Characterization and Transcriptome Studies of Autoinducer Synthase Gene from Multidrug Resistant Acinetobacter baumannii Strain 863.

abstract：:Long non-coding (lnc) RNAs serve a multitude of functions in cells. NEAT1 RNA is a highly abundant 4 kb lncRNA in nuclei, and coincides with paraspeckles, nuclear domains that control sequestration of paraspeckle proteins. We examined NEAT1 RNA levels and its function in 3T3-L1 cells during differentiation to adipocyt...

journal_title：Genes

authors： Cooper DR,Carter G,Li P,Patel R,Watson JE,Patel NA

更新日期：2014-11-27 00:00:00

abstract：:Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...

journal_title：Genes

authors： Moura J,Børsheim E,Carvalho E

更新日期：2014-09-29 00:00:00

abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...

journal_title：Genes

authors： Rick K,Ottewell K,Lohr C,Thavornkanlapachai R,Byrne M,Kennington WJ

更新日期：2019-10-28 00:00:00

abstract：:Droplet digital PCR is the most robust method for absolute nucleic acid quantification. However, RNA is a very versatile molecule and its abundance is tissue-dependent. RNA quantification is dependent on a reference control to estimate the abundance. Additionally, in cancer, many cellular processes are deregulated whi...

journal_title：Genes

authors： Villegas-Ruíz V,Olmos-Valdez K,Castro-López KA,Saucedo-Tepanecatl VE,Ramírez-Chiquito JC,Pérez-López EI,Medina-Vera I,Juárez-Méndez S

更新日期：2019-05-17 00:00:00

abstract：:Plant genomes generated by Sanger and Next Generation Sequencing (NGS) have provided insight into species diversity and evolution. However, Sanger sequencing is limited in its applications due to high cost, labor intensity, and low throughput, while NGS reads are too short to resolve abundant repeats and polyploidy, l...

journal_title：Genes

authors： Li C,Lin F,An D,Wang W,Huang R

更新日期：2017-12-28 00:00:00

abstract：:While the number of mammalian genome assemblies has proliferated, Y-chromosome assemblies have lagged behind. This discrepancy is caused by biological features of the Y-chromosome, such as its high repeat content, that present challenges to assembly with short-read, next-generation sequencing technologies. Partial Y-c...

journal_title：Genes

authors： Rando HM,Wadlington WH,Johnson JL,Stutchman JT,Trut LN,Farré M,Kukekova AV

更新日期：2019-05-28 00:00:00

abstract：:The P-type plasma membrane (PM) H+-ATPase plays a major role during the growth and development of a plant. It is also involved in plant resistance to a variety of biotic and abiotic factors, including salt stress. The PM H+-ATPase gene family has been well characterized in Arabidopsis and other crop plants such as ric...

journal_title：Genes

authors： Xu Z,Marowa P,Liu H,Du H,Zhang C,Li Y

更新日期：2020-03-27 00:00:00

abstract：:At each round of cell division, the DNA must be correctly duplicated and distributed between the two daughter cells to maintain genome identity. In order to achieve proper chromosome replication and segregation, sister chromatids must be recognized as such and kept together until their separation. This process of cohe...

journal_title：Genes

authors： Finardi A,Massari LF,Visintin R

更新日期：2020-08-07 00:00:00

abstract：:The histone-like nucleoid structuring protein (H-NS) has played a key role in shaping the evolution of Shigella spp., and provides the backdrop to the regulatory cascade that controls virulence by silencing many genes found on the large virulence plasmid. H-NS and its paralogue StpA are present in all four Shigella sp...

journal_title：Genes

authors： Picker MA,Wing HJ

更新日期：2016-12-01 00:00:00

abstract：:N6-methyladenosine (m6A) is the most abundant RNA modification. It has been involved in the regulation of RNA metabolism, including degradation and translation, in both physiological and disease conditions. A recent study showed that m6A-mediated degradation of key transcripts also plays a role in the control of T cel...

journal_title：Genes

authors： Furlan M,Galeota E,de Pretis S,Caselle M,Pelizzola M

更新日期：2019-01-08 00:00:00

abstract：:Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemi...

