Neutrophil-to-lymphocyte ratio: a marker of neuro-inflammation in multiple sclerosis?

Abstract:

BACKGROUND:The significance of neutrophil-to-lymphocyte ratio (NLR) has been explored in different diseases. Few studies addressed its role in patients with multiple sclerosis (MS), with promising results regarding its association with disease activity or disability. OBJECTIVES:We aimed at confirming the role of NLR as a marker of neuro-inflammation in a cohort of newly diagnosed MS and clinically isolated syndrome (CIS) patients. Furthermore, we compared the validity of NLR with established markers of neuro-inflammation, such as serum neurofilament light chain (Nfl), CSF microvesicles (CSF-MVs) and CSF IgG indices. METHODS:We retrospectively selected, from a prospectively collected cohort of newly diagnosed MS/CIS patients hospitalized for diagnostic work-up, 121 patients who underwent CSF examination, brain MRI and blood cell count within the time of hospitalization and did not receive steroid treatment before sample collection. Patients were grouped according to presence of gadolinium enhancement at brain MRI. RESULTS:No association was found between NLR and disease activity, nor with other clinical measures. Nfl, CSF-MVs, Link and Tourtellotte indices were significantly higher in patients with brain MRI activity. CONCLUSIONS:Our negative results do not support the use of NLR as a marker of disease activity and disability in patients with MS.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Gelibter S,Pisa M,Croese T,Dalla Costa G,Orrico M,Preziosa P,Sangalli F,Martinelli V,Furlan R,Filippi M

doi

10.1007/s00415-020-10322-7

subject

Has Abstract

pub_date

2021-01-03 00:00:00

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-020-10322-7

pub_type

杂志文章
  • Longitudinal evaluation of quality of life in 288 patients with neurofibromatosis 2.

    abstract::Advances in molecular biology have resulted in novel therapy for neurofibromatosis 2-related (NF2) tumours, highlighting the need for robust outcome measures. The disease-focused NF2 impact on quality of life (NFTI-QOL) patient questionnaire was assessed as an outcome measure for treatment in a multi-centre study. NFT...

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00415-014-7303-1

    authors: Ferner RE,Shaw A,Evans DG,McAleer D,Halliday D,Parry A,Raymond FL,Durie-Gair J,Hanemann CO,Hornigold R,Axon P,Golding JF

    更新日期:2014-05-01 00:00:00

  • Arterial ischemic stroke in infants, children, and adolescents: results of a Germany-wide surveillance study 2015-2017.

    abstract:OBJECTIVE:Childhood arterial ischaemic stroke (AIS) is rare, but causes significant morbidity and mortality. We aimed to investigate incidence, age-dependent clinical presentation, and risk factors and to discuss the medical care situation in Germany. METHODS:This prospective epidemiological study was conducted via ES...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09508-5

    authors: Gerstl L,Weinberger R,Heinen F,Bonfert MV,Borggraefe I,Schroeder AS,Tacke M,Landgraf MN,Vill K,Kurnik K,Sorg AL,Olivieri M

    更新日期:2019-12-01 00:00:00

  • L-2-hydroxyglutaric aciduria: two Japanese adult cases in one family.

    abstract::We report two adult Japanese sisters with L-2-hydroxy-glutaric aciduria (acidemia), both of whom were much older (aged 57, 47 years old) than previously reported patients (from neonate to 44 years old), and who presented with differing severity. Magnetic resonance imaging revealed typical subcortical white matter lesi...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150050367

    authors: Fujitake J,Ishikawa Y,Fujii H,Nishimura K,Hayakawa K,Inoue F,Terada N,Okochi M,Tatsuoka Y

    更新日期:1999-05-01 00:00:00

  • Systematic review of the clinical spectrum of CASPR2 antibody syndrome.

    abstract:BACKGROUND:Contactin-associated protein-like 2 (CASPR2) autoantibody disease has a variable clinical phenotype. We present a case report and performed a systematic review of the literature to summarize: (1) the clinical phenotype of patients with CASPR2 antibodies, (2) the findings in neurological investigations, and (...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09686-2

    authors: Boyko M,Au KLK,Casault C,de Robles P,Pfeffer G

    更新日期:2020-04-01 00:00:00

  • Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease.

    abstract::We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00900501

    authors: Bronzova J,van Duijn CM,Havekes LM,de Knijff P,Van Broeckhoven C,Hofman A

