Abstract:
:Smoking is one of the leading preventable causes of morbidity and mortality worldwide, prompting interest in its association with DNA methylation-based measures of biological aging. Considerable progress has been made in developing DNA methylation-based measures that correspond to self-reported smoking status. In addition, assessment of DNA methylation-based aging has been expanded to better capture individual differences in risk for morbidity and mortality. Untested to date, however, is whether smoking is similarly related to older and newer indices of DNA methylation-based aging, and whether DNA methylation-based indices of smoking can be used in lieu of self-reported smoking to examine effects on DNA methylation-based aging measures. In the current investigation we examine mediation of the impact of self-reported cigarette consumption on accelerated, intrinsic DNA methylation-based aging using indices designed to predict chronological aging, phenotypic aging, and mortality risk, as well as a newly developed DNA methylation-based measure of telomere length. Using a sample of 500 African American middle aged smokers and non-smokers, we found that a) self-reported cigarette consumption was associated with accelerated intrinsic DNA methylation-based aging on some but not all DNA methylation-based aging indices, b) for those aging outcomes associated with self-reported cigarette consumption, DNA methylation-based indicators of smoking typically accounted for greater variance than did self-reported cigarette consumption, and c) self-reported cigarette consumption effects on DNA methylation-based aging indices typically were fully mediated by DNA methylation-based indicators of smoking (e.g., PACKYRS from GrimAge; or cg05575921 CpG site). Results suggest that when DNA methylation-based indices of smoking are substituted for self-reported assessments of smoking, they will typically fully reflect the varied impact of cigarette smoking on intrinsic, accelerated DNA methylation-based aging.
journal_name
Genes (Basel)journal_title
Genesauthors
Lei MK,Gibbons FX,Simons RL,Philibert RA,Beach SRHdoi
10.3390/genes11030311subject
Has Abstractpub_date
2020-03-14 00:00:00issue
3issn
2073-4425pii
genes11030311journal_volume
11pub_type
杂志文章相关文献
Genes文献大全abstract::Asian rice (Oryza sativa) and African rice (Oryza glaberrima) are separately domesticated from their wild ancestors Oryza rufipogon and Oryza barthii, which are very sensitive to daylength. In the process of domestication, some traits that are favorable for the natural survival of wild rice such as seed dormancy and s...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9100489
更新日期:2018-10-10 00:00:00
abstract::Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020098
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091072
更新日期:2020-09-12 00:00:00
abstract::MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that act as post-transcriptional gene regulators. They can inhibit target protein-coding genes, through repressing messenger RNA (mRNA) translation or promoting their degradation. miRNAs were initially found to be originated from nuclear genome an...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes5040865
更新日期:2014-09-26 00:00:00
abstract::Circadian clocks in eukaryotes involve both transcriptional-translational feedback loops, post-translational regulation, and metabolic, non-transcriptional oscillations. We recently identified the involvement of circadian oscillations in the intracellular concentrations of magnesium ions (Mg2+i) that were conserved in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020158
更新日期:2019-02-19 00:00:00
abstract::Acquisition of mobile elements by horizontal gene transfer can play a major role in bacterial adaptation and genome evolution by providing traits that contribute to bacterial fitness. However, gaining foreign DNA can also impose significant fitness costs to the host bacteria and can even produce detrimental effects. T...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11020142
更新日期:2020-01-29 00:00:00
abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100269
更新日期:2017-10-13 00:00:00
abstract::Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy caused by biallelic variants in ALPK3. Genetic investigation was perfo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101201
更新日期:2020-10-15 00:00:00
abstract::Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120369
更新日期:2017-12-05 00:00:00
abstract::Deinococcus species display a high degree of resistance to radiation and desiccation due to their ability to protect critical proteome from oxidatively generated damage; however, the underlying mechanisms are not understood. Comparative analysis of DNA repair proteins reported here has identified 22 conserved signatur...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9030149
更新日期:2018-03-08 00:00:00
abstract::(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174) and integral membrane protein 2A (ITM2A) on the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphism...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080858
更新日期:2020-07-27 00:00:00
abstract::Golgi reassembly and stacking protein (GRASP) is required for polysaccharide secretion and virulence in Cryptococcus neoformans. In fungal species, extracellular vesicles (EVs) participate in the export of polysaccharides, proteins and RNA. In the present work, we investigated if EV-mediated RNA export is functionally...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9080400
更新日期:2018-08-08 00:00:00
abstract::We employed Illumina 450 K Infinium microarrays to profile DNA methylation (DNAm) in neuronal nuclei separated by fluorescence-activated sorting from the postmortem orbitofrontal cortex (OFC) of heroin users who died from heroin overdose (N = 37), suicide completers (N = 22) with no evidence of heroin use and from con...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8060152
