Abstract:
:A 40-year-old man suffered for 5 years from a progressive proximal myopathy mimicking an atypical limb-girdle dystrophy. A "myopathic" pattern with myotonic and pseudomyotonic discharges was determined by electromyography. Enzyme histochemical and ultrastructural investigations of muscle and liver biopsies pointed to a glycogenosis. Biochemical investigations of muscle and liver samples confirmed this diagnosis, disclosing an acid maltase deficiency. Glycogen filled lysosomes were also revealed electron optically in skin fibroblasts but not in white blood cells. The literature concerning the late onset forms of acid maltase deficiency (type II glycogenosis) has been reviewed, and the clinical course has been compared with that of the infantile form (Pompe's disease). In early infancy the disease has a short and fatal course, with involvement of many organs. primarily skeletal muscules, liver and heart. In the late infantile and juvenile forms the course of the disease is slower, the organ involvement beeing not as severe; muscular symptoms begin to prevail. In adults, type II glycogenosis mimics muscular dystrophy with its prolonged course and the almost exclusive clinical involvement of proximal muscles. Biochemical and ultrastructural investigations have nevertheless demonstrated that other organs and tissues are also involved. The reasons for the variability of organ involvements in different ages are as yet unknown.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Gullotta F,Stefan H,Mattern Hdoi
10.1007/BF00312870subject
Has Abstractpub_date
1976-01-01 00:00:00pages
199-216issue
3eissn
0340-5354issn
1432-1459journal_volume
213pub_type
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-015-7925-y
更新日期:2016-01-01 00:00:00
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journal_title:Journal of neurology
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journal_title:Journal of neurology
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journal_title:Journal of neurology
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journal_title:Journal of neurology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09593-6
更新日期:2020-02-01 00:00:00
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更新日期:2012-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-004-0449-5
更新日期:2004-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00869769
更新日期:1993-12-01 00:00:00
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journal_title:Journal of neurology
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journal_title:Journal of neurology
pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313641
更新日期:1983-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09786-4
更新日期:2020-07-01 00:00:00
abstract:: ...
journal_title:Journal of neurology
pub_type: 评论,杂志文章
doi:10.1007/s00415-018-9098-y
更新日期:2018-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09265-5
更新日期:2019-06-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313911
更新日期:1985-01-01 00:00:00