GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the X chromosome in Korean Children with Autoimmune Thyroid Disease.

abstract：:Lactobacillus ruminis is a commensal motile lactic acid bacterium living in the intestinal tract of humans and animals. Although a few genomes of L. ruminis were published, most of them were animal derived. To explore the genetic diversity and potential niche-specific adaptation changes of L. ruminis, in the current w...

journal_title：Genes

authors： Wang S,Yang B,Ross RP,Stanton C,Zhao J,Zhang H,Chen W

更新日期：2020-01-08 00:00:00

abstract：:Magnaportheoryzae is a devastating plant pathogen, which has a detrimental impact on rice production worldwide. Despite its agronomical importance, some newly-emerging pathotypes often overcome race-specific disease resistance rapidly. It is thus desirable to develop a novel strategy for the long-lasting resistance of...

journal_title：Genes

authors： Zhu L,Zhu J,Liu Z,Wang Z,Zhou C,Wang H

更新日期：2017-09-26 00:00:00

abstract：:A major technological shift in the research community in the past decade has been the adoption of high throughput (HT) technologies to interrogate the genome, epigenome, transcriptome, and proteome in a massively parallel fashion [...]. ...

journal_title：Genes

authors： Hardiman G

更新日期：2020-02-26 00:00:00

abstract：:The homeodomain-leucine zipper (HD-Zip) gene family, as plant-specific transcription factors, plays an important role in plant development and growth as well as in the response to diverse stresses. Although HD-Zip genes have been extensively studied in many plants, they had not yet been studied in wheat, especially th...

journal_title：Genes

authors： Yue H,Shu D,Wang M,Xing G,Zhan H,Du X,Song W,Nie X

更新日期：2018-02-01 00:00:00

abstract：:One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affe...

journal_title：Genes

authors： Villarino GH,Hu Q,Scanlon MJ,Mueller L,Bombarely A,Mattson NS

更新日期：2017-08-03 00:00:00

abstract：:Cerebral ischaemia is the most common cause of impaired brain function. Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH(4-7)PGP (Semax), has been used successfully in the treatment of patients with severe impairment...

journal_title：Genes

authors： Filippenkov IB,Stavchansky VV,Denisova AE,Yuzhakov VV,Sevan'kaeva LE,Sudarkina OY,Dmitrieva VG,Gubsky LV,Myasoedov NF,Limborska SA,Dergunova LV

更新日期：2020-06-22 00:00:00

abstract：:Smoking is one of the leading preventable causes of morbidity and mortality worldwide, prompting interest in its association with DNA methylation-based measures of biological aging. Considerable progress has been made in developing DNA methylation-based measures that correspond to self-reported smoking status. In addi...

journal_title：Genes

authors： Lei MK,Gibbons FX,Simons RL,Philibert RA,Beach SRH

更新日期：2020-03-14 00:00:00

abstract：:Hepatitis B virus (HBV) is divided into nine genotypes, A to I. Currently, it remains unclear how the individual genotypes contribute to the estimated 250 million chronic HBV infections. We performed a literature search on HBV genotyping data throughout the world. Over 900 publications were assessed and data were extr...

journal_title：Genes

authors： Velkov S,Ott JJ,Protzer U,Michler T

更新日期：2018-10-15 00:00:00

abstract：:Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...

journal_title：Genes

authors： Gimenez E,Manzano-Agugliaro F

更新日期：2017-10-30 00:00:00

abstract：:The homeodomain-leucine zipper (HD-Zip) transcription factor family is a key transcription factor family and unique to the plant kingdom. It consists of a homeodomain and a leucine zipper that serve in combination as a dimerization motif. The family can be classified into four subfamilies, and these subfamilies partic...

