The Effect of Tobacco Smoking Differs across Indices of DNA Methylation-Based Aging in an African American Sample: DNA Methylation-Based Indices of Smoking Capture These Effects.

Abstract:

:Smoking is one of the leading preventable causes of morbidity and mortality worldwide, prompting interest in its association with DNA methylation-based measures of biological aging. Considerable progress has been made in developing DNA methylation-based measures that correspond to self-reported smoking status. In addition, assessment of DNA methylation-based aging has been expanded to better capture individual differences in risk for morbidity and mortality. Untested to date, however, is whether smoking is similarly related to older and newer indices of DNA methylation-based aging, and whether DNA methylation-based indices of smoking can be used in lieu of self-reported smoking to examine effects on DNA methylation-based aging measures. In the current investigation we examine mediation of the impact of self-reported cigarette consumption on accelerated, intrinsic DNA methylation-based aging using indices designed to predict chronological aging, phenotypic aging, and mortality risk, as well as a newly developed DNA methylation-based measure of telomere length. Using a sample of 500 African American middle aged smokers and non-smokers, we found that a) self-reported cigarette consumption was associated with accelerated intrinsic DNA methylation-based aging on some but not all DNA methylation-based aging indices, b) for those aging outcomes associated with self-reported cigarette consumption, DNA methylation-based indicators of smoking typically accounted for greater variance than did self-reported cigarette consumption, and c) self-reported cigarette consumption effects on DNA methylation-based aging indices typically were fully mediated by DNA methylation-based indicators of smoking (e.g., PACKYRS from GrimAge; or cg05575921 CpG site). Results suggest that when DNA methylation-based indices of smoking are substituted for self-reported assessments of smoking, they will typically fully reflect the varied impact of cigarette smoking on intrinsic, accelerated DNA methylation-based aging.

journal_name

Genes (Basel)

journal_title

Genes

authors

Lei MK,Gibbons FX,Simons RL,Philibert RA,Beach SRH

doi

10.3390/genes11030311

subject

Has Abstract

pub_date

2020-03-14 00:00:00

issue

3

issn

2073-4425

pii

genes11030311

journal_volume

11

pub_type

杂志文章

相关文献

Genes文献大全
  • Genes Contributing to Domestication of Rice Seed Traits and Its Global Expansion.

    abstract::Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes9100489

    authors: Liu H,Li Q,Xing Y

    更新日期:2018-10-10 00:00:00

  • A Hybrid Clustering Algorithm for Identifying Cell Types from Single-Cell RNA-Seq Data.

    abstract::Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10020098

    authors: Zhu X,Li HD,Xu Y,Guo L,Wu FX,Duan G,Wang J

    更新日期:2019-01-29 00:00:00

  • Haploidy in Tobacco Induced by PsASGR-BBML Transgenes via Parthenogenesis.

    abstract:BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11091072

    authors: Zhang Z,Conner J,Guo Y,Ozias-Akins P

    更新日期:2020-09-12 00:00:00

  • The Role of microRNAs in Mitochondria: Small Players Acting Wide.

    abstract::MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that act as post-transcriptional gene regulators. They can inhibit target protein-coding genes, through repressing messenger RNA (mRNA) translation or promoting their degradation. miRNAs were initially found to be originated from nuclear genome an...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes5040865

    authors: Duarte FV,Palmeira CM,Rolo AP

    更新日期:2014-09-26 00:00:00

  • A Magnesium Transport Protein Related to Mammalian SLC41 and Bacterial MgtE Contributes to Circadian Timekeeping in a Unicellular Green Alga.

    abstract::Circadian clocks in eukaryotes involve both transcriptional-translational feedback loops, post-translational regulation, and metabolic, non-transcriptional oscillations. We recently identified the involvement of circadian oscillations in the intracellular concentrations of magnesium ions (Mg2+i) that were conserved in...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10020158

    authors: Feord HK,Dear FEG,Obbard DJ,van Ooijen G

    更新日期:2019-02-19 00:00:00

  • Horizontally Acquired Homologs of Xenogeneic Silencers: Modulators of Gene Expression Encoded by Plasmids, Phages and Genomic Islands.

