Palliative medicine training for physicians.

abstract：:18FDG-positron emission tomography performed at different stages in the course of subacute sclerosing panencephalitis revealed a changing pattern of metabolic disturbance. In clinical stage II patients the inflammation in the basal ganglia appeared to lead to neuronal excitation accompanied by hypermetabolism. Widespr...

journal_title：Journal of neurology

authors： Huber M,Pawlik G,Bamborschke S,Fink GR,Karbe H,Schlenker M,Bewermeyer H,Heiss WD

更新日期：1992-03-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease caused by both genetic and environmental factors. Sirtuins are highly-conserved, NAD-dependent class III deacetylases that regulate a variety of cellular functions. Most of the known sirtuins have been involved in animal models of neurodegenerative disorders, suc...

journal_title：Journal of neurology

authors： Jesús S,Gómez-Garre P,Carrillo F,Cáceres-Redondo MT,Huertas-Fernández I,Bernal-Bernal I,Bonilla-Toribio M,Vargas-González L,Carballo M,Mir P

更新日期：2013-09-01 00:00:00

abstract：:In a fatal case of neuroleptic malignant syndrome, a muscle sample taken within 1 h of death showed acute myopathic features with absence of muscle glycogen and neutral lipid. These features suggest that hyperpyrexia in this syndrome may be caused by heat production from uncoupled phosphorylation in muscle and imply t...

journal_title：Journal of neurology

authors： Martin DT,Swash M

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Glatiramer acetate (GA) therapy following brief, low-dose induction with mitoxantrone was safe and more effective than GA alone in suppressing inflammatory disease activity, as determined by a significant reduction in gadolinium (Gd)- enhancing MRI lesions, in a 15- month, randomized, single-blind study of r...

journal_title：Journal of neurology

authors： Arnold DL,Campagnolo D,Panitch H,Bar-Or A,Dunn J,Freedman MS,Gazda SK,Vollmer T

更新日期：2008-10-01 00:00:00

abstract：:This study of frontotemporal dementia (FTD) was carried out to determine whether MR spectroscopy can provide an in vivo marker for the neuronal loss and gliosis that occur in this condition. We compared spectra in frontal and temporal regions known to be affected early in the course of the disease with spectra in the ...

journal_title：Journal of neurology

authors： Coulthard E,Firbank M,English P,Welch J,Birchall D,O'Brien J,Griffiths TD

更新日期：2006-07-01 00:00:00

abstract：:The aim of our study was to compare the results obtained by intraoperative and postoperative subthalamic nucleus (STN) macrostimulation in Parkinson's disease (PD). One hundred three PD patients implanted with bilateral STN stimulation were included. The thresholds for efficacy and side effects (motor contraction; par...

journal_title：Journal of neurology

authors： Xie J,Adamec D,Decullier E,Bin-Dorel S,Mertens P,Polo G,Poisson A,Broussolle E,Thobois S

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Diagnostic delay of hereditary transthyretin amyloidosis (ATTRv, v for variant) prevents timely treatment and, therefore, concurs to the mortality of the disease. The aim of the present study was to explore with nerve ultrasound (US) possible red flags for early diagnosis in ATTRv patients with carpal tunnel...

journal_title：Journal of neurology

authors： Salvalaggio A,Coraci D,Cacciavillani M,Obici L,Mazzeo A,Luigetti M,Pastorelli F,Grandis M,Cavallaro T,Bisogni G,Lozza A,Gemelli C,Gentile L,Ermani M,Fabrizi GM,Plasmati R,Campagnolo M,Castellani F,Gasparotti R,Marti

更新日期：2021-01-01 00:00:00

abstract：:Ischaemic stroke, the most common type of stroke, is classified into three main subtypes: large-vessel disease, lacunar or small-vessel disease, and cardioembolic; two further subtypes include a determined aetiology of "other" and cryptogenic. Although a substantial amount of literature exists concerning current guide...

journal_title：Journal of neurology

authors： Kirshner HS

更新日期：2010-11-01 00:00:00

abstract：:Brain metastasis is a common complication occurring in about 15-20% of all cancer patients. For the initial management, distinguishing between three types of presentation is essential: de novo brain metastasis, simultaneous presentation of both brain metastasis and the primary tumour (usually lung carcinoma), and the ...

journal_title：Journal of neurology

authors： Vecht CJ

更新日期：1998-03-01 00:00:00

abstract：:Eye movements were studied in 13 patients with Friedreich's ataxia and correlated with MRI findings to investigate whether oculomotor abnormalities can be traced to cerebellar disturbances in this disease. One of the most prominent eye signs was fixation instability (square-wave jerks, SWJ.). Besides SWJ the patients ...