journal_title：Genes

authors： Song A,Li P,Xin J,Chen S,Zhao K,Wu D,Fan Q,Gao T,Chen F,Guan Z

更新日期：2016-05-17 00:00:00

abstract：:The etiology and reasons underlying the ethnic disparities in systemic sclerosis (SSc) remain unknown. African Americans are disproportionally affected by SSc and yet are underrepresented in research. The aim of this study was to comprehensively investigate the association of DNA methylation levels with SSc in dermal ...

journal_title：Genes

authors： Baker Frost D,da Silveira W,Hazard ES,Atanelishvili I,Wilson RC,Flume J,Day KL,Oates JC,Bogatkevich GS,Feghali-Bostwick C,Hardiman G,Ramos PS

更新日期：2021-01-20 00:00:00

abstract：:Quorum sensing (QS) is a cell-to-cell communication system that uses autoinducers as signaling molecules to enable inter-species and intra-species interactions in response to external stimuli according to the population density. QS allows bacteria such as Acinetobacter baumannii to react rapidly in response to environ...

journal_title：Genes

authors： Ng CK,How KY,Tee KK,Chan KG

更新日期：2019-04-08 00:00:00

abstract：:PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered...

journal_title：Genes

authors： Yvert T,Miyamoto-Mikami E,Tobina T,Shiose K,Kakigi R,Tsuzuki T,Takaragawa M,Ichinoseki-Sekine N,Pérez M,Kobayashi H,Tanaka H,Naito H,Fuku N

更新日期：2020-08-27 00:00:00

abstract：:The recently discovered Methanonatronarchaeia are extremely halophilic and moderately thermophilic methyl-reducing methanogens representing a novel class-level lineage in the phylum Euryarchaeota related to the class Halobacteria. Here we present a detailed analysis of 1D-nano liquid chromatography-electrospray ioniza...

journal_title：Genes

authors： Ferrer M,Sorokin DY,Wolf YI,Ciordia S,Mena MC,Bargiela R,Koonin EV,Makarova KS

更新日期：2018-01-23 00:00:00

abstract：:Cancer stem cells (CSCs), having both self-renewal and tumorigenic capacity, utilize an energy metabolism system different from that of non-CSCs. Lipid droplets (LDs) are organelles that store neutral lipids, including triacylglycerol. Previous studies demonstrated that LDs are formed and store lipids as an energy sou...

journal_title：Genes

authors： Kuramoto K,Yamamoto M,Suzuki S,Togashi K,Sanomachi T,Kitanaka C,Okada M

更新日期：2021-01-14 00:00:00

abstract：:Despite worldwide prevention programs, the incidence for cutaneous melanoma is continuously increasing. Mucosal melanoma (MM) represents a rare but highly aggressive phenotype of common melanoma with predilection in the sinonasal system. Far away from ultraviolet sun exposure, the molecular mechanisms underlying tumor...

journal_title：Genes

authors： Fritsche MK,Knopf A

更新日期：2017-12-13 00:00:00

abstract：:MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...

journal_title：Genes

authors： Bardot B,Toledo F

更新日期：2017-02-20 00:00:00

abstract：:The integration of phenotypes and genotypes is at an unprecedented level and offers new opportunities to establish deep phenotypes. There are a number of challenges to overcome, specifically, accelerated growth of data, data silos, incompleteness, inaccuracies, and heterogeneity within and across data sources. This pe...

journal_title：Genes

authors： Frey LJ

更新日期：2018-12-28 00:00:00

abstract：:Almost all eukaryotes have transposable elements (TEs) against which they have developed defense mechanisms. In the Drosophila germline, the main transposable element (TE) regulation pathway is mediated by specific Piwi-interacting small RNAs (piRNAs). Nonetheless, for unknown reasons, TEs sometimes escape cellular co...

journal_title：Genes

authors： Gámez-Visairas V,Romero-Soriano V,Martí-Carreras J,Segarra-Carrillo E,García Guerreiro MP

更新日期：2020-02-19 00:00:00

abstract：:Gene doping, an activity which abuses and misuses gene therapy, is a major concern in sports and horseracing industries. Effective methods capable of detecting and monitoring gene doping are urgently needed. Although several PCR-based methods that detect transgenes have been developed, many of them focus only on a sin...

