylloxera era and are still cultivated today on about 35 % of vineyard area, while some exist only in repositories. We pr...

journal_title：Genes

authors： Žulj Mihaljević M,Maletić E,Preiner D,Zdunić G,Bubola M,Zyprian E,Pejić I

更新日期：2020-07-02 00:00:00

abstract：:Smoltification and early seawater phase are critical developmental periods with physiological and biochemical changes in Atlantic salmon that facilitates survival in saltwater. MicroRNAs (miRNAs) are known to have important roles in development, but whether any miRNAs are involved in regulation of gene expression duri...

journal_title：Genes

authors： Shwe A,Østbye TK,Krasnov A,Ramberg S,Andreassen R

更新日期：2020-09-08 00:00:00

abstract：:Trees and their seeds regulate their germination, growth, and reproduction in response to environmental stimuli. These stimuli, through signal transduction, trigger transcription factors that alter the expression of various genes leading to the unfolding of the genetic program. A regulon is conceptually defined as a s...

journal_title：Genes

authors： Xia X

更新日期：2020-08-25 00:00:00

abstract：:Single-cell RNA-seq (scRNA-seq) is quite prevalent in studying transcriptomes, but it suffers from excessive zeros, some of which are true, but others are false. False zeros, which can be seen as missing data, obstruct the downstream analysis of single-cell RNA-seq data. How to distinguish true zeros from false ones i...

journal_title：Genes

authors： Chi W,Deng M

更新日期：2020-05-11 00:00:00

abstract：:Salinity is one of the major environment factors that limits the growth of plants and the productivity of crops worldwide. It has been shown that Na+ transporters play a central role in salt tolerance and development of plants. The objective of this study was to identify Na+/H+ antiporter (NHX) genes and investigate t...

journal_title：Genes

authors： Wu GQ,Wang JL,Li SJ

更新日期：2019-05-27 00:00:00

abstract：:Blumeria graminis f. sp. hordei (Bgh), the causal agent of barley powdery mildew (PM), is one of the most important barley leaf diseases and is prevalent in most barley growing regions. Infection decreases grain quality and yields on average by 30%. Multi-parent advanced generation inter-cross (MAGIC) populations comb...

journal_title：Genes

authors： Novakazi F,Krusell L,Jensen JD,Orabi J,Jahoor A,Bengtsson T,On Behalf Of The Ppp Barley Consortium

更新日期：2020-12-18 00:00:00

abstract：:Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in...

journal_title：Genes

authors： Panasiak L,Dobosz S,Ocalewicz K

更新日期：2020-07-13 00:00:00

abstract：:The contribution of chromatin dynamics to the regulation of human disease-associated loci such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the focus of intensive experimentation for many years. Recent technological advances in the analysis of transcriptional mechanisms across the en...

journal_title：Genes

authors： Gosalia N,Harris A

更新日期：2015-07-13 00:00:00

abstract：:Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated...

journal_title：Genes

authors： Agosto LM,Gagne M,Henderson AJ

更新日期：2015-09-30 00:00:00