journal_title：Journal of neurology

authors： Spieker S,Schulz JB,Petersen D,Fetter M,Klockgether T,Dichgans J

更新日期：1995-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS), which is the most serious form of degenerative motor neuron disease in adults, is characterized by upper and lower motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Some patients with respiratory-dependent ALS die of sudden cardiac arrest or anoxic encephalo...

journal_title：Journal of neurology

authors： Tanaka Y,Yamada M,Koumura A,Sakurai T,Hayashi Y,Kimura A,Hozumi I,Inuzuka T

更新日期：2013-09-01 00:00:00

abstract：:Focal transcranial magnetic stimulation (TMS) of the motor cortex was used to study excitatory and inhibitory stimulation effects in 25 patients with writer's cramp and 25 healthy volunteers. We investigated excitatory and inhibitory corticospinally mediated motor effects in muscles contralateral to the stimulation si...

journal_title：Journal of neurology

authors： Niehaus L,von Alt-Stutterheim K,Röricht S,Meyer BU

更新日期：2001-01-01 00:00:00

abstract：:Raised intracranial pressure in association with spinal meningeal cysts has rarely been reported. We describe four patients in whom evidence of paroxysmal raised intracranial pressure was found in association with spinal meningeal cysts. Cerebrospinal fluid diversion procedures have previously been shown to relieve lo...

journal_title：Journal of neurology

authors： Shams PN,Goadsby PJ,Crockard HA,Casey AT,Plant GT

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Spinocerebellar ataxias (SCAs) are rare dominantly inherited neurodegenerative disorders that lead to severe disability and premature death. OBJECTIVE:To better characterize the natural history of the most common SCAs, SCA1, SCA2, SCA3 and SCA6, we performed a meta-analysis of literature to determine diseas...

journal_title：Journal of neurology

authors： Diallo A,Jacobi H,Tezenas du Montcel S,Klockgether T

更新日期：2020-04-07 00:00:00

abstract：:The purpose of this study was to evaluate the contribution of posterior circulation to memory function by comparing memory scores between patients with and without a foetal-type posterior cerebral artery (FTP) during the intracarotid amobarbital procedure (IAP) in epilepsy patients. Patients undergoing bilateral IAP b...

journal_title：Journal of neurology

authors： Zijlmans M,Huibers CJ,Huiskamp GJ,de Kort GA,Alpherts WC,Leijten FS,Hendrikse J

更新日期：2012-08-01 00:00:00

abstract：:Multiple mononeuropathy (MM) occurs rarely during systemic lupus erythematosus (SLE) but may lead to major disability. The aim of this study was to investigate the clinic-pathological presentations of MM during SLE, as well as long-term outcomes. We conducted a multicentric retrospective study that included patients r...

journal_title：Journal of neurology

authors： Rivière E,Cohen Aubart F,Maisonobe T,Maurier F,Richez C,Gombert B,Gousseff M,Adoue D,Mathian A,Hié M,Haroche J,Amoura Z

更新日期：2017-06-01 00:00:00

abstract：:Pompe disease is an autosomal recessive disorder in which deficiency of the lysosomal enzyme acid alpha-glucosidase results in the accumulation of glycogen mostly in muscle tissues. Several reports suggest a higher incidence of intracranial vascular abnormalities (IVAs) in this condition, as well as brain microbleeds ...

journal_title：Journal of neurology

authors： Pichiecchio A,Sacco S,De Filippi P,Caverzasi E,Ravaglia S,Bastianello S,Danesino C

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVES:To determine demographic or disease-related factors that may influence the severity of autonomic dysfunction in idiopathic Parkinson's disease (IPD). METHODS:532 patients with IPD aged between 55 and 75 years were included. Severity of autonomic dysfunction was assessed using a 9-item autonomic dysfunction ...

journal_title：Journal of neurology

authors： Korchounov A,Kessler KR,Yakhno NN,Damulin IV,Schipper HI

更新日期：2005-12-01 00:00:00

abstract：:A patient with haemorrhage in the right tegmentum of the pons demonstrated ipsilateral disturbance of taste on both the anterior two-thirds and posterior one-third of the tongue. The contralateral medial lemniscus was not disturbed, contrary to the early descriptions that the secondary gustatory neurons from the nucle...

journal_title：Journal of neurology

authors： Nakajima Y,Utsumi H,Takahashi H

更新日期：1983-01-01 00:00:00

abstract：:Vanishing white matter disease (VWM) is one of the most prevalent inherited leukoencephalopathies in childhood. Infantile VWM is more severe but less understood than the classic early childhood type. We performed a follow-up study on 14 infantile and 26 childhood patients to delineate the natural history and neuroimag...

