Abstract:
:Epigenetic modifications are a mechanism conveying environmental information to subsequent generations via parental germ lines. Research on epigenetic responses to environmental changes in wild mammals has been widely neglected, as well as studies that compare responses to changes in different environmental factors. Here, we focused on the transmission of DNA methylation changes to naive male offspring after paternal exposure to either diet (~40% less protein) or temperature increase (10 °C increased temperature). Because both experiments focused on the liver as the main metabolic and thermoregulation organ, we were able to decipher if epigenetic changes differed in response to different environmental changes. Reduced representation bisulfite sequencing (RRBS) revealed differentially methylated regions (DMRs) in annotated genomic regions in sons sired before (control) and after the fathers' treatments. We detected both a highly specific epigenetic response dependent on the environmental factor that had changed that was reflected in genes involved in specific metabolic pathways, and a more general response to changes in outer stimuli reflected by epigenetic modifications in a small subset of genes shared between both responses. Our results indicated that fathers prepared their offspring for specific environmental changes by paternally inherited epigenetic modifications, suggesting a strong paternal contribution to adaptive processes.
journal_name
Genes (Basel)journal_title
Genesauthors
Weyrich A,Lenz D,Fickel Jdoi
10.3390/genes10010004subject
Has Abstractpub_date
2018-12-21 00:00:00issue
1issn
2073-4425pii
genes10010004journal_volume
10pub_type
杂志文章相关文献
Genes文献大全abstract::Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes5040926
更新日期:2014-09-29 00:00:00
abstract::The Himalayas are one of earth's hotspots of biodiversity. Among its many cryptic and undiscovered organisms, including vertebrates, this complex high-mountain ecosystem is expected to harbour many species with adaptations to life in high altitudes. However, modern evolutionary genomic studies in Himalayan vertebrates...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10110873
更新日期:2019-10-31 00:00:00
abstract::Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090639
更新日期:2019-08-23 00:00:00
abstract::A 9-month old male Jack Russell Terrier started showing paraparesis of the hindlimbs after a walk. Hospitalized, the dog went into cardiac arrest, and later died. Necroscopic examination revealed a severe thickness of the diaphragm, esophagus, and base of the tongue, leading to the diagnosis of muscular dystrophy. The...
journal_title:Genes
pub_type:
doi:10.3390/genes11101175
更新日期:2020-10-08 00:00:00
abstract::Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi [...]. ...
journal_title:Genes
pub_type: 社论
doi:10.3390/genes10020161
更新日期:2019-02-20 00:00:00
abstract::Coat color dilution corresponds to a specific pigmentation phenotype that leads to a dilution of wild type pigments. It affects both eumelanin and pheomelanin containing melanosomes. The mode of inheritance of the dilution phenotype is autosomal recessive. Candidate gene approaches focused on the melanophilin (MLPH) g...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090430
更新日期:2018-08-23 00:00:00
abstract::Histone acts as the core for nucleosomes and is a key protein component of chromatin. Among different histone variants, histone H3 (HH3) variants have been reported to play vital roles in plant development. However, biological information and evolutionary relationships of HH3 genes in cotton remain to be elucidated. T...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050355
更新日期:2019-05-09 00:00:00
abstract::Winged bean (Psophocarpus tetragonolobus) is an herbaceous multipurpose legume grown in hot and humid countries as a pulse, vegetable (leaves and pods), or root tuber crop depending on local consumption preferences. In addition to its different nutrient-rich edible parts which could contribute to food and nutritional ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8030100
更新日期:2017-03-09 00:00:00
abstract::Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060689
更新日期:2020-06-24 00:00:00
abstract::The pseudostratified olfactory epithelium (OE) may histologically appear relatively simple, but the cytological relations among its cell types, especially those between olfactory receptor neurons (ORNs) and olfactory sustentacular cells (OSCs), prove more complex and variable than previously believed. Adding to the co...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11050493
更新日期:2020-04-30 00:00:00
abstract::The multiple organellar RNA editing factors (MORF) gene family plays a key role in organelle RNA editing in flowering plants. MORF genes expressions are also affected by abiotic stress. Although seven OsMORF genes have been identified in rice, few reports have been published on their expression patterns in different t...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090694
更新日期:2019-09-10 00:00:00
abstract::The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their m...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030305
更新日期:2020-03-13 00:00:00
abstract::Gene duplication is an important evolutionary mechanism allowing to provide new genetic material and thus opportunities to acquire new gene functions for an organism, with major implications such as speciation events. Various processes are known to allow a gene to be duplicated and different models explain how duplica...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11091046