journal_title：Genes

authors： Prins FM,Said MA,van de Vegte YJ,Verweij N,Groot HE,van der Harst P

更新日期：2019-11-07 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome that results from dominant loss-of-function mutations mainly in the NF1 gene. Large rearrangements are present in 5-10% of affected patients, generally encompass NF1 neighboring genes, and are correlated with a more severe NF1 phenotype. Evident genoty...

journal_title：Genes

authors： Brussa Reis L,Turchetto-Zolet AC,Fonini M,Ashton-Prolla P,Rosset C

更新日期：2019-10-24 00:00:00

abstract：:Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...

journal_title：Genes

authors： Zhu X,Li HD,Xu Y,Guo L,Wu FX,Duan G,Wang J

更新日期：2019-01-29 00:00:00

abstract：:Xyloglucan endotransglycosylase/hydrolase (XTH) is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. In this study, 48 XTH genes were identified from two pineapple (Ananas comosus) cultivars ('F153' and 'MD2') and designated Ac(F153)XTH1 to -24 and Ac(MD2)XTH1...

journal_title：Genes

authors： Li Q,Li H,Yin C,Wang X,Jiang Q,Zhang R,Ge F,Chen Y,Yang L

更新日期：2019-07-16 00:00:00

abstract：:Cytochrome P450 enzymes encoded by MORE AXILLARY GROWTH1 (MAX1)-like genes produce most of the structural diversity of strigolactones during the final steps of strigolactone biosynthesis. The diverse copies of MAX1 in Oryza sativa provide a resource to investigate why plants produce such a wide range of strigolactones...

journal_title：Genes

authors： Marzec M,Situmorang A,Brewer PB,Brąszewska A

更新日期：2020-11-13 00:00:00

abstract：:RNA plays complex roles in normal health and disease and is becoming an important target for therapeutic intervention; accordingly, therapeutic strategies that modulate RNA function have gained great interest over the past decade. Antisense oligonucleotides (AOs) are perhaps the most promising strategy to modulate RNA...

journal_title：Genes

authors： Imbert M,Dias-Florencio G,Goyenvalle A

更新日期：2017-01-26 00:00:00

abstract：:Xeroderma pigmentosum group C (XPC) is a key component of the nucleotide excision repair (NER) pathway. Dysfunctional XPC protein may impair NER-mediated DNA repair capacity and further lead to genomic instability and carcinogenesis. Two common nonsynonymous polymorphisms in the XPC gene, Lys939Gln (rs2228001 A > C) a...

journal_title：Genes

authors： Hua RX,Zhu J,Jiang DH,Zhang SD,Zhang JB,Xue WQ,Li XZ,Zhang PF,He J,Jia WH

更新日期：2016-09-24 00:00:00

abstract：:Cyclocarya paliurus (Batal.) Iljinskaja, a unique species growing in southern China, is a multi-function tree species with medicinal, healthcare, material, and ornamental values. So far, sexual reproduction is the main method for extensive cultivation of C. paliurus plantations, but this is limited by low seed plumpne...

journal_title：Genes

authors： Chen X,Mao X,Huang P,Fang S

更新日期：2019-10-17 00:00:00

abstract：:The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a maj...

journal_title：Genes

authors： Nagpal S,Gibson G,Marigorta UM

更新日期：2018-08-14 00:00:00

abstract：:In forensics, mitochondrial DNA (mtDNA) analysis is foremost applied to rootless hairs often lacking detectable nuclear DNA. Sanger sequencing is the routine mtDNA method in most forensic laboratories, even though interpretation of mixed samples and heteroplasmic sites can be challenging. Individuals may hold cells wi...

journal_title：Genes

authors： Gaag KJV,Desmyter S,Smit S,Prieto L,Sijen T

更新日期：2020-11-16 00:00:00

abstract：:Histone acts as the core for nucleosomes and is a key protein component of chromatin. Among different histone variants, histone H3 (HH3) variants have been reported to play vital roles in plant development. However, biological information and evolutionary relationships of HH3 genes in cotton remain to be elucidated. T...

