Abstract:
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journal_name
J Neuroljournal_title
Journal of neurologyauthors
Hu M,Corkill Rdoi
10.1007/s00415-019-09192-5subject
pub_date
2019-03-01 00:00:00pages
790-792issue
3eissn
0340-5354issn
1432-1459pii
10.1007/s00415-019-09192-5journal_volume
266pub_type
杂志文章abstract:BACKGROUND:Classifying and diagnosing peripheral vestibular disorders based on their symptoms is challenging due to possible symptom overlap or atypical clinical presentation. To improve the diagnostic trajectory, gadolinium-based contrast-enhanced magnetic resonance imaging of the inner ear is nowadays frequently used...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-020-10278-8
更新日期:2020-12-01 00:00:00
abstract::Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing impairment present immense challenges in their own right, and their intersection in the auditory brain re...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-016-8208-y
更新日期:2016-11-01 00:00:00
abstract::From a family with essential familial myoclonus, 150 members in eight generations were studied. Twenty-five of them suffered from myoclonus of varying severity. The findings in routine examinations of blood, urine and cerebrospinal fluid, EEG and skull radiographs were normal. Therapeutic trials did not produce lastin...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313626
更新日期:1983-01-01 00:00:00
abstract::We report on a 14-year-old boy with congenital isolated hemifacial hyperplasia. Hemifacial hypertrophy most likely represents a minor form of congenital hemihypertrophy. MRI of the soft tissue is particularly suitable to support the diagnosis and reveal associated bony asymmetries. ...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5148-9
更新日期:2009-09-01 00:00:00
abstract::Degeneration of central dopaminergic neurons is the most characteristic pathological feature of Parkinson's disease. It remains to be established to what extent these lesions explain the motor, cognitive and affective disorders observed in patients, but there are now some interesting clues to a possible solution. ...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00819560
更新日期:1992-01-01 00:00:00
abstract::Secondary worsening of stroke symptoms is described in 13-37% of stroke patients, but the exact mechanism of this phenomenon remains unclear. The aim of this study is to find prognostic variables in correlation to secondary worsening of stroke symptoms in patients with lacunar or cortical strokes. In this prospective ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5577-5
更新日期:2010-09-01 00:00:00
abstract::Idiopathic hypereosinophilic syndrome (IHES) is a primary haematological condition characterised by persistent, otherwise unexplained hypereosinophilia sufficient to cause organ damage. Various neurological complications are reported, but very few have mentioned CNS pathology and none has included CNS vasculitis. Our ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-015-7720-9
更新日期:2015-05-01 00:00:00
abstract::Two right-handed patients who exhibited language disability after left frontal infarction are described. The patients spoke fluently and exhibited excellent repetition ability from the onset of infarction without exhibiting any oral apraxia, but had deficits in auditory comprehension, naming, reading and writing. In b...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050180
更新日期:1998-02-01 00:00:00
abstract::Three families are described which include members with "typical" Friedreich's disease (FD) and others who are ataxic but do not satisfy all the diagnostic criteria for that disease. In family A two patients have an early-onset, rapidly progressive FD, while two others have a late-onset, more benign form. In families ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00319681
更新日期:1991-06-01 00:00:00
abstract::The electrically elicited blink reflex was investigated in 25 patients with ischaemic lesions of the pons or the medulla oblongata. Only patients with a lesion on MRI appropriate to the clinical syndrome were included. Twenty patients had an infarction of the pons, bilateral in 5. Additional 5 patients had an infarcti...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00870670
更新日期:1993-11-01 00:00:00
abstract::Cerebrospinal fluid (CSF) levels of interleukin (IL)-6, IL-11 and leukaemia inhibitory factor (LIF) were evaluated in 43 patients with Alzheimer's disease (AD) and 24 patients with frontotemporal lobar degeneration (FTLD) as compared with 30 agematched controls (CON), and correlated with clinical and demographic data ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0737-6
更新日期:2008-04-01 00:00:00
abstract::Gilles de la Tourette's syndrome (GTS) and restless legs syndrome (RLS) are two different neurological disorders with common features such as involuntary movements. In both disorders a disturbance of the dopaminergic system has been considered among other possible mechanisms. Since periodic leg movements (PLMS) during...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050136
更新日期:1997-08-01 00:00:00
abstract::The primary cause of neurological syndromes with antibodies against glutamic acid decarboxylase 65 (GAD65-Ab) is unknown, but genetic predisposition may exist as it is suggested by the co-occurrence in patients and their relatives of other organ-specific autoimmune diseases, notably type 1 diabetes mellitus (T1DM), an...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09782-8
更新日期:2020-07-01 00:00:00
abstract::The number of dementia patients requesting euthanasia in the Netherlands has increased over the past five years. The issue is highly controversial. In this contribution we discuss some of the main arguments: the nature of suffering, the voluntariness of the request and the role of the physician. We argue that society ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-016-8095-2
更新日期:2016-07-01 00:00:00
abstract::Two patients are described, in whom MRI detected unilateral signal abnormalities in the region of the inferior olivary nuclei, suggesting an early stage of olivary hypertrophy. MRI was performed 4 and 7 weeks respectively after traumatic brain-stem injury. Palatal myoclonus was concomitantly observed in one patient, w...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00867352
更新日期:1993-07-01 00:00:00
abstract::The history of our understanding of the pathogenesis and pathophysiology of multiple sclerosis are reviewed in the context of Charcot's contribution. The implications for treatment of the new knowledge gained from studies during life of pathology and pathogenesis (by MRI) and pathophysiology (by evoked potentials) are...
