Abstract：
:The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively investigate the association of DNA methylation levels with SSc in dermal fibroblasts from patients of African ancestry. Reduced representation bisulfite sequencing (RRBS) was performed on primary dermal fibroblasts from 15 SSc patients and 15 controls of African ancestry, and over 3.8 million CpG sites were tested for differential methylation patterns between cases and controls. The dermal fibroblasts from African American patients exhibited widespread reduced DNA methylation. Differentially methylated CpG sites were most enriched in introns and intergenic regions while depleted in 5' UTR, promoters, and CpG islands. Seventeen genes and eleven promoters showed significant differential methylation, mostly in non-coding RNA genes and pseudogenes. Gene set enrichment analysis (GSEA) and gene ontology (GO) analyses revealed an enrichment of pathways related to interferon signaling and mesenchymal differentiation. The hypomethylation of DLX5 and TMEM140 was accompanied by these genes' overexpression in patients but underexpression for lncRNA MGC12916. These data show that differential methylation occurs in dermal fibroblasts from African American patients with SSc and identifies novel coding and non-coding genes.
journal_name
Genes (Basel)journal_title
Genesauthors
Baker Frost D,da Silveira W,Hazard ES,Atanelishvili I,Wilson RC,Flume J,Day KL,Oates JC,Bogatkevich GS,Feghali-Bostwick C,Hardiman G,Ramos PSdoi
10.3390/genes12020129subject
Has Abstractpub_date
2021-01-20 00:00:00issue
2issn
2073-4425pii
genes12020129journal_volume
12pub_type
杂志文章相关文献
Genes文献大全abstract：:Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyzed the right-ventricular systolic pressure (RVSP), right-ventricular hypertrophy (RVH), lung histology, and transcriptomes of six-week-old male rats with PH induced by (1) hypoxia (HO), (2) administration of monocrotalin...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11020126
更新日期：2020-01-23 00:00:00
abstract：:Use of genetic markers and genomic prediction might improve genetic gain for quality traits in wheat breeding programs. Here, flour yield and Alveograph quality traits were inspected in 635 F6 winter wheat breeding lines from two breeding cycles. Genome-wide association studies revealed single nucleotide polymorphisms...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10090669
更新日期：2019-08-31 00:00:00
abstract：:In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatmen...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes2030562
更新日期：2011-08-02 00:00:00
abstract：:Drosophila melanogaster is one of the most extensively used genetic model organisms for studying LTR retrotransposons that are represented by various groups in its genome. However, the phenomenon of molecular domestication of LTR retrotransposons has been insufficiently studied in Drosophila, as well as in other inver...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11040396
更新日期：2020-04-06 00:00:00
abstract：:Anti-Müllerian hormone (AMH) is a reliable and easily detectable reproductive marker for the fertility competence of many farm animal species. AMH is also a good predictor of superovulation in cattle, sheep, and mares. In this review, we have summarized the recent findings related to AMH and its predictive reliability...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10121009
更新日期：2019-12-04 00:00:00
abstract：:Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fert...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8050133
更新日期：2017-05-04 00:00:00
abstract：:Cancer stem cells (CSCs), having both self-renewal and tumorigenic capacity, utilize an energy metabolism system different from that of non-CSCs. Lipid droplets (LDs) are organelles that store neutral lipids, including triacylglycerol. Previous studies demonstrated that LDs are formed and store lipids as an energy sou...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes12010099
更新日期：2021-01-14 00:00:00
abstract：:This review looks back at five decades of research into genetic susceptibility to colorectal cancer (CRC) and the insights these studies have provided. Initial evidence of a genetic basis of CRC stems from epidemiological studies in the 1950s and is further provided by the existence of multiple dominant predisposition...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes5020270
更新日期：2014-03-27 00:00:00
abstract：:Neural stem cells (NSCs) are capable of producing a variety of neural cell types, and are indispensable for the development of the mammalian brain. NSCs can be induced in vitro from pluripotent stem cells, including embryonic stem cells and induced-pluripotent stem cells. Although the transplantation of these exogenou...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes2010107
更新日期：2011-01-14 00:00:00
abstract：:n/a. ...
