Endogenous DNA Double-Strand Breaks during DNA Transactions: Emerging Insights and Methods for Genome-Wide Profiling.

abstract：:Cerebral ischaemia is the most common cause of impaired brain function. Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH(4-7)PGP (Semax), has been used successfully in the treatment of patients with severe impairment...

journal_title：Genes

authors： Filippenkov IB,Stavchansky VV,Denisova AE,Yuzhakov VV,Sevan'kaeva LE,Sudarkina OY,Dmitrieva VG,Gubsky LV,Myasoedov NF,Limborska SA,Dergunova LV

更新日期：2020-06-22 00:00:00

abstract：:Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...

journal_title：Genes

authors： Badji A,Kwemoi DB,Machida L,Okii D,Mwila N,Agbahoungba S,Kumi F,Ibanda A,Bararyenya A,Solemanegy M,Odong T,Wasswa P,Otim M,Asea G,Ochwo-Ssemakula M,Talwana H,Kyamanywa S,Rubaihayo P

更新日期：2020-06-24 00:00:00

abstract：:White spot syndrome virus (WSSV), one of the major pathogens of Procambarus clarkii, has caused severe disruption to the aquaculture industry of P. clarkii in China. To reveal the gene regulatory mechanisms underlying WSSV infection, a comparative transcriptome analysis was performed among WSSV-infected susceptible in...

journal_title：Genes

authors： Yi S,Li Y,Shi L,Zhang L

更新日期：2017-11-10 00:00:00

abstract：:Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can seq...

journal_title：Genes

authors： Doksani Y

更新日期：2019-04-24 00:00:00

abstract：:Olfaction, which is mediated by olfactory receptor (OR) genes, is essential in the daily life of fish, especially in foraging. However, Chinese perch (Siniperca chuatsi) is believed to prey with reliance on vision and lateral sensation, but not on olfaction. Therefore, understanding the evolutionary dynamics of the Ch...

journal_title：Genes

authors： Lv LY,Liang XF,He S

更新日期：2019-02-25 00:00:00

abstract：:Lysosomal storage disorders (LSDs) represent a group of more than 50 severe metabolic diseases caused by the deficiency of specific lysosomal hydrolases, activators, carriers, or lysosomal integral membrane proteins, leading to the abnormal accumulation of substrates within the lysosomes. Numerous mutations have been ...

journal_title：Genes

authors： Dardis A,Buratti E

更新日期：2018-02-06 00:00:00

abstract：:In this review we present the developmental, histological, evolutionary and functional properties of insect chemosensory proteins (CSPs) in insect species. CSPs are small globular proteins folded like a prism and notoriously known for their complex and arguably obscure function(s), particularly in pheromone olfaction....

journal_title：Genes

authors： Liu G,Xuan N,Rajashekar B,Arnaud P,Offmann B,Picimbon JF

更新日期：2020-04-10 00:00:00

abstract：:Segments of the genome enriched in repetitive sequences still present a challenge and are omitted in genome assemblies. For that reason, the exact composition of DNA sequences underlying the heterochromatic regions and the active centromeres are still unexplored for many organisms. The centromere is a crucial region o...

journal_title：Genes

authors： Tunjić Cvitanić M,Vojvoda Zeljko T,Pasantes JJ,García-Souto D,Gržan T,Despot-Slade E,Plohl M,Šatović E

更新日期：2020-06-24 00:00:00

abstract：:Photoperiod is one of the important factors leading to seasonal reproduction of sheep. However, the molecular mechanisms underlying the photoperiod regulation of seasonal reproduction remain poorly understood. In this study, we compared the expression profiles of mRNAs, lncRNAs, and circRNAs in uterine tissues from Su...

journal_title：Genes

authors： La Y,He X,Zhang L,Di R,Wang X,Gan S,Zhang X,Zhang J,Hu W,Chu M

更新日期：2020-03-12 00:00:00

abstract：:Monogenic forms of beta cell diabetes account for approximately 1%-2% of all cases of diabetes, yet remain underdiagnosed. Overlapping clinical features with common forms of diabetes, make diagnosis challenging. A genetic diagnosis of monogenic diabetes in many cases alters therapy, affects prognosis, enables genetic ...

