Abstract:
:Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fertility rates in The Netherlands, shows signs of genetic isolation. For this purpose, genome-wide genotype data was collected of 72 unrelated individuals from this population as well as in a sample of 104 random control subjects from The Netherlands. Additional reference data from different populations and population isolates was available through HapMap and the Human Genome Diversity Project. We performed a number of analyses to compare the genetic structure between these populations: we calculated the pairwise genetic distance between populations, examined the extent of identical-by-descent (IBD) sharing and estimated the effective population size. Genetic analysis of this population showed consistent patterns of a population isolate at all levels tested. We confirmed that this population is most closely related to the Dutch control subjects, and detected high levels of IBD sharing and runs of homozygosity at equal or even higher levels than observed in previously described population isolates. The effective population size of this population was estimated to be several orders of magnitude smaller than that of the Dutch control sample. We conclude that the geographic isolation of this population combined with rapid population growth has resulted in a genetic isolate with great potential value for future genetic studies.
journal_name
Genes (Basel)journal_title
Genesauthors
Somers M,Olde Loohuis LM,Aukes MF,Pasaniuc B,de Visser KCL,Kahn RS,Sommer IE,Ophoff RAdoi
10.3390/genes8050133subject
Has Abstractpub_date
2017-05-04 00:00:00issue
5issn
2073-4425pii
genes8050133journal_volume
8pub_type
杂志文章相关文献
Genes文献大全abstract::A major technological shift in the research community in the past decade has been the adoption of high throughput (HT) technologies to interrogate the genome, epigenome, transcriptome, and proteome in a massively parallel fashion [...]. ...
journal_title:Genes
pub_type: 社论
doi:10.3390/genes11030245
更新日期:2020-02-26 00:00:00
abstract::Cultivation of faba bean (Vicia faba L.) in Tunisia is largely based on improved varieties of the crop. However, a few farmers continue to produce local cultivars or landraces. The National Gene Bank of Tunisia (NGBT) recently launched a collection project for faba bean landraces, with special focus on the regions of ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020236
更新日期:2020-02-24 00:00:00
abstract::The 2019 "Personal Genomes: Accessing, Sharing and Interpretation" conference (Hinxton, UK, 11-12 April 2019) brought together geneticists, bioinformaticians, clinicians and ethicists to promote openness and ethical sharing of personal genome data while protecting the privacy of individuals. The talks at the conferenc...
journal_title:Genes
pub_type:
doi:10.3390/genes10090643
更新日期:2019-08-25 00:00:00
abstract::The scale of genetic methods are presently being expanded: forensic genetic assays previously were limited to tens of loci, but now technologies allow for a transition to forensic genomic approaches that assess thousands to millions of loci. However, there are subtle distinctions between genetic assays and their genom...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes12020185
更新日期:2021-01-27 00:00:00
abstract::The facultative aerobic bacterium Escherichia coli adjusts its cell cycle to environmental conditions. Because of its lifestyle, the bacterium has to balance the use of oxygen with the potential lethal effects of its poisonous derivatives. Oxidative damages perpetrated by molecules such as hydrogen peroxide and supero...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9110565
更新日期:2018-11-21 00:00:00
abstract::Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes5040926
更新日期:2014-09-29 00:00:00
abstract::Vavilovia formosa is a relict leguminous plant growing in hard-to-reach habitats in the rocky highlands of the Caucasus and Middle East, and it is considered as the putative closest living relative of the last common ancestor (LCA) of the Fabeae tribe. Symbionts of Vavilovia belonging to Rhizobium leguminosarum bv. vi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10120990
更新日期:2019-12-01 00:00:00
abstract::Polyspermia is an adverse phenomenon during mammalian fertilization when more than one sperm fuses with a single oocyte. The egg cell is prepared to prevent polyspermia by, among other ways, producing cortical granules (CGs), which are specialized intracellular structures containing enzymes that aim to harden the zona...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070815
更新日期:2020-07-17 00:00:00
abstract::The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091052
更新日期:2020-09-07 00:00:00
abstract::More than fifteen genetic diseases, including Huntington's disease, myotonic dystrophy 1, fragile X syndrome and Friedreich ataxia, are caused by the aberrant expansion of a trinucleotide repeat. The mutation is unstable and further expands in specific cells or tissues with time, which can accelerate disease progressi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes4030375
更新日期:2013-07-25 00:00:00
abstract::Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060689
更新日期:2020-06-24 00:00:00
abstract::Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9010039
更新日期:2018-01-16 00:00:00
abstract::The microRNA (miR)-17 family is widely expressed in mammalian tissues and play important roles in various physiological and pathological processes. Here, the functions of miR-106a-5p, a member of miR-17 family, were explored during myogenic differentiation in C2C12 cell line. First, miR-106a-5p was found to be relativ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9070333
更新日期:2018-07-02 00:00:00
abstract::In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, we employed BE and PE mRNAs in conjunction with chemically synthesized sgRNAs and pegRNAs for efficient editing of human i...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050511
