An Introduction to Systems Analytics and Integration of Big Omics Data.

Abstract:

:A major technological shift in the research community in the past decade has been the adoption of high throughput (HT) technologies to interrogate the genome, epigenome, transcriptome, and proteome in a massively parallel fashion [...].

journal_name

Genes (Basel)

journal_title

Genes

authors

Hardiman G

doi

10.3390/genes11030245

subject

Has Abstract

pub_date

2020-02-26 00:00:00

issue

3

issn

2073-4425

pii

genes11030245

journal_volume

11

pub_type

社论

相关文献

Genes文献大全
  • TALEN-Mediated Gene Targeting for Cystic Fibrosis-Gene Therapy.

    abstract::Cystic fibrosis (CF) is an inherited monogenic disorder, amenable to gene-based therapies. Because CF lung disease is currently the major cause of mortality and morbidity, and the lung airway is readily accessible to gene delivery, the major CF gene therapy effort at present is directed to the lung. Although airway ep...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10010039

    authors: Xia E,Zhang Y,Cao H,Li J,Duan R,Hu J

    更新日期:2019-01-11 00:00:00

  • From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting.

    abstract::Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes6030469

    authors: Boeger H,Shelansky R,Patel H,Brown CR

    更新日期:2015-06-30 00:00:00

  • Epigenetic Control of Pancreatic Regeneration in Diabetes.

    abstract::Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes9090448

    authors: Balaji S,Napolitano T,Silvano S,Friano ME,Garrido-Utrilla A,Atlija J,Collombat P

    更新日期:2018-09-07 00:00:00

  • How Hormones and MADS-Box Transcription Factors Are Involved in Controlling Fruit Set and Parthenocarpy in Tomato.

    abstract::Fruit set is the earliest phase of fruit growth and represents the onset of ovary growth after successful fertilization. In parthenocarpy, fruit formation is less affected by environmental factors because it occurs in the absence of pollination and fertilization, making parthenocarpy a highly desired agronomic trait. ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11121441

    authors: Molesini B,Dusi V,Pennisi F,Pandolfini T

    更新日期:2020-11-30 00:00:00

  • Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing-G/C Substitution Stabilizes GuideRNAs against Editing.

    abstract::Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8010034

    authors: Heep M,Mach P,Reautschnig P,Wettengel J,Stafforst T

    更新日期:2017-01-14 00:00:00

  • An efficient estimator of the mutation parameter and analysis of polymorphism from the 1000 genomes project.

    abstract::The mutation parameter θ is fundamental and ubiquitous in the analysis of population samples of DNA sequences. This paper presents a new highly efficient estimator of θ by utilizing the phylogenetic information among distinct alleles in a sample of DNA sequences. The new estimator, called Allelic BLUE, is derived from...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes5030561

    authors: Fu Y

    更新日期:2014-07-22 00:00:00

  • PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?

    abstract::Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN i...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11070719

    authors: Fusco N,Sajjadi E,Venetis K,Gaudioso G,Lopez G,Corti C,Rocco EG,Criscitiello C,Malapelle U,Invernizzi M

    更新日期:2020-06-28 00:00:00

  • Fitness Costs of the Glutathione S-Transferase Epsilon 2 (L119F-GSTe2) Mediated Metabolic Resistance to Insecticides in the Major African Malaria Vector Anopheles Funestus.

    abstract::Metabolic resistance to insecticides threatens malaria control. However, little is known about its fitness cost in field populations of malaria vectors, thus limiting the design of suitable resistance management strategies. Here, we assessed the association between the glutathione S-transferase GSTe2-mediated metaboli...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9120645

    authors: Tchouakui M,Riveron JM,Djonabaye D,Tchapga W,Irving H,Soh Takam P,Njiokou F,Wondji CS

    更新日期:2018-12-19 00:00:00

  • Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.

    abstract::Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11050499

    authors: Moon CI,Tompkins W,Wang Y,Godec A,Zhang X,Pipkorn P,Miller CA,Dehner C,Dahiya S,Hirbe AC

    更新日期:2020-05-01 00:00:00

  • Ancient Ancestry Informative Markers for Identifying Fine-Scale Ancient Population Structure in Eurasians.

    abstract::The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for mo...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9120625

    authors: Esposito U,Das R,Syed S,Pirooznia M,Elhaik E

    更新日期:2018-12-12 00:00:00

  • Cryptic Diversity Hidden within the Leafminer Genus Liriomyza (Diptera: Agromyzidae).

    abstract::Leafminer insects of the genus Liriomyza are small flies whose larvae feed on the internal tissue of some of the most important crop plants for the human diet. Several of these pest species are highly uniform from the morphological point of view, meaning molecular data represents the only reliable taxonomic tool usefu...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9110554

    authors: Carapelli A,Soltani A,Leo C,Vitale M,Amri M,Mediouni-Ben Jemâa J

    更新日期:2018-11-15 00:00:00

  • NetR and AttR, Two New Bioinformatic Tools to Integrate Diverse Datasets into Cytoscape Network and Attribute Files.

