Abstract：
:The number of dementia patients requesting euthanasia in the Netherlands has increased over the past five years. The issue is highly controversial. In this contribution we discuss some of the main arguments: the nature of suffering, the voluntariness of the request and the role of the physician. We argue that society has a duty to care for patients who suffer from dementia and to make their lives as good and comfortable as possible. We also argue that it can be morally acceptable for those who do not want to continue their life with dementia to choose to die. The choice can be based on good reasons.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
de Beaufort ID,van de Vathorst Sdoi
10.1007/s00415-016-8095-2subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1463-7issue
7eissn
0340-5354issn
1432-1459pii
10.1007/s00415-016-8095-2journal_volume
263pub_type
杂志文章abstract：:Cluster headache (CH) is characterized by attacks of severe, strictly unilateral pain that is orbital, supraorbital, temporal, or any combination of these, lasts 15-180 min, and occurs from once every other day to eight times a day. The pain is associated with ipsilateral conjunctival injection, lacrimation, nasal con...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-018-9007-4
更新日期：2019-05-01 00:00:00
abstract：:Myasthenia gravis patients usually present with fluctuating, asymmetrical stress-dependent weakness in the absence of other neurological disturbances. In weak patients psychopathological disturbances are frequently reported and misdiagnosed as a psychiatric disorder. The question to what extent psychiatric symptoms ar...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-2022-5
更新日期：2007-05-01 00:00:00
abstract：:This review summarizes recent findings from clinical trials regarding the prevention of stroke and translates these into therapeutic guidelines. A distinction is made between patients with previous cerebrovascular disease and those without, and between patients with and those without atrial fibrillation. Although the ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050450
更新日期：1999-09-01 00:00:00
abstract：:To investigate the role of endogenous opioid peptides in the pathophysiology of cerebral ischaemia, the CSF levels of immunoreactive beta-endorphin and leu-enkephalin in 16 patients with cerebral infarction were measured. Both the CSF beta-endorphin and leu-enkephalin levels in the acute stage of cerebral infarction w...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314282
更新日期：1987-06-01 00:00:00
abstract：:We examined the peripheral nervous system (PNS) (nerve conduction velocity (NCV)) and the central nervous system (CNS) (basal ganglia-mediated psychomotor speed) in 93 males seropositive for human immunodeficiency virus type 1 (HIV-1) with no prior history of opportunistic brain disease, antiretroviral treatment or in...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0707-3
更新日期：2002-06-01 00:00:00
abstract：:We describe three patients with unilateral asterixis. One diabetic patient with a moderately-sized haematoma in the left putamen initially developed bilateral and symmetrical asterixis, which became confined to the right side as his diabetes mellitus was controlled. Two patients showed unilateral asterixis due to haem...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314766
更新日期：1990-12-01 00:00:00
abstract：:Currently, several disease-modifying therapies for the treatment of multiple sclerosis are established and more are likely to be introduced. These treatment options differ with respect to their application profile, mechanism of action, efficacy, safety, and tolerance. Here, we review current concepts of MS therapies, ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6101-2
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:Fabry disease (FD) is an X-linked lysosomal storage disorder resulting in vascular glycosphingolipid accumulation and increased stroke risk. MRI findings associated with FD include white matter hyperintensities (WMH) and cerebral microbleeds (CMBs), suggesting the presence of cerebral small vessel disease....
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10209-7
更新日期：2020-10-19 00:00:00
abstract：:Mutations in SCN2A cause epilepsy syndromes of variable severity including neonatal-infantile seizures. In one case, we previously described additional childhood-onset episodic ataxia. Here, we corroborate and detail the latter phenotype in three further cases. We describe the clinical characteristics, identify the ca...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7984-0
更新日期：2016-02-01 00:00:00
abstract：:The diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy (PML) in multiple sclerosis patients in an asymptomatic stage is crucial since it is associated with better clinical outcome measures. Current diagnostic criteria on PML diagnosis in asymptomatic patients require the detection of JC vir...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7336-5
更新日期：2014-06-01 00:00:00
abstract：:A rare form of plasma cell dyscrasia characterized by associated polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes has been termed the POEMS syndrome. The pathophysiology is unknown; plasma cell dyscrasia is essential; secondary manifestations are unexplained. We report a 67-year-old man with a ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00839213
更新日期：1992-01-01 00:00:00
abstract：:The various clinical features of multiple system atrophy (MSA) make the diagnosis of the disease difficult, especially in its early stages, when signs of differentiated neuroanatomical system involvement have not yet appeared. Mortality studies may be affected by the variability of the diagnostic criteria and selectio...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00868999
更新日期：1996-05-01 00:00:00
abstract：:Hirayama's disease is a benign juvenile form of focal amyotrophy affecting the upper limbs. Previous studies have suggested that the disorder is a neck flexion induced cervical myelopathy. We report clinical and magnetic resonance imaging findings in nine patients with Hirayama's disease. Cervical imaging of seven pat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050514
更新日期：1999-11-01 00:00:00
abstract：:We conducted an open-labeled clinical trial of interferon beta-1b (IFNB) treatment in 20 patients with primary progressive multiple sclerosis (PPMS) and longitudinally monitored autoantibodies against double-stranded DNA (dsDNA), thyroid peroxidase (TPO),myelin basic protein (MBP), myelin oligodendrocyte glycoprotein ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-004-0580-3
