Gait variability in Parkinson's disease: an indicator of non-dopaminergic contributors to gait dysfunction?

Abstract:

:Gait variability has potential utility as a predictive measure of dysfunction in Parkinson's disease (PD). Current understanding implicates non-dopaminergic pathways. This study investigated the explanatory characteristics of gait variability in PD on and off medication under single and dual task conditions. Fifty people with PD were assessed twice at home (on and off L: -dopa) whilst walking under single and dual task conditions, and variability (coefficient of variation, CV) was calculated for stride time and double limb support (DLS) time. Hierarchical regression analysis was used to identify predictors. The first block of variables included age, gait speed, depression (Hospital Anxiety and Depression Scale) and fatigue (Multidimensional Fatigue Inventory), and the second block included motor severity (UPDRS III), executive function (Hayling and Brixton) and attention (Test of Everyday Attention). Motor severity predicted stride time variability and DLS time variability independent of L: -dopa during single task gait. Dual task gait yielded a more complex picture. Depression made a unique contribution of 9.0% on medication and 5.0% off medication to stride time variability, and visual attention and younger age contributed to DLS variability on medication, explaining 3% and 2%, respectively. Motor severity predicted DLS variability off medication, explaining 74% of variance. Different characteristics explain the two measures of gait variability, pointing to different control mechanisms.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Lord S,Baker K,Nieuwboer A,Burn D,Rochester L

doi

10.1007/s00415-010-5789-8

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

566-72

issue

4

eissn

0340-5354

issn

1432-1459

journal_volume

258

pub_type

杂志文章
  • [Intracranial and spinal hemorrhage in haemophilia (author's transl)].

    abstract::Among 234 hemophiliacs, 14 patients (5.9%) with intracranial and 1 patient (0.4%) with intramedullary hemorrhage were observed and examined. The average age at the time of hemorrhage was 17 years in patients with severe hemophilia and 43 years in patients with moderate hemophilia. The patients with mild hemophilia and...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313358

    authors: Mamoli B,Sonneck G,Lechner K

    更新日期:1976-01-14 00:00:00

  • Two siblings with multiple intracranial haemangiomatosis with calcification.

    abstract::Two siblings with multiple intracranial haemangiomatosis are reported, each having psychomotor retardation, epilepsy and gyriform type calcification in the occipital and frontal lobes. There were haemangiomas in one autopsy case with calcification in the deep layers of the cortex and subcortical white matter. ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313911

    authors: Tateno A,Matsui A,Sakuragawa N,Nonaka I,Arima M

    更新日期:1985-01-01 00:00:00

  • Lateralized microstructural changes in early-stage Parkinson's disease in anterior olfactory structures, but not in substantia nigra.

    abstract::Parkinson's disease (PD) is a progressive neurological disorder characterized by motor symptoms as well as severe deficits in olfactory function and microstructural changes in olfactory brain regions. Because of the evidence of asymmetric neuropathological features in early-stage PD, we examined whether lateralized mi...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-017-8555-3

    authors: Joshi N,Rolheiser TM,Fisk JD,McKelvey JR,Schoffer K,Phillips G,Armstrong M,Khan MN,Leslie RA,Rusak B,Robertson HA,Good KP

    更新日期:2017-07-01 00:00:00

  • Vertebral artery stenosis in the Basilar Artery International Cooperation Study (BASICS): prevalence and outcome.

    abstract::We assessed the prevalence of vertebral artery (VA) stenosis or occlusion and its influence on outcome in patients with acute basilar artery occlusion (BAO). We studied 141 patients with acute BAO enrolled in the Basilar Artery International Cooperation Study (BASICS) registry of whom baseline CT angiography (CTA) of ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7583-5

    authors: Compter A,van der Hoeven EJ,van der Worp HB,Vos JA,Weimar C,Rueckert CM,Kappelle LJ,Algra A,Schonewille WJ,BASICS Study Group.

    更新日期:2015-02-01 00:00:00

  • Plasma levels of nitric oxide and stroke outcome.

    abstract::Production of reactive oxygen species after cerebral blood flow disruption may enhance tissue damage through multiple molecular pathways. Changes in nitric oxide (NO) metabolism and oxidative stress status were investigated in 47 patients with ischemic stroke by measuring plasma nitric oxide (NO) and peroxynitrite (ON...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-007-0700-y

    authors: Taffi R,Nanetti L,Mazzanti L,Bartolini M,Vignini A,Raffaelli F,Pasqualetti P,Vernieri F,Provinciali L,Silvestrini M

    更新日期:2008-01-01 00:00:00

  • Hematopoietic stem cell transplantation for chronic inflammatory demyelinating polyradiculoneuropathy.

