Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes.

abstract：:Smoking is one of the leading preventable causes of morbidity and mortality worldwide, prompting interest in its association with DNA methylation-based measures of biological aging. Considerable progress has been made in developing DNA methylation-based measures that correspond to self-reported smoking status. In addi...

journal_title：Genes

authors： Lei MK,Gibbons FX,Simons RL,Philibert RA,Beach SRH

更新日期：2020-03-14 00:00:00

abstract：:Spiders often produce multiple types of silk, each with unique properties suiting them to certain tasks and biological functions. Orb-weaver spiders can generate more than six types of silk fibroins, with pyriform silk used to form attachment discs, adhering silk to other surfaces and substances. The unique higher-ord...

journal_title：Genes

authors： Wang K,Wen R,Jia Q,Liu X,Xiao J,Meng Q

更新日期：2019-06-03 00:00:00

abstract：:Illumina and nanopore sequencing technologies are powerful tools that can be used to determine the bacterial composition of complex microbial communities. In this study, we compared nasal microbiota results at genus level using both Illumina and nanopore 16S rRNA gene sequencing. We also monitored the progression of n...

journal_title：Genes

authors： Heikema AP,Horst-Kreft D,Boers SA,Jansen R,Hiltemann SD,de Koning W,Kraaij R,de Ridder MAJ,van Houten CB,Bont LJ,Stubbs AP,Hays JP

更新日期：2020-09-21 00:00:00

abstract：:Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...

journal_title：Genes

authors： Boeger H,Shelansky R,Patel H,Brown CR

更新日期：2015-06-30 00:00:00

abstract：:The multiple organellar RNA editing factors (MORF) gene family plays a key role in organelle RNA editing in flowering plants. MORF genes expressions are also affected by abiotic stress. Although seven OsMORF genes have been identified in rice, few reports have been published on their expression patterns in different t...

journal_title：Genes

authors： Zhang Q,Shen L,Ren D,Hu J,Chen G,Zhu L,Gao Z,Zhang G,Guo L,Zeng D,Qian Q

更新日期：2019-09-10 00:00:00

abstract：:Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This revi...

journal_title：Genes

authors： Porazinski S,Ladomery M

更新日期：2018-03-13 00:00:00

abstract：:Vavilovia formosa is a relict leguminous plant growing in hard-to-reach habitats in the rocky highlands of the Caucasus and Middle East, and it is considered as the putative closest living relative of the last common ancestor (LCA) of the Fabeae tribe. Symbionts of Vavilovia belonging to Rhizobium leguminosarum bv. vi...

journal_title：Genes

authors： Chirak ER,Kimeklis AK,Karasev ES,Kopat VV,Safronova VI,Belimov AA,Aksenova TS,Kabilov MR,Provorov NA,Andronov EE

更新日期：2019-12-01 00:00:00

abstract：:The mutation parameter θ is fundamental and ubiquitous in the analysis of population samples of DNA sequences. This paper presents a new highly efficient estimator of θ by utilizing the phylogenetic information among distinct alleles in a sample of DNA sequences. The new estimator, called Allelic BLUE, is derived from...

journal_title：Genes

authors： Fu Y

更新日期：2014-07-22 00:00:00

abstract：:In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This study aimed to identity candidate genes related to growth of duck skele...

journal_title：Genes

authors： Hu Z,Cao J,Liu G,Zhang H,Liu X

更新日期：2020-10-20 00:00:00

abstract：:Gruiformes is a group with phylogenetic issues. Recent studies based on mitochondrial and genomic DNA have proposed the existence of a core Gruiformes, consisting of five families: Heliornithidae, Aramidae, Gruidae, Psophiidae and Rallidae. Karyotype studies on these species are still scarce, either by conventional st...

journal_title：Genes

authors： Furo IO,Kretschmer R,O'Brien PCM,Pereira JC,Ferguson-Smith MA,de Oliveira EHC

更新日期：2020-03-13 00:00:00

abstract：:Dwarfism is a condition defined by low harvest weight in fish, but also results in strange body figures which may have potential for the selective breeding of new ornamental fish strains. The objectives of this study are to reveal the physiological causes of dwarfism and identify the genetic loci controlling this trai...

journal_title：Genes

authors： Shao F,Liu J,Ren M,Li J,Bao H,Wu C

更新日期：2019-05-30 00:00:00

abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...

journal_title：Genes

authors： Rick K,Ottewell K,Lohr C,Thavornkanlapachai R,Byrne M,Kennington WJ

更新日期：2019-10-28 00:00:00

abstract：:Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease. About 2900 variants of LDLR, APOB, and PCSK9 genes potentially associated with FH have been described earlier. Nev...

journal_title：Genes

authors： Meshkov A,Ershova A,Kiseleva A,Zotova E,Sotnikova E,Petukhova A,Zharikova A,Malyshev P,Rozhkova T,Blokhina A,Limonova A,Ramensky V,Divashuk M,Khasanova Z,Bukaeva A,Kurilova O,Skirko O,Pokrovskaya M,Mikova V,Snigir E

更新日期：2021-01-06 00:00:00

abstract：:Quorum sensing (QS) is a cell-to-cell communication system that uses autoinducers as signaling molecules to enable inter-species and intra-species interactions in response to external stimuli according to the population density. QS allows bacteria such as Acinetobacter baumannii to react rapidly in response to environ...

journal_title：Genes

authors： Ng CK,How KY,Tee KK,Chan KG

更新日期：2019-04-08 00:00:00

abstract：BACKGROUND:Atopic dermatitis is a common inflammatory skin disorder that affects up to 15-20% of the population and is characterized by recurrent eczematous lesions with intense itching. As a heterogeneous disease, multiple factors have been suggested to explain the nature of atopic dermatitis (AD), and its high preval...