journal_title:Journal of neurology
pub_type: 传,历史文章,杂志文章
doi:10.1007/BF00838443
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Late-onset Pompe disease (LOPD) is an often misdiagnosed inherited myopathy for which treatment exists. We noticed a bright tongue sign on brain MRIs of two patients who were admitted to the ICU for respiratory failure of unclear origin, and who were eventually diagnosed with LOPD. This led us to systematica...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09455-1
更新日期:2019-10-01 00:00:00
abstract::In contrast to the distal sensory response, the somatosensory evoked response (SSER) is detectable in patients with A-alpha sensory fiber diseases such as Friedreich's ataxia. In four patients with this disease a combined histological and electro-physiological investigation of sensory propagation was performed. The su...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00312980
更新日期:1978-12-22 00:00:00
abstract::DWI has been described in some reports to be superior to FLAIR in early stage herpes simple virus encephalitis (HSE). Few data exist on detailed topographical MRI analysis in HSE. Our aim was to study DWI and FLAIR, and analyse topographically these sequences in non-neonatal HSE patients with MRI performed within 60 d...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-015-7818-0
更新日期:2015-09-01 00:00:00
abstract::Both neurologists and urologists might encounter patients with acute urinary retention due to benign inflammatory nervous diseases. Based on the mechanism of urinary retention, these disorders can be divided into two subgroups: disorders of the peripheral nervous system (e.g., sacral herpes) or the central nervous sys...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0189-9
更新日期:2006-08-01 00:00:00
abstract::To analyze the in vivo biological effect of anti-interferon beta (IFN-beta) neutralizing antibodies (NABs), blood concentrations of neopterin, beta2microglobulin (Beta2-MG), mRNA-dependent myxovirusresistant protein A (MxA) and dsRNA-dependent protein kinase (PKR) were measured before (predose) and 24 hours after (pos...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s00415-006-0332-7
更新日期:2007-05-01 00:00:00
abstract::18FDG-positron emission tomography performed at different stages in the course of subacute sclerosing panencephalitis revealed a changing pattern of metabolic disturbance. In clinical stage II patients the inflammation in the basal ganglia appeared to lead to neuronal excitation accompanied by hypermetabolism. Widespr...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00833917
更新日期:1992-03-01 00:00:00
abstract::Nystagmus is a rhythmical rotation of the eyeball. Its characteristics can be defined mathematically by the axis of rotation and the angular velocity around this axis. We analysed the axis of rotation for the nystagmus in benign paroxysmal positional vertigo (BPPV) to elucidate its pathophysiology. Thirteen patients w...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-002-0905-z
更新日期:2002-12-01 00:00:00
abstract::We investigated the efficacy of botulinum toxin A (BtxA) therapy in patients with atypical parkinsonian disorders (APD) exhibiting different types of disabling focal dystonia unresponsive to oral drug therapy. Eight patients with functionally disabling focal dystonia out of a series of 60 consecutive patients with APD...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150200009
更新日期:2002-03-01 00:00:00
abstract::Out of 72 patients treated for Borrelia burgdorferi meningopolyradiculoneuritis facial palsies occurred in 22 (12 unilateral, 10 bilateral). Eleven of the 32 pareses were initially complete. By the follow-up examination patients had recovered well with slight sequelae in 22% without cosmetically disfiguring pareses or...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00838171
更新日期:1993-05-01 00:00:00
abstract::An 18-year-old man suffered from acute Sydenham chorea appearing coincidently with beta-haemolytic streptococcal throat infection. Imaging techniques documented lesions of basal ganglia and substantia nigra. In the early course of the disease vascular lesions may be important pathogenetic mechanisms of this acquired m...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00858729
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Sleep disorders can occur in early Parkinson's disease (PD). However, the relationship between different sleep disturbances and their longitudinal evolution has not been fully explored. OBJECTIVE:To describe the frequency, coexistence, and longitudinal change in excessive daytime sleepiness (EDS), insomnia,...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10140-x
更新日期:2021-01-01 00:00:00
abstract::Biomarkers beyond clinical assessment are needed in patients who suffer from amyotrophic lateral sclerosis (ALS). Here, single-voxel proton magnetic resonance spectroscopy ((1)H MRS) of the gray matter of the motor cortex and the white matter including the pyramidal tracts was used to investigate concentrations of N-a...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0495-2
更新日期:2007-08-01 00:00:00
abstract::Autoradiographic investigations with 3H-thymidine were performed on cerebrospinal fluid (CSF) cells from a case of meningeal carcinomatosis following carcinoma of the breast. The cells were found to be anaplastic histologically. Within a period of 12 days 3 X 25 mg methotrexate were injected into the subarachnoid spac...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00316271
更新日期:1976-10-04 00:00:00
abstract::Cerebellar ataxia can have many genetic causes among which are the congenital disorders of glycosylation type I (CDG-I). In this group of disorders, a multisystem phenotype is generally observed including the involvement of many organs, the endocrine, hematologic and central nervous systems. A few cases of CDG-Ia have...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-007-0546-3
更新日期:2007-10-01 00:00:00