Abstract:
:A major technological shift in the research community in the past decade has been the adoption of high throughput (HT) technologies to interrogate the genome, epigenome, transcriptome, and proteome in a massively parallel fashion [...].
journal_name
Genes (Basel)journal_title
Genesauthors
Hardiman Gdoi
10.3390/genes11030245subject
Has Abstractpub_date
2020-02-26 00:00:00issue
3issn
2073-4425pii
genes11030245journal_volume
11pub_type
社论相关文献
Genes文献大全abstract::Cystic fibrosis (CF) is an inherited monogenic disorder, amenable to gene-based therapies. Because CF lung disease is currently the major cause of mortality and morbidity, and the lung airway is readily accessible to gene delivery, the major CF gene therapy effort at present is directed to the lung. Although airway ep...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010039
更新日期:2019-01-11 00:00:00
abstract::Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6030469
更新日期:2015-06-30 00:00:00
abstract::Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9090448
更新日期:2018-09-07 00:00:00
abstract::Fruit set is the earliest phase of fruit growth and represents the onset of ovary growth after successful fertilization. In parthenocarpy, fruit formation is less affected by environmental factors because it occurs in the absence of pollination and fertilization, making parthenocarpy a highly desired agronomic trait. ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11121441
更新日期:2020-11-30 00:00:00
abstract::Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010034
更新日期:2017-01-14 00:00:00
abstract::The mutation parameter θ is fundamental and ubiquitous in the analysis of population samples of DNA sequences. This paper presents a new highly efficient estimator of θ by utilizing the phylogenetic information among distinct alleles in a sample of DNA sequences. The new estimator, called Allelic BLUE, is derived from...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes5030561
更新日期:2014-07-22 00:00:00
abstract::Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN i...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11070719
更新日期:2020-06-28 00:00:00
abstract::Metabolic resistance to insecticides threatens malaria control. However, little is known about its fitness cost in field populations of malaria vectors, thus limiting the design of suitable resistance management strategies. Here, we assessed the association between the glutathione S-transferase GSTe2-mediated metaboli...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9120645
更新日期:2018-12-19 00:00:00
abstract::Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050499
更新日期:2020-05-01 00:00:00
abstract::The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for mo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9120625
更新日期:2018-12-12 00:00:00
abstract::Leafminer insects of the genus Liriomyza are small flies whose larvae feed on the internal tissue of some of the most important crop plants for the human diet. Several of these pest species are highly uniform from the morphological point of view, meaning molecular data represents the only reliable taxonomic tool usefu...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9110554
更新日期:2018-11-15 00:00:00
abstract::High-throughput technologies have allowed researchers to obtain genome-wide data from a wide array of experimental model systems. Unfortunately, however, new data generation tends to significantly outpace data re-utilization, and most high throughput datasets are only rarely used in subsequent studies or to generate n...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060423
更新日期:2019-06-01 00:00:00
abstract::Polyspermia is an adverse phenomenon during mammalian fertilization when more than one sperm fuses with a single oocyte. The egg cell is prepared to prevent polyspermia by, among other ways, producing cortical granules (CGs), which are specialized intracellular structures containing enzymes that aim to harden the zona...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070815
更新日期:2020-07-17 00:00:00
abstract::Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes5040926
更新日期:2014-09-29 00:00:00
abstract::This special issue of Genes demonstrates clearly that research in epigenetics has proceeded at a very rapid pace in the last decade. [...]. ...
journal_title:Genes
pub_type: 社论
doi:10.3390/genes11010023
更新日期:2019-12-23 00:00:00
abstract::Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070786
更新日期:2020-07-13 00:00:00
abstract::DNA damage leads to genome instability by interfering with DNA replication. Cells possess several damage bypass pathways that mitigate the effects of DNA damage during replication. These pathways include translesion synthesis and template switching. These pathways are regulated largely through post-translational modif...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11020138
更新日期:2020-01-29 00:00:00
abstract::In addition to its wide geographical distribution, osteoglossiform fishes represent one of the most ancient freshwater teleost lineages; making it an important group for systematic and evolutionary studies. These fishes had a Gondwanan origin and their past distribution may have contributed to the diversity present in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060306
更新日期:2018-06-19 00:00:00
abstract::Plants grown under highly variable natural light regimes differ strongly from plants grown under constant light (CL) regimes. Plant phenotype and adaptation responses are important for plant biomass and fitness. However, the underlying regulatory mechanisms are still poorly understood, particularly from a transcriptio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090662
更新日期:2019-08-29 00:00:00
abstract::White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010094
更新日期:2020-01-14 00:00:00
abstract::In forensics, mitochondrial DNA (mtDNA) analysis is foremost applied to rootless hairs often lacking detectable nuclear DNA. Sanger sequencing is the routine mtDNA method in most forensic laboratories, even though interpretation of mixed samples and heteroplasmic sites can be challenging. Individuals may hold cells wi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111355
更新日期:2020-11-16 00:00:00
abstract::Cytochrome P450 enzymes encoded by MORE AXILLARY GROWTH1 (MAX1)-like genes produce most of the structural diversity of strigolactones during the final steps of strigolactone biosynthesis. The diverse copies of MAX1 in Oryza sativa provide a resource to investigate why plants produce such a wide range of strigolactones...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111348
更新日期:2020-11-13 00:00:00
abstract::Individual cells in an organism are variable, which strongly impacts cellular processes. Advances in sequencing technologies have enabled single-cell genomic analysis to become widespread, addressing shortcomings of analyses conducted on populations of bulk cells. While the field of single-cell plant genomics is in it...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9010050
更新日期:2018-01-22 00:00:00
abstract::B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9080388
更新日期:2018-07-31 00:00:00
abstract::There is an ongoing worldwide coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, confirmatory diagnosis is by reverse transcription polymerase chain reaction (RT-PCR), typically taking several hours and requiring a molecular laboratory to pe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060664
更新日期:2020-06-18 00:00:00
abstract::The 2019 "Personal Genomes: Accessing, Sharing and Interpretation" conference (Hinxton, UK, 11-12 April 2019) brought together geneticists, bioinformaticians, clinicians and ethicists to promote openness and ethical sharing of personal genome data while protecting the privacy of individuals. The talks at the conferenc...
journal_title:Genes
pub_type:
doi:10.3390/genes10090643
更新日期:2019-08-25 00:00:00
abstract::This study investigated the effects of dietary terrestrial animal and plant proteins on the intestinal transcriptomes of yellowtail kingfish (YTK), Seriola lalandi, an ecologically and economically important marine species in Australia. Five diets containing fish meal (FM), poultry by-product meal (PBM), blood meal (B...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060621
更新日期:2020-06-05 00:00:00
abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100269
更新日期:2017-10-13 00:00:00
abstract::Droplet digital PCR is the most robust method for absolute nucleic acid quantification. However, RNA is a very versatile molecule and its abundance is tissue-dependent. RNA quantification is dependent on a reference control to estimate the abundance. Additionally, in cancer, many cellular processes are deregulated whi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050376
更新日期:2019-05-17 00:00:00
abstract::The microRNA (miR)-17 family is widely expressed in mammalian tissues and play important roles in various physiological and pathological processes. Here, the functions of miR-106a-5p, a member of miR-17 family, were explored during myogenic differentiation in C2C12 cell line. First, miR-106a-5p was found to be relativ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9070333
更新日期:2018-07-02 00:00:00