Abstract:
:Cell Division Autoantigen 1 (CDA1) was discovered following screening a human expression library with serum from a patient with Discoid Lupus Erythematosus. CDA1, encoded by TSPYL2 on the X chromosome, shares anti-proliferative and pro‑fibrotic properties with TGF-b. It inhibits cell growth through p53, pERK1/2 and p21‑mediated pathways and is implicated in tumorigenesis and the DNA damage response. Its pro-fibrotic property is mediated through cross-talk with TGF-b that results in upregulation of extracellular matrix proteins. The latter properties have identified a key role for CDA1 in diabetes associated atherosclerosis. These dual properties place CDA1 as an attractive molecular target for treating tumors and vascular fibrosis including atherosclerosis and other vascular disorders associated with enhanced TGF-β action and tissue scarring.
journal_name
Genes (Basel)journal_title
Genesauthors
Toh BH,Tu Y,Cao Z,Cooper ME,Chai Zdoi
10.3390/genes1030335subject
Has Abstractpub_date
2010-09-30 00:00:00pages
335-48issue
3issn
2073-4425pii
genes1030335journal_volume
1pub_type
杂志文章相关文献
Genes文献大全abstract::Cytokinin oxidase/dehydrogenases (CKXs) play a critical role in the irreversible degradation of cytokinins, thereby regulating plant growth and development. Brassica napus is one of the most widely cultivated oilseed crops worldwide. With the completion of whole-genome sequencing of B. napus, genome-wide identificatio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9030168
更新日期:2018-03-16 00:00:00
abstract::Candida albicans mutants deficient in homologous recombination (HR) are extremely sensitive to the alkylating agent methyl-methane-sulfonate (MMS). Here, we have investigated the role of HR genes in the protection and repair of C. albicans chromosomes by taking advantage of the heat-labile property (55 °C) of MMS-indu...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090447
更新日期:2018-09-07 00:00:00
abstract::Leafminer insects of the genus Liriomyza are small flies whose larvae feed on the internal tissue of some of the most important crop plants for the human diet. Several of these pest species are highly uniform from the morphological point of view, meaning molecular data represents the only reliable taxonomic tool usefu...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9110554
更新日期:2018-11-15 00:00:00
abstract::Fusarium head blight (FHB), caused primarily by the fungus Fusarium graminearum, is one of the most damaging diseases of wheat, causing significant loss of yield and quality worldwide. Warm and wet conditions during flowering, a lack of resistant wheat varieties, and high inoculum pressure from corn stubble contribute...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060699
更新日期:2020-06-25 00:00:00
abstract::In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatmen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes2030562
更新日期:2011-08-02 00:00:00
abstract::Recent advances in next-generation sequencing technology have led to the production of an unprecedented volume of genomic data, thus further advancing our understanding of the role of genetic variation in clinical pharmacogenomics. In the present study, we used whole exome sequencing data from 50,726 participants, as ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050561
更新日期:2020-05-18 00:00:00
abstract::This review looks back at five decades of research into genetic susceptibility to colorectal cancer (CRC) and the insights these studies have provided. Initial evidence of a genetic basis of CRC stems from epidemiological studies in the 1950s and is further provided by the existence of multiple dominant predisposition...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes5020270
更新日期:2014-03-27 00:00:00
abstract::Accurate species identification from ancient DNA samples is a difficult task that would shed light on the evolutionary history of pathogenic microorganisms. The field of palaeomicrobiology has undoubtedly benefited from the advent of untargeted metagenomic approaches that use next-generation sequencing methodologies. ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080418
更新日期:2018-08-20 00:00:00
abstract::Ehlers-Danlos syndrome (EDS) comprises clinically heterogeneous connective tissue disorders with diverse molecular etiologies. The 2017 International Classification for EDS recognized 13 distinct subtypes caused by pathogenic variants in 19 genes mainly encoding fibrillar collagens and collagen-modifying or processing...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020135
更新日期:2019-02-12 00:00:00
abstract::In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120394
更新日期:2017-12-19 00:00:00
abstract::Hemp is a Pb-tolerant and Pb-accumulating plant and the study of its tolerance mechanisms could facilitate the breeding of hemp with enhanced Pb tolerance and accumulation. In the present study, we took advantage of sequential window acquisition of all theoretical mass spectra (SWATH) technology to study the differenc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10050396
更新日期:2019-05-22 00:00:00
abstract::Continuous cultures assure the invariability of environmental conditions and the metabolic state of cultured microorganisms, whereas batch-cultured cells undergo constant changes in nutrients availability. For that reason, continuous culture is sometimes employed in the whole transcriptome, whole proteome, or whole me...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11121419
更新日期:2020-11-27 00:00:00
abstract::Exposure to Formaldehyde (FA) results in many pathophysiological symptoms, however the underlying mechanisms are not well understood. Given the complicated modulatory role of intestinal microbiota on human health, we hypothesized that interactions between FA and the gut microbiome may account for FA's toxicity. Balb/c...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9040192
更新日期:2018-04-03 00:00:00
abstract::Silver-Russell syndrome (SRS) is a rare growth-related genetic disorder that is mainly associated with prenatal and postnatal growth retardation. Molecular causes are not clear in all cases, the most common ones being loss of methylation on chromosome 11p15 (≈50%) and maternal uniparental disomy for chromosome 7 (upd(...
