Abstract：
BACKGROUND:More research is needed to understand the contribution of comorbidities to MS symptomatology. OBJECTIVES:To examine the dose-response relationship between the number of comorbidities and severity of MS symptoms and to assess the relative contribution of comorbidity groups and individual comorbidities to the severity of each symptom. METHODS:We surveyed 1223 participants of the Australian MS Longitudinal Study for the presence of 30 comorbidities and the severity of 13 MS symptoms (0-10 scale). The associations between comorbidities and symptoms were assessed using negative binomial regression. The relative contributions of comorbidities to the severity of symptoms were assessed using general dominance analysis. RESULTS:Higher number of comorbidities was most strongly associated with a higher severity of pain and feelings of anxiety and depression (ratios of means ≥ 0.12 per comorbidity increase). Comorbidities explained between 3.7% (spasticity) and 22.0% (feelings of anxiety) of the total variance of symptom severity. Mental health and musculoskeletal disorders contributed most strongly to the severity of the most common symptoms in MS. CONCLUSIONS:Our findings support that early recognition and optimal management of comorbidities, particularly of mental health and musculoskeletal disorders, could have a positive impact on the severity of symptoms of people with MS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Lo LMP,Taylor BV,Winzenberg T,Palmer AJ,Blizzard L,van der Mei Idoi
10.1007/s00415-020-10192-zsubject
Has Abstractpub_date
2020-09-02 00:00:00eissn
0340-5354issn
1432-1459pii
10.1007/s00415-020-10192-zpub_type
杂志文章abstract：BACKGROUND AND PURPOSE:Protein Z (PZ), a vitamin Kdependent protein, plays a role in inhibiting coagulation. Its plasma level or PZ gene polymorphisms have been discussed as risk factors for stroke with conflicting results reported between various studies. Only one of these polymorphisms was studied in a cohort of pati...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0958-8
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:The symptomatic treatment of myotonia and myalgia in patients with dystrophic and non-dystrophic myotonias is often not satisfactory. Some patients anecdotally report symptoms' relief through consumption of cannabis. METHODS:A combination of cannabidiol and tetrahydrocannabinol (CBD/THC) was prescribed as c...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09593-6
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Nusinersen recently became available as the first treatment for Spinal Muscular Atrophy (SMA) and data on its effectiveness and safety in adult SMA patients are still scarce. METHODS:We evaluated the effectiveness and safety of nusinersen treatment during 14 months in 16 adult patients with SMA types 3 and ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10223-9
更新日期：2020-09-15 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09192-5
更新日期：2019-03-01 00:00:00
abstract：:The objective of this study was to investigate cognitive dysfunction in 24-60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00415-016-8345-3
更新日期：2017-08-01 00:00:00
abstract：:Focal transcranial magnetic stimulation (TMS) of the motor cortex was used to study excitatory and inhibitory stimulation effects in 25 patients with writer's cramp and 25 healthy volunteers. We investigated excitatory and inhibitory corticospinally mediated motor effects in muscles contralateral to the stimulation si...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170269
更新日期：2001-01-01 00:00:00
abstract：:Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) pr...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09689-z
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:Amyotrophic lateral sclerosis type 8 (ALS8) is a familial form of motor neuron disease, with predominance of lower motor neuron degeneration, and is caused by mutation of the vesicle-associated membrane protein-associated protein B (VAPB). We aimed to compare the cognitive profile of patients with ALS8 and he...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09369-y
更新日期：2019-08-01 00:00:00
abstract：:Four patients from three unrelated families, with clinical and electrophysiological findings compatible with the diagnosis of hereditary motor and sensory neuropathy, are presented. The molecular analysis showed that the affected individuals were homozygous for the mutation in the X25 gene, characteristic of Friedreic...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0902-2
更新日期：2002-11-01 00:00:00
abstract：:The effect of furosemide (Lasix) therapy on a standardized experimental cerebral edema, induced in rats by applying a cooling stamp to the right side of the skull over the right coronal suture by means of a stereotactic instrument, was examined. The hemispherically separated water and electrolyte contents of the brain...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00705536
更新日期：1979-05-02 00:00:00
abstract：:This article describes the clinical features of anterior semicircular canal benign paroxysmal positional vertigo (AC-BPPV) and a new therapeutic maneuver for its management. Our study was a retrospective review of cases from an ambulatory tertiary referral center. Thirteen patients afflicted with positional paroxysmal...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5208-1
更新日期：2009-11-01 00:00:00
abstract：:Multi-modality evoked potentials and computed cranial tomography (CT) were performed in ten patients with Wilson's disease to determine if any of these studies would correlate reliably with neurologic status. While all four patients with CT abnormality had neurologic signs, two additional patients with neurologic find...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314035
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:The significance of neutrophil-to-lymphocyte ratio (NLR) has been explored in different diseases. Few studies addressed its role in patients with multiple sclerosis (MS), with promising results regarding its association with disease activity or disability. OBJECTIVES:We aimed at confirming the role of NLR a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10322-7
更新日期：2021-01-03 00:00:00
abstract：:Recessive mutations in GJC2, the gene-encoding connexin 47 (Cx47), cause Pelizaeus-Merzbacher-like disease type 1, a severe dysmyelinating disorder. One recessive mutation (p.Ile33Met) has been associated with a much milder phenotype--hereditary spastic paraplegia type 44. Here, we present evidence that a novel Arg98L...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7429-1