    abstract:OBJECTIVE:Determine toxicity and efficacy of autologous hematopoietic stem cell transplantation (HSCT) for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who are dependent on intravenous immunoglobulins or plasmapheresis. METHODS:Unselected peripheral blood stem cells were re-infused on...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10010-6

    authors: Burt RK,Balabanov R,Tavee J,Han X,Sufit R,Ajroud-Driss S,Jovanovic B,Quigley K,Arnautovic I,Helenowski I,Sharrack B

    更新日期:2020-11-01 00:00:00

  • Thalamic aphasia. A conceptional critique.

    abstract::Four patients with aphasia due to small circumscribed thalamic lesions are presented. A review of the literature on thalamic aphasia revealed 16 similar cases. While the general consensus that only left-sided thalmic lesions are associated with aphasia is confirmed, analysis of the sites of the thalamic infarctions an...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00314212

    authors: Bruyn RP

    更新日期:1989-01-01 00:00:00

  • Chronic borrelia encephalomyeloradiculitis with severe mental disturbance: immunosuppressive versus antibiotic therapy.

    abstract::A 57-year-old male was repeatedly admitted to hospital because of complex neurological symptoms, including radicular pain, disturbance of micturition, seizures, and severely impaired mental state. The diagnosis was encephalomyeloradiculitis possibly of viral origin, and treatment with immunosuppressants was initiated....

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314303

    authors: Kollikowski HH,Schwendemann G,Schulz M,Wilhelm H,Lehmann HJ

    更新日期:1988-01-01 00:00:00

  • The "hype" of hydrops in classifying vestibular disorders: a narrative review.

    abstract:BACKGROUND:Classifying and diagnosing peripheral vestibular disorders based on their symptoms is challenging due to possible symptom overlap or atypical clinical presentation. To improve the diagnostic trajectory, gadolinium-based contrast-enhanced magnetic resonance imaging of the inner ear is nowadays frequently used...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-020-10278-8

    authors: van der Lubbe MFJA,Vaidyanathan A,Van Rompaey V,Postma AA,Bruintjes TD,Kimenai DM,Lambin P,van Hoof M,van de Berg R

    更新日期:2020-12-01 00:00:00

  • Acute convexity subarachnoid hemorrhage (cSAH) in infectious endocarditis (IE): imaging features and follow-up.

    abstract:AIM:To assess: (1) the prevalence of convexity subarachnoid hemorrhage (cSAH) in infective endocarditis (IE); (2) its relationship with IE features; (3) the associated lesions; (4) whether cSAH is a predictor of future hemorrhage; (5) whether cSAH could cause cortical superficial siderosis (cSS). METHODS:We retrospect...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-09953-7

    authors: Boukobza M,Ilic-Habensus E,Duval X,Laissy JP

    更新日期:2020-10-01 00:00:00

  • Early atrophy of pallidum and accumbens nucleus in Huntington's disease.

    abstract::In Huntington's disease (HD) atrophy of the caudate nucleus and putamen has been described many years before clinical manifestation. Volume changes of the pallidum, thalamus, brainstem, accumbens nucleus, hippocampus, and amygdala are less well investigated, or reported with contradicting results. The aim of our study...

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00415-010-5768-0

    authors: van den Bogaard SJ,Dumas EM,Acharya TP,Johnson H,Langbehn DR,Scahill RI,Tabrizi SJ,van Buchem MA,van der Grond J,Roos RA,TRACK-HD Investigator Group.

    更新日期:2011-03-01 00:00:00

  • Medial temporal lobe epilepsy associated with hippocampal sclerosis is a distinctive syndrome.

    abstract::Epileptic syndromes are distinctive disorders with specific features, which when taken together, permit a specific diagnosis. There is actually a debate on that medial temporal lobe epilepsy with hippocampal sclerosis is an epileptic syndrome. To address this issue, we searched for discriminative semiological features...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-017-8441-z

    authors: No YJ,Zavanone C,Bielle F,Nguyen-Michel VH,Samson Y,Adam C,Navarro V,Dupont S

    更新日期:2017-05-01 00:00:00

  • Hereditary neuropathy with liability to pressure palsies.

    abstract::Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent sensory and motor neuropathy in individual nerves starting in adolescence or young adulthood, focal conduction abnormalities at entrapment sites on nerve conduction studies, and sausage-like swellings (tomacula) of the myelin...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-019-09319-8

    authors: Attarian S,Fatehi F,Rajabally YA,Pareyson D

    更新日期:2020-08-01 00:00:00

  • Proton magnetic resonance spectroscopy of normal appearing white matter in familial and sporadic multiple sclerosis.

    abstract:OBJECTIVE:To assess metabolite levels in normal-appearing white matter in sporadic and familial multiple sclerosis (MS). METHODS:Using H-MRS and applying one voxel measure we assessed NAA/Cho, NAA/Cr and Cho/Cr ratios in 26 patients with sporadic and in 25 with familial MS and compared them with healthy subjects. RES...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0754-7

    authors: Siger-Zajdel M,Selmaj KW

    更新日期:2005-07-01 00:00:00

  • Dumb-bell sarcoma of the foramen jugulare with syringomyelia. A radio-induced tumour?

