Relationship between cortex and pulvinar abnormalities on diffusion-weighted imaging in status epilepticus.


:The aim of this study was to analyze the pattern of magnetic resonance diffusion-weighted imaging (DWI) findings in status epilepticus in terms of clinical characteristics. Participants comprised 106 patients with status epilepticus who were admitted to our hospital and underwent DWI. Forty-five patients (42.5 %) showed abnormal findings on DWI and were divided into two groups, comprising 26 patients (24.5 %) with cortex lesions alone and 19 patients (17.9 %) with cortex and pulvinar lesions in the same hemisphere. A long duration of status epilepticus (>120 min) tended to be more prevalent among patients with cortex and pulvinar lesions (57.9 %) than among patients with cortex lesions alone (30.8 %) by univariate and multivariate analyses. Todd's palsy tended to be more frequent in patients with abnormalities on DWI (24/45, 53.3 %) than in patients with normal DWI (21/61, 34.4 %). Six of the 26 patients with cortex lesions alone (23.1 %) had taken anti-epileptic drugs before the attack compared to none of the 19 patients with both cortex and pulvinar lesions. The trend toward a longer duration of status epilepticus in patients with both cortex and pulvinar lesions favors a spreading pattern of seizure discharge from cortex to pulvinar via cortico-pulvinar pathways, and anti-epileptic drugs might, to some extent, prevent spreading of seizure discharge from cortex to pulvinar. In addition, existence of high-intensity areas on DWI at the onset of epilepsy may be a predictive factor for the occurrence of Todd's palsy.


J Neurol


Journal of neurology


Nakae Y,Kudo Y,Yamamoto R,Dobashi Y,Kawabata Y,Ikeda S,Yokoyama M,Higashiyama Y,Doi H,Johkura K,Tanaka F




Has Abstract


2016-01-01 00:00:00














  • Verbal laterality and handedness in patients with intracranial arachnoid cysts.

    abstract::Left-handedness is most often genetic, but may also follow early, localised damage to the developing brain. This so-called "pathological" left-handedness syndrome is often associated with right hemisphere speech dominance. To find out whether verbal laterality or handedness were affected by congenital, intracranial ar...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Wester K,Hugdahl K

    更新日期:2003-01-01 00:00:00

  • Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

    abstract::Recent studies have shown that cerebrospinal fluid (CSF) levels of α-synuclein (α-syn) are highly elevated in patients with Creutzfeldt-Jakob disease (CJD) compared to controls. However, the diagnostic value of CSF α-syn in CJD has not been established. To confirm whether CSF α-syn is increased in CJD and is a useful ...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Kasai T,Tokuda T,Ishii R,Ishigami N,Tsuboi Y,Nakagawa M,Mizuno T,El-Agnaf OM

    更新日期:2014-06-01 00:00:00

  • Association between polymorphism in the promoter region of Interleukin 6 (-174 G/C) and risk of Alzheimer's disease: a meta-analysis.

    abstract::Studies of the relationship between Alzheimer's disease (AD) and polymorphism in the promoter region of Interleukin 6 (IL-6) -174 G/C have reported inconsistent results. To assess the association between IL-6 -174 G/C promoter polymorphism and AD risk, a meta-analysis containing 3,101 AD cases and 3,860 controls from ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,meta分析,评审


    authors: Dai L,Liu D,Guo H,Wang Y,Bai Y

    更新日期:2012-03-01 00:00:00

  • Pharmacokinetics of total and free valproic acid during monotherapy in infants.

    abstract::The pharmacokinetics of free and total valproic acid (VPA) in plasma and whole blood after oral administration during steady state was investigated in seven infants (mean age 10.7 months) receiving monotherapy. The VPA concentrations in whole blood closely followed those in plasma but at a reduced level. A positive co...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Herngren L,Lundberg B,Nergårdh A

    更新日期:1991-09-01 00:00:00

  • Longitudinal evaluation of quality of life in 288 patients with neurofibromatosis 2.

    abstract::Advances in molecular biology have resulted in novel therapy for neurofibromatosis 2-related (NF2) tumours, highlighting the need for robust outcome measures. The disease-focused NF2 impact on quality of life (NFTI-QOL) patient questionnaire was assessed as an outcome measure for treatment in a multi-centre study. NFT...