journal_title：Genes
pub_type： 杂志文章,已发布勘误
doi：10.3390/genes8030091
更新日期：2017-03-03 00:00:00
abstract：:Oral clefts are composed of cleft of the lip, cleft of the lip and palate, or cleft of the palate, and they are associated with a wide range of expression and severity. When cleft of the palate is associated with cleft of the lip with preservation of the primary palate, it defines an atypical phenotype called disconti...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10100833
更新日期：2019-10-22 00:00:00
abstract：:Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11070786
更新日期：2020-07-13 00:00:00
abstract：:Tetralin (1,2,3,4-tetrahydonaphthalene) is a recalcitrant compound that consists of an aromatic and an alicyclic ring. It is found in crude oils, produced industrially from naphthalene or anthracene, and widely used as an organic solvent. Its toxicity is due to the alteration of biological membranes by its hydrophobic...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10050339
更新日期：2019-05-06 00:00:00
abstract：:microRNA (miRNA) activity and regulation are of increasing interest as new therapeutic targets. Traditional approaches to assess miRNA levels in cells rely on RNA sequencing or quantitative PCR. While useful, these approaches are based on RNA extraction and cannot be applied in real-time to observe miRNA activity with...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060305
更新日期：2018-06-19 00:00:00
abstract：:In the frog genus Pseudis, previous works found a sex-linked heteromorphism of the PcP190 satellite DNA in the nucleolus organizer region (NOR)-bearing chromosome pairs of Pseudis bolbodactyla and Pseudis tocantins, which possess a ZZ/ZW sex determination system. A pericentromeric inversion was inferred to have occurr...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10020160
更新日期：2019-02-19 00:00:00
abstract：:Warmblood fragile foal syndrome (WFFS) is an autosomal recessive disorder caused by a single nucleotide variant in the procollagen-lysine-2-oxoglutarate-5-dioxygenase 1 gene (PLOD1:c.2032G>A, p.Gly678Arg). Homozygosity for the PLOD1 variant causes an Ehler-Danlos-like syndrome, which has to date only been reported in ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121518
更新日期：2020-12-18 00:00:00
abstract：:Meiosis yields haploid gametes following two successive divisions of a germ cell in the absence of intervening DNA replication. Balanced segregation of homologous chromosomes in Meiosis I is aided by a proteinaceous structure, the synaptonemal complex (SC). The objective of this study was to determine total average au...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes1030505
更新日期：2010-12-15 00:00:00
abstract：:The autophagy-lysosome pathway, which involves many crucial genes and proteins, plays crucial roles in the maintenance of intracellular homeostasis by the degradation of damaged components. At present, some of these genes and proteins have been identified but their specific functions are largely unknown. This study wa...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10100751
更新日期：2019-09-25 00:00:00
abstract：:A large number of studies have focused on identifying molecular biomarkers, including microRNAs (miRNAs) to aid in the diagnosis and prognosis of the most common subtypes of non-Hodgkin lymphoma (NHL), Diffuse Large B-cell Lymphoma and Follicular Lymphoma. NHL is difficult to diagnose and treat with many cases becomin...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes7120130
更新日期：2016-12-17 00:00:00
abstract：:Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8010027
更新日期：2017-01-11 00:00:00
abstract：:Olfaction, which is mediated by olfactory receptor (OR) genes, is essential in the daily life of fish, especially in foraging. However, Chinese perch (Siniperca chuatsi) is believed to prey with reliance on vision and lateral sensation, but not on olfaction. Therefore, understanding the evolutionary dynamics of the Ch...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10020178
更新日期：2019-02-25 00:00:00
abstract：:Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9090448
更新日期：2018-09-07 00:00:00
abstract：BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10080568
更新日期：2019-07-26 00:00:00
abstract：:During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9050242
更新日期：2018-05-04 00:00:00
abstract：:During speciation-with-gene-flow, a transition from single-locus to multi-locus processes can occur, as strong coupling of multiple loci creates a barrier to gene flow. Testing predictions about such transitions with empirical data requires building upon past theoretical work and the continued development of quantitat...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060274
更新日期：2018-05-24 00:00:00
abstract：:The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derive...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11101192
更新日期：2020-10-14 00:00:00
abstract：:Post-translational modification (PTM) is a critical biological reaction which adds to the diversification of the proteome. With numerous known modifications being studied, pupylation has gained focus in the scientific community due to its significant role in regulating biological processes. The traditional experimenta...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121431
更新日期：2020-11-28 00:00:00
abstract：:Accurate species identification from ancient DNA samples is a difficult task that would shed light on the evolutionary history of pathogenic microorganisms. The field of palaeomicrobiology has undoubtedly benefited from the advent of untargeted metagenomic approaches that use next-generation sequencing methodologies. ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9080418
更新日期：2018-08-20 00:00:00
abstract：:B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9080388
更新日期：2018-07-31 00:00:00
abstract：:Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during protein synthesis, tRNAs are also the source of a heterogeneous class of small RNAs, tRNA-derived small RNAs (tsRNAs). Occurrence and th...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9120607
更新日期：2018-12-05 00:00:00
