Accuracy and inter-observer variation in the classification of dysarthria from speech recordings.

Abstract:

BACKGROUND:Dysarthria may be classified as flaccid, spastic, ataxic, hypokinetic, choreatic, dystonic, or mixed. We hypothesized that in routine neurological practice the reliability and accuracy of perceptual analysis alone in the classification of dysarthria is low and that this classification is mainly based on the clinical context rather than on the perception of speech. We therefore studied the accuracy and the inter- observer agreement in the classification of dysarthrias on the basis of perceptual analysis alone. METHODS:Seventy two neurologists and neurological trainees classified recorded speech samples of 100 patients as flaccid, spastic, ataxic, extrapyramidal, or mixed dysarthria, or as not dysarthric. All observers were blinded to the patients' final diagnosis, which was based on all clinical features and investigations. In the analysis the observers were arranged in eight groups of nine observers, or four paired groups with similar levels of clinical experience. Together, the observers in a given group rated all 100 recordings. RESULTS:The accuracy of the classification was poor (35 % were classified correctly) and the inter-observer agreement between paired groups low (kappa 0.16 to 0.32). The level of experience in neurology did not have a significant influence. CONCLUSION:Neurological trainees as well as experienced neurologists have great difficulty in identifying specific types of dysarthria on the basis of perceptual analysis alone. In clinical practice this probably means that most neurologists will classify dysarthria in the context of other features from neurological examination or ancillary investigations.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Fonville S,van der Worp HB,Maat P,Aldenhoven M,Algra A,van Gijn J

doi

10.1007/s00415-008-0978-4

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1545-8

issue

10

eissn

0340-5354

issn

1432-1459

journal_volume

255

pub_type

杂志文章
  • A service development study of the assessment and management of fracture risk in Parkinson's disease.

    abstract::Parkinson's disease (PD) is associated with an increased risk of fragility fracture. FRAX and Qfracture are risk calculators that estimate the 10-year risk of hip and major fractures and guide definitive investigation for osteoporosis using dual X-ray absorptiometry (DEXA) imaging. It is unclear which PD patients shou...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7333-8

    authors: Shribman S,Torsney KM,Noyce AJ,Giovannoni G,Fearnley J,Dobson R

    更新日期:2014-06-01 00:00:00

  • Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.

    abstract::It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative diseases, particularly the fact that ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-015-7682-y

    authors: Josephs KA

    更新日期:2015-03-01 00:00:00

  • Progression of sleep disturbances in Parkinson's disease: a 5-year longitudinal study.

    abstract:BACKGROUND:Sleep disorders can occur in early Parkinson's disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. OBJECTIVE:To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia,...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10140-x

    authors: Xu Z,Anderson KN,Saffari SE,Lawson RA,Chaudhuri KR,Brooks D,Pavese N

    更新日期:2021-01-01 00:00:00

  • Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75.

    abstract::Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this diagnosis initially se...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-015-7766-8

    authors: Krumbholz M,Hofstadt-van Oy U,Angstwurm K,Kleiter I,Jarius S,Paul F,Aktas O,Buchholz G,Kern P,Straube A,Kümpfel T

    更新日期:2015-05-01 00:00:00

  • Amyotrophic lateral sclerosis: early predictors of prolonged survival.

    abstract:OBJECTIVE:In order to define the predictors of prolonged survival available at the time of first examination we performed a historical cohort study of amyotrophis sclerosis (ALS) patients referred to our ALS Clinic over the last 20 years. METHODS:In a group of 1034 patients with the diagnosis of definite or probable A...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0226-8

    authors: Czaplinski A,Yen AA,Appel SH

    更新日期:2006-11-01 00:00:00

  • Three-dimensional topographic analysis of spinal accessory motoneurons under chronic mechanical compression: an experimental study in the mouse.

    abstract::We investigated the effect of chronic mechanical compression of the cervical spinal cord on the number of spinal accessory motoneurons in 25 tiptoe-walking Yoshimura mice. The animals had calcified deposits in the atlantoaxial membrane at the C1-C2 vertebral level, compressing the spinal cord posterolaterally. Motoneu...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150050076

    authors: Baba H,Maezawa Y,Uchida K,Imura S,Kawahara N,Tomita K,Kudo M

    更新日期:1997-04-01 00:00:00

  • Electrophysiological diagnosis of motor neuron disease and pure motor neuropathy.