journal_title：Journal of neurology

authors： Zhou L,Zhang H,Chen N,Zhang Z,Liu M,Dai L,Wang J,Jiang Y,Wu Y

更新日期：2018-06-01 00:00:00

abstract：:Amyloid positron emission tomography ([18F] florbetaben (FBB) PET) can be used to determine concomitant Alzheimer's disease (AD) in idiopathic normal pressure hydrocephalus (iNPH) patients. FBB PET scans and the tap test were performed in 31 patients with clinically suspected iNPH, and amyloid positive (iNPH/FBB+) and...

journal_title：Journal of neurology

authors： Jang H,Park SB,Kim Y,Kim KW,Lee JI,Kim ST,Lee KH,Kang ES,Choe YS,Seo SW,Kim HJ,Kim YJ,Yoon CW,Na DL

更新日期：2018-01-01 00:00:00

abstract：:The management of high-grade glioma (HGG) has evolved significantly over the last decade. Patients are managed in a multidisciplinary team setting in order to ensure their care is guided by the most current evidenced based treatments. The outcome in patients with HGG, while still poor, has improved in terms of both su...

journal_title：Journal of neurology

authors： Bradley D,Rees J

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The treatment of MS has always been a focus of neurological research. To date, the US Food and Drug Administration has approved 15 medications for modifying the course of multiple sclerosis. In this study, we exami...

journal_title：Journal of neurology

authors： Li H,Hu F,Zhang Y,Li K

更新日期：2020-12-01 00:00:00

abstract：:The age-related structural changes of the human hippocampus are not entirely understood. The goal of the present investigation was to understand better the nature of age-related hippocampal changes by a comparative MR-analysis of four complementary aspects of hippocampal integrity: total volume, metabolite concentrati...

journal_title：Journal of neurology

authors： Szentkuti A,Guderian S,Schiltz K,Kaufmann J,Münte TF,Heinze HJ,Düzel E

更新日期：2004-11-01 00:00:00

abstract：:Nystagmus is a rhythmical rotation of the eyeball. Its characteristics can be defined mathematically by the axis of rotation and the angular velocity around this axis. We analysed the axis of rotation for the nystagmus in benign paroxysmal positional vertigo (BPPV) to elucidate its pathophysiology. Thirteen patients w...

journal_title：Journal of neurology

authors： Hayashi Y,Kanzaki J,Etoh N,Higashino K,Goto F,Schneider E,Kunihiro T

更新日期：2002-12-01 00:00:00

abstract：:Limb-girdle muscular dystrophies (LGMDs) are genetically heterogeneous and the diagnostic work-up including conventional genetic testing using Sanger sequencing remains complex and often unsatisfactory. We performed targeted sequencing of 23 LGMD-related genes and 15 genes in which alterations result in a similar phen...

journal_title：Journal of neurology

authors： Kuhn M,Gläser D,Joshi PR,Zierz S,Wenninger S,Schoser B,Deschauer M

更新日期：2016-04-01 00:00:00

abstract：:Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case-control study, we observed sign...

journal_title：Journal of neurology

authors： Forster K,Poppert H,Conrad B,Sander D

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence and characteristics of the cricopharyngeal bar (CPB), defined as marked protrusion with lacking relaxation and stricture of the upper esophageal sphincter on videofluoroscopy, in patients with inclusion body myositis (IBM). METHODS:We conducted a case-control study of comprehensiv...

journal_title：Journal of neurology

authors： Taira K,Yamamoto T,Mori-Yoshimura M,Sajima K,Takizawa H,Shinmi J,Oya Y,Nishino I,Takahashi Y

更新日期：2020-09-26 00:00:00

abstract：:There is increasing evidence that inflammation plays an important role in the progression of acute ischemic stroke (AIS). The primary aims of this study were to examine the serum levels of 13 cytokines, C-reactive protein (CRP), glucose, and hemoglobin in AIS patients, and their relationship to stroke lateralization, ...

journal_title：Journal of neurology

authors： Ormstad H,Aass HC,Lund-Sørensen N,Amthor KF,Sandvik L

更新日期：2011-04-01 00:00:00

abstract：:In Parkinson's disease (PD), nonmotor symptoms manifest before motor symptoms. In this report, we present a remarkable case of a semiprofessional painter with PD whose painting style dramatically changed from abstract painting to realism before he developed motor, psychiatric, and autonomic nerve disorders. This case ...

journal_title：Journal of neurology

authors： Shimura H,Tanaka R,Urabe T,Tanaka S,Hattori N

更新日期：2012-05-01 00:00:00