Model-Based Clustering with Measurement or Estimation Errors.


:Model-based clustering with finite mixture models has become a widely used clustering method. One of the recent implementations is MCLUST. When objects to be clustered are summary statistics, such as regression coefficient estimates, they are naturally associated with estimation errors, whose covariance matrices can often be calculated exactly or approximated using asymptotic theory. This article proposes an extension to Gaussian finite mixture modeling-called MCLUST-ME-that properly accounts for the estimation errors. More specifically, we assume that the distribution of each observation consists of an underlying true component distribution and an independent measurement error distribution. Under this assumption, each unique value of estimation error covariance corresponds to its own classification boundary, which consequently results in a different grouping from MCLUST. Through simulation and application to an RNA-Seq data set, we discovered that under certain circumstances, explicitly, modeling estimation errors, improves clustering performance or provides new insights into the data, compared with when errors are simply ignored, whereas the degree of improvement depends on factors such as the distribution of error covariance matrices.


Genes (Basel)




Zhang W,Di Y




Has Abstract


2020-02-10 00:00:00












  • Transcriptome Analysis of Landrace Pig Subcutaneous Preadipocytes during Adipogenic Differentiation.

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  • The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia.

    abstract::Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease. About 2900 variants of LDLR, APOB, and PCSK9 genes potentially associated with FH have been described earlier. Nev...


    pub_type: 杂志文章


    authors: Meshkov A,Ershova A,Kiseleva A,Zotova E,Sotnikova E,Petukhova A,Zharikova A,Malyshev P,Rozhkova T,Blokhina A,Limonova A,Ramensky V,Divashuk M,Khasanova Z,Bukaeva A,Kurilova O,Skirko O,Pokrovskaya M,Mikova V,Snigir E

    更新日期:2021-01-06 00:00:00

  • Multigene Expression Assay for Assessment of the Immune Status of Atlantic Salmon.

    abstract::We report the development of a multigene gene expression assay on the BioMark HD platform for the evaluation of immune competence (ImCom) in farmed Atlantic salmon. The first version of the assay included 92 genes selected on the basis of transcriptome analyses in 54 trials that challenged the immune system; annotatio...


    pub_type: 杂志文章


    authors: Krasnov A,Afanasyev S,Nylund S,Rebl A

    更新日期:2020-10-22 00:00:00

  • Biodegradation of Tetralin: Genomics, Gene Function and Regulation.

    abstract::Tetralin (1,2,3,4-tetrahydonaphthalene) is a recalcitrant compound that consists of an aromatic and an alicyclic ring. It is found in crude oils, produced industrially from naphthalene or anthracene, and widely used as an organic solvent. Its toxicity is due to the alteration of biological membranes by its hydrophobic...


    pub_type: 杂志文章,评审


    authors: Floriano B,Santero E,Reyes-Ramírez F

    更新日期:2019-05-06 00:00:00

  • TALEN-Mediated Gene Targeting for Cystic Fibrosis-Gene Therapy.

    abstract::Cystic fibrosis (CF) is an inherited monogenic disorder, amenable to gene-based therapies. Because CF lung disease is currently the major cause of mortality and morbidity, and the lung airway is readily accessible to gene delivery, the major CF gene therapy effort at present is directed to the lung. Although airway ep...


    pub_type: 杂志文章


    authors: Xia E,Zhang Y,Cao H,Li J,Duan R,Hu J

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    pub_type: 杂志文章


    authors: Bao W,Tang KFJ,Alcivar-Warren A

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  • Phased Haplotype Resolution of the SLC6A4 Promoter Using Long-Read Single Molecule Real-Time (SMRT) Sequencing.

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    pub_type: 杂志文章


    authors: Botton MR,Yang Y,Scott ER,Desnick RJ,Scott SA

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  • Evolutionary Insights of the ZW Sex Chromosomesin Snakes: A New Chapter Added by the AmazonianPuffing Snakes of the Genus Spilotes.

