The Genome of the Northern Sea Otter (Enhydra lutris kenyoni).

Abstract:

:The northern sea otter inhabits coastal waters of the northern Pacific Ocean and is the largest member of the Mustelidae family. DNA sequencing methods that utilize microfluidic partitioned and non-partitioned library construction were used to establish the sea otter genome. The final assembly provided 2.426 Gbp of highly contiguous assembled genomic sequences with a scaffold N50 length of over 38 Mbp. We generated transcriptome data derived from a lymphoma to aid in the determination of functional elements. The assembled genome sequence and underlying sequence data are available at the National Center for Biotechnology Information (NCBI) under the BioProject accession number PRJNA388419.

journal_name

Genes (Basel)

journal_title

Genes

authors

Jones SJ,Haulena M,Taylor GA,Chan S,Bilobram S,Warren RL,Hammond SA,Mungall KL,Choo C,Kirk H,Pandoh P,Ally A,Dhalla N,Tam AKY,Troussard A,Paulino D,Coope RJN,Mungall AJ,Moore R,Zhao Y,Birol I,Ma Y,Marra M,Jo

doi

10.3390/genes8120379

subject

Has Abstract

pub_date

2017-12-11 00:00:00

issue

12

issn

2073-4425

pii

genes8120379

journal_volume

8

pub_type

杂志文章

相关文献

Genes文献大全
  • Hair of the Dog: Identification of a Cis-Regulatory Module Predicted to Influence Canine Coat Composition.

    abstract::Each domestic dog breed is characterized by a strict set of physical and behavioral characteristics by which breed members are judged and rewarded in conformation shows. One defining feature of particular interest is the coat, which is comprised of either a double- or single-layer of hair. The top coat contains coarse...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10050323

    authors: Whitaker DT,Ostrander EA

    更新日期:2019-04-26 00:00:00

  • Genomic Insights into the Carbon and Energy Metabolism of a Thermophilic Deep-Sea Bacterium Deferribacter autotrophicus Revealed New Metabolic Traits in the Phylum Deferribacteres.

    abstract::Information on the biochemical pathways of carbon and energy metabolism in representatives of the deep lineage bacterial phylum Deferribacteres are scarce. Here, we report the results of the sequencing and analysis of the high-quality draft genome of the thermophilic chemolithoautotrophic anaerobe Deferribacter autotr...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10110849

    authors: Slobodkin A,Slobodkina G,Allioux M,Alain K,Jebbar M,Shadrin V,Kublanov I,Toshchakov S,Bonch-Osmolovskaya E

    更新日期:2019-10-26 00:00:00

  • Transitions from Single- to Multi-Locus Processes during Speciation with Gene Flow.

    abstract::During speciation-with-gene-flow, a transition from single-locus to multi-locus processes can occur, as strong coupling of multiple loci creates a barrier to gene flow. Testing predictions about such transitions with empirical data requires building upon past theoretical work and the continued development of quantitat...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9060274

    authors: Schilling MP,Mullen SP,Kronforst M,Safran RJ,Nosil P,Feder JL,Gompert Z,Flaxman SM

    更新日期:2018-05-24 00:00:00

  • Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.

    abstract::Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11050499

    authors: Moon CI,Tompkins W,Wang Y,Godec A,Zhang X,Pipkorn P,Miller CA,Dehner C,Dahiya S,Hirbe AC

    更新日期:2020-05-01 00:00:00

  • The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck.

    abstract::Despite worldwide prevention programs, the incidence for cutaneous melanoma is continuously increasing. Mucosal melanoma (MM) represents a rare but highly aggressive phenotype of common melanoma with predilection in the sinonasal system. Far away from ultraviolet sun exposure, the molecular mechanisms underlying tumor...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes8120384

    authors: Fritsche MK,Knopf A

    更新日期:2017-12-13 00:00:00

  • Heat Stress Affects H3K9me3 Level at Human Alpha Satellite DNA Repeats.

    abstract::Satellite DNAs are tandemly repeated sequences preferentially assembled into large arrays within constitutive heterochromatin and their transcription is often activated by stress conditions, particularly by heat stress. Bioinformatic analyses of sequenced genomes however reveal single repeats or short arrays of satell...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11060663

    authors: Feliciello I,Sermek A,Pezer Ž,Matulić M,Ugarković Đ

    更新日期:2020-06-18 00:00:00

  • Unravelling the Roles of Susceptibility Loci for Autoimmune Diseases in the Post-GWAS Era.

    abstract::Although genome-wide association studies (GWAS) have identified several hundred loci associated with autoimmune diseases, their mechanistic insights are still poorly understood. The human genome is more complex than single nucleotide polymorphisms (SNPs) that are interrogated by GWAS arrays. Apart from SNPs, it also c...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes9080377

    authors: Ye J,Gillespie KM,Rodriguez S

    更新日期:2018-07-27 00:00:00

  • Serendipitous In Situ Conservation of Faba Bean Landraces in Tunisia: A Case Study.

