Association between dopaminergic medications and REM sleep behavior disorder in Parkinson's disease: a preliminary cohort study.

Abstract:

BACKGROUND:Rapid eye movement sleep behavior disorder (RBD) is highly comorbid with Parkinson's disease (PD). Emerging evidence suggests that dopamine-replacement therapies (DRTs) for PD may modify the course of RBD, yet the nature of the association between DRTs and RBD remains unclear. To begin addressing this issue, we conducted a preliminary retrospective study to document whether DRTs are associated with the occurrence of RBD symptoms in PD patients. METHODS:The study included 250 PD patients who were screened for probable RBD via the RBD Screening Questionnaire (RBDSQ). For each patient, disease severity data were collected, in addition to their therapy and the associated levodopa equivalent daily dose (LEDD). The association between DRTs and RBDSQ scores was analyzed using logistic regression and correlation models. RESULTS:RBD scores were found to be associated with the LEDD of levodopa alone, but not of dopaminergic agonists (mainly D2/D3 receptor agonists) or their combination with levodopa. This association was not accounted for patient age or Hoehn and Yahr (H&Y) severity scores. CONCLUSIONS:Our study detected a significant association between doses of levodopa and RBD symptoms in PD patients. Future longitudinal studies are needed to establish what causal nexus may link these variables.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Meloni M,Bortolato M,Cannas A,Laccu I,Figorilli M,Congiu P,Defazio G,Meloni F,Puligheddu M

doi

10.1007/s00415-020-09956-4

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

2926-2931

issue

10

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-020-09956-4

journal_volume

267

pub_type

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