    abstract::Motor neuron disease (MND) is a group of disorders in which there is degeneration of upper and lower motor neurons to a variable degree. Amyotrophic lateral sclerosis is the most frequent form of the disease, presenting with both upper and lower motor neuron involvement. Frequently, especially in the early stages of t...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s004150050397

    authors: Bouche P,Le Forestier N,Maisonobe T,Fournier E,Willer JC

    更新日期:1999-07-01 00:00:00

  • [The occurrence of diabetes mellitus, diabetes insipidus, optic atrophy and neurogenic deafness in one patient (author's transl)].

    abstract::Report of a further case with coexisting diabetes mellitus, diabetes insipidus, optic atrophy und neurogenic deafness. It was not possible to find a cause for these symptoms. The cases reported in the literature are brought together and discussed. ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314325

    authors: Foerster K,Spranger J,Beyer J,Regli F

    更新日期:1975-08-04 00:00:00

  • Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-P.

    abstract::We investigated the visual event-related potentials (ERPs) in two subtypes of multisystem atrophy (MSA) in 15 MSA-C patients, 12 MSA-P patients, and 21 normal control (NC) subjects. We used a visual oddball task to elicit ERPs. No significant changes were seen in N1 or N2 latency, in either MSA-C or MSA-P, compared wi...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-002-0764-7

    authors: Kamitani T,Kuroiwa Y,Wang L,Li M,Suzuki Y,Takahashi T,Ikegami T,Matsubara S

    更新日期:2002-08-01 00:00:00

  • Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures.

    abstract::The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assesse...

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00415-017-8618-5

    authors: Villanueva V,Holtkamp M,Delanty N,Rodriguez-Uranga J,McMurray R,Santagueda P

    更新日期:2017-11-01 00:00:00

  • Art and Parkinson's disease: a dramatic change in an artist's style as an initial symptom.

    abstract::In Parkinson's disease (PD), nonmotor symptoms manifest before motor symptoms. In this report, we present a remarkable case of a semiprofessional painter with PD whose painting style dramatically changed from abstract painting to realism before he developed motor, psychiatric, and autonomic nerve disorders. This case ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-011-6271-y

    authors: Shimura H,Tanaka R,Urabe T,Tanaka S,Hattori N

    更新日期:2012-05-01 00:00:00

  • Effect of furosemide (lasix) on acute severe experimental cerebral edema.

    abstract::The effect of furosemide (Lasix) therapy on a standardized experimental cerebral edema, induced in rats by applying a cooling stamp to the right side of the skull over the right coronal suture by means of a stereotactic instrument, was examined. The hemispherically separated water and electrolyte contents of the brain...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00705536

    authors: Gaab M,Knoblich OE,Schupp J,Herrmann F,Fuhrmeister U,Pflughaupt KW

    更新日期:1979-05-02 00:00:00

  • Posterior reversible encephalopathy syndrome.

    abstract::The posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of (sub)acute onset characterized by varied neurological symptoms, which may include headache, impaired visual acuity or visual field deficits, disorders of consciousness, confusion, seizures, and focal neurological deficits. In a major...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-016-8377-8

    authors: Fischer M,Schmutzhard E

    更新日期:2017-08-01 00:00:00

  • Searching for prognostic variables for secondary worsening after ischaemic stroke.

    abstract::Secondary worsening of stroke symptoms is described in 13-37% of stroke patients, but the exact mechanism of this phenomenon remains unclear. The aim of this study is to find prognostic variables in correlation to secondary worsening of stroke symptoms in patients with lacunar or cortical strokes. In this prospective ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-010-5577-5

    authors: Schweitzer JR,Koehler PJ,Voogd AC,Franke CL

    更新日期:2010-09-01 00:00:00

  • Long-term outcomes of refractory neurosarcoidosis treated with infliximab.

    abstract::Central nervous system localizations of sarcoidosis may be refractory to conventional treatment such as steroids and immunosuppressive drugs. Infliximab, a TNF-α antagonist chimeric antibody, has been shown to be effective for treatment of these localizations. The aim of this study was to evaluate the efficacy and saf...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-017-8444-9

    authors: Cohen Aubart F,Bouvry D,Galanaud D,Dehais C,Mathey G,Psimaras D,Haroche J,Pottier C,Hie M,Mathian A,Devilliers H,Nunes H,Valeyre D,Amoura Z