更新日期：2014-10-01 00:00:00
abstract：:A rare form of plasma cell dyscrasia characterized by associated polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes has been termed the POEMS syndrome. The pathophysiology is unknown; plasma cell dyscrasia is essential; secondary manifestations are unexplained. We report a 67-year-old man with a ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00839213
更新日期：1992-01-01 00:00:00
abstract：:A myasthenia gravis (MG) patient who seems to have recovered can later have recurrence of myasthenic signs. Clearly clinical remission does not always correspond to the normalization of all the factors involved in the pathogenesis of the disease. In ten patients who had apparently recovered from MG, electromyographic ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313771
更新日期：1982-01-01 00:00:00
abstract：:Cerebral perfusion patterns in 18 cases with vascular dementia of Binswanger type (VDBT) (8 moderate and 10 severe cases) were compared with 25 cases with senile dementia of Alzheimer type (SDAT) (16 moderate and 9 severe cases) and 14 controls by single photon emission computed tomography using N-isopropyl-p-123I iod...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00319853
更新日期：1991-10-01 00:00:00
abstract：:Idiopathic intracranial hypertension is a neurological syndrome determined by a rise in intracranial pressure without a detectable cause. Course and prognosis may be changeable, requiring a multidisciplinary approach for its diagnosis and management. Although its precise pathogenesis is still unknown, many studies hav...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09943-9
更新日期：2020-05-27 00:00:00
abstract：:Polymerase chain reaction (PCR) based automated high-resolution fragment analysis of rearranged immunoglobulin heavy-chain genes is a highly sensitive means for identifying clonal B-cell responses. We used this technique to distinguish polyclonal inflammatory from monoclonal neoplastic B-cell populations in the cerebr...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170247
更新日期：2001-02-01 00:00:00
abstract：:SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute respiratory distress syndrome. Occurrence of acute and subacute neurological manifestations (encephalitis, stroke, headache, seizures, Guillain-Barrè syn...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-10131-y
更新日期：2020-08-27 00:00:00
abstract：OBJECTIVE:Widespread metabolic changes are seen in neurodegenerative disease and could be used as biomarkers for diagnosis and disease monitoring. They may also reveal disease mechanisms that could be a target for therapy. In this study we looked for blood-based biomarkers in syndromes associated with frontotemporal lo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09824-1
更新日期：2020-08-01 00:00:00
abstract：:Evoked urethral and anal responses are produced by electrical stimulation of penis, bladder neck and anus. Latency and duration of the responses after bladder neck and anal stimulation are greatly dependent on stimulus parameters, suggesting a polysynaptic reflex; penile stimulation probably involves an oligosynaptic ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313567
更新日期：1982-01-01 00:00:00
abstract：:The pathogenesis of myopathies occurring in critically ill patients (critical illness myopathy, CIM) is poorly understood. Both local and systemic responses to sepsis and other severe insults to the body are presumed to be involved but the precise mechanisms by which muscle function is impaired are far from clear. To ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-0272-z
更新日期：2004-01-01 00:00:00
abstract：:Muscle glucose-6-phosphate dehydrogenase (G6PD) deficiency is described in four clinically heterogeneous patients: an athlete who developed myoglobinuria after physical exercise; a 7-year-old, mildly mentally retarded boy, who had episodes of dark urine and high creatine kinase; and two brothers of Sardinian origin, t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314498
更新日期：1989-05-01 00:00:00
abstract：:We studied the diagnostic value of computed tomographic angiography (CTA) in the posterior circulation as a noninvasive substitute for intra-arterial digital subtraction angiography (DSA). We prospectively investigated 103 patients with acute stroke in the posterior circulation. All patients underwent CTA and Doppler ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150070089
更新日期：2000-10-01 00:00:00
abstract：:Little is known about the pattern of subacute cognitive domain impairments after ischaemic stroke, nor the temporal evolution of such impairments. Our objective was to investigate the pattern of cognitive impairment in different neuropsychological domains up to a year after ischaemic stroke. We included prospectively ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6625-0
更新日期：2013-01-01 00:00:00
abstract：:There is still uncertainty regarding risk factors for cancer occurrence in patients with myasthenia gravis (MG). The objective of this study is to determine the prevalence of extrathymic neoplasms in patients with MG and the factors associated with tumor occurrence. The archives of four tertiary MG centers were consul...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5091-9
更新日期：2009-08-01 00:00:00
abstract：:Magnetisation transfer (MT) imaging provides indirect information on tissue structure abnormalities in areas that otherwise may appear normal on conventional MRI. We determined the evolution of MT changes in normal appearing white matter (NAWM) and lesion on serial examination of 9 multiple sclerosis (MS) patients and...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1115-z
更新日期：2003-08-01 00:00:00
abstract：:Cerebellar ataxia can have many genetic causes among which are the congenital disorders of glycosylation type I (CDG-I). In this group of disorders, a multisystem phenotype is generally observed including the involvement of many organs, the endocrine, hematologic and central nervous systems. A few cases of CDG-Ia have...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-0546-3
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Dysarthria may be classified as flaccid, spastic, ataxic, hypokinetic, choreatic, dystonic, or mixed. We hypothesized that in routine neurological practice the reliability and accuracy of perceptual analysis alone in the classification of dysarthria is low and that this classification is mainly based on the ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0978-4
更新日期：2008-10-01 00:00:00
