Immature Immunoglobulin Gene Rearrangements Are Recurrent in B Precursor Adult Acute Lymphoblastic Leukemia Carrying TP53 Molecular Alterations.

Abstract:

:Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.

journal_name

Genes (Basel)

journal_title

Genes

authors

Salmoiraghi S,Cavagna R,Guinea Montalvo ML,Ubiali G,Tosi M,Peruta B,Intermesoli T,Oldani E,Salvi A,Pavoni C,Giussani U,Bassan R,Rambaldi A,Spinelli O

doi

10.3390/genes11090960

subject

Has Abstract

pub_date

2020-08-20 00:00:00

issue

9

issn

2073-4425

pii

genes11090960

journal_volume

11

pub_type

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