Extracurricular Functions of tRNA Modifications in Microorganisms.

abstract：:Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease. About 2900 variants of LDLR, APOB, and PCSK9 genes potentially associated with FH have been described earlier. Nev...

journal_title：Genes

authors： Meshkov A,Ershova A,Kiseleva A,Zotova E,Sotnikova E,Petukhova A,Zharikova A,Malyshev P,Rozhkova T,Blokhina A,Limonova A,Ramensky V,Divashuk M,Khasanova Z,Bukaeva A,Kurilova O,Skirko O,Pokrovskaya M,Mikova V,Snigir E

更新日期：2021-01-06 00:00:00

abstract：:There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of linc...

journal_title：Genes

authors： Zou C,Li S,Deng L,Guan Y,Chen D,Yuan X,Xia T,He X,Shan Y,Li C

更新日期：2017-08-18 00:00:00

abstract：:As a major infectious disease in chickens, Newcastle disease virus (NDV) causes considerable economic losses in the poultry industry, especially in developing countries where there is limited access to effective vaccination. Therefore, enhancing resistance to the virus in commercial chickens through breeding is a prom...

journal_title：Genes

authors： Zhang J,Kaiser MG,Gallardo RA,Kelly TR,Dekkers JCM,Zhou H,Lamont SJ

更新日期：2020-08-26 00:00:00

abstract：:In this paper, we present a two-phase microfluidic system capable of incubating and quantifying microbead-based agglutination assays. The microfluidic system is based on a simple fabrication solution, which requires only laboratory tubing filled with carrier oil, driven by negative pressure using a syringe pump. We pr...

journal_title：Genes

authors： Castro D,Conchouso D,Kodzius R,Arevalo A,Foulds IG

更新日期：2018-06-04 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) signaling pathway plays key roles in sensing extracellular signals and transmitting them from the cell membrane to the nucleus in response to various environmental stimuli. A MAPKKK protein CgMck1 in Colletotrichum gloeosporioides was characterized. Phenotypic analyses of the ∆C...

journal_title：Genes

authors： Fang YL,Xia LM,Wang P,Zhu LH,Ye JR,Huang L

更新日期：2018-11-08 00:00:00

abstract：:At each round of cell division, the DNA must be correctly duplicated and distributed between the two daughter cells to maintain genome identity. In order to achieve proper chromosome replication and segregation, sister chromatids must be recognized as such and kept together until their separation. This process of cohe...

journal_title：Genes

authors： Finardi A,Massari LF,Visintin R

更新日期：2020-08-07 00:00:00

abstract：:Fusarium head blight (FHB), caused primarily by the fungus Fusarium graminearum, is one of the most damaging diseases of wheat, causing significant loss of yield and quality worldwide. Warm and wet conditions during flowering, a lack of resistant wheat varieties, and high inoculum pressure from corn stubble contribute...

journal_title：Genes

authors： Castro Aviles A,Alan Harrison S,Joseph Arceneaux K,Brown-Guidera G,Esten Mason R,Baisakh N

更新日期：2020-06-25 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic diseases. It is caused by mutations in the NF1 gene encoding for the large protein, neurofibromin. Genetic testing of NF1 is cumbersome because 50% of cases are sporadic, and there are no mutation hot spots. In addition, the most recog...

journal_title：Genes

authors： Stella A,Lastella P,Loconte DC,Bukvic N,Varvara D,Patruno M,Bagnulo R,Lovaglio R,Bartolomeo N,Serio G,Resta N

更新日期：2018-04-17 00:00:00

abstract：:The southern elephant seal Mirounga leonina is the largest phocid seal and one of the two species of elephant seals. They are listed as 'least concern' by the International Union for Conservation of Nature (IUCN) Red List of Threatened Species 2015. Here, we have assembled the reference genome for M. leonina using the...

journal_title：Genes

authors： Kim BM,Lee YJ,Kim JH,Kim JH,Kang S,Jo E,Lee SJ,Lee JH,Chi YM,Park H

更新日期：2020-02-03 00:00:00

abstract：:Death investigations often include an effort to establish the postmortem interval (PMI) in cases in which the time of death is uncertain. The postmortem interval can lead to the identification of the deceased and the validation of witness statements and suspect alibis. Recent research has demonstrated that microbes pr...