    更新日期:2017-05-01 00:00:00

  • What is pathological with gaze shift fragmentation in Parkinson's disease?

    abstract::Oculomotor dysfunction in Parkinson's disease (PD) is mainly characterized by a fragmentation of memory-guided gaze shifts (target is reached by several hypometric saccades). Since this phenomenon can also be observed in normal subjects, we scrutinized its pathophysiological significance in PD patients. We recorded ho...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-002-0691-7

    authors: Kimmig H,Haussmann K,Mergner T,Lücking CH

    更新日期:2002-06-01 00:00:00

  • Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

    abstract::Recent studies have shown that cerebrospinal fluid (CSF) levels of α-synuclein (α-syn) are highly elevated in patients with Creutzfeldt-Jakob disease (CJD) compared to controls. However, the diagnostic value of CSF α-syn in CJD has not been established. To confirm whether CSF α-syn is increased in CJD and is a useful ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7334-7

    authors: Kasai T,Tokuda T,Ishii R,Ishigami N,Tsuboi Y,Nakagawa M,Mizuno T,El-Agnaf OM

    更新日期:2014-06-01 00:00:00

  • The dynamics of multiple sclerosis. The Charcot Lecture.

    abstract::The history of our understanding of the pathogenesis and pathophysiology of multiple sclerosis are reviewed in the context of Charcot's contribution. The implications for treatment of the new knowledge gained from studies during life of pathology and pathogenesis (by MRI) and pathophysiology (by evoked potentials) are...

    journal_title:Journal of neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/BF00838443

    authors: McDonald WI

    更新日期:1993-01-01 00:00:00

  • Accepting or declining non-invasive ventilation or gastrostomy in amyotrophic lateral sclerosis: patients' perspectives.

    abstract::The objective was to identify factors associated with decisions made by patients with amyotrophic lateral sclerosis (ALS) to accept or decline non-invasive ventilation (NIV) and/or gastrostomy in a prospective population-based study. Twenty-one people with ALS, recruited from the South-East ALS Register who made an in...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-015-7665-z

    authors: Greenaway LP,Martin NH,Lawrence V,Janssen A,Al-Chalabi A,Leigh PN,Goldstein LH

    更新日期:2015-01-01 00:00:00

  • Congenital isolated hemifacial hyperplasia.

    abstract::We report on a 14-year-old boy with congenital isolated hemifacial hyperplasia. Hemifacial hypertrophy most likely represents a minor form of congenital hemihypertrophy. MRI of the soft tissue is particularly suitable to support the diagnosis and reveal associated bony asymmetries. ...

    journal_title:Journal of neurology

    pub_type: 信件

    doi:10.1007/s00415-009-5148-9

    authors: Urban PP,Bruening R

    更新日期:2009-09-01 00:00:00

  • Smile-wink phenomenon: aggravated narrowing of palpebral fissure by smiling after lenticulocapsular stroke.

    abstract::Five patients are described who developed unilateral narrowing of the palpebral fissure that was aggravated by smiling. They had ischaemic lesions involving mainly the contralateral lenticulocapsular area. This rare but distinct symptom may be an action induced focal eyelid dystonia, and could be described as'smile-wi...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150170179

    authors: Kim JS

    更新日期:2001-05-01 00:00:00

  • Cricopharyngeal bar on videofluoroscopy: high specificity for inclusion body myositis.

    abstract:OBJECTIVE:To determine the prevalence and characteristics of the cricopharyngeal bar (CPB), defined as marked protrusion with lacking relaxation and stricture of the upper esophageal sphincter on videofluoroscopy, in patients with inclusion body myositis (IBM). METHODS:We conducted a case-control study of comprehensiv...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10241-7

    authors: Taira K,Yamamoto T,Mori-Yoshimura M,Sajima K,Takizawa H,Shinmi J,Oya Y,Nishino I,Takahashi Y

    更新日期:2020-09-26 00:00:00

  • Transcortical sensory aphasia following left frontal infarction.