    abstract::Cultivation of faba bean (Vicia faba L.) in Tunisia is largely based on improved varieties of the crop. However, a few farmers continue to produce local cultivars or landraces. The National Gene Bank of Tunisia (NGBT) recently launched a collection project for faba bean landraces, with special focus on the regions of ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11020236

    authors: Babay E,Khamassi K,Sabetta W,Miazzi MM,Montemurro C,Pignone D,Danzi D,Finetti-Sialer MM,Mangini G

    更新日期:2020-02-24 00:00:00

  • Genome Maintenance by DNA Helicase B.

    abstract::DNA Helicase B (HELB) is a conserved helicase in higher eukaryotes with roles in the initiation of DNA replication and in the DNA damage and replication stress responses. HELB is a predominately nuclear protein in G1 phase where it is involved in initiation of DNA replication through interactions with DNA topoisomeras...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11050578

    authors: Hazeslip L,Zafar MK,Chauhan MZ,Byrd AK

    更新日期:2020-05-21 00:00:00

  • Impact of Chromatin on HIV Replication.

    abstract::Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes6040957

    authors: Agosto LM,Gagne M,Henderson AJ

    更新日期:2015-09-30 00:00:00

  • Study of mcr-1 Gene-Mediated Colistin Resistance in Enterobacteriaceae Isolated from Humans and Animals in Different Countries.

    abstract::In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8120394

    authors: Hadjadj L,Riziki T,Zhu Y,Li J,Diene SM,Rolain JM

    更新日期:2017-12-19 00:00:00

  • Evolution, Composition and Regulation of Supernumerary B Chromosomes.

    abstract::Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi [...]. ...

    journal_title:Genes

    pub_type: 社论

    doi:10.3390/genes10020161

    authors: Houben A,Jones N,Martins C,Trifonov V

    更新日期:2019-02-20 00:00:00

  • The MAPKKK CgMck1 Is Required for Cell Wall Integrity, Appressorium Development, and Pathogenicity in Colletotrichum gloeosporioides.

    abstract::Mitogen-activated protein kinase (MAPK) signaling pathway plays key roles in sensing extracellular signals and transmitting them from the cell membrane to the nucleus in response to various environmental stimuli. A MAPKKK protein CgMck1 in Colletotrichum gloeosporioides was characterized. Phenotypic analyses of the ∆C...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9110543

    authors: Fang YL,Xia LM,Wang P,Zhu LH,Ye JR,Huang L

    更新日期:2018-11-08 00:00:00

  • Alternative Splicing in the Hippo Pathway-Implications for Disease and Potential Therapeutic Targets.

    abstract::Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This revi...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes9030161

    authors: Porazinski S,Ladomery M

    更新日期:2018-03-13 00:00:00

  • Insights into Xylan Degradation and Haloalkaline Adaptation through Whole-Genome Analysis of Alkalitalea saponilacus, an Anaerobic Haloalkaliphilic Bacterium Capable of Secreting Novel Halostable Xylanase.

    abstract::The obligately anaerobic haloalkaliphilic bacterium Alkalitalea saponilacus can use xylan as the sole carbon source and produce propionate as the main fermentation product. Using mixed carbon sources of 0.4% (w/v) sucrose and 0.1% (w/v) birch xylan, xylanase production from A. saponilacus was 3.2-fold greater than tha...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes10010001

    authors: Liao Z,Holtzapple M,Yan Y,Wang H,Li J,Zhao B

    更新日期:2018-12-20 00:00:00

  • Genetic Basis of Maize Resistance to Multiple Insect Pests: Integrated Genome-Wide Comparative Mapping and Candidate Gene Prioritization.

    abstract::Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance to fall armyworm (FAW), whilst bulke...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11060689

    authors: Badji A,Kwemoi DB,Machida L,Okii D,Mwila N,Agbahoungba S,Kumi F,Ibanda A,Bararyenya A,Solemanegy M,Odong T,Wasswa P,Otim M,Asea G,Ochwo-Ssemakula M,Talwana H,Kyamanywa S,Rubaihayo P

    更新日期:2020-06-24 00:00:00

  • DNA Damage Repair System in Plants: A Worldwide Research Update.

    abstract::Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes8110299

    authors: Gimenez E,Manzano-Agugliaro F

    更新日期:2017-10-30 00:00:00

  • Evolution of NIN and NIN-like Genes in Relation to Nodule Symbiosis.

    abstract::Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11070777

    authors: Liu J,Bisseling T

    更新日期:2020-07-11 00:00:00

  • Female Choice Undermines the Emergence of Strong Sexual Isolation between Locally Adapted Populations of Atlantic Mollies (Poecilia mexicana).

    abstract::Divergent selection between ecologically dissimilar habitats promotes local adaptation, which can lead to reproductive isolation (RI). Populations in the Poecilia mexicana species complex have independently adapted to toxic hydrogen sulfide and show varying degrees of RI. Here, we examined the variation in the mate ch...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9050232

    authors: Zimmer C,Riesch R,Jourdan J,Bierbach D,Arias-Rodriguez L,Plath M

    更新日期:2018-05-02 00:00:00

  • Extracurricular Functions of tRNA Modifications in Microorganisms.