journal_title：Genes

authors： Carroll RW,Murphy R

更新日期：2013-09-26 00:00:00

abstract：:Oral clefts are composed of cleft of the lip, cleft of the lip and palate, or cleft of the palate, and they are associated with a wide range of expression and severity. When cleft of the palate is associated with cleft of the lip with preservation of the primary palate, it defines an atypical phenotype called disconti...

journal_title：Genes

authors： Demeer B,Revencu N,Helaers R,Gbaguidi C,Dakpe S,François G,Devauchelle B,Bayet B,Vikkula M

更新日期：2019-10-22 00:00:00

abstract：:Hemp is a Pb-tolerant and Pb-accumulating plant and the study of its tolerance mechanisms could facilitate the breeding of hemp with enhanced Pb tolerance and accumulation. In the present study, we took advantage of sequential window acquisition of all theoretical mass spectra (SWATH) technology to study the differenc...

journal_title：Genes

authors： Xia C,Hong L,Yang Y,Yanping X,Xing H,Gang D

更新日期：2019-05-22 00:00:00

abstract：:RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing 11-cis retinal. To date, almost 200 loss-of-function mutations have ...

journal_title：Genes

authors： Kiang AS,Kenna PF,Humphries MM,Ozaki E,Koenekoop RK,Campbell M,Farrar GJ,Humphries P

更新日期：2020-11-27 00:00:00

abstract：:Fat deposition in pigs, which significantly contributes to meat quality, fattening efficiency, reproductive performance, and immunity, is critically affected by preadipocyte adipogenic differentiation. We elucidated adipogenesis in pigs using transcriptome analysis. Preadipocytes from subcutaneous adipose tissue (SAT)...

journal_title：Genes

authors： Zhao X,Chen S,Tan Z,Wang Y,Zhang F,Yang T,Liu Y,Ao H,Xing K,Wang C

更新日期：2019-07-19 00:00:00

abstract：:The yeast Exophiala dermatitidis exhibits high resistance to γ-radiation in comparison to many other fungi. Several aspects of this phenotype have been characterized, including its dependence on homologous recombination for the repair of radiation-induced DNA damage, and the transcriptomic response invoked by acute γ-...

journal_title：Genes

authors： Schultzhaus ZS,Schultzhaus JN,Romsdahl J,Chen A,Hervey Iv WJ,Leary DH,Wang Z

更新日期：2020-09-25 00:00:00

abstract：:The filamenting temperature-sensitive Z proteins (FtsZs) play an important role in plastid division. In this study, three FtsZ genes were isolated from the cassava genome, and named MeFtsZ1, MeFtsZ2-1, and MeFtsZ2-2, respectively. Based on phylogeny, the MeFtsZs were classified into two groups (FtsZ1 and FtsZ2). MeFts...

journal_title：Genes

authors： Geng MT,Min Y,Yao Y,Chen X,Fan J,Yuan S,Wang L,Sun C,Zhang F,Shang L,Wang YL,Li RM,Fu SP,Duan RJ,Liu J,Hu XW,Guo JC

更新日期：2017-12-15 00:00:00

abstract：:Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type of genetic variation, namely changes in tandem repeat number. Historically, tandem repeats have been designated as...

journal_title：Genes

authors： Gemayel R,Cho J,Boeynaems S,Verstrepen KJ

更新日期：2012-07-26 00:00:00

abstract：:Histone acts as the core for nucleosomes and is a key protein component of chromatin. Among different histone variants, histone H3 (HH3) variants have been reported to play vital roles in plant development. However, biological information and evolutionary relationships of HH3 genes in cotton remain to be elucidated. T...

journal_title：Genes

authors： Qanmber G,Ali F,Lu L,Mo H,Ma S,Wang Z,Yang Z

更新日期：2019-05-09 00:00:00

abstract：:B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...

