Abstract：
:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. An ALS drug, Riluzole, has been shown to induce two different anticancer effects on hepatocellular carcinoma (HCC). In light of this finding, we explore the relationship between ALS and cancer, especially for HCC, from the molecular biological viewpoint. We establish biomarkers that can discriminate between ALS patients and healthy controls. A principal component analysis (PCA) based unsupervised feature extraction (FE) is used to find gene biomarkers of ALS based on microarray gene expression data. Based on this method, 101 probes were selected as biomarkers for ALS with 95% high accuracy to discriminate between ALS patients and controls. Most of the genes corresponding to these probes are shown to be related to various cancers. These findings might provide a new insight for developing new therapeutic options or drugs for both ALS and cancer.
journal_name
Genes (Basel)journal_title
Genesauthors
Taguchi YH,Wang Hdoi
10.3390/genes8100243subject
Has Abstractpub_date
2017-09-27 00:00:00issue
10issn
2073-4425pii
genes8100243journal_volume
8pub_type
杂志文章相关文献
Genes文献大全abstract：:Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9020115
更新日期：2018-02-21 00:00:00
abstract：:Photoperiod is one of the important factors leading to seasonal reproduction of sheep. However, the molecular mechanisms underlying the photoperiod regulation of seasonal reproduction remain poorly understood. In this study, we compared the expression profiles of mRNAs, lncRNAs, and circRNAs in uterine tissues from Su...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11030301
更新日期：2020-03-12 00:00:00
abstract：:Lactobacillus ruminis is a commensal motile lactic acid bacterium living in the intestinal tract of humans and animals. Although a few genomes of L. ruminis were published, most of them were animal derived. To explore the genetic diversity and potential niche-specific adaptation changes of L. ruminis, in the current w...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11010070
更新日期：2020-01-08 00:00:00
abstract：:Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11070777
更新日期：2020-07-11 00:00:00
abstract：:Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9010039
更新日期：2018-01-16 00:00:00
abstract：:Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the mRNA translation machinery, yet they possess numerous non-canonical functions developed during the evolution of complex organisms. The aaRSs and aaRS-interacting multi-functional proteins (AIMPs) are continually being implicated in tumorigenesis, but these conn...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11111384
更新日期：2020-11-22 00:00:00
abstract：:Serotonin receptor 2A (HTR2A) is an important signalling factor implicated in cognitive functions and known to be associated with schizophrenia. The biological significance of HTR2A in schizophrenia remains unclear as molecular analyses including genetic association, mRNA expression and methylation studies have report...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8010014
更新日期：2017-01-04 00:00:00
abstract：:In this paper, we present a two-phase microfluidic system capable of incubating and quantifying microbead-based agglutination assays. The microfluidic system is based on a simple fabrication solution, which requires only laboratory tubing filled with carrier oil, driven by negative pressure using a syringe pump. We pr...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060281
更新日期：2018-06-04 00:00:00
abstract：BACKGROUND:HER2 (human epidermal growth factor 2)-positive breast cancer is an aggressive type of breast cancer characterized by the overexpression of the receptor-type protein tyrosine kinase HER2 or amplification of the HER2 gene. It is commonly treated by the drug trastuzumab (Herceptin), but resistance to its actio...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10080568
更新日期：2019-07-26 00:00:00
abstract：:In this review we present the developmental, histological, evolutionary and functional properties of insect chemosensory proteins (CSPs) in insect species. CSPs are small globular proteins folded like a prism and notoriously known for their complex and arguably obscure function(s), particularly in pheromone olfaction....
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11040413
更新日期：2020-04-10 00:00:00
abstract：:This special issue of Genes demonstrates clearly that research in epigenetics has proceeded at a very rapid pace in the last decade. [...]. ...
journal_title：Genes
pub_type： 社论
doi：10.3390/genes11010023
更新日期：2019-12-23 00:00:00
abstract：:The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively investigate the association of DNA methylation levels with SSc in dermal ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes12020129
更新日期：2021-01-20 00:00:00
abstract：:Terpenoids play important roles in plant defense. Although some terpene synthases have been characterized, terpenoids and their biosynthesis in wheat (Triticumaestivum L.) still remain largely unknown. Here, we describe the identification of a terpene synthase gene in wheat. It encodes a sesquiterpene synthase that ca...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10060441
更新日期：2019-06-10 00:00:00
abstract：:Silver-Russell syndrome (SRS) is a rare growth-related genetic disorder that is mainly associated with prenatal and postnatal growth retardation. Molecular causes are not clear in all cases, the most common ones being loss of methylation on chromosome 11p15 (≈50%) and maternal uniparental disomy for chromosome 7 (upd(...
