Abstract:
:While the clinical benefit of proteasome inhibitors (PIs) for multiple myeloma (MM) treatment remains unchallenged, dose-limiting toxicities and the inevitable emergence of drug resistance limit their long-term utility. Disease eradication is compromised by drug resistance that is either present de novo or therapy-induced, which accounts for the majority of tumor relapses and MM-related deaths. Non-coding RNAs (ncRNAs) are a broad class of RNA molecules, including long non-coding RNAs (lncRNAs), that do not encode proteins but play a major role in regulating the fundamental cellular processes that control cancer initiation, metastasis, and therapeutic resistance. While lncRNAs have recently attracted significant attention as therapeutic targets to potentially improve cancer treatment, identification of lncRNAs that are deregulated in cells resistant to PIs has not been previously addressed. We have modeled drug resistance by generating three MM cell lines with acquired resistance to either bortezomib, carfilzomib, or ixazomib. Genome-wide profiling identified lncRNAs that were significantly deregulated in all three PIresistant cell lines relative to the drug-sensitive parental cell line. Strikingly, certain lncRNAs deregulated in the three PI-resistant cell lines were also deregulated in MM plasma cells isolated from newly diagnosed patients compared to healthy plasma cells. Taken together, these preliminary studies strongly suggest that lncRNAs represent potential therapeutic targets to prevent or overcome drug resistance. More investigations are ongoing to expand these initial studies in a greater number of MM patients to better define lncRNAs signatures that contribute to PI resistance in MM.
journal_name
Genes (Basel)journal_title
Genesauthors
Malek E,Kim BG,Driscoll JJdoi
10.3390/genes7100084subject
Has Abstractpub_date
2016-10-06 00:00:00issue
10issn
2073-4425pii
genes7100084journal_volume
7pub_type
杂志文章相关文献
Genes文献大全abstract::Lysosomal storage disorders (LSDs) represent a group of more than 50 severe metabolic diseases caused by the deficiency of specific lysosomal hydrolases, activators, carriers, or lysosomal integral membrane proteins, leading to the abnormal accumulation of substrates within the lysosomes. Numerous mutations have been ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9020073
更新日期:2018-02-06 00:00:00
abstract::Amazonian puffing snakes (Spilotes; Colubridae) are snakes widely distributed in the Neotropical region. However, chromosomal data are scarce in this group and, when available, are only limited to karyotype description using conventional staining. In this paper, we focused on the process of karyotype evolution and tre...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10040288
更新日期:2019-04-09 00:00:00
abstract::This review looks back at five decades of research into genetic susceptibility to colorectal cancer (CRC) and the insights these studies have provided. Initial evidence of a genetic basis of CRC stems from epidemiological studies in the 1950s and is further provided by the existence of multiple dominant predisposition...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes5020270
更新日期:2014-03-27 00:00:00
abstract::Fusarium head blight (FHB), caused primarily by the fungus Fusarium graminearum, is one of the most damaging diseases of wheat, causing significant loss of yield and quality worldwide. Warm and wet conditions during flowering, a lack of resistant wheat varieties, and high inoculum pressure from corn stubble contribute...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060699
更新日期:2020-06-25 00:00:00
abstract::Advances in sequencing technologies have enabled the exploration of the genetic basis for several clinical disorders by allowing identification of causal mutations in rare genetic diseases. Sequencing technology has also facilitated genome-wide association studies to gather single nucleotide polymorphisms in common di...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10020076
更新日期:2019-01-23 00:00:00
abstract::Pleurotus tuoliensis (Pt) and P. eryngii var. eryngii (Pe) are important edible mushrooms. The epigenetic and gene expression signatures characterizing major developmental transitions in these two mushrooms remain largely unknown. Here, we report global analyses of DNA methylation and gene expression in both mushrooms...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060465
更新日期:2019-06-17 00:00:00
abstract::GOLDEN2-LIKE (GLK) is a member of the myeloblastosis (MYB) family transcription factor and it plays an important role in the regulation of plastid development and stress tolerance. In this study, a gene named AhGLK1b was identified from a cultivated peanut showing down-regulation in response to low calcium with a comp...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030343
更新日期:2020-03-24 00:00:00
abstract::The MinION sequencer has made in situ sequencing feasible in remote locations. Following our initial demonstration of its high performance off planet with Earth-prepared samples, we developed and tested an end-to-end, sample-to-sequencer process that could be conducted entirely aboard the International Space Station (...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010076
更新日期:2020-01-09 00:00:00
abstract::The Zn(II)₂Cys₆ zinc cluster gene family is a subclass of zinc-finger proteins, which are transcriptional regulators involved in a wide variety of biological processes in fungi. We performed genome-wide identification and characterization of Zn(II)₂Cys₆ zinc-cluster gene (C6 zinc gene) family in Tolypocladiumguangdong...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10030179
更新日期:2019-02-26 00:00:00
abstract:BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10110936
更新日期:2019-11-16 00:00:00
abstract::Despite recent genetic advances and numerous ongoing therapeutic trials, malignant melanoma remains fatal, and prognostic factors as well as more efficient treatments are needed. The development of such research strongly depends on the availability of appropriate models recapitulating all the features of human melanom...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10070501
更新日期:2019-06-30 00:00:00
abstract::The impacts and interactions between hatchery-bred fish and wild fish populations has been a topic of active investigation in recent decades. In some instances, the benefits of stocking can be overshadowed by negative effects such as genetic introgression with natural populations, loss of genetic diversity, and diluti...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020184
更新日期:2020-02-10 00:00:00
