Abstract：
:Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fertility rates in The Netherlands, shows signs of genetic isolation. For this purpose, genome-wide genotype data was collected of 72 unrelated individuals from this population as well as in a sample of 104 random control subjects from The Netherlands. Additional reference data from different populations and population isolates was available through HapMap and the Human Genome Diversity Project. We performed a number of analyses to compare the genetic structure between these populations: we calculated the pairwise genetic distance between populations, examined the extent of identical-by-descent (IBD) sharing and estimated the effective population size. Genetic analysis of this population showed consistent patterns of a population isolate at all levels tested. We confirmed that this population is most closely related to the Dutch control subjects, and detected high levels of IBD sharing and runs of homozygosity at equal or even higher levels than observed in previously described population isolates. The effective population size of this population was estimated to be several orders of magnitude smaller than that of the Dutch control sample. We conclude that the geographic isolation of this population combined with rapid population growth has resulted in a genetic isolate with great potential value for future genetic studies.
journal_name
Genes (Basel)journal_title
Genesauthors
Somers M,Olde Loohuis LM,Aukes MF,Pasaniuc B,de Visser KCL,Kahn RS,Sommer IE,Ophoff RAdoi
10.3390/genes8050133subject
Has Abstractpub_date
2017-05-04 00:00:00issue
5issn
2073-4425pii
genes8050133journal_volume
8pub_type
杂志文章相关文献
Genes文献大全abstract：:In this review we present the developmental, histological, evolutionary and functional properties of insect chemosensory proteins (CSPs) in insect species. CSPs are small globular proteins folded like a prism and notoriously known for their complex and arguably obscure function(s), particularly in pheromone olfaction....
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11040413
更新日期：2020-04-10 00:00:00
abstract：:In the years since the first complete human genome sequence was reported, there has been a rapid development of technologies to facilitate high-throughput sequence analysis of DNA (termed "next-generation" sequencing). These novel approaches to DNA sequencing offer the promise of complete genomic analysis at a cost fe...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes1010038
更新日期：2010-05-25 00:00:00
abstract：:We analysed nine microsatellite markers for 626 individuals representing the geographic range of eight closely related endemic New Zealand species of Sophora. Structure analysis identified the optimal K value as seven, with samples identified as Sophorachathamica, Sophorafulvida, Sophoralongicarinata, and Sophoraprost...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9020111
更新日期：2018-02-20 00:00:00
abstract：:Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic diseases. It is caused by mutations in the NF1 gene encoding for the large protein, neurofibromin. Genetic testing of NF1 is cumbersome because 50% of cases are sporadic, and there are no mutation hot spots. In addition, the most recog...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9040216
更新日期：2018-04-17 00:00:00
abstract：:The actin depolymerizing factor (ADF) proteins have growth, development, defense-related and growth regulatory functions in plants. The present study used genome-wide analysis to investigate ADF family genes in tomato. Eleven tomato ADF genes were identified and differential expression patterns were found in different...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes7100079
更新日期：2016-09-29 00:00:00
abstract：:Cancer stem cells (CSCs), having both self-renewal and tumorigenic capacity, utilize an energy metabolism system different from that of non-CSCs. Lipid droplets (LDs) are organelles that store neutral lipids, including triacylglycerol. Previous studies demonstrated that LDs are formed and store lipids as an energy sou...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes12010099
更新日期：2021-01-14 00:00:00
abstract：:Fruit set is the earliest phase of fruit growth and represents the onset of ovary growth after successful fertilization. In parthenocarpy, fruit formation is less affected by environmental factors because it occurs in the absence of pollination and fertilization, making parthenocarpy a highly desired agronomic trait. ...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11121441
更新日期：2020-11-30 00:00:00
abstract：:Roan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-roan ratio of foals ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11060680
更新日期：2020-06-22 00:00:00
abstract：:Spiders often produce multiple types of silk, each with unique properties suiting them to certain tasks and biological functions. Orb-weaver spiders can generate more than six types of silk fibroins, with pyriform silk used to form attachment discs, adhering silk to other surfaces and substances. The unique higher-ord...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10060425
更新日期：2019-06-03 00:00:00
abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110851
更新日期：2019-10-28 00:00:00
abstract：:Fig wasps are a peculiar group of insects which, for millions of years, have inhabited the enclosed syconia of fig trees. Considering the relatively closed and dark environment of fig syconia, we hypothesize that the fig wasps' oxidative phosphorylation (OXPHOS) pathway, which is the main oxygen consumption and adenos...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11111353
更新日期：2020-11-15 00:00:00