journal_title：Genes

authors： Martin MJ,Estravís M,García-Sánchez A,Dávila I,Isidoro-García M,Sanz C

更新日期：2020-04-18 00:00:00

abstract：:The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA subunit is present in two major splicing isoforms, NF-YAl ("long") and NF-YAs ("short"). Little is known about the expression levels of NF-Y subunits in tumors, and nothing in lung cancer. By interrogating RNA-seq TCGA and GEO datasets,...

journal_title：Genes

authors： Bezzecchi E,Ronzio M,Dolfini D,Mantovani R

更新日期：2019-11-17 00:00:00

abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

journal_title：Genes

authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

更新日期：2020-04-27 00:00:00

abstract：:(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174) and integral membrane protein 2A (ITM2A) on the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphism...

journal_title：Genes

authors： Cho WK,Shin HR,Lee NY,Kim SK,Ahn MB,Baek IC,Kim TG,Suh BK

更新日期：2020-07-27 00:00:00

abstract：:Epigenetic alterations at imprinted genes on different chromosomes have been linked to several imprinting disorders (IDs) such as Beckwith-Wiedemann syndrome (BWS) and pseudohypoparathyroidism type 1b (PHP1b). Here, we present a male patient with these two distinct IDs caused by two independent mechanisms-loss of meth...

journal_title：Genes

authors： Choufani S,Ko JM,Lou Y,Shuman C,Fishman L,Weksberg R

更新日期：2021-01-27 00:00:00

abstract：:The revolution in next-generation DNA sequencing technologies is leading to explosive data growth in genomics, posing a significant challenge to the computing infrastructure and software algorithms for genomics analysis. Various big data technologies have been explored to scale up/out current bioinformatics solutions ...

journal_title：Genes

authors： Shi L,Wang Z

更新日期：2019-12-06 00:00:00

abstract：:Adverse environmental exposures in pregnancy can significantly alter the development of the fetus resulting in impaired child neurodevelopment. Such exposures can lead to epigenetic alterations like DNA methylation, which may be a marker of poor cognitive, motor and behavioral outcomes in the infant. Here we review st...

journal_title：Genes

authors： Hodyl NA,Roberts CT,Bianco-Miotto T

更新日期：2016-12-03 00:00:00

abstract：:Network medicine relies on different types of networks: from the molecular level of protein⁻protein interactions to gene regulatory network and correlation studies of gene expression. Among network approaches based on the analysis of the topological properties of protein⁻protein interaction (PPI) networks, we discuss ...

journal_title：Genes

authors： Fiscon G,Conte F,Farina L,Paci P

更新日期：2018-08-31 00:00:00

abstract：:Perennial agriculture has been proposed as an option to improve the sustainability of cropping systems, by increasing the efficiency of resource use, while also providing ecosystem services. Neo-domestication, the contemporary domestication of plants that have not previously been used in agriculture, can be used to ge...

journal_title：Genes

authors： Kantar MB,Hüber S,Herman A,Bock DG,Baute G,Betts K,Ott M,Brandvain Y,Wyse D,Stupar RM,Rieseberg LH

更新日期：2018-08-21 00:00:00

abstract：:Balanced chromosome rearrangements are one of the main etiological factors contributing to hypoprolificacy in the domestic pig. Amongst domestic animals, the pig is considered to have the highest prevalence of chromosome rearrangements. To date over 200 unique chromosome rearrangements have been identified. The factor...

journal_title：Genes

authors： Donaldson B,Villagomez DAF,Revay T,Rezaei S,King WA

更新日期：2019-09-30 00:00:00

abstract：:Despite recent genetic advances and numerous ongoing therapeutic trials, malignant melanoma remains fatal, and prognostic factors as well as more efficient treatments are needed. The development of such research strongly depends on the availability of appropriate models recapitulating all the features of human melanom...

journal_title：Genes

authors： Prouteau A,André C

更新日期：2019-06-30 00:00:00

abstract：:The efficient extraction of DNA from challenging samples, such as bones, is critical for the success of downstream genotyping analysis in molecular genetic disciplines. Even though the ancient DNA community has developed several protocols targeting small DNA fragments that are typically present in decomposed or old sp...

journal_title：Genes

authors： Xavier C,Eduardoff M,Bertoglio B,Amory C,Berger C,Casas-Vargas A,Pallua J,Parson W

更新日期：2021-01-22 00:00:00

abstract：:The contribution of chromatin dynamics to the regulation of human disease-associated loci such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the focus of intensive experimentation for many years. Recent technological advances in the analysis of transcriptional mechanisms across the en...

journal_title：Genes

authors： Gosalia N,Harris A

更新日期：2015-07-13 00:00:00

abstract：:Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...

journal_title：Genes

authors： Zhu X,Li HD,Xu Y,Guo L,Wu FX,Duan G,Wang J

更新日期：2019-01-29 00:00:00

abstract：:Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...

journal_title：Genes

authors： Li S,Zhou H,Gong H,Zhao F,Wang J,Liu X,Luo Y,Hickford JG

更新日期：2017-01-11 00:00:00

abstract：:Marek's Disease is a lymphoproliferative disease of chickens caused by Marek's Disease Virus. Similar to other herpesviruses, Marek's Disease Virus (MDV) encodes its own small non-coding regulatory RNAs termed microRNAs (miRNAs). We previously found that the expression profile of these viral miRNAs is affected by vacc...

journal_title：Genes

authors： Hicks JA,Liu HC

更新日期：2019-02-05 00:00:00