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究


    authors: Ferner RE,Shaw A,Evans DG,McAleer D,Halliday D,Parry A,Raymond FL,Durie-Gair J,Hanemann CO,Hornigold R,Axon P,Golding JF

    更新日期:2014-05-01 00:00:00

  • Engineering cells to secrete growth factors.

    abstract::The neutrotrophins stimulate survival and differentiation of a range of target neurons. A wealth of evidence suggests that central cholinergic neurons depend on nerve growth factor (NGF) for trophic support. Grafts of NGF-producing cells rescue axotomized basal forebrain cholinergic neurons and reduce cholinergic cell...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Ebendal T,Lönnerberg P,Pei G,Kylberg A,Kullander K,Persson H,Olson L

    更新日期:1994-12-01 00:00:00

  • An unusual association of dentato-rubral degeneration with spinal ataxia, ophthalmoplegia and multiple cranial nerve palsies.

    abstract::Clinical and neuropathological data of a 50-year-old woman with an unusual multisystem degeneration are presented. Clinically the illness was characterized by progressive ataxia with ophthalmoplegia and multiple cranial nerve palsies. Neuropathological investigation showed a severe and selective degeneration of the de...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Janzer RC,Barontini F

    更新日期:1985-01-01 00:00:00

  • Fasciculations and cramps: how benign? Report of four cases progressing to ALS.

    abstract::Clinical diagnosis of amyotrophic lateral sclerosis (ALS) in patients presenting with cramps and fasciculations may not be evident at the first consultation. Sequential reviews, clinical and neurophysiological, form an important part of clinical practice in such cases. Recent attempts to delineate a more benign group ...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Singh V,Gibson J,McLean B,Boggild M,Silver N,White R

    更新日期:2011-04-01 00:00:00

  • Correction to: The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland.

    abstract::The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran...

    journal_title:Journal of neurology

    pub_type: 已发布勘误


    authors: Glasmacher SA,Larraz J,Mehta AR,Kearns PKA,Wong M,Newton J,Davenport R,Gorrie G,Morrison I,Carod Artal J,Chandran S,Pal S,CARE-MND Consortium.

    更新日期:2020-10-20 00:00:00

  • Nusinersen treatment significantly improves hand grip strength, hand motor function and MRC sum scores in adult patients with spinal muscular atrophy types 3 and 4.

    abstract:BACKGROUND:Nusinersen recently became available as the first treatment for Spinal Muscular Atrophy (SMA) and data on its effectiveness and safety in adult SMA patients are still scarce. METHODS:We evaluated the effectiveness and safety of nusinersen treatment during 14 months in 16 adult patients with SMA types 3 and ...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: De Wel B,Goosens V,Sobota A,Van Camp E,Geukens E,Van Kerschaver G,Jagut M,Claes K,Claeys KG

    更新日期:2020-09-15 00:00:00

  • The value of CT in diagnosis and prognosis of different inborn neurodegenerative disorders in childhood.

    abstract::Inborn errors of metabolism in 40 children have been investigated by computed tomography to obtain data on the degree of cerebral involvement in neurodegenerative and storage disorders: 20 children had various mucopolysaccharidoses, 8 sphingolipidoses , 3 mucolipidoses, 2 oligosaccharidoses , 3 ceroidlipofuscinoses an...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Wende S,Ludwig B,Kishikawa T,Rochel M,Gehler J

    更新日期:1984-01-01 00:00:00

  • Dopamine D2 receptor binding and cerebral glucose metabolism recover after D-penicillamine-therapy in Wilson's disease.

    abstract::Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and 18F-deoxyglucose and 18F-methylspiperone ([18F]MSP), respectively. There was a severe re...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Schlaug G,Hefter H,Nebeling B,Engelbrecht V,Weiss P,Stöcklin G,Seitz RJ

    更新日期:1994-10-01 00:00:00

  • Primary DQ effect in the association between HLA and neurological syndromes with anti-GAD65 antibodies.

    abstract::The primary cause of neurological syndromes with antibodies against glutamic acid decarboxylase 65 (GAD65-Ab) is unknown, but genetic predisposition may exist as it is suggested by the co-occurrence in patients and their relatives of other organ-specific autoimmune diseases, notably type 1 diabetes mellitus (T1DM), an...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Muñiz-Castrillo S,Ambati A,Dubois V,Vogrig A,Joubert B,Rogemond V,Picard G,Lin L,Fabien N,Mignot E,Honnorat J

    更新日期:2020-07-01 00:00:00

  • Is screening for urinary porphobilinogen useful among patients with acute polyneuropathy or encephalopathy?

    abstract::Acute porphyrias are a group of inherited metabolic disorders representing overproduction syndromes with the formation of neurotoxic haem precursors. Clinical manifestations consist of acute attacks, which include abdominal pain, dysautonomia, mental symptoms, polyneuropathy and seizures mimicking many other acute neu...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Pischik E,Kazakov V,Kauppinen R

    更新日期:2008-07-01 00:00:00

  • Fatigue and magnetic resonance imaging activity in multiple sclerosis.

    abstract::Fatigue is a frequent and often severe symptom in multiple sclerosis. Pathogenic mechanisms proposed for fatigue include the release of proinflammatory cytokines, which is thought to have an important effect on changes in the blood-brain barrier (BBB). To investigate whether fatigue is related to BBB disruption we stu...