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    pub_type: 杂志文章


    authors: Viana PF,Ezaz T,de Bello Cioffi M,Jackson Almeida B,Feldberg E

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  • Genomic Characterization of Listeria monocytogenes Isolates Associated with Clinical Listeriosis and the Food Production Environment in Ireland.

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    pub_type: 杂志文章


    authors: Hilliard A,Leong D,O'Callaghan A,Culligan EP,Morgan CA,DeLappe N,Hill C,Jordan K,Cormican M,Gahan CGM

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  • Sustentacular Cell Enwrapment of Olfactory Receptor Neuronal Dendrites: An Update.

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    authors: Liang F

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  • Germline-Specific Repetitive Elements in Programmatically Eliminated Chromosomes of the Sea Lamprey (Petromyzon marinus).

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    authors: Timoshevskiy VA,Timoshevskaya NY,Smith JJ

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    authors: Habyarimana E,Lopez-Cruz M,Baloch FS

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  • An Introduction to Systems Analytics and Integration of Big Omics Data.

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    pub_type: 社论


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  • Characterization and Transcriptome Studies of Autoinducer Synthase Gene from Multidrug Resistant Acinetobacter baumannii Strain 863.

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    authors: Ng CK,How KY,Tee KK,Chan KG

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  • Characterization of the Transcriptome and Gene Expression of Brain Tissue in Sevenband Grouper (Hyporthodus septemfasciatus) in Response to NNV Infection.

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    abstract::Rapeseed contains glucosinolates, a toxic group of sulfur-containing glucosides, which play critical roles in defense against herbivores and microbes. However, the presence of glucosinolates in rapeseed reduces the value of the meal as feed for livestock. We performed association mapping of seed glucosinolate (GS) con...


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    authors: Qu CM,Li SM,Duan XJ,Fan JH,Jia LD,Zhao HY,Lu K,Li JN,Xu XF,Wang R

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  • Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA.

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    authors: Pickard MR,Williams GT

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  • Intestinal Transcriptome Analysis Highlights Key Differentially Expressed Genes Involved in Nutrient Metabolism and Digestion in Yellowtail Kingfish (Seriola lalandi) Fed Terrestrial Animal and Plant Proteins.

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    authors: Dam CTM,Ventura T,Booth M,Pirozzi I,Salini M,Smullen R,Elizur A

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  • Genome-Wide Identification and Analysis of P-Type Plasma Membrane H+-ATPase Sub-Gene Family in Sunflower and the Role of HHA4 and HHA11 in the Development of Salt Stress Resistance.

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    pub_type: 杂志文章


    authors: Xu Z,Marowa P,Liu H,Du H,Zhang C,Li Y

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  • H-NS, Its Family Members and Their Regulation of Virulence Genes in Shigella Species.

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    pub_type: 杂志文章,评审


    authors: Picker MA,Wing HJ

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    pub_type: 杂志文章


    authors: Erzurumluoglu AM,Baird D,Richardson TG,Timpson NJ,Rodriguez S

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  • The POU Transcription Factor POU-M2 Regulates Vitellogenin Receptor Gene Expression in the Silkworm, Bombyx mori.

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    authors: Shen G,Chen E,Ji X,Liu L,Liu J,Hua X,Li D,Xiao Y,Xia Q

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  • Factors behind junk DNA in bacteria.

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    pub_type: 杂志文章


    authors: Gil R,Latorre A

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    pub_type: 杂志文章


    authors: Teboul N,Gadri Y,Berkovich Z,Reifen R,Peleg Z

    更新日期:2020-10-18 00:00:00

  • Effects of 5'-3' Exonuclease Xrn1 on Cell Size, Proliferation and Division, and mRNA Levels of Periodic Genes in Cryptococcus neoformans.

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    pub_type: 杂志文章


    authors: Zhao X,Li X,Zhang P,Li C,Feng W,Zhu X,Wei D

    更新日期:2020-04-16 00:00:00