journal_title：Genes

authors： Belk A,Xu ZZ,Carter DO,Lynne A,Bucheli S,Knight R,Metcalf JL

更新日期：2018-02-16 00:00:00

abstract：:Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and...

journal_title：Genes

authors： Pewan SB,Otto JR,Huerlimann R,Budd AM,Mwangi FW,Edmunds RC,Holman BWB,Henry MLE,Kinobe RT,Adegboye OA,Malau-Aduli AEO

更新日期：2020-05-25 00:00:00

abstract：:Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...

journal_title：Genes

authors： Badji A,Kwemoi DB,Machida L,Okii D,Mwila N,Agbahoungba S,Kumi F,Ibanda A,Bararyenya A,Solemanegy M,Odong T,Wasswa P,Otim M,Asea G,Ochwo-Ssemakula M,Talwana H,Kyamanywa S,Rubaihayo P

更新日期：2020-06-24 00:00:00

abstract：:DNA methylation plays several roles in regulating neuronal proliferation, differentiation, and physiological functions. The major de novo methyltransferase, DNMT3, controls the DNA methylation pattern in neurons according to environmental stimulations and behavioral regulations. Previous studies demonstrated that knoc...

journal_title：Genes

authors： Lai YH,Audira G,Liang ST,Siregar P,Suryanto ME,Lin HC,Villalobos O,Villaflores OB,Hao E,Lim KH,Hsiao CD

更新日期：2020-11-07 00:00:00

abstract：:Amazonian puffing snakes (Spilotes; Colubridae) are snakes widely distributed in the Neotropical region. However, chromosomal data are scarce in this group and, when available, are only limited to karyotype description using conventional staining. In this paper, we focused on the process of karyotype evolution and tre...

journal_title：Genes

authors： Viana PF,Ezaz T,de Bello Cioffi M,Jackson Almeida B,Feldberg E

更新日期：2019-04-09 00:00:00

abstract：:Adverse environmental exposures in pregnancy can significantly alter the development of the fetus resulting in impaired child neurodevelopment. Such exposures can lead to epigenetic alterations like DNA methylation, which may be a marker of poor cognitive, motor and behavioral outcomes in the infant. Here we review st...

journal_title：Genes

authors： Hodyl NA,Roberts CT,Bianco-Miotto T

更新日期：2016-12-03 00:00:00

abstract：:The development of high-throughput sequencing technologies and screening of big patient cohorts with familial and sporadic amyotrophic lateral sclerosis (ALS) led to the identification of a significant number of genetic variants, which are sometimes difficult to interpret. The American College of Medical Genetics and ...

journal_title：Genes

authors： Lattante S,Marangi G,Doronzio PN,Conte A,Bisogni G,Zollino M,Sabatelli M

更新日期：2020-09-24 00:00:00

abstract：:White Spot Syndrome Virus (WSSV) is one of the main threats to farming Litopenaeus vannamei, the most important crustacean commercialized in aquaculture worldwide. Here, we performed RNA-seq analyses in hepatopancreas and muscle from WSSV-negative (healthy) and WSSV-positive (unhealthy) L. vannamei, previously exposed...

journal_title：Genes

authors： Santos CA,Andrade SCS,Fernandes JMO,Freitas PD

更新日期：2020-07-16 00:00:00

abstract：:The development of the udder and the milk yield are closely related to the number and vitality of mammary epithelial cells. Many previous studies have proved that non-coding RNAs (ncRNAs) are widely involved in mammary gland development and the physiological activities of lactation. Our laboratory previous sequencing ...

journal_title：Genes

authors： Zhang M,Ma L,Liu Y,He Y,Li G,An X,Cao B

更新日期：2020-06-28 00:00:00

abstract：:The sea lamprey (Petromyzon marinus) is one of few vertebrate species known to reproducibly eliminate large fractions of its genome during normal embryonic development. This germline-specific DNA is lost in the form of large fragments, including entire chromosomes, and available evidence suggests that DNA elimination ...

journal_title：Genes

authors： Timoshevskiy VA,Timoshevskaya NY,Smith JJ

更新日期：2019-10-22 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is a reliable and easily detectable reproductive marker for the fertility competence of many farm animal species. AMH is also a good predictor of superovulation in cattle, sheep, and mares. In this review, we have summarized the recent findings related to AMH and its predictive reliability...