    更新日期:1996-06-01 00:00:00

  • Electromyographic findings in the so-called non-progressive myopathies.

    abstract::Electrophysiological findings in 40 cases of non-progressive myopathies are reported, and compared with a group of 20 cases of Duchenne progressive muscular dystrophy and a control group. In all cases the electrophysiological changes were of the mild s. c. myogenic type. The involvement of proximal and distal muscles ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313234

    authors: Hausmanowa-Petrusewicz I,Ryniewicz B

    更新日期:1976-02-13 00:00:00

  • Nerve ultrasound in hereditary transthyretin amyloidosis: red flags and possible progression biomarkers.

    abstract:BACKGROUND:Diagnostic delay of hereditary transthyretin amyloidosis (ATTRv, v for variant) prevents timely treatment and, therefore, concurs to the mortality of the disease. The aim of the present study was to explore with nerve ultrasound (US) possible red flags for early diagnosis in ATTRv patients with carpal tunnel...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10127-8

    authors: Salvalaggio A,Coraci D,Cacciavillani M,Obici L,Mazzeo A,Luigetti M,Pastorelli F,Grandis M,Cavallaro T,Bisogni G,Lozza A,Gemelli C,Gentile L,Ermani M,Fabrizi GM,Plasmati R,Campagnolo M,Castellani F,Gasparotti R,Marti

    更新日期:2021-01-01 00:00:00

  • Association between polymorphism in the promoter region of Interleukin 6 (-174 G/C) and risk of Alzheimer's disease: a meta-analysis.

    abstract::Studies of the relationship between Alzheimer's disease (AD) and polymorphism in the promoter region of Interleukin 6 (IL-6) -174 G/C have reported inconsistent results. To assess the association between IL-6 -174 G/C promoter polymorphism and AD risk, a meta-analysis containing 3,101 AD cases and 3,860 controls from ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00415-011-6164-0

    authors: Dai L,Liu D,Guo H,Wang Y,Bai Y

    更新日期:2012-03-01 00:00:00

  • Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer's disease.

    abstract::Infectious agents have been proposed as potential causes of Alzheimer's disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cogniti...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00415-009-5011-z

    authors: Kountouras J,Boziki M,Gavalas E,Zavos C,Grigoriadis N,Deretzi G,Tzilves D,Katsinelos P,Tsolaki M,Chatzopoulos D,Venizelos I

    更新日期:2009-05-01 00:00:00

  • Proton magnetic resonance spectroscopy in frontotemporal dementia.

    abstract::This study of frontotemporal dementia (FTD) was carried out to determine whether MR spectroscopy can provide an in vivo marker for the neuronal loss and gliosis that occur in this condition. We compared spectra in frontal and temporal regions known to be affected early in the course of the disease with spectra in the ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0045-y

    authors: Coulthard E,Firbank M,English P,Welch J,Birchall D,O'Brien J,Griffiths TD

    更新日期:2006-07-01 00:00:00

  • The dynamics of multiple sclerosis. The Charcot Lecture.

    abstract::The history of our understanding of the pathogenesis and pathophysiology of multiple sclerosis are reviewed in the context of Charcot's contribution. The implications for treatment of the new knowledge gained from studies during life of pathology and pathogenesis (by MRI) and pathophysiology (by evoked potentials) are...

    journal_title:Journal of neurology

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/BF00838443

    authors: McDonald WI

    更新日期:1993-01-01 00:00:00

  • Temporal evolution of electroencephalographic abnormalities in Creutzfeldt-Jakob disease.

    abstract::Frequent serial EEG investigations of three patients with neuropathologically confirmed Creutzfeldt-Jakob disease lasting 13, 24 and 68 weeks revealed typical periodic activity of short duration with stereotyped bilateral sharp waves at the 7th, 8th, and 12th week, respectively, after the onset of symptoms. During the...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00328506

    authors: Schlenska GK,Walter GF

    更新日期:1989-12-01 00:00:00

  • Bulbocavernosus reflex latencies and somatosensory evoked potentials after pudendal nerve stimulation in the diagnosis of impotence.

    abstract::The bulbocavernosus reflex (BCR) was examined in 39 normal potent men and in 252 patients with impaired potency of varying aetiology. For BCR evaluation minimum, maximum and mean latencies, the temporal dispersion in ten successive responses, together with minimum and maximum side differences from simultaneous recordi...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314350

    authors: Tackmann W,Porst H,van Ahlen H

    更新日期:1988-03-01 00:00:00

  • The R495W mutation in SPG3A causes spastic paraplegia associated with axonal neuropathy.

