Abstract：
:The spectrum of modern horse populations encompasses populations with a long history of development in isolation and relatively recently formed types. To increase our understanding of the evolutionary history and provide information on how to optimally conserve or improve these populations with varying development and background for the future, we analyzed genotype data of 184 horses from 9 Dutch or common horse populations in the Netherlands: The Belgian draft horse, Friesian horse, Shetland pony, Icelandic horse, Gelder horse, Groninger horse, harness horse, KWPN sport horse and the Lipizzaner horse population. Various parameters were estimated (e.g., runs of homozygosity and FST values) to gain insight into genetic diversity and relationships within and among these populations. The identified genomic makeup and quantified relationships did mostly conform to the development of these populations as well as past and current breeding practices. In general, populations that allow gene-flow showed less inbreeding and homozygosity. Also, recent bottlenecks (e.g., related to high selective pressure) caused a larger contribution of long ROHs to inbreeding. Maintaining genetic diversity through tailor-made breeding practices is crucial for a healthy continuation of the investigated, mostly inbred and (effectively) small sized horse populations, of which several already experience inbreeding related issues.
journal_name
Genes (Basel)journal_title
Genesauthors
Schurink A,Shrestha M,Eriksson S,Bosse M,Bovenhuis H,Back W,Johansson AM,Ducro BJdoi
10.3390/genes10060480subject
Has Abstractpub_date
2019-06-25 00:00:00issue
6issn
2073-4425pii
genes10060480journal_volume
10pub_type
杂志文章相关文献
Genes文献大全abstract：:The complete mutational spectrum of dystrophinopathies and limb-girdle muscular dystrophy (LGMD) remains unknown in Mexican population. Seventy-two unrelated Mexican male patients (73% of pediatric age) with clinical suspicion of muscular dystrophy and no evidence of DMD gene deletion on multiplex polymerase chain rea...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110856
更新日期：2019-10-29 00:00:00
abstract：:Chinese kale is a native vegetable in Southern China and the flowering stalk is the most commonly used edible part due to its high glucosinolate content and other nutritional qualities. The GTR protein played important roles in the glucosinolate transport process. In this study, three BocGTR1 genes were cloned from Ch...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10030202
更新日期：2019-03-08 00:00:00
abstract：:Circadian clocks in eukaryotes involve both transcriptional-translational feedback loops, post-translational regulation, and metabolic, non-transcriptional oscillations. We recently identified the involvement of circadian oscillations in the intracellular concentrations of magnesium ions (Mg2+i) that were conserved in...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10020158
更新日期：2019-02-19 00:00:00
abstract：:Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi [...]. ...
journal_title：Genes
pub_type： 社论
doi：10.3390/genes10020161
更新日期：2019-02-20 00:00:00
abstract：:Hypersialylation caused by the overexpression of sialyltransferases (STs) is a common feature in cancer that is associated with several characteristics of tumorigenesis. Thus, identifying cancer-associated STs is critical for cancer therapy. However, ST screening has been frequently conducted in cell line models. In t...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121436
更新日期：2020-11-28 00:00:00
abstract：:The Himalayas are one of earth's hotspots of biodiversity. Among its many cryptic and undiscovered organisms, including vertebrates, this complex high-mountain ecosystem is expected to harbour many species with adaptations to life in high altitudes. However, modern evolutionary genomic studies in Himalayan vertebrates...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110873
更新日期：2019-10-31 00:00:00
abstract：:The homeodomain-leucine zipper (HD-Zip) transcription factor family is a key transcription factor family and unique to the plant kingdom. It consists of a homeodomain and a leucine zipper that serve in combination as a dimerization motif. The family can be classified into four subfamilies, and these subfamilies partic...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes7050019
更新日期：2016-05-17 00:00:00
abstract：:Due to its extraordinary longevity and wide distribution, the ocean quahog Arctica islandica has become an important species model in both aging and environmental change research. Notwithstanding that, most genetic studies on ocean quahogs have been focused on fishery related, phylogeographic and phylogenetic aspects ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060299
更新日期：2018-06-13 00:00:00
abstract：:Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alzheimer's disease ma...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10090705
更新日期：2019-09-12 00:00:00
abstract：:In this contribution, the aspects of reptile and amphibian speciation that emerged from research performed over the past decade are reviewed. First, this study assesses how patterns and processes of speciation depend on knowing the taxonomy of the group in question, and discuss how integrative taxonomy has contributed...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10090646
更新日期：2019-08-26 00:00:00
abstract：:The dog population of Southern East Asia is unique in harboring virtually the full range of the universal mtDNA gene pool, and consequently, it has the highest genetic diversity worldwide. Despite this, limited research has been performed on dog genetics within this region. Here we present the first comprehensive stud...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11030253
更新日期：2020-02-27 00:00:00
abstract：:Bupleurum falcatum, which belongs to the family Apiaceae, has long been applied for curative treatments, especially as a liver tonic, in herbal medicine. The chloroplast (cp) genome has been an ideal model to perform the evolutionary and comparative studies because of its highly conserved features and simple structure...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes7050020