更新日期:2017-05-30 00:00:00
abstract::Spiders often produce multiple types of silk, each with unique properties suiting them to certain tasks and biological functions. Orb-weaver spiders can generate more than six types of silk fibroins, with pyriform silk used to form attachment discs, adhering silk to other surfaces and substances. The unique higher-ord...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060425
更新日期:2019-06-03 00:00:00
abstract::Loss of seed shattering is a key trait in crop domestication, particularly for grain crops. For wild plants, seed shattering is a crucial mechanism to achieve greater fitness, although in the agricultural context, this mechanism reduces harvesting efficiency, especially under dry conditions. Loss of seed shattering wa...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10010068
更新日期:2019-01-19 00:00:00
abstract::Pancreatic ductal adenocarcinoma is an extremely aggressive disease with a high metastatic potential. Most patients are diagnosed with metastatic disease, at which the five-year survival rate is only 3%. A better understanding of the mechanisms that drive metastasis is imperative for the development of better therapeu...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11010006
更新日期:2019-12-19 00:00:00
abstract::The spread of food allergens is a topic of global importance due to its impact on public health. National and International regulations ask food producers and manufacturers to declare product compositions on the label, especially in case of processed raw materials. Wheat flour (Triticum aestivum) can be contaminated b...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10030234
更新日期:2019-03-19 00:00:00
abstract::Fruit set is the earliest phase of fruit growth and represents the onset of ovary growth after successful fertilization. In parthenocarpy, fruit formation is less affected by environmental factors because it occurs in the absence of pollination and fertilization, making parthenocarpy a highly desired agronomic trait. ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11121441
更新日期:2020-11-30 00:00:00
abstract::Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmo...
journal_title:Genes
pub_type:
doi:10.3390/genes7120108
更新日期:2016-11-29 00:00:00
abstract::Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA play significant roles in optimal cardiovascular, retinal, maternal and...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11050587
更新日期:2020-05-25 00:00:00
abstract::Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6030469
更新日期:2015-06-30 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is a progressive hereditary muscular disease with X-linked recessive inheritance, that leads patients to premature death. The loss of dystrophin determines membrane instability, causing cell damage and inflammatory response. Macrophage migration inhibitory factor (MIF) is a cytokine t...
journal_title:Genes
pub_type: 杂志文章,meta分析
doi:10.3390/genes10110939
更新日期:2019-11-18 00:00:00
abstract::Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010034
更新日期:2017-01-14 00:00:00
abstract::B chromosomes (Bs) were discovered a century ago, and since then, most studies have focused on describing their distribution and abundance using traditional cytogenetics. Only recently have attempts been made to understand their structure and evolution at the level of DNA sequence. Many questions regarding the origin,...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9120610
更新日期:2018-12-05 00:00:00
abstract::The MinION sequencer has made in situ sequencing feasible in remote locations. Following our initial demonstration of its high performance off planet with Earth-prepared samples, we developed and tested an end-to-end, sample-to-sequencer process that could be conducted entirely aboard the International Space Station (...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010076
更新日期:2020-01-09 00:00:00
abstract::Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8110299
更新日期:2017-10-30 00:00:00
abstract::Repetitive DNA including tandem repeats (TRs) is a significant part of most eukaryotic genomes. TRs include rapidly evolving satellite DNA (satDNA) that can be shared by closely related species, their abundance may be associated with evolutionary divergence, and they have been widely used for chromosome karyotyping us...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020113
更新日期:2019-02-01 00:00:00
abstract::Diploid Alnus glutinosa s. str. and autotetraploid A. rohlenae form a narrow hybrid zone in a study area in southern Serbia, which results in triploid hybrid formation. The vast majority of previous studies have been focused on studies of maternal plants, but the offspring resulting from their crossing have not been m...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070770
更新日期:2020-07-09 00:00:00
abstract::B-cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the Janus kinase (JAK) gene family. Among them, tyrosine kinase 2 (TYK2) is involved in signal transduction of cytokines such as interferon (IFN) α/β through IFN-α/β receptor alpha chain (IF...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11121434
更新日期:2020-11-28 00:00:00
abstract::Prader-Willi Syndrome Association (USA) monitors the ongoing health and welfare of individuals with Prader-Willi syndrome (PWS) through active communication with members by membership surveys and data registries. Thromboembolism and blood clots have emerged in clinical studies as significant risk factors for injury an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10070550
更新日期:2019-07-19 00:00:00