journal_title：Genes

authors： Tozaki T,Ohnuma A,Kikuchi M,Ishige T,Kakoi H,Hirota KI,Kusano K,Nagata SI

更新日期：2020-04-23 00:00:00

abstract：:In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process. In rat, two splicing events produce several isoforms of ADAR2, called ADAR2a, ADAR2b, ADAR2e, and ADAR2f, but only ADAR2a and AD...

journal_title：Genes

authors： Filippini A,Bonini D,Giacopuzzi E,La Via L,Gangemi F,Colombi M,Barbon A

更新日期：2018-02-08 00:00:00

abstract：:GOLDEN2-LIKE (GLK) is a member of the myeloblastosis (MYB) family transcription factor and it plays an important role in the regulation of plastid development and stress tolerance. In this study, a gene named AhGLK1b was identified from a cultivated peanut showing down-regulation in response to low calcium with a comp...

journal_title：Genes

authors： Ali N,Chen H,Zhang C,Khan SA,Gandeka M,Xie D,Zhuang W

更新日期：2020-03-24 00:00:00

abstract：:Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...

journal_title：Genes

authors： Josling GA,Selvarajah SA,Petter M,Duffy MF

更新日期：2012-05-29 00:00:00

abstract：:The pseudostratified olfactory epithelium (OE) may histologically appear relatively simple, but the cytological relations among its cell types, especially those between olfactory receptor neurons (ORNs) and olfactory sustentacular cells (OSCs), prove more complex and variable than previously believed. Adding to the co...

journal_title：Genes

authors： Liang F

更新日期：2020-04-30 00:00:00

abstract：:Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa an...

journal_title：Genes

authors： Djuicy DD,Hearn J,Tchouakui M,Wondji MJ,Irving H,Okumu FO,Wondji CS

更新日期：2020-11-05 00:00:00

abstract：:DNA methylation patterns have been shown to change throughout the normal aging process. Several studies have found epigenetic aging markers using age predictors, but these studies only focused on blood-specific or tissue-common methylation patterns. Here, we constructed nine tissue-specific age prediction models using...

journal_title：Genes

authors： Choi H,Joe S,Nam H

更新日期：2019-11-04 00:00:00

abstract：:Cisplatin is a chemotherapeutic agent widely used for multiple indications. Unfortunately, in a substantial set of patients treated with cisplatin, dose-limiting acute kidney injury (AKI) occurs. Here, we assessed the association of 3 catechol-O-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) with incr...

journal_title：Genes

authors： Agema BC,Koolen SLW,With M,Doorn NV,Heersche N,Hoop EO,Visser S,Aerts JGJV,Bins S,Schaik RHNV,Mathijssen RHJ

更新日期：2020-03-27 00:00:00

abstract：:Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type of genetic variation, namely changes in tandem repeat number. Historically, tandem repeats have been designated as...

journal_title：Genes

authors： Gemayel R,Cho J,Boeynaems S,Verstrepen KJ

更新日期：2012-07-26 00:00:00

abstract：:Histone acts as the core for nucleosomes and is a key protein component of chromatin. Among different histone variants, histone H3 (HH3) variants have been reported to play vital roles in plant development. However, biological information and evolutionary relationships of HH3 genes in cotton remain to be elucidated. T...

journal_title：Genes

authors： Qanmber G,Ali F,Lu L,Mo H,Ma S,Wang Z,Yang Z

更新日期：2019-05-09 00:00:00

abstract：:Each domestic dog breed is characterized by a strict set of physical and behavioral characteristics by which breed members are judged and rewarded in conformation shows. One defining feature of particular interest is the coat, which is comprised of either a double- or single-layer of hair. The top coat contains coarse...

journal_title：Genes

authors： Whitaker DT,Ostrander EA

更新日期：2019-04-26 00:00:00