    abstract::Acquisition of mobile elements by horizontal gene transfer can play a major role in bacterial adaptation and genome evolution by providing traits that contribute to bacterial fitness. However, gaining foreign DNA can also impose significant fitness costs to the host bacteria and can even produce detrimental effects. T...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11020142

    authors: Piña-Iturbe A,Suazo ID,Hoppe-Elsholz G,Ulloa-Allendes D,González PA,Kalergis AM,Bueno SM

    更新日期:2020-01-29 00:00:00

  • The Plasticizer Bisphenol A Perturbs the Hepatic Epigenome: A Systems Level Analysis of the miRNome.

    abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8100269

    authors: Renaud L,Silveira WAD,Hazard ES,Simpson J,Falcinelli S,Chung D,Carnevali O,Hardiman G

    更新日期:2017-10-13 00:00:00

  • Two New Cases of Hypertrophic Cardiomyopathy and Skeletal Muscle Features Associated with ALPK3 Homozygous and Compound Heterozygous Variants.

    abstract::Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy caused by biallelic variants in ALPK3. Genetic investigation was perfo...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11101201

    authors: Jorholt J,Formicheva Y,Vershinina T,Kiselev A,Muravyev A,Demchenko E,Fedotov P,Zlotina A,Rygkov A,Vasichkina E,Sejersen T,Kostareva A

    更新日期:2020-10-15 00:00:00

  • Comparative Analysis of Cotton Small RNAs and Their Target Genes in Response to Salt Stress.

    abstract::Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8120369

    authors: Yin Z,Han X,Li Y,Wang J,Wang D,Wang S,Fu X,Ye W

    更新日期:2017-12-05 00:00:00

  • Novel Sequence Features of DNA Repair Genes/Proteins from Deinococcus Species Implicated in Protection from Oxidatively Generated Damage.

    abstract::Deinococcus species display a high degree of resistance to radiation and desiccation due to their ability to protect critical proteome from oxidatively generated damage; however, the underlying mechanisms are not understood. Comparative analysis of DNA repair proteins reported here has identified 22 conserved signatur...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9030149

    authors: Hassan FMN,Gupta RS

    更新日期:2018-03-08 00:00:00

  • GPR174 and ITM2A Gene Polymorphisms rs3827440 and rs5912838 on the X chromosome in Korean Children with Autoimmune Thyroid Disease.

    abstract::(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174) and integral membrane protein 2A (ITM2A) on the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphism...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11080858

    authors: Cho WK,Shin HR,Lee NY,Kim SK,Ahn MB,Baek IC,Kim TG,Suh BK

    更新日期:2020-07-27 00:00:00

  • Golgi Reassembly and Stacking Protein (GRASP) Participates in Vesicle-Mediated RNA Export in Cryptococcus Neoformans.

    abstract::Golgi reassembly and stacking protein (GRASP) is required for polysaccharide secretion and virulence in Cryptococcus neoformans. In fungal species, extracellular vesicles (EVs) participate in the export of polysaccharides, proteins and RNA. In the present work, we investigated if EV-mediated RNA export is functionally...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9080400

    authors: Peres da Silva R,Martins ST,Rizzo J,Dos Reis FCG,Joffe LS,Vainstein M,Kmetzsch L,Oliveira DL,Puccia R,Goldenberg S,Rodrigues ML,Alves LR

    更新日期:2018-08-08 00:00:00

  • DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age.

    abstract::We employed Illumina 450 K Infinium microarrays to profile DNA methylation (DNAm) in neuronal nuclei separated by fluorescence-activated sorting from the postmortem orbitofrontal cortex (OFC) of heroin users who died from heroin overdose (N = 37), suicide completers (N = 22) with no evidence of heroin use and from con...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8060152

    authors: Kozlenkov A,Jaffe AE,Timashpolsky A,Apontes P,Rudchenko S,Barbu M,Byne W,Hurd YL,Horvath S,Dracheva S

    更新日期:2017-05-30 00:00:00

  • Analysis of the Full-Length Pyriform Spidroin Gene Sequence.