    abstract::Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11080907

    authors: Edwards AM,Addo MA,Dos Santos PC

    更新日期:2020-08-07 00:00:00

  • Factors behind junk DNA in bacteria.

    abstract::Although bacterial genomes have been traditionally viewed as being very compact, with relatively low amounts of repetitive and non-coding DNA, this view has dramatically changed in recent years. The increase of available complete bacterial genomes has revealed that many species present abundant repetitive DNA (i.e., i...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes3040634

    authors: Gil R,Latorre A

    更新日期:2012-10-12 00:00:00

  • Cryptic Diversity Hidden within the Leafminer Genus Liriomyza (Diptera: Agromyzidae).

    abstract::Leafminer insects of the genus Liriomyza are small flies whose larvae feed on the internal tissue of some of the most important crop plants for the human diet. Several of these pest species are highly uniform from the morphological point of view, meaning molecular data represents the only reliable taxonomic tool usefu...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes9110554

    authors: Carapelli A,Soltani A,Leo C,Vitale M,Amri M,Mediouni-Ben Jemâa J

    更新日期:2018-11-15 00:00:00

  • Genes and Gut Bacteria Involved in Luminal Butyrate Reduction Caused by Diet and Loperamide.

    abstract::Unbalanced dietary habits and gut dysmotility are causative factors in metabolic and functional gut disorders, including obesity, diabetes, and constipation. Reduction in luminal butyrate synthesis is known to be associated with gut dysbioses, and studies have suggested that restoring butyrate formation in the colon m...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8120350

    authors: Hwang N,Eom T,Gupta SK,Jeong SY,Jeong DY,Kim YS,Lee JH,Sadowsky MJ,Unno T

    更新日期:2017-11-28 00:00:00

  • Synthesis of Biomaterials Utilizing Microfluidic Technology.

    abstract::Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extreme...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes9060283

    authors: Wang X,Liu J,Wang P,deMello A,Feng L,Zhu X,Wen W,Kodzius R,Gong X

    更新日期:2018-06-05 00:00:00

  • DNMTs and Impact of CpG Content, Transcription Factors, Consensus Motifs, lncRNAs, and Histone Marks on DNA Methylation.

    abstract::DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the dynamic DNA methylation patterns of embryonic and adult cells. We summarize the current knowledge on the molecular mechanism of DNMTs' fun...

    journal_title:Genes

    pub_type: 杂志文章,评审

    doi:10.3390/genes11111336

    authors: Loaeza-Loaeza J,Beltran AS,Hernández-Sotelo D

    更新日期:2020-11-12 00:00:00

  • Allelic imbalances in radiation-associated acute myeloid leukemia.

    abstract::Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For ...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes2020384

    authors: Klymenko SV,Smida J,Atkinson MJ,Bebeshko VG,Nathrath M,Rosemann M

    更新日期:2011-05-31 00:00:00

  • Genetic Differentiation in Hatchery and Stocked Populations of Sea Trout in the Southern Baltic: Selection Evidence at SNP Loci.

    abstract::The impacts and interactions between hatchery-bred fish and wild fish populations has been a topic of active investigation in recent decades. In some instances, the benefits of stocking can be overshadowed by negative effects such as genetic introgression with natural populations, loss of genetic diversity, and diluti...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11020184

    authors: Bernaś R,Poćwierz-Kotus A,Árnyasi M,Kent MP,Lien S,Wenne R

    更新日期:2020-02-10 00:00:00

  • The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population.

    abstract::The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derive...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11101192

    authors: León-Reyes G,Rivera-Paredez B,López JCF,Ramírez-Salazar EG,Aquino-Gálvez A,Gallegos-Carrillo K,Denova-Gutiérrez E,Salmerón J,Velázquez-Cruz R

    更新日期:2020-10-14 00:00:00

  • Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing-G/C Substitution Stabilizes GuideRNAs against Editing.

    abstract::Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes8010034

    authors: Heep M,Mach P,Reautschnig P,Wettengel J,Stafforst T

    更新日期:2017-01-14 00:00:00

  • Genetic Subtype-Phenotype Analysis of Growth Hormone Treatment on Psychiatric Behavior in Prader-Willi Syndrome.

    abstract::Prader-Willi syndrome (PWS) is a complex multisystemic condition caused by a lack of paternal expression of imprinted genes from the 15q11.2-q13 region. Limited literature exists on the association between molecular classes, growth hormone use, and the prevalence of psychiatric phenotypes in PWS. In this study, we ana...

    journal_title:Genes

    pub_type: 杂志文章

    doi:10.3390/genes11111250

    authors: Montes AS,Osann KE,Gold JA,Tamura RN,Driscoll DJ,Butler MG,Kimonis VE

    更新日期:2020-10-23 00:00:00