journal_title：Genes
pub_type：
doi：10.3390/genes11121461
更新日期：2020-12-05 00:00:00
abstract：:DNA double-strand breaks (DSBs) jeopardize genome integrity and can-when repaired unfaithfully-give rise to structural rearrangements associated with cancer. Exogenous agents such as ionizing radiation or chemotherapy can invoke DSBs, but a vast amount of breakage arises during vital endogenous DNA transactions, such ...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9120632
更新日期：2018-12-14 00:00:00
abstract：:Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes2020384
更新日期：2011-05-31 00:00:00
abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110851
更新日期：2019-10-28 00:00:00
abstract：:Although a number of methods have been proposed for identifying differentially expressed pathways (DEPs), few efforts consider the dynamic components of pathway networks, i.e., gene links. We here propose a signaling dynamics detection method for identification of DEPs, DynSig, which detects the molecular signaling ch...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9070323
更新日期：2018-06-27 00:00:00
abstract：:Divergent selection between ecologically dissimilar habitats promotes local adaptation, which can lead to reproductive isolation (RI). Populations in the Poecilia mexicana species complex have independently adapted to toxic hydrogen sulfide and show varying degrees of RI. Here, we examined the variation in the mate ch...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9050232
更新日期：2018-05-02 00:00:00
abstract：:In genome analysis, k-mer-based comparison methods have become standard tools. However, even though they are able to deliver reliable results, other algorithms seem to work better in some cases. To improve k-mer-based DNA sequence analysis and comparison, we successfully checked whether adding positional resolution is...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8040122
更新日期：2017-04-19 00:00:00
abstract：:MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that act as post-transcriptional gene regulators. They can inhibit target protein-coding genes, through repressing messenger RNA (mRNA) translation or promoting their degradation. miRNAs were initially found to be originated from nuclear genome an...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes5040865
更新日期：2014-09-26 00:00:00
abstract：:Due to its extraordinary longevity and wide distribution, the ocean quahog Arctica islandica has become an important species model in both aging and environmental change research. Notwithstanding that, most genetic studies on ocean quahogs have been focused on fishery related, phylogeographic and phylogenetic aspects ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060299
更新日期：2018-06-13 00:00:00
abstract：:In cystic fibrosis (CF), mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene disrupt the capacity of the encoded protein to function as a channel to transport chloride ions and water across cell membranes. The consequences are deleterious, system-wide, and immensely variable, even among pa...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10030180
更新日期：2019-02-26 00:00:00
abstract：:Pleurotus tuoliensis (Pt) and P. eryngii var. eryngii (Pe) are important edible mushrooms. The epigenetic and gene expression signatures characterizing major developmental transitions in these two mushrooms remain largely unknown. Here, we report global analyses of DNA methylation and gene expression in both mushrooms...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10060465
更新日期：2019-06-17 00:00:00
abstract：:Background: The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (AMPD1) is associated with muscular energy metabolism in exercise. However, the role of its potential modifying impact on exercise-induced changes in obesity related parameters is unknown. The aim of the study was to determine ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11050558
更新日期：2020-05-16 00:00:00
abstract：:Approximately 150 fungal species are considered as primary pathogens of humans and animals[...]. ...
journal_title：Genes
pub_type： 社论
doi：10.3390/genes10020136
更新日期：2019-02-12 00:00:00
abstract：:A large number of studies have focused on identifying molecular biomarkers, including microRNAs (miRNAs) to aid in the diagnosis and prognosis of the most common subtypes of non-Hodgkin lymphoma (NHL), Diffuse Large B-cell Lymphoma and Follicular Lymphoma. NHL is difficult to diagnose and treat with many cases becomin...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes7120130
更新日期：2016-12-17 00:00:00
abstract：:Marek's Disease is a lymphoproliferative disease of chickens caused by Marek's Disease Virus. Similar to other herpesviruses, Marek's Disease Virus (MDV) encodes its own small non-coding regulatory RNAs termed microRNAs (miRNAs). We previously found that the expression profile of these viral miRNAs is affected by vacc...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10020115
更新日期：2019-02-05 00:00:00
abstract：:The availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to understand the evolutionary dynamics of their tandem repeat sequences (satellites), as a result of ev...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8120351
更新日期：2017-11-28 00:00:00
abstract：:The development of high-throughput sequencing technologies and screening of big patient cohorts with familial and sporadic amyotrophic lateral sclerosis (ALS) led to the identification of a significant number of genetic variants, which are sometimes difficult to interpret. The American College of Medical Genetics and ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11101123
更新日期：2020-09-24 00:00:00