journal_title:Genes
pub_type:
doi:10.3390/genes11121461
更新日期:2020-12-05 00:00:00
abstract::Intercellular karyotypic variability has been a focus of genetic research for more than 50 years. It has been repeatedly shown that chromosome heterogeneity manifesting as chromosomal mosaicism is associated with a variety of human diseases. Due to the ability of changing dynamically throughout the ontogeny, chromosom...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10050379
更新日期:2019-05-19 00:00:00
abstract::Terpenoids play important roles in plant defense. Although some terpene synthases have been characterized, terpenoids and their biosynthesis in wheat (Triticumaestivum L.) still remain largely unknown. Here, we describe the identification of a terpene synthase gene in wheat. It encodes a sesquiterpene synthase that ca...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060441
更新日期:2019-06-10 00:00:00
abstract::Mobile DNA elements play a significant evolutionary role by promoting genome plasticity. Insertion sequences are the smallest prokaryotic transposable elements. They are highly diverse elements, and the ability to accurately identify, annotate, and infer the full genomic impact of insertion sequences is lacking. Halan...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050484
更新日期:2020-04-29 00:00:00
abstract::We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090978
更新日期:2020-08-22 00:00:00
abstract::The obligately anaerobic haloalkaliphilic bacterium Alkalitalea saponilacus can use xylan as the sole carbon source and produce propionate as the main fermentation product. Using mixed carbon sources of 0.4% (w/v) sucrose and 0.1% (w/v) birch xylan, xylanase production from A. saponilacus was 3.2-fold greater than tha...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010001
更新日期:2018-12-20 00:00:00
abstract::In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, we employed BE and PE mRNAs in conjunction with chemically synthesized sgRNAs and pegRNAs for efficient editing of human i...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050511
更新日期:2020-05-06 00:00:00
abstract::The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derive...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101192
更新日期:2020-10-14 00:00:00
abstract::Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy caused by biallelic variants in ALPK3. Genetic investigation was perfo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101201
更新日期:2020-10-15 00:00:00
abstract::Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050476
更新日期:2020-04-27 00:00:00
abstract::Gene duplication is an important evolutionary mechanism allowing to provide new genetic material and thus opportunities to acquire new gene functions for an organism, with major implications such as speciation events. Various processes are known to allow a gene to be duplicated and different models explain how duplica...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11091046
更新日期:2020-09-04 00:00:00
abstract:BACKGROUND:Large-scale screening of drug sensitivity on cancer cell models can mimic in vivo cellular behavior providing wider scope for biological research on cancer. Since the therapeutic effect of a single drug or drug combination depends on the individual patient's genome characteristics and cancer cells integratio...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030263
更新日期:2020-02-28 00:00:00
abstract::Golgi reassembly and stacking protein (GRASP) is required for polysaccharide secretion and virulence in Cryptococcus neoformans. In fungal species, extracellular vesicles (EVs) participate in the export of polysaccharides, proteins and RNA. In the present work, we investigated if EV-mediated RNA export is functionally...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080400
更新日期:2018-08-08 00:00:00
abstract::Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111314
更新日期:2020-11-05 00:00:00
abstract::Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alte...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090960
更新日期:2020-08-20 00:00:00
abstract::White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010094
更新日期:2020-01-14 00:00:00
abstract::DNA double-strand breaks (DSBs) jeopardize genome integrity and can-when repaired unfaithfully-give rise to structural rearrangements associated with cancer. Exogenous agents such as ionizing radiation or chemotherapy can invoke DSBs, but a vast amount of breakage arises during vital endogenous DNA transactions, such ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9120632
更新日期:2018-12-14 00:00:00