    abstract::Spiders often produce multiple types of silk, each with unique properties suiting them to certain tasks and biological functions. Orb-weaver spiders can generate more than six types of silk fibroins, with pyriform silk used to form attachment discs, adhering silk to other surfaces and substances. The unique higher-ord...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10060425

    authors: Wang K,Wen R,Jia Q,Liu X,Xiao J,Meng Q

    更新日期:2019-06-03 00:00:00

  • Convergent Evolution of the Seed Shattering Trait.

    abstract::Loss of seed shattering is a key trait in crop domestication, particularly for grain crops. For wild plants, seed shattering is a crucial mechanism to achieve greater fitness, although in the agricultural context, this mechanism reduces harvesting efficiency, especially under dry conditions. Loss of seed shattering wa...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes10010068

    authors: Di Vittori V,Gioia T,Rodriguez M,Bellucci E,Bitocchi E,Nanni L,Attene G,Rau D,Papa R

    更新日期:2019-01-19 00:00:00

  • Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies.

    abstract::Pancreatic ductal adenocarcinoma is an extremely aggressive disease with a high metastatic potential. Most patients are diagnosed with metastatic disease, at which the five-year survival rate is only 3%. A better understanding of the mechanisms that drive metastasis is imperative for the development of better therapeu...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11010006

    authors: Ayres Pereira M,Chio IIC

    更新日期:2019-12-19 00:00:00

  • Development of a DNA Barcoding-Like Approach to Detect Mustard Allergens in Wheat Flours.

    abstract::The spread of food allergens is a topic of global importance due to its impact on public health. National and International regulations ask food producers and manufacturers to declare product compositions on the label, especially in case of processed raw materials. Wheat flour (Triticum aestivum) can be contaminated b...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10030234

    authors: Frigerio J,Pellesi R,Mezzasalma V,De Mattia F,Galimberti A,Lambertini F,Suman M,Zanardi S,Leporati A,Labra M

    更新日期:2019-03-19 00:00:00

  • How Hormones and MADS-Box Transcription Factors Are Involved in Controlling Fruit Set and Parthenocarpy in Tomato.

    abstract::Fruit set is the earliest phase of fruit growth and represents the onset of ovary growth after successful fertilization. In parthenocarpy, fruit formation is less affected by environmental factors because it occurs in the absence of pollination and fertilization, making parthenocarpy a highly desired agronomic trait. ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11121441

    authors: Molesini B,Dusi V,Pennisi F,Pandolfini T

    更新日期:2020-11-30 00:00:00

  • Novel PIGT Variant in Two Brothers: Expansion of the Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 Phenotype.

    abstract::Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmo...

    journal_title:Genes

    pub_type:

    doi:10.3390/genes7120108

    authors: Skauli N,Wallace S,Chiang SC,Barøy T,Holmgren A,Stray-Pedersen A,Bryceson YT,Strømme P,Frengen E,Misceo D

    更新日期:2016-11-29 00:00:00

  • Genetics of Omega-3 Long-Chain Polyunsaturated Fatty Acid Metabolism and Meat Eating Quality in Tattykeel Australian White Lambs.

    abstract::Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11050587

    authors: Pewan SB,Otto JR,Huerlimann R,Budd AM,Mwangi FW,Edmunds RC,Holman BWB,Henry MLE,Kinobe RT,Adegboye OA,Malau-Aduli AEO

    更新日期:2020-05-25 00:00:00

  • From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting.

    abstract::Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes6030469

    authors: Boeger H,Shelansky R,Patel H,Brown CR

    更新日期:2015-06-30 00:00:00

  • Transcriptomic Analysis Reveals Involvement of the Macrophage Migration Inhibitory Factor Gene Network in Duchenne Muscular Dystrophy.

    abstract::Duchenne muscular dystrophy (DMD) is a progressive hereditary muscular disease with X-linked recessive inheritance, that leads patients to premature death. The loss of dystrophin determines membrane instability, causing cell damage and inflammatory response. Macrophage migration inhibitory factor (MIF) is a cytokine t...

    journal_title:Genes

    pub_type: 杂志文章,meta分析

    doi:10.3390/genes10110939

    authors: Lombardo SD,Mazzon E,Mangano K,Basile MS,Cavalli E,Mammana S,Fagone P,Nicoletti F,Petralia MC