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究


    authors: Mainero C,Faroni J,Gasperini C,Filippi M,Giugni E,Ciccarelli O,Rovaris M,Bastianello S,Comi G,Pozzilli C

    更新日期:1999-06-01 00:00:00

  • Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic Parkinson's disease from those with striatonigral degeneration.

    abstract::Multiple System Atrophy (MSA) and idiopathic Parkinson's disease (PD) can be difficult to distinguish. There is an ongoing debate about the diagnostic value of the growth-hormone response to clonidine (CGH-test) in PD and MSA. We investigated whether the CGH-test can identify individual patients in the early stages of...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Strijks E,van't Hof M,Sweep F,Lenders JW,Oyen WJ,Horstink MW

    更新日期:2002-09-01 00:00:00

  • A new mutation in GJC2 associated with subclinical leukodystrophy.

    abstract::Recessive mutations in GJC2, the gene-encoding connexin 47 (Cx47), cause Pelizaeus-Merzbacher-like disease type 1, a severe dysmyelinating disorder. One recessive mutation (p.Ile33Met) has been associated with a much milder phenotype--hereditary spastic paraplegia type 44. Here, we present evidence that a novel Arg98L...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Abrams CK,Scherer SS,Flores-Obando R,Freidin MM,Wong S,Lamantea E,Farina L,Scaioli V,Pareyson D,Salsano E

    更新日期:2014-10-01 00:00:00

  • Magnesium deficiency as a cause of acute intractable seizures.

    abstract::Clinical and experimental investigations have shown that magnesium depletion causes a marked irritability of the nervous system, eventually resulting in epileptic seizures. Although magnesium deficiency as a cause of epilepsy is uncommon, its recognition and correction may prove life-saving. Two case reports are prese...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Nuytten D,Van Hees J,Meulemans A,Carton H

    更新日期:1991-08-01 00:00:00

  • The MoSt Project--more steps in multiple sclerosis: a Delphi method consensus initiative for the evaluation of mobility management of MS patients in Italy.

    abstract::The aim of the study was to identify the main factors that impact mobility impairment in multiple sclerosis (MS) patients in Italy. Clinicians from a large number of Italian MS centers took part in a Delphi process aimed at obtaining consensus statements among the participants. Large consensus was obtained for stateme...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Capra R,Battaglia MA,Gaudioso A,Lopes L,Paolicelli D,Paoloni M,Pozzilli C,Santilli V,Solaro C,Trojano M

    更新日期:2014-03-01 00:00:00

  • Paroxysmal raised intracranial pressure associated with spinal meningeal cysts.

    abstract::Raised intracranial pressure in association with spinal meningeal cysts has rarely been reported. We describe four patients in whom evidence of paroxysmal raised intracranial pressure was found in association with spinal meningeal cysts. Cerebrospinal fluid diversion procedures have previously been shown to relieve lo...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Shams PN,Goadsby PJ,Crockard HA,Casey AT,Plant GT

    更新日期:2005-03-01 00:00:00

  • Epidemiology of paraneoplastic neurological syndromes: a population-based study.

    abstract:BACKGROUND:The epidemiology of paraneoplastic neurological syndromes (PNS) remains to be defined. We present here the first population-based incidence study and report the clinical spectrum and antibody profile of PNS in a large area in Northeastern Italy. METHODS:We performed a 9-year (2009-2017) population-based epi...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Vogrig A,Gigli GL,Segatti S,Corazza E,Marini A,Bernardini A,Valent F,Fabris M,Curcio F,Brigo F,Iacono D,Passadore P,Rana M,Honnorat J,Valente M

    更新日期:2020-01-01 00:00:00

  • Transcranial magnetic stimulation primes the effects of exercise therapy in multiple sclerosis.