    abstract::The clinicopathological findings of a 50-year-old man, who developed cervicothoracic syringomyelia at the age of 25 are presented. He was given radiation therapy at the age of 33. At the age of 57 he developed a foramen jugulare syndrome on the left, caused by a low grade leiomyosarcoma. Etiologically, the most attrac...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313150

    authors: Sieben G,Sieben-Praet M,De Reuck J,De Coster W,Remouchamps A,Roels H,vander Eecken H

    更新日期:1980-01-01 00:00:00

  • Long-term results from a phase 2 extension study of fingolimod at high and approved dose in relapsing multiple sclerosis.

    abstract::Fingolimod safety and efficacy data in relapsing-remitting multiple sclerosis (RRMS) are available up to 5 years, from an extension of a randomized, placebo-controlled, double-blind, phase 2 study, at a dose higher (5.0/1.25 mg) than the approved dose of 0.5 mg. The objective of the study is to present the end-of-stud...

    journal_title:Journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00415-015-7834-0

    authors: Montalban X,Comi G,Antel J,O'Connor P,de Vera A,Cremer M,Sfikas N,von Rosenstiel P,Kappos L

    更新日期:2015-12-01 00:00:00

  • Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis.

    abstract:OBJECTIVE:To assess the changes of muscle-related biomarkers at the early stage of amyotrophic lateral sclerosis, and to confirm these findings in an experimental animal model. METHODS:Thirty-nine subjects with sporadic amyotrophic lateral sclerosis and 20 healthy controls were enrolled and longitudinally evaluated. W...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09507-6

    authors: Ito D,Hashizume A,Hijikata Y,Yamada S,Iguchi Y,Iida M,Kishimoto Y,Moriyoshi H,Hirakawa A,Katsuno M

    更新日期:2019-12-01 00:00:00

  • PRRT2-related disorders: further PKD and ICCA cases and review of the literature.

    abstract::Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an importan...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-012-6777-y

    authors: Becker F,Schubert J,Striano P,Anttonen AK,Liukkonen E,Gaily E,Gerloff C,Müller S,Heußinger N,Kellinghaus C,Robbiano A,Polvi A,Zittel S,von Oertzen TJ,Rostasy K,Schöls L,Warner T,Münchau A,Lehesjoki AE,Zara F,Lerch

    更新日期:2013-05-01 00:00:00

  • Mitochondrial encephalomyopathy, lactic acidosis and stroke in adults: two cases.

    abstract::Two previously healthy women are described who in their late thirties suffered transient strokelike episodes, consisting of initial headache and vomiting, with various subsequent neurological signs that were only partially reversible. Investigations revealed elevated serum creatine kinase, lactic acidosis, hypertrigly...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00818708

    authors: Kremer HP,Keyser A,Wintzen AR,Scholte HR,van Hellenberg Hubar JG,Poorthuis BJ,Ruitenbeek W

    更新日期:1993-01-01 00:00:00

  • Botulinum toxin therapy for treatment of spasticity in multiple sclerosis: review and recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders task force.

    abstract::Botulinum toxin (BT) therapy is an established treatment of spasticity due to stroke. For multiple sclerosis (MS) spasticity this is not the case. IAB-Interdisciplinary Working Group for Movement Disorders formed a task force to explore the use of BT therapy for treatment of MS spasticity. A formalised PubMed literatu...

    journal_title:Journal of neurology

    pub_type: 指南,杂志文章,评审

    doi:10.1007/s00415-016-8304-z

    authors: Dressler D,Bhidayasiri R,Bohlega S,Chahidi A,Chung TM,Ebke M,Jacinto LJ,Kaji R,Koçer S,Kanovsky P,Micheli F,Orlova O,Paus S,Pirtosek Z,Relja M,Rosales RL,Sagástegui-Rodríguez JA,Schoenle PW,Shahidi GA,Timerbaeva S,

    更新日期:2017-01-01 00:00:00

  • Dementia and assisted suicide and euthanasia.

    abstract::The number of dementia patients requesting euthanasia in the Netherlands has increased over the past five years. The issue is highly controversial. In this contribution we discuss some of the main arguments: the nature of suffering, the voluntariness of the request and the role of the physician. We argue that society ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-016-8095-2

    authors: de Beaufort ID,van de Vathorst S

    更新日期:2016-07-01 00:00:00

  • Palliative medicine training for physicians.