abstract::In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process. In rat, two splicing events produce several isoforms of ADAR2, called ADAR2a, ADAR2b, ADAR2e, and ADAR2f, but only ADAR2a and AD...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9020079
更新日期:2018-02-08 00:00:00
abstract::Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9020115
更新日期:2018-02-21 00:00:00
abstract::Quorum sensing (QS) is a cell-to-cell communication system that uses autoinducers as signaling molecules to enable inter-species and intra-species interactions in response to external stimuli according to the population density. QS allows bacteria such as Acinetobacter baumannii to react rapidly in response to environ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10040282
更新日期:2019-04-08 00:00:00
abstract::In genome analysis, k-mer-based comparison methods have become standard tools. However, even though they are able to deliver reliable results, other algorithms seem to work better in some cases. To improve k-mer-based DNA sequence analysis and comparison, we successfully checked whether adding positional resolution is...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8040122
更新日期:2017-04-19 00:00:00
abstract::Transcriptional reprograming after the exposure of plants to elevated temperatures is a hallmark of stress response which is required for the manifestation of thermotolerance. Central transcription factors regulate the stress survival and recovery mechanisms and many of the core responses controlled by these factors a...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060655
更新日期:2020-06-16 00:00:00
abstract::The genus Lactobacillus includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, although some species may become pathogenic and exert negative effects on h...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101234
更新日期:2020-10-21 00:00:00
abstract::Yersinia enterocolitica is the causative agent of yersiniosis, a zoonotic disease of growing epidemiological importance with significant consequences for public health. This pathogenic species has been intensively studied for many years. Six biotypes (1A, 1B, 2, 3, 4, 5) and more than 70 serotypes of Y. enterocolitica...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9050235
更新日期:2018-05-03 00:00:00
abstract::Repetitive DNA including tandem repeats (TRs) is a significant part of most eukaryotic genomes. TRs include rapidly evolving satellite DNA (satDNA) that can be shared by closely related species, their abundance may be associated with evolutionary divergence, and they have been widely used for chromosome karyotyping us...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020113
更新日期:2019-02-01 00:00:00
abstract::The spectrum of modern horse populations encompasses populations with a long history of development in isolation and relatively recently formed types. To increase our understanding of the evolutionary history and provide information on how to optimally conserve or improve these populations with varying development and...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060480
更新日期:2019-06-25 00:00:00
abstract::Grouper is one of the favorite sea food resources in Southeast Asia. However, the outbreaks of the viral nervous necrosis (VNN) disease due to nervous necrosis virus (NNV) infection have caused mass mortality of grouper larvae. Many aqua-farms have suffered substantial financial loss due to the occurrence of VNN. To b...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010031
更新日期:2017-01-13 00:00:00
abstract::The pseudostratified olfactory epithelium (OE) may histologically appear relatively simple, but the cytological relations among its cell types, especially those between olfactory receptor neurons (ORNs) and olfactory sustentacular cells (OSCs), prove more complex and variable than previously believed. Adding to the co...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11050493
更新日期:2020-04-30 00:00:00
abstract::The spread of food allergens is a topic of global importance due to its impact on public health. National and International regulations ask food producers and manufacturers to declare product compositions on the label, especially in case of processed raw materials. Wheat flour (Triticum aestivum) can be contaminated b...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10030234
更新日期:2019-03-19 00:00:00
abstract::Bacterial fruit blotch (BFB) causes losses in melon marketable yield. However, until now, there has been no information about the genetic loci responsible for resistance to the disease or their pattern of inheritance. We determined the inheritance pattern of BFB resistance from a segregating population of 491 F2 indiv...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020220
更新日期:2020-02-19 00:00:00
abstract::Biogerontological research highlighted a complex and dynamic connection between aging, health and longevity, partially determined by genetic factors. Multifunctional proteins with moonlighting features, by integrating different cellular activities in the space and time, may explain part of this complexity. Inositol Po...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020125
更新日期:2019-02-08 00:00:00
abstract::In the frog genus Pseudis, previous works found a sex-linked heteromorphism of the PcP190 satellite DNA in the nucleolus organizer region (NOR)-bearing chromosome pairs of Pseudis bolbodactyla and Pseudis tocantins, which possess a ZZ/ZW sex determination system. A pericentromeric inversion was inferred to have occurr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020160
更新日期:2019-02-19 00:00:00
abstract::RNA-binding proteins (RBPs) are important regulators of cellular functions, playing critical roles on the survival of bacteria and in the case of pathogens, on their interaction with the host. RBPs are involved in transcriptional, post-transcriptional, and translational processes. However, except for model organisms l...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020231
更新日期:2020-02-21 00:00:00
abstract::In this study, we aim to characterize the genetic environment of the plasmid-mediated colistin resistance gene mcr-1 in 25 Escherichia coli and seven Klebsiella pneumoniae strains from different countries and continents. Multilocus sequence typing, conjugation experiments, plasmid typing, and the presence and location...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120394
更新日期:2017-12-19 00:00:00
abstract::The conserved Notch pathway is reported to be involved in progesterone synthesis and secretion; however, the exact effects remain controversial. To determine the role and potential mechanisms of the Notch signaling pathway in progesterone biosynthesis in porcine granulosa cells (pGCs), we first used a pharmacological ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11020120
更新日期:2020-01-22 00:00:00