    abstract::Exercise therapy (ET) can be beneficial in disabled multiple sclerosis (MS) patients. Intermittent transcranial magnetic theta burst stimulation (iTBS) induces long-term excitability changes of the cerebral cortex and may ameliorate spasticity in MS. We investigated whether the combination of iTBS and a program of ET ...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mori F,Ljoka C,Magni E,Codecà C,Kusayanagi H,Monteleone F,Sancesario A,Bernardi G,Koch G,Foti C,Centonze D

    更新日期:2011-07-01 00:00:00

  • Evaluation of the smooth pursuit tests in multiple sclerosis patients.

    abstract::In multiple sclerosis (MS), randomly located demyelination lesions may involve a large part of the central nervous system and disturb oculomotor activity, including impairment of saccadic and pursuit systems. The aim of the work was to determine the frequency of smooth pursuit disturbances in MS patients and assess th...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Jozefowicz-Korczynska M,Pajor AM

    更新日期:2011-10-01 00:00:00

  • Variants of windmill nystagmus.

    abstract::Windmill nystagmus is characterized by a clock-like rotation of the beating direction of a jerk nystagmus suggesting separate horizontal and vertical oscillators, usually 90° out of phase. We report oculographic characteristics in three patients with variants of windmill nystagmus in whom the common denominator was pr...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Choi KD,Shin HK,Kim JS,Kim SH,Choi JH,Kim HJ,Zee DS

    更新日期:2016-07-01 00:00:00

  • Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients.

    abstract::Patients in a minimally conscious state (MCS) show restricted signs of awareness but are unable to communicate. We assessed cerebral glucose metabolism in MCS patients and tested the hypothesis that this entity can be subcategorized into MCS- (i.e., patients only showing nonreflex behavior such as visual pursuit, loca...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Bruno MA,Majerus S,Boly M,Vanhaudenhuyse A,Schnakers C,Gosseries O,Boveroux P,Kirsch M,Demertzi A,Bernard C,Hustinx R,Moonen G,Laureys S

    更新日期:2012-06-01 00:00:00

  • Compound heterozygous PNPLA6 mutations cause Boucher-Neuhäuser syndrome with late-onset ataxia.

    abstract::PNPLA6 mutations, known to be associated with the development of motor neuron phenotypes, have recently been identified in families with Boucher-Neuhäuser syndrome. Boucher-Neuhäuser is a rare autosomal recessive syndrome characterized by the co-occurrence of cerebellar ataxia, hypogonadotropic hypogonadism, and chori...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Deik A,Johannes B,Rucker JC,Sánchez E,Brodie SE,Deegan E,Landy K,Kajiwara Y,Scelsa S,Saunders-Pullman R,Paisán-Ruiz C

    更新日期:2014-12-01 00:00:00

  • Apathy and the basal ganglia.

    abstract::We should like to emphasize the following points: 1. Apathy is defined here as a quantified and observable behavioral syndrome consisting in a quantitative reduction of voluntary (or goal-directed) behaviors; 2. Therefore, apathy occurs when the systems that generate and control voluntary actions are altered; 3. These...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Levy R,Czernecki V

    更新日期:2006-12-01 00:00:00

  • Neopterin concentrations in serum and cerebrospinal fluid in HTLV-I infected individuals.

    abstract::The concentration of neopterin was measured in serum samples taken from individuals infected with HTLV-I: 5 from asymptomatic individuals, 1 from a patient with adult T-cell leukaemia and 30 from patients with tropical spastic paraparesis (TSP). In addition, cerebrospinal fluid (CSF) was available from 22 of the TSP p...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Ali A,Rudge P,Dalgleish AG

    更新日期:1992-05-01 00:00:00

  • The effect of transcranial direct current stimulation on upper limb motor performance in Parkinson's disease: a systematic review.

    abstract:BACKGROUND AND PURPOSE:Parkinson's disease (PD) reduces independence and quality of life through deterioration of upper limb motor function. Transcranial direct current stimulation (tDCS) may offer an alternative, adjunctive therapy for PD. However, the efficacy of tDCS for upper limb motor rehabilitation in PD is unkn...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审


    authors: Simpson MW,Mak M

    更新日期:2020-12-01 00:00:00

  • Myoclonus and adult coeliac disease.

    abstract::A 56-year-old woman with coeliac disease developed myoclonus of cortical origin and palatal myoclonus with lesions of subcortical white matter on magnetic resonance imaging. Myoclonus can thus be a prominent feature of coeliac disease encephalopathy. A slight vitamin E deficiency was found but does not satisfactorily ...

    journal_title:Journal of neurology

    pub_type: 杂志文章


    authors: Tison F,Arne P,Henry P

    更新日期:1989-07-01 00:00:00