    abstract::High-throughput technologies have allowed researchers to obtain genome-wide data from a wide array of experimental model systems. Unfortunately, however, new data generation tends to significantly outpace data re-utilization, and most high throughput datasets are only rarely used in subsequent studies or to generate n...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10060423

    authors: Halajyan A,Weingart N,Yeahia M,Loza-Coll M

    更新日期:2019-06-01 00:00:00

  • Cortical Granule Distribution and Expression Pattern of Genes Regulating Cellular Component Size, Morphogenesis, and Potential to Differentiation are Related to Oocyte Developmental Competence and Maturational Capacity In Vivo and In Vitro.

    abstract::Polyspermia is an adverse phenomenon during mammalian fertilization when more than one sperm fuses with a single oocyte. The egg cell is prepared to prevent polyspermia by, among other ways, producing cortical granules (CGs), which are specialized intracellular structures containing enzymes that aim to harden the zona...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11070815

    authors: Kulus M,Kranc W,Jeseta M,Sujka-Kordowska P,Konwerska A,Ciesiółka S,Celichowski P,Moncrieff L,Kocherova I,Józkowiak M,Kulus J,Wieczorkiewicz M,Piotrowska-Kempisty H,Skowroński MT,Bukowska D,Machatkova M,Hanulakova S,Mozd

    更新日期:2020-07-17 00:00:00

  • The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing.

    abstract::Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes5040926

    authors: Moura J,Børsheim E,Carvalho E

    更新日期:2014-09-29 00:00:00

  • The Epigenetics Dilemma.

    abstract::This special issue of Genes demonstrates clearly that research in epigenetics has proceeded at a very rapid pace in the last decade. [...]. ...

    journal_title:Genes

    pub_type: 社论

    doi:10.3390/genes11010023

    authors: Grunau C,Le Luyer J,Laporte M,Joly D

    更新日期:2019-12-23 00:00:00

  • Telomere Dynamics in the Diploid and Triploid Rainbow Trout (Oncorhynchus mykiss) Assessed by Q-FISH Analysis.

    abstract::Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11070786

    authors: Panasiak L,Dobosz S,Ocalewicz K

    更新日期:2020-07-13 00:00:00

  • Control of DNA Damage Bypass by Ubiquitylation of PCNA.

    abstract::DNA damage leads to genome instability by interfering with DNA replication. Cells possess several damage bypass pathways that mitigate the effects of DNA damage during replication. These pathways include translesion synthesis and template switching. These pathways are regulated largely through post-translational modif...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11020138

    authors: Ripley BM,Gildenberg MS,Washington MT

    更新日期:2020-01-29 00:00:00

  • From Chromosomes to Genome: Insights into the Evolutionary Relationships and Biogeography of Old World Knifefishes (Notopteridae; Osteoglossiformes).

    abstract::In addition to its wide geographical distribution, osteoglossiform fishes represent one of the most ancient freshwater teleost lineages; making it an important group for systematic and evolutionary studies. These fishes had a Gondwanan origin and their past distribution may have contributed to the diversity present in...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9060306

    authors: Barby FF,Ráb P,Lavoué S,Ezaz T,Bertollo LAC,Kilian A,Maruyama SR,Aguiar de Oliveira E,Artoni RF,Santos MH,Ilesanmi Jegede O,Hatanaka T,Tanomtong A,Liehr T,Cioffi MB

    更新日期:2018-06-19 00:00:00

  • Comparative Transcriptome Analysis of Gene Expression Patterns in Tomato Under Dynamic Light Conditions.

    abstract::Plants grown under highly variable natural light regimes differ strongly from plants grown under constant light (CL) regimes. Plant phenotype and adaptation responses are important for plant biomass and fitness. However, the underlying regulatory mechanisms are still poorly understood, particularly from a transcriptio...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10090662

    authors: Ding J,Zhao J,Pan T,Xi L,Zhang J,Zou Z

    更新日期:2019-08-29 00:00:00

  • The Complete Genome of an Endogenous Nimavirus (Nimav-1_LVa) From the Pacific Whiteleg Shrimp Penaeus (Litopenaeus) Vannamei.

    abstract::White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11010094

    authors: Bao W,Tang KFJ,Alcivar-Warren A

    更新日期:2020-01-14 00:00:00

  • Reducing the Number of Mismatches between Hairs and Buccal References When Analysing mtDNA Heteroplasmic Variation by Massively Parallel Sequencing.

