Extracellular Vesicles-Mediated Transfer of miRNA Let-7b from PC3 Cells to Macrophages.

abstract：:Bone mineral density (BMD) is of concern in Prader-Willi syndrome (PWS). This study compared responses to a physical activity intervention in bone parameters and remodeling markers in youth with PWS (n = 45) and youth with non-syndromic obesity (NSO; n = 66). Measurements occurred at baseline (PRE) and after 24 weeks ...

journal_title：Genes

authors： Rubin DA,Wilson KS,Orsso CE,Gertz ER,Haqq AM,Castner DM,Dumont-Driscoll M

更新日期：2020-08-24 00:00:00

abstract：:While the number of mammalian genome assemblies has proliferated, Y-chromosome assemblies have lagged behind. This discrepancy is caused by biological features of the Y-chromosome, such as its high repeat content, that present challenges to assembly with short-read, next-generation sequencing technologies. Partial Y-c...

journal_title：Genes

authors： Rando HM,Wadlington WH,Johnson JL,Stutchman JT,Trut LN,Farré M,Kukekova AV

更新日期：2019-05-28 00:00:00

abstract：:At each round of cell division, the DNA must be correctly duplicated and distributed between the two daughter cells to maintain genome identity. In order to achieve proper chromosome replication and segregation, sister chromatids must be recognized as such and kept together until their separation. This process of cohe...

journal_title：Genes

authors： Finardi A,Massari LF,Visintin R

更新日期：2020-08-07 00:00:00

abstract：:Self/foreign discrimination by the innate immune system depends on receptors that identify molecular patterns as associated to pathogens. Among others, this group includes endosomal Toll-like receptors, among which Toll-like receptors (TLR) 3, 7, 8, and 13 recognize and discriminate mammalian from microbial, potential...

journal_title：Genes

authors： Freund I,Eigenbrod T,Helm M,Dalpke AH

更新日期：2019-01-29 00:00:00

abstract：:Epigenetic modifications are a mechanism conveying environmental information to subsequent generations via parental germ lines. Research on epigenetic responses to environmental changes in wild mammals has been widely neglected, as well as studies that compare responses to changes in different environmental factors. H...

journal_title：Genes

authors： Weyrich A,Lenz D,Fickel J

更新日期：2018-12-21 00:00:00

abstract：:We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...

journal_title：Genes

authors： Zafar S,Shahzad M,Ishaq R,Yousaf A,Shaikh RS,Akram J,Ahmed ZM,Riazuddin S

更新日期：2020-08-22 00:00:00

abstract：:The microRNA (miR)-17 family is widely expressed in mammalian tissues and play important roles in various physiological and pathological processes. Here, the functions of miR-106a-5p, a member of miR-17 family, were explored during myogenic differentiation in C2C12 cell line. First, miR-106a-5p was found to be relativ...

journal_title：Genes

authors： Li X,Zhu Y,Zhang H,Ma G,Wu G,Xiang A,Shi X,Yang GS,Sun S

更新日期：2018-07-02 00:00:00

abstract：:The sea lamprey (Petromyzon marinus) is one of few vertebrate species known to reproducibly eliminate large fractions of its genome during normal embryonic development. This germline-specific DNA is lost in the form of large fragments, including entire chromosomes, and available evidence suggests that DNA elimination ...

journal_title：Genes

authors： Timoshevskiy VA,Timoshevskaya NY,Smith JJ

更新日期：2019-10-22 00:00:00

abstract：:Sex chromosomes form once recombination is halted around the sex-determining locus between a homologous pair of chromosomes, resulting in a male-limited Y chromosome. We recently characterized the nascent sex chromosome system in the Trinidadian guppy (Poeciliareticulata). The guppy Y is one of the youngest animal sex...

journal_title：Genes

authors： Morris J,Darolti I,Bloch NI,Wright AE,Mank JE

更新日期：2018-05-03 00:00:00

abstract：:During CRISPR/Cas9 mediated genome editing, site-specific double strand breaks are introduced and repaired either unspecific by non-homologous end joining (NHEJ) or sequence dependent by homology directed repair (HDR). Whereas NHEJ-based generation of gene knock-out is widely performed, the HDR-based knock-in of speci...