更新日期：2016-05-13 00:00:00
abstract：:Soil salinity is a serious threat to plant growth and crop productivity. Tall fescue utilization in saline areas is limited by its inferior salt tolerance. Thus, a transcriptome study is a prerequisite for future research aimed at providing deeper insights into the molecular mechanisms of tall fescue salt tolerance as...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9100466
更新日期：2018-09-21 00:00:00
abstract：:Here, we describe the creation of three integration vectors, pPEPX, pPEPY and pPEPZ, for use with the opportunistic human pathogen Streptococcus pneumoniae. The constructed vectors, named PEP for Pneumococcal Engineering Platform (PEP), employ an IPTG-inducible promoter and BglBrick and BglFusion compatible multiple c...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10050394
更新日期：2019-05-22 00:00:00
abstract：:The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their m...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11030305
更新日期：2020-03-13 00:00:00
abstract：:The reconstruction of ancient metagenomes from archaeological material, and their implication in human health and evolution, is one of the most recent advances in paleomicrobiological studies. However, as for all ancient DNA (aDNA) studies, environmental and laboratory contamination need to be specifically addressed. ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9090436
更新日期：2018-08-31 00:00:00
abstract：:Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9020089
更新日期：2018-02-14 00:00:00
abstract：:For medical genetic counseling, estimating the chance of a child being born with chromosome abnormality is crucially important. Cytogenetic diagnostics of parents with a balanced karyotype are a special case. Such chromosome rearrangements cannot be detected with comprehensive chromosome screening. In the current pape...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121511
更新日期：2020-12-17 00:00:00
abstract：:MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes8020082
更新日期：2017-02-20 00:00:00
abstract：:Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extreme...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9060283
更新日期：2018-06-05 00:00:00
abstract：:Trees and their seeds regulate their germination, growth, and reproduction in response to environmental stimuli. These stimuli, through signal transduction, trigger transcription factors that alter the expression of various genes leading to the unfolding of the genetic program. A regulon is conceptually defined as a s...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11090995
更新日期：2020-08-25 00:00:00
abstract：:Maize kernel development is a complex biological process that involves the temporal and spatial expression of many genes and fine gene regulation at a transcriptional and post-transcriptional level, and microRNAs (miRNAs) play vital roles during this process. To gain insight into miRNA-mediated regulation of maize ker...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8120385
更新日期：2017-12-14 00:00:00
abstract：:The yeast Exophiala dermatitidis exhibits high resistance to γ-radiation in comparison to many other fungi. Several aspects of this phenotype have been characterized, including its dependence on homologous recombination for the repair of radiation-induced DNA damage, and the transcriptomic response invoked by acute γ-...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11101128
更新日期：2020-09-25 00:00:00
abstract：:Fig wasps are a peculiar group of insects which, for millions of years, have inhabited the enclosed syconia of fig trees. Considering the relatively closed and dark environment of fig syconia, we hypothesize that the fig wasps' oxidative phosphorylation (OXPHOS) pathway, which is the main oxygen consumption and adenos...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11111353
更新日期：2020-11-15 00:00:00
abstract：:Silver-Russell syndrome (SRS) is a rare growth-related genetic disorder that is mainly associated with prenatal and postnatal growth retardation. Molecular causes are not clear in all cases, the most common ones being loss of methylation on chromosome 11p15 (≈50%) and maternal uniparental disomy for chromosome 7 (upd(...
journal_title：Genes
pub_type：
doi：10.3390/genes11121461
更新日期：2020-12-05 00:00:00
abstract：:The telomerase RNA in yeasts is large, usually >1000 nt, and contains functional elements that have been extensively studied experimentally in several disparate species. Nevertheless, they are very difficult to detect by homology-based methods and so far have escaped annotation in the majority of the genomes of Saccha...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9080372
更新日期：2018-07-26 00:00:00
abstract：:A major technological shift in the research community in the past decade has been the adoption of high throughput (HT) technologies to interrogate the genome, epigenome, transcriptome, and proteome in a massively parallel fashion [...]. ...
journal_title：Genes
pub_type： 社论
doi：10.3390/genes11030245
更新日期：2020-02-26 00:00:00
abstract：:As a highly nutritious crop, Tartary buckwheat (Fagopyrum tartaricum) strongly adapts and grows in adverse environments and is widely grown in Asia. However, its flour contains a large proportion of the hull that adheres to the testa layer of the groats and is difficult to be removed in industrial processing. Fortunat...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11040459
更新日期：2020-04-23 00:00:00
abstract：:We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11090978
更新日期：2020-08-22 00:00:00
abstract：:Continuous cultures assure the invariability of environmental conditions and the metabolic state of cultured microorganisms, whereas batch-cultured cells undergo constant changes in nutrients availability. For that reason, continuous culture is sometimes employed in the whole transcriptome, whole proteome, or whole me...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121419
更新日期：2020-11-27 00:00:00
