Abstract：
BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a neurodegenerative disorder characterized by deposition of intraneural inclusion bodies in the brain as well as the enteric nervous system. Emerging concepts regarding the brain-gut axis have been proposed for neurological disorders. Thus, the present study investigated the associations between colectomy and developing PD. METHODS:We conducted a retrospective cohort study using National Health Insurance Service-National Sample Cohort of Korea. This study included patients who underwent colectomy during 2003-2009, and up to 10 individuals per patient, matched in terms of age and sex, who did not undergo colectomy. The colectomy group was subdivided by the causes and surgical methods of colectomy. The risk of PD occurrence was evaluated over a follow-up period of at least 6 years using Cox regression analyses. RESULTS:Colectomy was associated with a higher risk of developing PD (adjusted hazard ratio [HR]: 1.962; 95% confidence interval [CI] 1.002-3.840). There was no significant difference in the occurrence of PD among the subgroups classified by the causes or surgical methods of colectomy. CONCLUSIONS:Colectomy was associated with the development of PD, suggesting that colon issues play an important role in the pathophysiological mechanisms of PD.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Kim YJ,Lee CM,Kim S,Jang JW,Lee SY,Lee SHdoi
10.1007/s00415-019-09617-1subject
Has Abstractpub_date
2020-02-01 00:00:00pages
513-521issue
2eissn
0340-5354issn
1432-1459pii
10.1007/s00415-019-09617-1journal_volume
267pub_type
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