journal_title：Genes

authors： Gerlach M,Kraft T,Brenner B,Petersen B,Niemann H,Montag J

更新日期：2018-06-13 00:00:00

abstract：:Ring chromosome 8 (r(8)) is one of the least frequent ring chromosomes. Usually, maternal chromosome 8 forms a ring, which can be lost from cells due to mitotic instability. The 8q24 region contains the imprinted KCNK9 gene, which is expressed from the maternal allele. Heterozygous KCNK9 mutations are associated with ...

journal_title：Genes

authors： Kashevarova AA,Nikitina TV,Mikhailik LI,Belyaeva EO,Vasilyev SA,Lopatkina ME,Fedotov DA,Fonova EA,Zarubin AA,Sivtsev AA,Skryabin NA,Nazarenko LP,Lebedev IN

更新日期：2020-12-09 00:00:00

abstract：:Inherited retinal degenerations are the leading cause of blindness in the working population. X-linked retinitis pigmentosa (XLRP), caused by mutations in the Retinitis pigmentosa GTPase regulator (RPGR) gene is one of the more severe forms, and female carriers of RPGR mutations have a variable presentation. A retrosp...

journal_title：Genes

authors： Nanda A,Salvetti AP,Clouston P,Downes SM,MacLaren RE

更新日期：2018-12-18 00:00:00

abstract：:The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a maj...

journal_title：Genes

authors： Nagpal S,Gibson G,Marigorta UM

更新日期：2018-08-14 00:00:00

abstract：:Feed cost accounts for approximately 65-75% of overall commercial pork production costs. Therefore, improving the feed efficiency of pig production is important. In this study, 12 individuals with either extremely high (HE) or low (LE) feed efficiency were selected from 225 Duroc × (Landrace × Yorkshire) (DLY) pigs. A...

journal_title：Genes

authors： Wang X,Li S,Wu J,Ding R,Quan J,Zheng E,Yang J,Wu Z

更新日期：2019-09-18 00:00:00

abstract：:White spot syndrome virus (WSSV), one of the major pathogens of Procambarus clarkii, has caused severe disruption to the aquaculture industry of P. clarkii in China. To reveal the gene regulatory mechanisms underlying WSSV infection, a comparative transcriptome analysis was performed among WSSV-infected susceptible in...

journal_title：Genes

authors： Yi S,Li Y,Shi L,Zhang L

更新日期：2017-11-10 00:00:00

abstract：:The increasing availability of large-scale time series data allows the inference of microbial community dynamics by association network analysis. However, correlation-based association network analyses are noninformative of causal, mediating and time-dependent relationships between microbial community functional facto...

journal_title：Genes

authors： Ai D,Li X,Liu G,Liang X,Xia LC

更新日期：2019-03-14 00:00:00

abstract：:Fig wasps are a peculiar group of insects which, for millions of years, have inhabited the enclosed syconia of fig trees. Considering the relatively closed and dark environment of fig syconia, we hypothesize that the fig wasps' oxidative phosphorylation (OXPHOS) pathway, which is the main oxygen consumption and adenos...

journal_title：Genes

authors： Zhou Y,Huang D,Xin Z,Xiao J

更新日期：2020-11-15 00:00:00

abstract：:Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...

journal_title：Genes

authors： Liu H,Li Q,Xing Y

更新日期：2018-10-10 00:00:00

abstract：:Transfer RNA (tRNA) is a dynamic molecule used by all forms of life as a key component of the translation apparatus. Each tRNA is highly processed, structured, and modified, to accurately deliver amino acids to the ribosome for protein synthesis. The tRNA molecule is a critical component in synthetic biology methods f...

journal_title：Genes

authors： Hoffman KS,Crnković A,Söll D

更新日期：2018-11-07 00:00:00

abstract：:n/a. ...

journal_title：Genes

authors： Gu S,Xue Q,Liu Q,Xiong M,Wang W,Zhang H

更新日期：2017-03-03 00:00:00

abstract：:Gene duplication is an important evolutionary mechanism allowing to provide new genetic material and thus opportunities to acquire new gene functions for an organism, with major implications such as speciation events. Various processes are known to allow a gene to be duplicated and different models explain how duplica...

