Abstract:
:Gait variability has potential utility as a predictive measure of dysfunction in Parkinson's disease (PD). Current understanding implicates non-dopaminergic pathways. This study investigated the explanatory characteristics of gait variability in PD on and off medication under single and dual task conditions. Fifty people with PD were assessed twice at home (on and off L: -dopa) whilst walking under single and dual task conditions, and variability (coefficient of variation, CV) was calculated for stride time and double limb support (DLS) time. Hierarchical regression analysis was used to identify predictors. The first block of variables included age, gait speed, depression (Hospital Anxiety and Depression Scale) and fatigue (Multidimensional Fatigue Inventory), and the second block included motor severity (UPDRS III), executive function (Hayling and Brixton) and attention (Test of Everyday Attention). Motor severity predicted stride time variability and DLS time variability independent of L: -dopa during single task gait. Dual task gait yielded a more complex picture. Depression made a unique contribution of 9.0% on medication and 5.0% off medication to stride time variability, and visual attention and younger age contributed to DLS variability on medication, explaining 3% and 2%, respectively. Motor severity predicted DLS variability off medication, explaining 74% of variance. Different characteristics explain the two measures of gait variability, pointing to different control mechanisms.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Lord S,Baker K,Nieuwboer A,Burn D,Rochester Ldoi
10.1007/s00415-010-5789-8subject
Has Abstractpub_date
2011-04-01 00:00:00pages
566-72issue
4eissn
0340-5354issn
1432-1459journal_volume
258pub_type
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313358
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abstract::Two siblings with multiple intracranial haemangiomatosis are reported, each having psychomotor retardation, epilepsy and gyriform type calcification in the occipital and frontal lobes. There were haemangiomas in one autopsy case with calcification in the deep layers of the cortex and subcortical white matter. ...
journal_title:Journal of neurology
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abstract::Parkinson's disease (PD) is a progressive neurological disorder characterized by motor symptoms as well as severe deficits in olfactory function and microstructural changes in olfactory brain regions. Because of the evidence of asymmetric neuropathological features in early-stage PD, we examined whether lateralized mi...
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doi:10.1007/s00415-017-8555-3
更新日期:2017-07-01 00:00:00
abstract::We assessed the prevalence of vertebral artery (VA) stenosis or occlusion and its influence on outcome in patients with acute basilar artery occlusion (BAO). We studied 141 patients with acute BAO enrolled in the Basilar Artery International Cooperation Study (BASICS) registry of whom baseline CT angiography (CTA) of ...
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doi:10.1007/s00415-014-7583-5
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abstract::Production of reactive oxygen species after cerebral blood flow disruption may enhance tissue damage through multiple molecular pathways. Changes in nitric oxide (NO) metabolism and oxidative stress status were investigated in 47 patients with ischemic stroke by measuring plasma nitric oxide (NO) and peroxynitrite (ON...
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abstract:OBJECTIVE:Determine toxicity and efficacy of autologous hematopoietic stem cell transplantation (HSCT) for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who are dependent on intravenous immunoglobulins or plasmapheresis. METHODS:Unselected peripheral blood stem cells were re-infused on...
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doi:10.1007/s00415-020-10010-6
更新日期:2020-11-01 00:00:00
abstract::Four patients with aphasia due to small circumscribed thalamic lesions are presented. A review of the literature on thalamic aphasia revealed 16 similar cases. While the general consensus that only left-sided thalmic lesions are associated with aphasia is confirmed, analysis of the sites of the thalamic infarctions an...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00314212
更新日期:1989-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314303
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章,评审
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doi:10.1007/s00415-020-09953-7
更新日期:2020-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-010-5768-0
更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-017-8441-z
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-019-09319-8
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To assess metabolite levels in normal-appearing white matter in sporadic and familial multiple sclerosis (MS). METHODS:Using H-MRS and applying one voxel measure we assessed NAA/Cho, NAA/Cr and Cho/Cr ratios in 26 patients with sporadic and in 25 with familial MS and compared them with healthy subjects. RES...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0754-7
更新日期:2005-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313150
更新日期:1980-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00415-015-7834-0
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To assess the changes of muscle-related biomarkers at the early stage of amyotrophic lateral sclerosis, and to confirm these findings in an experimental animal model. METHODS:Thirty-nine subjects with sporadic amyotrophic lateral sclerosis and 20 healthy controls were enrolled and longitudinally evaluated. W...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09507-6
更新日期:2019-12-01 00:00:00
abstract::Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an importan...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-012-6777-y
更新日期:2013-05-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00818708
更新日期:1993-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 指南,杂志文章,评审
doi:10.1007/s00415-016-8304-z
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-016-8095-2
更新日期:2016-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/pl00007722
更新日期:1997-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s004150050437
更新日期:1999-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 历史文章,杂志文章
doi:10.1007/s00415-011-6355-8
更新日期:2012-07-01 00:00:00
abstract::We reviewed the records of all patients who had received an epidural catheter for management of chronic cancer pain in a 3-year period (1993-1996). Patients with nervous system infections were identified, and pertinent clinical, radiological (magnetic resonance imaging), and bacteriological data were analyzed. We iden...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150050460
更新日期:1999-09-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09925-x
更新日期:2020-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0790-3
更新日期:2005-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF02430346
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-004-1706-3
更新日期:2004-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0912-y
更新日期:2006-01-01 00:00:00