Abstract：
:Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development, making use of diverse cell sources or converting pre-existing pancreatic cells. Despite impressive progresses and promising successes, it appears that we still need to gain further insight into the molecular mechanisms underlying β-cell development. This becomes even more obvious with the emergence of a relatively new field of research, epigenetics. The current review therefore focuses on the latest advances in this field in the context of β-cell (neo-)genesis research.
journal_name
Genes (Basel)journal_title
Genesauthors
Balaji S,Napolitano T,Silvano S,Friano ME,Garrido-Utrilla A,Atlija J,Collombat Pdoi
10.3390/genes9090448subject
Has Abstractpub_date
2018-09-07 00:00:00issue
9issn
2073-4425pii
genes9090448journal_volume
9pub_type
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