    更新日期:2019-11-18 00:00:00

  • Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing-G/C Substitution Stabilizes GuideRNAs against Editing.

    abstract::Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8010034

    authors: Heep M,Mach P,Reautschnig P,Wettengel J,Stafforst T

    更新日期:2017-01-14 00:00:00

  • Genomic Characterization of a B Chromosome in Lake Malawi Cichlid Fishes.

    abstract::B chromosomes (Bs) were discovered a century ago, and since then, most studies have focused on describing their distribution and abundance using traditional cytogenetics. Only recently have attempts been made to understand their structure and evolution at the level of DNA sequence. Many questions regarding the origin,...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9120610

    authors: Clark FE,Conte MA,Kocher TD

    更新日期:2018-12-05 00:00:00

  • Off Earth Identification of Bacterial Populations Using 16S rDNA Nanopore Sequencing.

    abstract::The MinION sequencer has made in situ sequencing feasible in remote locations. Following our initial demonstration of its high performance off planet with Earth-prepared samples, we developed and tested an end-to-end, sample-to-sequencer process that could be conducted entirely aboard the International Space Station (...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11010076

    authors: Burton AS,Stahl SE,John KK,Jain M,Juul S,Turner DJ,Harrington ED,Stoddart D,Paten B,Akeson M,Castro-Wallace SL

    更新日期:2020-01-09 00:00:00

  • DNA Damage Repair System in Plants: A Worldwide Research Update.

    abstract::Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes8110299

    authors: Gimenez E,Manzano-Agugliaro F

    更新日期:2017-10-30 00:00:00

  • Pipeline for the Rapid Development of Cytogenetic Markers Using Genomic Data of Related Species.

    abstract::Repetitive DNA including tandem repeats (TRs) is a significant part of most eukaryotic genomes. TRs include rapidly evolving satellite DNA (satDNA) that can be shared by closely related species, their abundance may be associated with evolutionary divergence, and they have been widely used for chromosome karyotyping us...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10020113

    authors: Kroupin P,Kuznetsova V,Romanov D,Kocheshkova A,Karlov G,Dang TX,Khuat TML,Kirov I,Alexandrov O,Polkhovskiy A,Razumova O,Divashuk M

    更新日期:2019-02-01 00:00:00

  • Analyses of Hybrid Viability across a Hybrid Zone between Two Alnus Species Using Microsatellites and cpDNA Markers.

    abstract::Diploid Alnus glutinosa s. str. and autotetraploid A. rohlenae form a narrow hybrid zone in a study area in southern Serbia, which results in triploid hybrid formation. The vast majority of previous studies have been focused on studies of maternal plants, but the offspring resulting from their crossing have not been m...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11070770

    authors: Šmíd J,Douda J,Krak K,Mandák B

    更新日期:2020-07-09 00:00:00

  • TYK2 Variants in B-Acute Lymphoblastic Leukaemia.

    abstract::B-cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the Janus kinase (JAK) gene family. Among them, tyrosine kinase 2 (TYK2) is involved in signal transduction of cytokines such as interferon (IFN) α/β through IFN-α/β receptor alpha chain (IF...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11121434

    authors: Turrubiartes-Martínez E,Bodega-Mayor I,Delgado-Wicke P,Molina-Jiménez F,Casique-Aguirre D,González-Andrade M,Rapado I,Camós M,Díaz-de-Heredia C,Barragán E,Ramírez-Orellana M,Aguado B,Figuera Á,Martínez-López J,Fernández-Ruiz

    更新日期:2020-11-28 00:00:00

  • Venous Thromboembolism in Prader-Willi Syndrome: A Questionnaire Survey.

    abstract::Prader-Willi Syndrome Association (USA) monitors the ongoing health and welfare of individuals with Prader-Willi syndrome (PWS) through active communication with members by membership surveys and data registries. Thromboembolism and blood clots have emerged in clinical studies as significant risk factors for injury an...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10070550

    authors: Manzardo AM,Heinemann J,McManus B,Loker C,Loker J,Butler MG

    更新日期:2019-07-19 00:00:00