journal_title：Genes

authors： Lallemand T,Leduc M,Landès C,Rizzon C,Lerat E

更新日期：2020-09-04 00:00:00

abstract：:Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and autism spectrum disorder, and among those with fragile X syndrome, approximately 1/3rd meet a threshold for an autism spectrum disorder (ASD) diagnosis. Previous functional imaging studies of fragile X syndrome have typically fo...

journal_title：Genes

authors： McKechanie AG,Campbell S,Eley SEA,Stanfield AC

更新日期：2019-12-17 00:00:00

abstract：:RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing 11-cis retinal. To date, almost 200 loss-of-function mutations have ...

journal_title：Genes

authors： Kiang AS,Kenna PF,Humphries MM,Ozaki E,Koenekoop RK,Campbell M,Farrar GJ,Humphries P

更新日期：2020-11-27 00:00:00

abstract：:Modulated electromagnetic fields (wEMFs), as generated by modern communication technologies, have raised concerns about adverse health effects. The International Agency for Research on Cancer (IARC) classifies them as "possibly carcinogenic to humans" (Group 2B), yet, the underlying molecular mechanisms initiating and...

journal_title：Genes

authors： Schuermann D,Ziemann C,Barekati Z,Capstick M,Oertel A,Focke F,Murbach M,Kuster N,Dasenbrock C,Schär P

更新日期：2020-03-25 00:00:00

abstract：:Loss of seed shattering is a key trait in crop domestication, particularly for grain crops. For wild plants, seed shattering is a crucial mechanism to achieve greater fitness, although in the agricultural context, this mechanism reduces harvesting efficiency, especially under dry conditions. Loss of seed shattering wa...

journal_title：Genes

authors： Di Vittori V,Gioia T,Rodriguez M,Bellucci E,Bitocchi E,Nanni L,Attene G,Rau D,Papa R

更新日期：2019-01-19 00:00:00

abstract：:microRNA (miRNA) activity and regulation are of increasing interest as new therapeutic targets. Traditional approaches to assess miRNA levels in cells rely on RNA sequencing or quantitative PCR. While useful, these approaches are based on RNA extraction and cannot be applied in real-time to observe miRNA activity with...

journal_title：Genes

authors： Turk MA,Chung CZ,Manni E,Zukowski SA,Engineer A,Badakhshi Y,Bi Y,Heinemann IU

更新日期：2018-06-19 00:00:00

abstract：:RabGTPase activating proteins (RabGAP) are responsible for directing the deactivation of vesicular trafficking master regulators associated to plant development, the RabGTPase proteins. Recently, RabGAPs were identified in Arabidopsis and rice, but studies were not yet reported in tomato. Herein, we identified 24 RabG...

journal_title：Genes

authors： Madrid-Espinoza J,Salinas-Cornejo J,Ruiz-Lara S

更新日期：2019-08-23 00:00:00

abstract：:White coat color in mammals has been selected several times during the domestication process. Numerous dog breeds are fixed for one form of white coat color that involves darkly pigmented skin. The genetic basis of this color, due to the absence of pigment in the hairs, was suggested to correspond to extreme dilution ...

journal_title：Genes

authors： Hédan B,Cadieu E,Botherel N,Dufaure de Citres C,Letko A,Rimbault M,Drögemüller C,Jagannathan V,Derrien T,Schmutz S,Leeb T,André C

更新日期：2019-05-21 00:00:00

abstract：:Pleurotus tuoliensis (Pt) and P. eryngii var. eryngii (Pe) are important edible mushrooms. The epigenetic and gene expression signatures characterizing major developmental transitions in these two mushrooms remain largely unknown. Here, we report global analyses of DNA methylation and gene expression in both mushrooms...

journal_title：Genes

authors： Wen J,Zhang Z,Gong L,Xun H,Li J,Qi B,Wang Q,Li X,Li Y,Liu B

更新日期：2019-06-17 00:00:00

abstract：:Coat color dilution corresponds to a specific pigmentation phenotype that leads to a dilution of wild type pigments. It affects both eumelanin and pheomelanin containing melanosomes. The mode of inheritance of the dilution phenotype is autosomal recessive. Candidate gene approaches focused on the melanophilin (MLPH) g...

journal_title：Genes

authors： Demars J,Iannuccelli N,Utzeri VJ,Auvinet G,Riquet J,Fontanesi L,Allain D

更新日期：2018-08-23 00:00:00