更新日期：2004-12-01 00:00:00
abstract：:Cognitive deficits mainly involving visuospatial functions have been defined in patients with bilateral and even unilateral vestibular loss (UVL). We compared the cognitive test results of 21 patients with acute UVL with age- and education-matched healthy controls. The diagnosis of UVL was based on the clinical findin...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09829-w
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Diagnostic delay of hereditary transthyretin amyloidosis (ATTRv, v for variant) prevents timely treatment and, therefore, concurs to the mortality of the disease. The aim of the present study was to explore with nerve ultrasound (US) possible red flags for early diagnosis in ATTRv patients with carpal tunnel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10127-8
更新日期：2021-01-01 00:00:00
abstract：:A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No cha...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313729
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:In order to define the predictors of prolonged survival available at the time of first examination we performed a historical cohort study of amyotrophis sclerosis (ALS) patients referred to our ALS Clinic over the last 20 years. METHODS:In a group of 1034 patients with the diagnosis of definite or probable A...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0226-8
更新日期：2006-11-01 00:00:00
abstract：:Various ancillary investigations can assist clinicians in the differential diagnosis of patients with parkinsonism. It is unknown which test offers greatest diagnostic value in clinical practice. We included 156 consecutive patients with parkinsonism, but with an initially uncertain diagnosis. At baseline, all patient...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7568-4
更新日期：2015-02-01 00:00:00
abstract：:During recent years, evidence has come up that bipedal locomotion is based on a quadrupedal limb coordination. A task-dependent neuronal coupling of upper and lower limbs allows one to involve the arms during gait but to uncouple this connection during voluntarily guided arm/hand movements. Hence, despite the evolutio...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6063-4
更新日期：2011-08-01 00:00:00
abstract：:Four patients from three unrelated families, with clinical and electrophysiological findings compatible with the diagnosis of hereditary motor and sensory neuropathy, are presented. The molecular analysis showed that the affected individuals were homozygous for the mutation in the X25 gene, characteristic of Friedreic...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0902-2
更新日期：2002-11-01 00:00:00
abstract：:Parkinson's disease (PD) is a progressive neurological disorder characterized by motor symptoms as well as severe deficits in olfactory function and microstructural changes in olfactory brain regions. Because of the evidence of asymmetric neuropathological features in early-stage PD, we examined whether lateralized mi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8555-3
更新日期：2017-07-01 00:00:00
abstract：:Relapses are a characteristic clinical feature of multiple sclerosis (MS), but an appreciation of factors that cause them remains elusive. In this study, we have examined seasonal variation of relapse in a large population-based MS cohort and correlated observed patterns with age, sex, disease course, and climatic fac...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8485-0
更新日期：2017-06-01 00:00:00
abstract：:A case is reported of severe agnosia for verbal and non-verbal sounds without associated aphasic disorder. A CT scan revealed bilateral, temporal lobe lesions from two ischaemic accidents that had occurred 9 months apart. The search for subtle deficits in the patient showed normal sensitivity to changes in the intensi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313543
更新日期：1982-01-01 00:00:00
abstract：:Acute porphyrias are a group of inherited metabolic disorders representing overproduction syndromes with the formation of neurotoxic haem precursors. Clinical manifestations consist of acute attacks, which include abdominal pain, dysautonomia, mental symptoms, polyneuropathy and seizures mimicking many other acute neu...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0779-9
更新日期：2008-07-01 00:00:00
abstract：:Whole genome screening is increasingly used to identify genetic risk factors for complex diseases. In this study, a genome wide linkage disequilibrium (LD) screen was performed in a cohort of Parkinson's disease (PD) patients from the UK (n = 195) using pooled DNA to facilitate efficient genotyping of 5546 microsatell...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0686-2
更新日期：2005-05-01 00:00:00
abstract：:Among the hereditary cerebellar ataxias (CAs), there are at least 36 different forms of autosomal dominant cerebellar ataxia (ADCAs), 20 autosomal recessive cerebellar ataxias (ARCAs), two X-linked ataxias, and several forms of ataxia associated with mitochondrial defects. Despite the steady increase in the number of ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-014-7387-7
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Spinocerebellar ataxias (SCAs) are rare dominantly inherited neurodegenerative disorders that lead to severe disability and premature death. OBJECTIVE:To better characterize the natural history of the most common SCAs, SCA1, SCA2, SCA3 and SCA6, we performed a meta-analysis of literature to determine diseas...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09815-2
更新日期：2020-04-07 00:00:00
abstract：:Apoptotic deletion of autoreactive T-cells is defective in patients with multiple sclerosis (MS). Glatiramer acetate (GA) treatment seems to restore apoptosis of detrimental T-cells. We analyzed the mitochondria membrane pro- (Bax) and anti-apoptotic (Bcl- 2) and cytosolic pro-apoptotic (Cyt-c, APAF-1) proteins expres...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0965-y
更新日期：2006-02-01 00:00:00
abstract：:We evaluated the health economic burden of patients with Gilles de la Tourette's syndrome (GTS) in Germany over a 3-month observation period. Direct and indirect costs were evaluated in 200 outpatients with GTS (mean age 35 +/- 11.5 years) in Germany. Patients were recruited from three outpatient departments that spec...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5458-y
更新日期：2010-07-01 00:00:00
