Evaluation of the VISAGE Basic Tool for Appearance and Ancestry Prediction Using PowerSeq Chemistry on the MiSeq FGx System.

abstract：:Vitellogenin receptors (VgRs) play critical roles in egg formation by transporting vitellogenin (Vg) into oocytes in insects. Although the function of VgR in insects is well studied, the transcriptional regulation of this gene is still unclear. Here, we cloned the promoter of the VgR gene from Bombyx mori (BmVgR), and...

journal_title：Genes

authors： Shen G,Chen E,Ji X,Liu L,Liu J,Hua X,Li D,Xiao Y,Xia Q

更新日期：2020-04-06 00:00:00

abstract：:While methods for detecting SNVs and indels in circulating tumor DNA (ctDNA) with hybridization capture-based next-generation sequencing (NGS) have been available, copy number variations (CNVs) detection is more challenging. Here, we present a method enabling CNV detection from a 150-gene panel using a very low amount...

journal_title：Genes

authors： Peng H,Lu L,Zhou Z,Liu J,Zhang D,Nan K,Zhao X,Li F,Tian L,Dong H,Yao Y

更新日期：2019-11-14 00:00:00

abstract：BACKGROUND:Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer to sexually reproducing species is an important step. The PsASGR-BABYBOOM-l...

journal_title：Genes

authors： Zhang Z,Conner J,Guo Y,Ozias-Akins P

更新日期：2020-09-12 00:00:00

abstract：:MYO6 is known as a genetic cause of autosomal dominant and autosomal recessive inherited hearing loss. In this study, to clarify the frequency and clinical characteristics of hearing loss caused by MYO6 gene mutations, a large-scale genetic analysis of Japanese patients with hearing loss was performed. By means of mas...

journal_title：Genes

authors： Oka SI,Day TF,Nishio SY,Moteki H,Miyagawa M,Morita S,Izumi S,Ikezono T,Abe S,Nakayama J,Hyogo M,Okamoto N,Uehara N,Oshikawa C,Kitajiri SI,Usami SI

更新日期：2020-03-04 00:00:00

abstract：:Cerebral ischaemia is the most common cause of impaired brain function. Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH(4-7)PGP (Semax), has been used successfully in the treatment of patients with severe impairment...

journal_title：Genes

authors： Filippenkov IB,Stavchansky VV,Denisova AE,Yuzhakov VV,Sevan'kaeva LE,Sudarkina OY,Dmitrieva VG,Gubsky LV,Myasoedov NF,Limborska SA,Dergunova LV

更新日期：2020-06-22 00:00:00

abstract：:The plant circadian clock coordinates environmental signals with internal processes including secondary metabolism, growth, flowering, and volatile emission. Plant tissues are specialized in different functions, and petals conceal the sexual organs while attracting pollinators. Here we analyzed the transcriptional str...

journal_title：Genes

authors： Terry MI,Carrera-Alesina M,Weiss J,Egea-Cortines M

更新日期：2019-10-30 00:00:00

abstract：:Prostate-derived extracellular vesicles (pEVs) may represent a way to selectively transport cargo molecules from the producing cells to the target cells to allow biological events, both in physiological and pathological circumstances. pEVs cargo participates in the modulation of the inflammatory responses in physiolog...

journal_title：Genes

authors： Costanzi E,Romani R,Scarpelli P,Bellezza I

更新日期：2020-12-12 00:00:00

abstract：:The central goal of medical genomics is to understand the inherited basis of sequence variation that underlies human physiology, evolution, and disease. Functional association studies currently ignore millions of bases that span each centromeric region and acrocentric short arm. These regions are enriched in long arra...

journal_title：Genes

authors： Miga KH

更新日期：2019-05-08 00:00:00

abstract：:Tetralin (1,2,3,4-tetrahydonaphthalene) is a recalcitrant compound that consists of an aromatic and an alicyclic ring. It is found in crude oils, produced industrially from naphthalene or anthracene, and widely used as an organic solvent. Its toxicity is due to the alteration of biological membranes by its hydrophobic...

journal_title：Genes

authors： Floriano B,Santero E,Reyes-Ramírez F

更新日期：2019-05-06 00:00:00

abstract：:While the clinical benefit of proteasome inhibitors (PIs) for multiple myeloma (MM) treatment remains unchallenged, dose-limiting toxicities and the inevitable emergence of drug resistance limit their long-term utility. Disease eradication is compromised by drug resistance that is either present de novo or therapy-ind...

journal_title：Genes

authors： Malek E,Kim BG,Driscoll JJ

更新日期：2016-10-06 00:00:00

abstract：:DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that needs to be faithfully replicated during mitosis in order to maintain cell phenotype during successive cell divisions. This epigenetic mark is located on the 5'-carbon of the cytosine mainly within cytosine⁻phosphate⁻guanine (CpG)...

journal_title：Genes

authors： Bronner C,Alhosin M,Hamiche A,Mousli M

更新日期：2019-01-18 00:00:00

abstract：:During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...

journal_title：Genes

authors： Argyridou E,Parsch J

更新日期：2018-05-04 00:00:00

abstract：:Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyzed the right-ventricular systolic pressure (RVSP), right-ventricular hypertrophy (RVH), lung histology, and transcriptomes of six-week-old male rats with PH induced by (1) hypoxia (HO), (2) administration of monocrotalin...

journal_title：Genes

authors： Mathew R,Huang J,Iacobas S,Iacobas DA

更新日期：2020-01-23 00:00:00

abstract：:In this contribution, the aspects of reptile and amphibian speciation that emerged from research performed over the past decade are reviewed. First, this study assesses how patterns and processes of speciation depend on knowing the taxonomy of the group in question, and discuss how integrative taxonomy has contributed...