journal_title：Genes

authors： Umer S,Zhao SJ,Sammad A,Weldegebriall Sahlu B,Yunwei P,Zhu H

更新日期：2019-12-04 00:00:00

abstract：:Due to its extraordinary longevity and wide distribution, the ocean quahog Arctica islandica has become an important species model in both aging and environmental change research. Notwithstanding that, most genetic studies on ocean quahogs have been focused on fishery related, phylogeographic and phylogenetic aspects ...

journal_title：Genes

authors： García-Souto D,Pasantes JJ

更新日期：2018-06-13 00:00:00

abstract：:Terpenoids play important roles in plant defense. Although some terpene synthases have been characterized, terpenoids and their biosynthesis in wheat (Triticumaestivum L.) still remain largely unknown. Here, we describe the identification of a terpene synthase gene in wheat. It encodes a sesquiterpene synthase that ca...

journal_title：Genes

authors： Pu Q,Liang J,Shen Q,Fu J,Pu Z,Liu J,Wang X,Wang Q

更新日期：2019-06-10 00:00:00

abstract：:The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derive...

journal_title：Genes

authors： León-Reyes G,Rivera-Paredez B,López JCF,Ramírez-Salazar EG,Aquino-Gálvez A,Gallegos-Carrillo K,Denova-Gutiérrez E,Salmerón J,Velázquez-Cruz R

更新日期：2020-10-14 00:00:00

abstract：:Background: Congenital disorder of glycosylation (CDG) is a severe morphogenic and metabolic disorder that affects all of the systems of organs and is caused by a mutation of the gene PMM2, having a mortality rate of 20% during the first months of life. Results: Here we report the outcome of an in vitro fertilisation ...

journal_title：Genes

authors： Doroftei B,Nemtanu L,Ilie OD,Simionescu G,Ivanov I,Anton E,Puiu M,Maftei R

更新日期：2020-06-25 00:00:00

abstract：:Synthesis of chromosomal DNA is initiated from multiple origins of replication in higher eukaryotes; however, little is known about these origins' structures. We isolated the origin-derived nascent DNAs from a human repair-deficient cell line by blocking the replication forks near the origins using two different origi...

journal_title：Genes

authors： Eki T,Murakami Y,Hanaoka F

更新日期：2013-04-17 00:00:00

abstract：:Transcriptional reprograming after the exposure of plants to elevated temperatures is a hallmark of stress response which is required for the manifestation of thermotolerance. Central transcription factors regulate the stress survival and recovery mechanisms and many of the core responses controlled by these factors a...

journal_title：Genes

authors： Hu Y,Fragkostefanakis S,Schleiff E,Simm S

更新日期：2020-06-16 00:00:00

abstract：:Helicobacter pylori (H. pylori) is one of the main causes of gastric gancer. TNF-related apoptosis-inducing ligand (TRAIL) is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via TRAIL. It is believed that MicroRNA-106b-5p might be involved in t...

journal_title：Genes

authors： Pereira J,Santos M,Delabio R,Barbosa M,Smith M,Payão S,Rasmussen L

更新日期：2020-04-05 00:00:00

abstract：:The liver plays a key role in metabolism and affects pig production. However, the functional annotation of noncoding regions of the pig liver remains poorly understood. We revealed the landscape of cis-regulatory elements and their functional characterization in pig liver. We identified 102,373 cis-regulatory elements...

journal_title：Genes

authors： Luan Y,Zhang L,Hu M,Xu Y,Hou Y,Li X,Zhao S,Zhao Y,Li C

更新日期：2019-05-07 00:00:00

abstract：:Spiders often produce multiple types of silk, each with unique properties suiting them to certain tasks and biological functions. Orb-weaver spiders can generate more than six types of silk fibroins, with pyriform silk used to form attachment discs, adhering silk to other surfaces and substances. The unique higher-ord...

journal_title：Genes

authors： Wang K,Wen R,Jia Q,Liu X,Xiao J,Meng Q

更新日期：2019-06-03 00:00:00

abstract：:MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...

journal_title：Genes

authors： Bardot B,Toledo F

更新日期：2017-02-20 00:00:00