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Large-scale screening of drug sensitivity on cancer cell models can mimic in vivo cellular behavior providing wider scope for biological research on cancer. Since the therapeutic effect of a single drug or drug combination depends on the individual patient's genome characteristics and cancer cells integratio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030263
更新日期:2020-02-28 00:00:00
abstract::The Sichuan partridge (Arborophila rufipectus, Phasianidae, Galliformes) is distributed in south-west China, and classified as endangered grade. To examine the evolution and genomic features of Sichuan partridge, we de novo assembled the Sichuan partridge reference genome. The final draft assembly consisted of approxi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090677
更新日期:2019-09-05 00:00:00
abstract::Protein sequence, structure, and function are inherently linked through evolution and population genetics. Our knowledge of protein structure comes from solved structures in the Protein Data Bank (PDB), our knowledge of sequence through sequences found in the NCBI sequence databases (http://www.ncbi.nlm.nih.gov/), and...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes2040748
更新日期:2011-10-28 00:00:00
abstract::Pancreatic ductal adenocarcinoma is an extremely aggressive disease with a high metastatic potential. Most patients are diagnosed with metastatic disease, at which the five-year survival rate is only 3%. A better understanding of the mechanisms that drive metastasis is imperative for the development of better therapeu...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11010006
更新日期:2019-12-19 00:00:00
abstract::Genomic imprinting in domestic animals contributes to the variance of performance traits. However, research remains to be done on large-scale detection of epigenetic landscape of porcine imprinted loci including the GNAS complex locus. The purpose of this study was to generate porcine parthenogenetic fetuses and compr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010096
更新日期:2020-01-14 00:00:00
abstract::Fusarium head blight (FHB), caused primarily by the fungus Fusarium graminearum, is one of the most damaging diseases of wheat, causing significant loss of yield and quality worldwide. Warm and wet conditions during flowering, a lack of resistant wheat varieties, and high inoculum pressure from corn stubble contribute...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060699
更新日期:2020-06-25 00:00:00
abstract::Elymus sibiricus, which is a perennial and self-pollinated grass, is the typical species of the genus Elymus, which plays an important role in forage production and ecological restoration. No reports have, so far, systematically described the selection of optimal reference genes for reverse transcriptase quantitative ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060451
更新日期:2019-06-13 00:00:00
abstract::The continuous development of new genotyping technologies requires awareness of their potential advantages and limitations concerning utility for pharmacogenomics (PGx). In this review, we provide an overview of technologies that can be applied in PGx research and clinical practice. Most commonly used are single nucle...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11121456
更新日期:2020-12-04 00:00:00
abstract::Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050476
更新日期:2020-04-27 00:00:00
abstract::Soil salinity is a serious threat to plant growth and crop productivity. Tall fescue utilization in saline areas is limited by its inferior salt tolerance. Thus, a transcriptome study is a prerequisite for future research aimed at providing deeper insights into the molecular mechanisms of tall fescue salt tolerance as...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9100466
更新日期:2018-09-21 00:00:00
abstract::RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing 11-cis retinal. To date, almost 200 loss-of-function mutations have ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11121420
更新日期:2020-11-27 00:00:00
abstract::Chlorella is a popular microalga with robust physiological and biochemical characteristics, which can be cultured under various conditions. The exploration of the small RNA content of Chlorella could improve strategies for the enhancement of metabolite production from this microalga. In this study, stress was introduc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101131
更新日期:2020-09-25 00:00:00
abstract::Crested wheatgrass (Agropyron cristatum L.) breeding programs aim to develop later maturing cultivars for extending early spring grazing in Western Canada. Plant maturity is a complex genetic trait, and little is known about genes associated with late maturity in this species. An attempt was made using RNA-Seq to prof...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8110291
更新日期:2017-10-25 00:00:00
abstract::Chinese kale is a native vegetable in Southern China and the flowering stalk is the most commonly used edible part due to its high glucosinolate content and other nutritional qualities. The GTR protein played important roles in the glucosinolate transport process. In this study, three BocGTR1 genes were cloned from Ch...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10030202
更新日期:2019-03-08 00:00:00
abstract::Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trai...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060418
更新日期:2019-05-30 00:00:00
abstract::Meiosis yields haploid gametes following two successive divisions of a germ cell in the absence of intervening DNA replication. Balanced segregation of homologous chromosomes in Meiosis I is aided by a proteinaceous structure, the synaptonemal complex (SC). The objective of this study was to determine total average au...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes1030505
更新日期:2010-12-15 00:00:00