    abstract::Mutations in the SPG3A gene cause a form of pure, early-onset autosomal dominant hereditary spastic paraplegia linked to chromosome 14q. The encoded protein, atlastin, is a putative member of the dynamin superfamily of large GTPases involved in cellular trafficking patterns. We report a new atlastin mutation causing s...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0768-1

    authors: Scarano V,Mancini P,Criscuolo C,De Michele G,Rinaldi C,Tucci T,Tessa A,Santorelli FM,Perretti A,Santoro L,Filla A

    更新日期:2005-08-01 00:00:00

  • Early Parkinson's disease and non-motor issues.

    abstract::Non motor symptoms (NMS) of PD are a key determinant of health, quality of life and societal cost of PD. Contrary to common perception, many NMS of PD occur early in PD and some may even predate the diagnosis of PD which is based on motor signs. These include olfactory deficit, sleep problems such as REM behaviour dis...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-008-5006-1

    authors: Chaudhuri KR,Naidu Y

    更新日期:2008-09-01 00:00:00

  • Multifocal motor neuropathy: clinical and electrophysiological findings.

    abstract::Multifocal motor neuropathy (MMN) can be differentiated from motor neuron disease by electrophysiological evidence of conduction block. To increase the probability of recording conduction block, we studied the whole nerve length including proximal segments in 84 patients with pure motor syndromes, using a special stim...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00873973

    authors: Jaspert A,Claus D,Grehl H,Neundörfer B

    更新日期:1996-10-01 00:00:00

  • Change and onset-type differences in the prevalence of comorbidities in people with multiple sclerosis.

    abstract:BACKGROUND:Little is known about the change in prevalence of comorbidities during the disease course of people with multiple sclerosis (MS) and whether the prevalences vary by MS onset type. OBJECTIVE:To calculate the change in prevalence of comorbidities between symptom onset and the time of study, to compare the pre...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10194-x

    authors: Lo LMP,Taylor BV,Winzenberg T,Palmer AJ,Blizzard L,van der Mei I

    更新日期:2020-09-03 00:00:00

  • CSF beta-endorphin and leu-enkephalin levels in the acute and chronic stages of cerebral infarction.

    abstract::To investigate the role of endogenous opioid peptides in the pathophysiology of cerebral ischaemia, the CSF levels of immunoreactive beta-endorphin and leu-enkephalin in 16 patients with cerebral infarction were measured. Both the CSF beta-endorphin and leu-enkephalin levels in the acute stage of cerebral infarction w...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314282

    authors: Kobari M,Ishihara N,Yunoki K

    更新日期:1987-06-01 00:00:00

  • [The "off-on" phenomenon during treatment of parkinson's disease with levodopa (author's transl)].

    abstract::The fluctuation in daily performance of Parkinson patients on long-term L-dopa therapy is known as the so called "off-on" phenomenon. Cotzias et al. found that a low protein diet is able to control this phenomenon in patients taking L-dopa alone but not in those receiving a combination of L-dopa and decarboxylase inhi...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00312550

    authors: Wajsbort J

    更新日期:1977-04-28 00:00:00

  • The effect of transcranial direct current stimulation on upper limb motor performance in Parkinson's disease: a systematic review.

    abstract:BACKGROUND AND PURPOSE:Parkinson's disease (PD) reduces independence and quality of life through deterioration of upper limb motor function. Transcranial direct current stimulation (tDCS) may offer an alternative, adjunctive therapy for PD. However, the efficacy of tDCS for upper limb motor rehabilitation in PD is unkn...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-019-09385-y

    authors: Simpson MW,Mak M

    更新日期:2020-12-01 00:00:00

  • An update on idiopathic intracranial hypertension in adults: a look at pathophysiology, diagnostic approach and management.

    abstract::Idiopathic intracranial hypertension is a neurological syndrome determined by a rise in intracranial pressure without a detectable cause. Course and prognosis may be changeable, requiring a multidisciplinary approach for its diagnosis and management. Although its precise pathogenesis is still unknown, many studies hav...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-020-09943-9

    authors: Toscano S,Lo Fermo S,Reggio E,Chisari CG,Patti F,Zappia M

    更新日期:2020-05-27 00:00:00

  • Cognitive dysfunction in adult patients with neuromyelitis optica: a systematic review and meta-analysis.

