Abstract:
:We evaluated the health economic burden of patients with Gilles de la Tourette's syndrome (GTS) in Germany over a 3-month observation period. Direct and indirect costs were evaluated in 200 outpatients with GTS (mean age 35 +/- 11.5 years) in Germany. Patients were recruited from three outpatient departments that specialized in GTS and completed a semi-structured and self-rating interview with questionnaires screening for direct and indirect medical and non-medical costs, health status, depression, amount and severity of symptoms. Costs were obtained from various German medical economic resources. Indirect costs for lost productivity were calculated using the human capital approach. Costs were calculated from the point of view of healthcare and transfer payment providers and the individual patient. Multivariate regression analyses were performed to identify independent cost predictors. Costs are in year 2006-2007 values. Direct costs were 620 +/- 1,697.1euro, including rehabilitation 98.8 +/- 993.6euro, hospitalization 195.8 +/- 1,267.8euro, outpatient treatment 14.0 +/- 40.6euro, ancillary treatment 51.9 +/- 137.4euro. Drug costs were 223.1 +/- 430.4. The indirect medical costs amounted to 2,511.3 +/- 3,809.5euro for productivity loss and to 220.0 +/- 1,092euro for absenteeism. The following variables were found to impact on direct costs: employment status, occupational advancement, depression, quality of life, age. Disease severity had no influence on cost. Because of the earlier age of disease onset, indirect costs are higher than direct costs. Interestingly, disease severity did not influence the resource need in this population. Unfortunately, no cost of illness studies are available for comparison. Further health economic studies, especially cost-effectiveness studies, are necessary for a basis for rational resource allocation.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Dodel I,Reese JP,Müller N,Münchau A,Balzer-Geldsetzer M,Wasem J,Oertel WH,Dodel R,Müller-Vahl Kdoi
10.1007/s00415-010-5458-ysubject
Has Abstractpub_date
2010-07-01 00:00:00pages
1055-61issue
7eissn
0340-5354issn
1432-1459journal_volume
257pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Current demographic changes indicate that more people will be care-dependent due to increasing life expectancy. Little is known about impact of preexisting dependency on stroke outcome after endovascular treatment (EVT). METHODS:We compared prospectively collected baseline and outcome data of pr...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10172-3
更新日期:2020-08-31 00:00:00
abstract::Gilles de la Tourette's syndrome (GTS) and restless legs syndrome (RLS) are two different neurological disorders with common features such as involuntary movements. In both disorders a disturbance of the dopaminergic system has been considered among other possible mechanisms. Since periodic leg movements (PLMS) during...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050136
更新日期:1997-08-01 00:00:00
abstract::Collective evidence supports the notion that multiple sclerosis is principally an autoimmune disease. Much of it stems from models of experimental autoimmune encephalomyelitis, generated by inoculation of animals with central nervous system antigens such as MBP, PLP, S100 and MOG or peptides thereof. Different ways of...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-005-5006-3
更新日期:2005-11-01 00:00:00
abstract::Cerebellar syndrome is one of the most disabling developments in multiple sclerosis (MS). In neurodegenerative disorders, cerebellar syndrome is thought to be related to a neurochemical deficit of 5-hydroxytryptamine (5-HT). Previous studies found that a levorotatory form of 5-hydroxytryptophan, a 5-HT precursor, and ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00415-003-0176-3
更新日期:2003-10-01 00:00:00
abstract::A 40-year-old man suffered for 5 years from a progressive proximal myopathy mimicking an atypical limb-girdle dystrophy. A "myopathic" pattern with myotonic and pseudomyotonic discharges was determined by electromyography. Enzyme histochemical and ultrastructural investigations of muscle and liver biopsies pointed to ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00312870
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. METHODS:We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative t...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10271-1
更新日期:2020-10-21 00:00:00
abstract::The spinocerebellar ataxias (SCAs) with autosomal dominant inheritance are a clinically and genetically heterogeneous group of neurological disorders with overlapping as well as highly variable phenotypes primarily affecting the cerebellum. To date, 28 different loci have been identified. Nine SCAs are caused by repea...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5209-0
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early onset neurodegenerative disease that typically results in ataxia, upper motor neuron dysfunction and sensorimotor peripheral neuropathy. Dysarthria and dysphagia are anecdotally described as key features of ARSACS but the natu...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-8950-4
更新日期:2018-09-01 00:00:00
abstract::Four patients from three unrelated families, with clinical and electrophysiological findings compatible with the diagnosis of hereditary motor and sensory neuropathy, are presented. The molecular analysis showed that the affected individuals were homozygous for the mutation in the X25 gene, characteristic of Friedreic...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-002-0902-2
更新日期:2002-11-01 00:00:00
abstract::Botulinum neurotoxin (BoNT) is an effective treatment for cervical dystonia (CD). Long-term changes of several variables, including the dose of BoNT, in these patients is largely unknown. We reviewed the clinical charts of 275 patients with CD treated with BoNT type A (BoNT-A) for at least 5 years since 1989 at ten te...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-010-5880-1
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To characterize the relation between brain functional connectivity and disability in patients with multiple sclerosis; to investigate the existence of critical values of both disability and functional connectivity corresponding to exhaustion of functional adaptive mechanisms. METHODS:Hundred-and-nineteen pat...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9075-5
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Myelin oligodendrocyte glycoprotein immunoglobulin G associated optic neuritis (MOG-ON) is a recently described entity. Recent studies have shown that MOG-ON has a more severe clinical presentation than classic optic neuritis (ON). OBJECTIVE:This study aimed to define morphological characteristics of MOG-ON...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10097-x
更新日期:2021-01-01 00:00:00
abstract::Mutations in the mitofusin 2 (MFN2) gene are a major cause of primary axonal Charcot- Marie-Tooth (CMT) neuropathy. This study aims at further characterization of cerebral white matter alterations observed in patients with MFN2 mutations. Molecular genetic, magnetic resonance imaging (MRI), magnetic resonance spectros...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0847-1