    abstract::In recent years, it has been widely recognised that modern doctors are not receiving the training they need to provide appropriate and effective palliative care. Deficiencies in care have been reported in several formal studies and, anecdotally, in many professional and popular lay publications. Doctors themselves hav...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/pl00007722

    authors: Doyle D

    更新日期:1997-10-01 00:00:00

  • Dissections after childbirth.

    abstract::The occurrence of spontaneous internal carotid or vertebral artery dissection after childbirth remains rare. To our knowledge, seven cases of arterial dissection in the postpartum period have been described in the literature as single case reports. We report four additional cases of internal carotid and vertebral arte...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s004150050437

    authors: Gasecki AP,Kwiecinski H,Lyrer PA,Lynch TG,Baxter T

    更新日期:1999-08-01 00:00:00

  • The case of the Marquis de Causan (1804): an early account of visual loss associated with spinal cord inflammation.

    abstract::The recent discovery of disease specific and pathogenic autoantibodies in neuromyelitis optica (NMO, Devic's disease) has revived the interest in this intriguing yet often devastating condition. While the history of classic multiple sclerosis has been studied extensively, only very little is known so far about the ear...

    journal_title:Journal of neurology

    pub_type: 历史文章,杂志文章

    doi:10.1007/s00415-011-6355-8

    authors: Jarius S,Wildemann B

    更新日期:2012-07-01 00:00:00

  • Spinal epidural abscess complicating chronic epidural analgesia in 11 cancer patients: clinical findings and magnetic resonance imaging.

    abstract::We reviewed the records of all patients who had received an epidural catheter for management of chronic cancer pain in a 3-year period (1993-1996). Patients with nervous system infections were identified, and pertinent clinical, radiological (magnetic resonance imaging), and bacteriological data were analyzed. We iden...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s004150050460

    authors: Sillevis Smitt P,Tsafka A,van den Bent M,de Bruin H,Hendriks W,Vecht C,Teng-van de Zande F

    更新日期:1999-09-01 00:00:00

  • Visual hallucinations and illusions in Parkinson's disease: the role of ocular pathology.

    abstract:INTRODUCTION:Whether different mechanisms, particularly ocular pathology, could lead to the emergence of visual hallucinations (VH) (defined as false perceptions with no external stimulus) versus visual illusions (VI) (defined as a misperception of a real stimulus) in Parkinson's disease (PD) remains debated. We assess...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-09925-x

    authors: Marques A,Beze S,Pereira B,Chassain C,Monneyron N,Delaby L,Lambert C,Fontaine M,Derost P,Debilly B,Rieu I,Lewis SJG,Chiambaretta F,Durif F

    更新日期:2020-10-01 00:00:00

  • Is lumbar spondylosis a cause of urinary retention in elderly women?

    abstract:OBJECTIVES:Lumbar spondylosis (LS) is a common spinal degenerative disorder which causes various types of lower urinary tract dysfunction (LUTD). However, it is not certain whether LS may cause urinary retention in elderly women. METHODS:In a period covering the past 3 years, we retrospectively reviewed: a) urodynamic...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0790-3

    authors: Sakakibara R,Yamamoto T,Uchiyama T,Liu Z,Ito T,Yamazaki M,Awa Y,Yamanishi T,Hattori T

    更新日期:2005-08-01 00:00:00

  • [Global aphasia. The clinical picture and a consideration of the neurolinguistic structure (author's transl)].

    abstract::Global aphasia is described as a unitary syndrome which is characterized by a severe impairment of all linguistic capabilities. Speech production is extremely limited and consists of stereotyped phrases, recurring utterances or a few isolated words which are usually neologistically distorted. The patients are unable t...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF02430346

    authors: Stachowiak FJ,Huber W,Kerschensteiner M,Poeck K,Weniger D

    更新日期:1977-01-13 00:00:00

  • Life style risks of Parkinson's disease: association between decreased water intake and constipation.

    abstract::Gastrointestinal dysfunction, especially constipation, is one of the major problems in the daily life of patients with Parkinson's disease (PD). About 60 to 80% of PD patients suffer from constipation. Several studies have proven that constipation appears about 10 to 20 years prior to motor symptoms. More recently, Ab...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-004-1706-3

    authors: Ueki A,Otsuka M

    更新日期:2004-10-01 00:00:00

  • SMN2 copy number predicts acute or chronic spinal muscular atrophy but does not account for intrafamilial variability in siblings.

    abstract::Spinal muscular atrophy (SMA) is an autosomal recessive disorder that affects motor neurons. It is caused by mutations in the survival motor neuron gene 1 (SMN1). The SMN2 gene, which is the highly homologous SMN1 copy that is present in all the patients, is unable to prevent the disease. An SMN2 dosage method was app...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0912-y

    authors: Cuscó I,Barceló MJ,Rojas-García R,Illa I,Gámez J,Cervera C,Pou A,Izquierdo G,Baiget M,Tizzano EF

    更新日期:2006-01-01 00:00:00