    abstract::The objective of this study was to investigate cognitive dysfunction in 24-60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library...

    journal_title:Journal of neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00415-016-8345-3

    authors: Meng H,Xu J,Pan C,Cheng J,Hu Y,Hong Y,Shen Y,Dai H

    更新日期:2017-08-01 00:00:00

  • The neurological sequelae of pandemics and epidemics.

    abstract::Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limited treatments often available. The under-recognition of neurological manifestat...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-020-10261-3

    authors: Valerio F,Whitehouse DP,Menon DK,Newcombe VFJ

    更新日期:2020-10-26 00:00:00

  • Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.

    abstract::It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative diseases, particularly the fact that ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-015-7682-y

    authors: Josephs KA

    更新日期:2015-03-01 00:00:00

  • Botulinum toxin treatment in atypical parkinsonian disorders associated with disabling focal dystonia.

    abstract::We investigated the efficacy of botulinum toxin A (BtxA) therapy in patients with atypical parkinsonian disorders (APD) exhibiting different types of disabling focal dystonia unresponsive to oral drug therapy. Eight patients with functionally disabling focal dystonia out of a series of 60 consecutive patients with APD...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s004150200009

    authors: Müller J,Wenning GK,Wissel J,Seppi K,Poewe W

    更新日期:2002-03-01 00:00:00

  • Severe familial paroxysmal exercise-induced dyskinesia.

    abstract::Familial paroxysmal exercise-induced dyskinesia (PED) is a rare movement disorder that is mostly caused by mutations in the solute carrier family 2, member 1 (SLC2A1) gene and inherited in an autosomal dominant manner. Clinical, laboratory, and genetic studies were performed in three family members. The proband's symp...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7441-5

    authors: Tacik P,Loens S,Schrader C,Gayde-Stephan S,Biskup S,Dressler D

    更新日期:2014-10-01 00:00:00

  • POLR3A-related spastic ataxia: new mutations and a look into the phenotype.

    abstract::Adolescent-onset spastic ataxia is a proposed novel phenotype in compound heterozygous carriers of an intronic mutation (c.1909 + 22G > A) in the POLR3A gene. Here, we present ten new cases of POLR3A-related spastic ataxia and discuss the genetic, clinical and imaging findings. Patients belonged to six pedigrees with ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09574-9

    authors: Infante J,Serrano-Cárdenas KM,Corral-Juan M,Farré X,Sánchez I,de Lucas EM,García A,Martín-Gurpegui JL,Berciano J,Matilla-Dueñas A

    更新日期:2020-02-01 00:00:00

  • Transcranial magnetic stimulation: specific and non-specific facilitation of magnetic motor evoked potentials.

    abstract::Different physiological mechanisms of facilitation of latencies and amplitudes of magnetic motor evoked potentials (MEPs) were evaluated in a cohort of 140 healthy volunteers. The potentials were induced at the vertex and recorded at the abductor pollicis brevis. The aim of the present investigation was to compare phy...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314732

    authors: Hufnagel A,Jaeger M,Elger CE

    更新日期:1990-11-01 00:00:00

  • Bilateral reductions of hippocampal volume, glucose metabolism, and wada hemispheric memory performance are related to the duration of mesial temporal lobe epilepsy.

    abstract::In refractory temporal lobe epilepsy (TLE) temporal lobe structures and functions are continuously or intermittently affected by abnormal brain electrical events, noxious neurochemical agents, and metabolic disturbances. There is conflicting evidence regarding the relationship between the duration of refractory mesial...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150050484

    authors: Jokeit H,Ebner A,Arnold S,Schüller M,Antke C,Huang Y,Steinmetz H,Seitz RJ,Witte OW

    更新日期:1999-10-01 00:00:00

  • SOD2 as a potential modifier of X-linked adrenoleukodystrophy clinical phenotypes.

    abstract::X-linked adrenoleukodystrophy (XALD), a neurological disorder caused by mutations in the peroxisomal membrane protein gene ABCD1, presents as a rapidly progressing, inflammatory cerebral demyelination (cerebral cases) or a slowly progressing, distal axonopathy (non-cerebral cases). Specific ABCD1 defects do not explai...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-011-6371-8

    authors: Brose RD,Avramopoulos D,Smith KD

    更新日期:2012-07-01 00:00:00