journal_title：Genes

authors： Jones RN

更新日期：2018-07-31 00:00:00

abstract：:Modulated electromagnetic fields (wEMFs), as generated by modern communication technologies, have raised concerns about adverse health effects. The International Agency for Research on Cancer (IARC) classifies them as "possibly carcinogenic to humans" (Group 2B), yet, the underlying molecular mechanisms initiating and...

journal_title：Genes

authors： Schuermann D,Ziemann C,Barekati Z,Capstick M,Oertel A,Focke F,Murbach M,Kuster N,Dasenbrock C,Schär P

更新日期：2020-03-25 00:00:00

abstract：:In the years since the first complete human genome sequence was reported, there has been a rapid development of technologies to facilitate high-throughput sequence analysis of DNA (termed "next-generation" sequencing). These novel approaches to DNA sequencing offer the promise of complete genomic analysis at a cost fe...

journal_title：Genes

authors： Anderson MW,Schrijver I

更新日期：2010-05-25 00:00:00

abstract：:Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For ...

journal_title：Genes

authors： Klymenko SV,Smida J,Atkinson MJ,Bebeshko VG,Nathrath M,Rosemann M

更新日期：2011-05-31 00:00:00

abstract：:Elymus sibiricus, which is a perennial and self-pollinated grass, is the typical species of the genus Elymus, which plays an important role in forage production and ecological restoration. No reports have, so far, systematically described the selection of optimal reference genes for reverse transcriptase quantitative ...

journal_title：Genes

authors： Zhang J,Xie W,Yu X,Zhang Z,Zhao Y,Wang N,Wang Y

更新日期：2019-06-13 00:00:00

abstract：:Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...

journal_title：Genes

authors： Lima AR,Santos L,Correia M,Soares P,Sobrinho-Simões M,Melo M,Máximo V

更新日期：2018-02-21 00:00:00

abstract：:Cancers can be categorized into two groups: those whose frequency increases with age, and those resulting from errors during mammalian development. The first group is linked to DNA replication through the accumulation of genetic mutations that occur during proliferation of developmentally acquired stem cells that give...

journal_title：Genes

authors： Vassilev A,DePamphilis ML

更新日期：2017-01-25 00:00:00

abstract：BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...

journal_title：Genes

authors： Zhang Z,Conner J,Guo Y,Ozias-Akins P

更新日期：2020-09-12 00:00:00

abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...

journal_title：Genes

authors： Rick K,Ottewell K,Lohr C,Thavornkanlapachai R,Byrne M,Kennington WJ

更新日期：2019-10-28 00:00:00

abstract：:Yersinia enterocolitica is the causative agent of yersiniosis, a zoonotic disease of growing epidemiological importance with significant consequences for public health. This pathogenic species has been intensively studied for many years. Six biotypes (1A, 1B, 2, 3, 4, 5) and more than 70 serotypes of Y. enterocolitica...

journal_title：Genes

authors： Bancerz-Kisiel A,Pieczywek M,Łada P,Szweda W

更新日期：2018-05-03 00:00:00

abstract：:DNA methylation plays several roles in regulating neuronal proliferation, differentiation, and physiological functions. The major de novo methyltransferase, DNMT3, controls the DNA methylation pattern in neurons according to environmental stimulations and behavioral regulations. Previous studies demonstrated that knoc...

journal_title：Genes

authors： Lai YH,Audira G,Liang ST,Siregar P,Suryanto ME,Lin HC,Villalobos O,Villaflores OB,Hao E,Lim KH,Hsiao CD

更新日期：2020-11-07 00:00:00

abstract：:Perennial agriculture has been proposed as an option to improve the sustainability of cropping systems, by increasing the efficiency of resource use, while also providing ecosystem services. Neo-domestication, the contemporary domestication of plants that have not previously been used in agriculture, can be used to ge...

journal_title：Genes

authors： Kantar MB,Hüber S,Herman A,Bock DG,Baute G,Betts K,Ott M,Brandvain Y,Wyse D,Stupar RM,Rieseberg LH

更新日期：2018-08-21 00:00:00