journal_title：Genes

authors： Wollenberg Valero KC,Marshall JC,Bastiaans E,Caccone A,Camargo A,Morando M,Niemiller ML,Pabijan M,Russello MA,Sinervo B,Werneck FP,Sites JW,Jr.,Wiens JJ,Steinfartz S

更新日期：2019-08-26 00:00:00

abstract：:Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...

journal_title：Genes

authors： Balaji S,Napolitano T,Silvano S,Friano ME,Garrido-Utrilla A,Atlija J,Collombat P

更新日期：2018-09-07 00:00:00

abstract：:Coat color dilution corresponds to a specific pigmentation phenotype that leads to a dilution of wild type pigments. It affects both eumelanin and pheomelanin containing melanosomes. The mode of inheritance of the dilution phenotype is autosomal recessive. Candidate gene approaches focused on the melanophilin (MLPH) g...

journal_title：Genes

authors： Demars J,Iannuccelli N,Utzeri VJ,Auvinet G,Riquet J,Fontanesi L,Allain D

更新日期：2018-08-23 00:00:00

abstract：:A large number of studies have focused on identifying molecular biomarkers, including microRNAs (miRNAs) to aid in the diagnosis and prognosis of the most common subtypes of non-Hodgkin lymphoma (NHL), Diffuse Large B-cell Lymphoma and Follicular Lymphoma. NHL is difficult to diagnose and treat with many cases becomin...

journal_title：Genes

authors： Bradshaw G,Sutherland HG,Haupt LM,Griffiths LR

更新日期：2016-12-17 00:00:00

abstract：:Hexokinase (HK) is a key enzyme in chitin biosynthesis in insects and plays an important role in development and energy regulation. It also performs a crucial role in the synthesis of Glucose-6-phosphate and its putative functions are studied via injection of dsRNA corresponding to the hexokinase gene from Cnaphalocro...

journal_title：Genes

authors： Shakeel M,Du J,Li SW,Zhou YJ,Sarwar N,Bukhari SAH

更新日期：2020-10-26 00:00:00

abstract：:Blumeria graminis f. sp. hordei (Bgh), the causal agent of barley powdery mildew (PM), is one of the most important barley leaf diseases and is prevalent in most barley growing regions. Infection decreases grain quality and yields on average by 30%. Multi-parent advanced generation inter-cross (MAGIC) populations comb...

journal_title：Genes

authors： Novakazi F,Krusell L,Jensen JD,Orabi J,Jahoor A,Bengtsson T,On Behalf Of The Ppp Barley Consortium

更新日期：2020-12-18 00:00:00

abstract：:Segments of the genome enriched in repetitive sequences still present a challenge and are omitted in genome assemblies. For that reason, the exact composition of DNA sequences underlying the heterochromatic regions and the active centromeres are still unexplored for many organisms. The centromere is a crucial region o...

journal_title：Genes

authors： Tunjić Cvitanić M,Vojvoda Zeljko T,Pasantes JJ,García-Souto D,Gržan T,Despot-Slade E,Plohl M,Šatović E

更新日期：2020-06-24 00:00:00

abstract：:Hemp is a Pb-tolerant and Pb-accumulating plant and the study of its tolerance mechanisms could facilitate the breeding of hemp with enhanced Pb tolerance and accumulation. In the present study, we took advantage of sequential window acquisition of all theoretical mass spectra (SWATH) technology to study the differenc...

journal_title：Genes

authors： Xia C,Hong L,Yang Y,Yanping X,Xing H,Gang D

更新日期：2019-05-22 00:00:00

abstract：:Yersinia enterocolitica is the causative agent of yersiniosis, a zoonotic disease of growing epidemiological importance with significant consequences for public health. This pathogenic species has been intensively studied for many years. Six biotypes (1A, 1B, 2, 3, 4, 5) and more than 70 serotypes of Y. enterocolitica...

journal_title：Genes

authors： Bancerz-Kisiel A,Pieczywek M,Łada P,Szweda W

更新日期：2018-05-03 00:00:00

abstract：:Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant...

journal_title：Genes

authors： Pixberg CF,Schulz WA,Stoecklein NH,Neves RP

更新日期：2015-10-21 00:00:00

abstract：:The dog population of Southern East Asia is unique in harboring virtually the full range of the universal mtDNA gene pool, and consequently, it has the highest genetic diversity worldwide. Despite this, limited research has been performed on dog genetics within this region. Here we present the first comprehensive stud...

journal_title：Genes

authors： Zhang L,Liu Y,Thai Ke Q,Ardalan A,Boonyaprakob U,Savolainen P

更新日期：2020-02-27 00:00:00

abstract：:The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a maj...

journal_title：Genes

authors： Nagpal S,Gibson G,Marigorta UM

更新日期：2018-08-14 00:00:00

abstract：:We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...

journal_title：Genes

authors： Zafar S,Shahzad M,Ishaq R,Yousaf A,Shaikh RS,Akram J,Ahmed ZM,Riazuddin S

更新日期：2020-08-22 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:Smoking is one of the leading preventable causes of morbidity and mortality worldwide, prompting interest in its association with DNA methylation-based measures of biological aging. Considerable progress has been made in developing DNA methylation-based measures that correspond to self-reported smoking status. In addi...

journal_title：Genes

authors： Lei MK,Gibbons FX,Simons RL,Philibert RA,Beach SRH

更新日期：2020-03-14 00:00:00

abstract：:Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...

journal_title：Genes

authors： Zhang L,Feng S,Duan G,Li Y,Liu G

更新日期：2019-10-17 00:00:00

abstract：:Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...

journal_title：Genes

authors： Li S,Zhou H,Gong H,Zhao F,Wang J,Liu X,Luo Y,Hickford JG

更新日期：2017-01-11 00:00:00