abstract：:Transcriptional regulation of the genome arguably provides the basis for the anatomical elaboration and dynamic operation of the human brain. It logically follows that genetic variations affecting gene transcription contribute to mental health disorders, including autism spectrum disorder (ASD). A number of recent stu...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11050535
更新日期：2020-05-11 00:00:00
abstract：:The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFts...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8120391
更新日期：2017-12-15 00:00:00
abstract：:Preimplantation genetic testing (PGT) has evolved into a well-established alternative to invasive prenatal diagnosis, even though genetic testing of single or few cells is quite challenging. PGT-M is in theory available for any monogenic disorder for which the disease-causing locus has been unequivocally identified. I...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11080871
更新日期：2020-07-31 00:00:00
abstract：:Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is s...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9010045
更新日期：2018-01-22 00:00:00
abstract：:Segments of the genome enriched in repetitive sequences still present a challenge and are omitted in genome assemblies. For that reason, the exact composition of DNA sequences underlying the heterochromatic regions and the active centromeres are still unexplored for many organisms. The centromere is a crucial region o...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11060695
更新日期：2020-06-24 00:00:00
abstract：:One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by the activation of a telomere maintenance mechanism (TMM). The majority of cancers reactivate the reverse transcriptase, telomerase, to maintain their telomere length but a minority (10% to 15%) utilize an alternative lengt...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11020133
更新日期：2020-01-27 00:00:00
abstract：:During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9050242
更新日期：2018-05-04 00:00:00
abstract：:We set out to assess the NIH/3T3 cell proliferation activity of Arabidopsis oil body-expressed recombinant oleosin-hEGF-hEGF protein. Normally, human epidermal growth factor (hEGF) is purified through complex process, however, oleosin fusion technology provides an inexpensive and scalable platform for its purification...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11090959
更新日期：2020-08-19 00:00:00
abstract：:Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during protein synthesis, tRNAs are also the source of a heterogeneous class of small RNAs, tRNA-derived small RNAs (tsRNAs). Occurrence and th...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9120607
更新日期：2018-12-05 00:00:00
abstract：:The genus Lactobacillus includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on h...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11101234
更新日期：2020-10-21 00:00:00
abstract：:Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9020089
更新日期：2018-02-14 00:00:00
abstract：:EuAP2 genes are well-known for their role in flower development, a legacy of the founding member of this subfamily of transcription factors, whose mutants lacked petals in Arabidopsis. However, studies of euAP2 genes in several species have accumulated evidence highlighting the diverse roles of euAP2 genes in other as...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10120994
更新日期：2019-12-01 00:00:00
abstract：:Amazonian puffing snakes (Spilotes; Colubridae) are snakes widely distributed in the Neotropical region. However, chromosomal data are scarce in this group and, when available, are only limited to karyotype description using conventional staining. In this paper, we focused on the process of karyotype evolution and tre...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10040288
更新日期：2019-04-09 00:00:00
abstract：:We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11090978
更新日期：2020-08-22 00:00:00
abstract：:Transcriptional reprograming after the exposure of plants to elevated temperatures is a hallmark of stress response which is required for the manifestation of thermotolerance. Central transcription factors regulate the stress survival and recovery mechanisms and many of the core responses controlled by these factors a...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11060655
更新日期：2020-06-16 00:00:00
abstract：:Feed cost accounts for approximately 65-75% of overall commercial pork production costs. Therefore, improving the feed efficiency of pig production is important. In this study, 12 individuals with either extremely high (HE) or low (LE) feed efficiency were selected from 225 Duroc × (Landrace × Yorkshire) (DLY) pigs. A...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10090725
更新日期：2019-09-18 00:00:00
abstract：:The southern elephant seal Mirounga leonina is the largest phocid seal and one of the two species of elephant seals. They are listed as 'least concern' by the International Union for Conservation of Nature (IUCN) Red List of Threatened Species 2015. Here, we have assembled the reference genome for M. leonina using the...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11020160
更新日期：2020-02-03 00:00:00
abstract：:The northern sea otter inhabits coastal waters of the northern Pacific Ocean and is the largest member of the Mustelidae family. DNA sequencing methods that utilize microfluidic partitioned and non-partitioned library construction were used to establish the sea otter genome. The final assembly provided 2.426 Gbp of hi...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8120379
更新日期：2017-12-11 00:00:00
abstract：:Each domestic dog breed is characterized by a strict set of physical and behavioral characteristics by which breed members are judged and rewarded in conformation shows. One defining feature of particular interest is the coat, which is comprised of either a double- or single-layer of hair. The top coat contains coarse...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10050323
更新日期：2019-04-26 00:00:00