    abstract::Two right-handed patients who exhibited language disability after left frontal infarction are described. The patients spoke fluently and exhibited excellent repetition ability from the onset of infarction without exhibiting any oral apraxia, but had deficits in auditory comprehension, naming, reading and writing. In b...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150050180

    authors: Otsuki M,Soma Y,Koyama A,Yoshimura N,Furukawa H,Tsuji S

    更新日期:1998-02-01 00:00:00

  • Relationship between cortex and pulvinar abnormalities on diffusion-weighted imaging in status epilepticus.

    abstract::The aim of this study was to analyze the pattern of magnetic resonance diffusion-weighted imaging (DWI) findings in status epilepticus in terms of clinical characteristics. Participants comprised 106 patients with status epilepticus who were admitted to our hospital and underwent DWI. Forty-five patients (42.5 %) show...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-015-7948-4

    authors: Nakae Y,Kudo Y,Yamamoto R,Dobashi Y,Kawabata Y,Ikeda S,Yokoyama M,Higashiyama Y,Doi H,Johkura K,Tanaka F

    更新日期:2016-01-01 00:00:00

  • Neopterin concentrations in serum and cerebrospinal fluid in HTLV-I infected individuals.

    abstract::The concentration of neopterin was measured in serum samples taken from individuals infected with HTLV-I: 5 from asymptomatic individuals, 1 from a patient with adult T-cell leukaemia and 30 from patients with tropical spastic paraparesis (TSP). In addition, cerebrospinal fluid (CSF) was available from 22 of the TSP p...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00810351

    authors: Ali A,Rudge P,Dalgleish AG

    更新日期:1992-05-01 00:00:00

  • Botulinum toxin in multiple sclerosis.

    abstract::Local administration of botulinum toxin (BoTx) inhibits presynaptic acetylcholine release. All cholinergically innervated muscles and glands can be paralyzed accordingly. Studies on the application of BoTx in multiple sclerosis have shown good results for focal spasticity, in particular, of the extremities. The first ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-006-1104-0

    authors: Jost WH

    更新日期:2006-02-01 00:00:00

  • Platelet-derived extracellular vesicles in Huntington's disease.

    abstract::The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently dem...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-018-9022-5

    authors: Denis HL,Lamontagne-Proulx J,St-Amour I,Mason SL,Weiss A,Chouinard S,Barker RA,Boilard E,Cicchetti F

    更新日期:2018-11-01 00:00:00

  • Distinct neuromuscular phenotypes in myotonic dystrophy types 1 and 2 : a whole body highfield MRI study.

    abstract::Myotonic Dystrophy Type 1 (DM1) and 2 (DM2) present with distinct though overlapping clinical phenotypes. Comparative imaging data on skeletal muscle involvement are not at present available. We used the novel technique of whole body 3.0 Tesla (T) Magnetic Resonance Imaging (MRI) to further characterize musculoskeleta...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0111-5

    authors: Kornblum C,Lutterbey G,Bogdanow M,Kesper K,Schild H,Schröder R,Wattjes MP

    更新日期:2006-06-01 00:00:00

  • Neurological involvement of coronavirus disease 2019: a systematic review.

    abstract:BACKGROUND:In December 2019, unexplained cases of pneumonia emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease 2019 (COVID-2019) outbreak, a pandemic. OBJECTIVE:To clarify the neurological complications of SARS-CoV-...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-09990-2

    authors: Ghannam M,Alshaer Q,Al-Chalabi M,Zakarna L,Robertson J,Manousakis G

    更新日期:2020-11-01 00:00:00

  • Spinal cord atrophy in spinocerebellar ataxia type 3 and 6 : impact on clinical disability.

    abstract:OBJECTIVE:To quantify spinal cord atrophy and its impact on clinical disability in spinocerebellar ataxia (SCA) type 3 and 6. METHODS:Atrophy of the upper spinal cord was assessed by high resolution T1-weighted MRI of patients with SCA3 (n = 14) and SCA6 (n = 10). Furthermore, two groups of age- and sex-matched health...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-008-0907-6

    authors: Lukas C,Hahn HK,Bellenberg B,Hellwig K,Globas C,Schimrigk SK,Köster O,Schöls L

    更新日期:2008-08-01 00:00:00