    abstract::In forensics, mitochondrial DNA (mtDNA) analysis is foremost applied to rootless hairs often lacking detectable nuclear DNA. Sanger sequencing is the routine mtDNA method in most forensic laboratories, even though interpretation of mixed samples and heteroplasmic sites can be challenging. Individuals may hold cells wi...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111355

    authors: Gaag KJV,Desmyter S,Smit S,Prieto L,Sijen T

    更新日期:2020-11-16 00:00:00

  • Diverse Roles of MAX1 Homologues in Rice.

    abstract::Cytochrome P450 enzymes encoded by MORE AXILLARY GROWTH1 (MAX1)-like genes produce most of the structural diversity of strigolactones during the final steps of strigolactone biosynthesis. The diverse copies of MAX1 in Oryza sativa provide a resource to investigate why plants produce such a wide range of strigolactones...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111348

    authors: Marzec M,Situmorang A,Brewer PB,Brąszewska A

    更新日期:2020-11-13 00:00:00

  • Single-Cell Genomic Analysis in Plants.

    abstract::Individual cells in an organism are variable, which strongly impacts cellular processes. Advances in sequencing technologies have enabled single-cell genomic analysis to become widespread, addressing shortcomings of analyses conducted on populations of bulk cells. While the field of single-cell plant genomics is in it...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes9010050

    authors: Yuan Y,Lee H,Hu H,Scheben A,Edwards D

    更新日期:2018-01-22 00:00:00

  • Transmission and Drive Involving Parasitic B Chromosomes.

    abstract::B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes9080388

    authors: Jones RN

    更新日期:2018-07-31 00:00:00

  • Rapid Direct Nucleic Acid Amplification Test without RNA Extraction for SARS-CoV-2 Using a Portable PCR Thermocycler.

    abstract::There is an ongoing worldwide coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, confirmatory diagnosis is by reverse transcription polymerase chain reaction (RT-PCR), typically taking several hours and requiring a molecular laboratory to pe...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11060664

    authors: Wee SK,Sivalingam SP,Yap EPH

    更新日期:2020-06-18 00:00:00

  • Opportunities and Challenges in Interpreting and Sharing Personal Genomes.

    abstract::The 2019 "Personal Genomes: Accessing, Sharing and Interpretation" conference (Hinxton, UK, 11-12 April 2019) brought together geneticists, bioinformaticians, clinicians and ethicists to promote openness and ethical sharing of personal genome data while protecting the privacy of individuals. The talks at the conferenc...

    journal_title:Genes

    pub_type:

    doi:10.3390/genes10090643

    authors: Rubin IR,Glusman G

    更新日期:2019-08-25 00:00:00

  • Intestinal Transcriptome Analysis Highlights Key Differentially Expressed Genes Involved in Nutrient Metabolism and Digestion in Yellowtail Kingfish (Seriola lalandi) Fed Terrestrial Animal and Plant Proteins.

    abstract::This study investigated the effects of dietary terrestrial animal and plant proteins on the intestinal transcriptomes of yellowtail kingfish (YTK), Seriola lalandi, an ecologically and economically important marine species in Australia. Five diets containing fish meal (FM), poultry by-product meal (PBM), blood meal (B...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11060621

    authors: Dam CTM,Ventura T,Booth M,Pirozzi I,Salini M,Smullen R,Elizur A

    更新日期:2020-06-05 00:00:00

  • The Plasticizer Bisphenol A Perturbs the Hepatic Epigenome: A Systems Level Analysis of the miRNome.

    abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8100269

    authors: Renaud L,Silveira WAD,Hazard ES,Simpson J,Falcinelli S,Chung D,Carnevali O,Hardiman G

    更新日期:2017-10-13 00:00:00

  • Identification and Validation of Novel Reference Genes in Acute Lymphoblastic Leukemia for Droplet Digital PCR.

    abstract::Droplet digital PCR is the most robust method for absolute nucleic acid quantification. However, RNA is a very versatile molecule and its abundance is tissue-dependent. RNA quantification is dependent on a reference control to estimate the abundance. Additionally, in cancer, many cellular processes are deregulated whi...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10050376

    authors: Villegas-Ruíz V,Olmos-Valdez K,Castro-López KA,Saucedo-Tepanecatl VE,Ramírez-Chiquito JC,Pérez-López EI,Medina-Vera I,Juárez-Méndez S

    更新日期:2019-05-17 00:00:00

  • MicroRNA-106a-5p Inhibited C2C12 Myogenesis via Targeting PIK3R1 and Modulating the PI3K/AKT Signaling.

    abstract::The microRNA (miR)-17 family is widely expressed in mammalian tissues and play important roles in various physiological and pathological processes. Here, the functions of miR-106a-5p, a member of miR-17 family, were explored during myogenic differentiation in C2C12 cell line. First, miR-106a-5p was found to be relativ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9070333

    authors: Li X,Zhu Y,Zhang H,Ma G,Wu G,Xiang A,Shi X,Yang GS,Sun S

    更新日期:2018-07-02 00:00:00