更新日期:2008-07-01 00:00:00
abstract::Acanthocytosis occurs because of ultrastructural abnormalities of the erythrocyte membranous skeleton resulting in reduced membrane fluidity. At least three hereditary neurological conditions are associated with it, although as yet the pathogenesis of the neurological features is unknown. In abetalipoproteinaemia, an ...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s004150170241
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence and characteristics of the cricopharyngeal bar (CPB), defined as marked protrusion with lacking relaxation and stricture of the upper esophageal sphincter on videofluoroscopy, in patients with inclusion body myositis (IBM). METHODS:We conducted a case-control study of comprehensiv...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10241-7
更新日期:2020-09-26 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS), which is the most serious form of degenerative motor neuron disease in adults, is characterized by upper and lower motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Some patients with respiratory-dependent ALS die of sudden cardiac arrest or anoxic encephalo...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7005-0
更新日期:2013-09-01 00:00:00
abstract::Weight loss is a common symptom of Parkinson's disease and is associated with impaired quality of life. Predictors of weight loss have not been studied in large clinical cohorts. We previously observed an association between change in body mass index and change in Unified Parkinson's Disease Rating Scale (UPDRS) motor...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00415-017-8562-4
更新日期:2017-08-01 00:00:00
abstract::From a family with essential familial myoclonus, 150 members in eight generations were studied. Twenty-five of them suffered from myoclonus of varying severity. The findings in routine examinations of blood, urine and cerebrospinal fluid, EEG and skull radiographs were normal. Therapeutic trials did not produce lastin...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313626
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Nusinersen recently became available as the first treatment for Spinal Muscular Atrophy (SMA) and data on its effectiveness and safety in adult SMA patients are still scarce. METHODS:We evaluated the effectiveness and safety of nusinersen treatment during 14 months in 16 adult patients with SMA types 3 and ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10223-9
更新日期:2020-09-15 00:00:00
abstract::In this review, we describe the wide clinical spectrum of features that can be seen in multiple system atrophy (MSA) with a focus on the premotor phase and the non-motor symptoms providing an up-to-date overview of the current understanding in this fast-growing field. First, we highlight the non-motor features at dise...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09881-6
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Parkinson's disease (PD) reduces independence and quality of life through deterioration of upper limb motor function. Transcranial direct current stimulation (tDCS) may offer an alternative, adjunctive therapy for PD. However, the efficacy of tDCS for upper limb motor rehabilitation in PD is unkn...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-019-09385-y
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Anti-myelin oligodendrocyte glycoprotein antibodies (anti-MOG), directed against a component of the myelin sheath, are sometimes detected in the blood or cerebrospinal fluid (CSF) of patients with acute demyelinating conditions. Cortical encephalitic presentations in anti-MOG-antibody-positive patients are reco...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10260-4
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:Rapid eye movement sleep behavior disorder (RBD) is highly comorbid with Parkinson's disease (PD). Emerging evidence suggests that dopamine-replacement therapies (DRTs) for PD may modify the course of RBD, yet the nature of the association between DRTs and RBD remains unclear. To begin addressing this issue,...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09956-4
更新日期:2020-10-01 00:00:00
abstract::The effect of furosemide (Lasix) therapy on a standardized experimental cerebral edema, induced in rats by applying a cooling stamp to the right side of the skull over the right coronal suture by means of a stereotactic instrument, was examined. The hemispherically separated water and electrolyte contents of the brain...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00705536
更新日期:1979-05-02 00:00:00
abstract::A case of CT-diagnosed brain-stem haematoma associated with signs of dorsal medullary involvement is reported. The patient recovered completely within 1 month. ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313834
更新日期:1985-01-01 00:00:00
abstract::In all the sera of four patients with meningoradiculitis of Bannwarth admitted to the neurological department of the University Clinic Grosshadern in Munich in 1983, we found antibodies against Ixodes dammini spirochetes. In three patients antibodies were also present in the CSF. In one patient, we isolated spirochete...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313682
更新日期:1984-01-01 00:00:00
abstract::X-linked adrenoleukodystrophy (XALD), a neurological disorder caused by mutations in the peroxisomal membrane protein gene ABCD1, presents as a rapidly progressing, inflammatory cerebral demyelination (cerebral cases) or a slowly progressing, distal axonopathy (non-cerebral cases). Specific ABCD1 defects do not explai...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6371-8
更新日期:2012-07-01 00:00:00
abstract::We report two adult Japanese sisters with L-2-hydroxy-glutaric aciduria (acidemia), both of whom were much older (aged 57, 47 years old) than previously reported patients (from neonate to 44 years old), and who presented with differing severity. Magnetic resonance imaging revealed typical subcortical white matter lesi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050367
更新日期:1999-05-01 00:00:00
abstract::Neurological complications in the acquired immunodeficiency syndrome (AIDS) are an important aspect of this new infectious disease and occur frequently. The existence of neurotropic variants of the human immunodeficiency virus (HIV), the causative agent of AIDS, is probable. Direct infection of the nervous system with...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00314279
更新日期:1987-06-01 00:00:00
abstract::Continuous intrathecal administration of baclofen with implanted programmable pump systems is recommended in the treatment of severe spasticity of cerebral origin. Prior to pump implantation, a baclofen bolus test (BBT) is used to assess the effectiveness of intrathecal baclofen using the modified Ashworth Scale (MAS)...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-002-0825-y
更新日期:2002-09-01 00:00:00