Cerebrospinal fluid proteins and cells in normal-pressure hydrocephalus.

Abstract:

:A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No characteristic changes could be found in the "CSF-specific" protein fraction. After the shunt operation 65% of the patients had a BBB dysfunction to macromolecules and 70% had two additional acidic protein bands in the CSF-specific fraction. Ventricular CSF protein content was 73% of lumbar CSF content when shunts were patent. Isotope encephalography showed a radionuclide accumulation at the intracranial part of the shunt system, indicating that the BBB damage might be located round the shunt catheter.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Wikkelsø C,Blomstrand C

doi

10.1007/BF00313729

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

171-80

issue

3

eissn

0340-5354

issn

1432-1459

journal_volume

228

pub_type

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