更新日期:2020-09-04 00:00:00
abstract::Cancer stem cells (CSCs), having both self-renewal and tumorigenic capacity, utilize an energy metabolism system different from that of non-CSCs. Lipid droplets (LDs) are organelles that store neutral lipids, including triacylglycerol. Previous studies demonstrated that LDs are formed and store lipids as an energy sou...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes12010099
更新日期:2021-01-14 00:00:00
abstract::Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyzed the right-ventricular systolic pressure (RVSP), right-ventricular hypertrophy (RVH), lung histology, and transcriptomes of six-week-old male rats with PH induced by (1) hypoxia (HO), (2) administration of monocrotalin...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020126
更新日期:2020-01-23 00:00:00
abstract::Cultivation of faba bean (Vicia faba L.) in Tunisia is largely based on improved varieties of the crop. However, a few farmers continue to produce local cultivars or landraces. The National Gene Bank of Tunisia (NGBT) recently launched a collection project for faba bean landraces, with special focus on the regions of ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020236
更新日期:2020-02-24 00:00:00
abstract::Terpenoids play important roles in plant defense. Although some terpene synthases have been characterized, terpenoids and their biosynthesis in wheat (Triticumaestivum L.) still remain largely unknown. Here, we describe the identification of a terpene synthase gene in wheat. It encodes a sesquiterpene synthase that ca...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060441
更新日期:2019-06-10 00:00:00
abstract::Death investigations often include an effort to establish the postmortem interval (PMI) in cases in which the time of death is uncertain. The postmortem interval can lead to the identification of the deceased and the validation of witness statements and suspect alibis. Recent research has demonstrated that microbes pr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9020104
更新日期:2018-02-16 00:00:00
abstract::Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN i...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11070719
更新日期:2020-06-28 00:00:00
abstract::The relationship between variation of the repetitive component of the genome and domestication in plant species is not fully understood. In previous work, variations in the abundance and proximity to genes of long terminal repeats (LTR)-retrotransposons of sunflower (Helianthus annuus L.) were investigated by Illumina...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090433
更新日期:2018-08-29 00:00:00
abstract::Mitogen-activated protein kinase (MAPK) signaling pathway plays key roles in sensing extracellular signals and transmitting them from the cell membrane to the nucleus in response to various environmental stimuli. A MAPKKK protein CgMck1 in Colletotrichum gloeosporioides was characterized. Phenotypic analyses of the ∆C...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9110543
更新日期:2018-11-08 00:00:00
abstract::Hemp is a Pb-tolerant and Pb-accumulating plant and the study of its tolerance mechanisms could facilitate the breeding of hemp with enhanced Pb tolerance and accumulation. In the present study, we took advantage of sequential window acquisition of all theoretical mass spectra (SWATH) technology to study the differenc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050396
更新日期:2019-05-22 00:00:00
abstract::In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatmen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes2030562
更新日期:2011-08-02 00:00:00
abstract::Despite the extensive research conducted in recent decades, the molecular mechanisms underlying major depressive disorder (MDD) and relative evidence-based treatments remain unclear. Various hypotheses have been successively proposed, involving different biological systems. This narrative review aims to critically ill...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11091089
更新日期:2020-09-18 00:00:00
abstract::Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is involved in DNA repair pathways as it mends the topoisomerase I-DNA covalent complexes. In plants, a small Tdp1 gene family, composed by Tdp1α and Tdp1β genes, was identified, but the roles of these genes in abiotic stress responses are not fully understood. To investigate the...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8110305
更新日期:2017-11-03 00:00:00
abstract::The contribution of chromatin dynamics to the regulation of human disease-associated loci such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the focus of intensive experimentation for many years. Recent technological advances in the analysis of transcriptional mechanisms across the en...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6030543
更新日期:2015-07-13 00:00:00
abstract::Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11070777
更新日期:2020-07-11 00:00:00
abstract::Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes3020320
更新日期:2012-05-29 00:00:00
abstract::PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091012
更新日期:2020-08-27 00:00:00
abstract::Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9020115
更新日期:2018-02-21 00:00:00