journal_title：Genes

authors： Qanmber G,Ali F,Lu L,Mo H,Ma S,Wang Z,Yang Z

更新日期：2019-05-09 00:00:00

abstract：:Preimplantation genetic testing (PGT) has evolved into a well-established alternative to invasive prenatal diagnosis, even though genetic testing of single or few cells is quite challenging. PGT-M is in theory available for any monogenic disorder for which the disease-causing locus has been unequivocally identified. I...

journal_title：Genes

authors： De Rycke M,Berckmoes V

更新日期：2020-07-31 00:00:00

abstract：:The Muraenidae is one of the largest and most complex anguilliform families. Despite their abundance and important ecological roles, morays are little studied, especially cytogenetically, and both their phylogenetic relationships and the taxonomy of their genera are controversial. With the aim of extending the karyolo...

journal_title：Genes

authors： Coluccia E,Deidda F,Lobina C,Melis R,Porcu C,Agus B,Salvadori S

更新日期：2020-11-06 00:00:00

abstract：:Serotonin receptor 2A (HTR2A) is an important signalling factor implicated in cognitive functions and known to be associated with schizophrenia. The biological significance of HTR2A in schizophrenia remains unclear as molecular analyses including genetic association, mRNA expression and methylation studies have report...

journal_title：Genes

authors： Cheah SY,Lawford BR,Young RM,Morris CP,Voisey J

更新日期：2017-01-04 00:00:00

abstract：:White coat color in mammals has been selected several times during the domestication process. Numerous dog breeds are fixed for one form of white coat color that involves darkly pigmented skin. The genetic basis of this color, due to the absence of pigment in the hairs, was suggested to correspond to extreme dilution ...

journal_title：Genes

authors： Hédan B,Cadieu E,Botherel N,Dufaure de Citres C,Letko A,Rimbault M,Drögemüller C,Jagannathan V,Derrien T,Schmutz S,Leeb T,André C

更新日期：2019-05-21 00:00:00

abstract：:Genome wide association studies (GWAS) are a well established methodology to identify genomic variants and genes that are responsible for traits of interest in all branches of the life sciences. Despite the long time this methodology has had to mature the reliable detection of genotype-phenotype associations is still ...

journal_title：Genes

authors： Ramzan F,Gültas M,Bertram H,Cavero D,Schmitt AO

更新日期：2020-08-05 00:00:00

abstract：:Hexokinase (HK) is a key enzyme in chitin biosynthesis in insects and plays an important role in development and energy regulation. It also performs a crucial role in the synthesis of Glucose-6-phosphate and its putative functions are studied via injection of dsRNA corresponding to the hexokinase gene from Cnaphalocro...

journal_title：Genes

authors： Shakeel M,Du J,Li SW,Zhou YJ,Sarwar N,Bukhari SAH

更新日期：2020-10-26 00:00:00

abstract：:Model-based clustering with finite mixture models has become a widely used clustering method. One of the recent implementations is MCLUST. When objects to be clustered are summary statistics, such as regression coefficient estimates, they are naturally associated with estimation errors, whose covariance matrices can o...

journal_title：Genes

authors： Zhang W,Di Y

更新日期：2020-02-10 00:00:00

abstract：:Mgaloblishvili, a Vitis vinifera cultivar, exhibits unique resistance traits against Plasmopara viticola, the downy mildew agent. This offers the unique opportunity of exploring the molecular responses in compatible and incompatible plant-pathogen interaction. In this study, whole transcriptomes of Mgaloblishvili, Pin...

journal_title：Genes

authors： Toffolatti SL,De Lorenzis G,Brilli M,Moser M,Shariati V,Tavakol E,Maddalena G,Passera A,Casati P,Pindo M,Cestaro A,Maghradze D,Failla O,Bianco PA,Quaglino F

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Atopic dermatitis is a common inflammatory skin disorder that affects up to 15-20% of the population and is characterized by recurrent eczematous lesions with intense itching. As a heterogeneous disease, multiple factors have been suggested to explain the nature of atopic dermatitis (AD), and its high preval...

journal_title：Genes

authors： Martin MJ,Estravís M,García-Sánchez A,Dávila I,Isidoro-García M,Sanz C

更新日期：2020-04-18 00:00:00