The "hype" of hydrops in classifying vestibular disorders: a narrative review.

Abstract:

BACKGROUND:Classifying and diagnosing peripheral vestibular disorders based on their symptoms is challenging due to possible symptom overlap or atypical clinical presentation. To improve the diagnostic trajectory, gadolinium-based contrast-enhanced magnetic resonance imaging of the inner ear is nowadays frequently used for the in vivo confirmation of endolymphatic hydrops in humans. However, hydrops is visualized in both healthy subjects and patients with vestibular disorders, which might make the clinical value of hydrops detection on MRI questionable. OBJECTIVE:To investigate the diagnostic value of clinical and radiological features, including the in vivo visualization of endolymphatic hydrops, for the classification and diagnosis of vestibular disorders. METHODS:A literature search was performed in February and March 2019 to estimate the prevalence of various features in healthy subjects and in common vestibular disorders to make a graphical comparison between healthy and abnormal. RESULTS:Of the features studied, hydrops was found to be a highly prevalent feature in Menière's disease (99.4%). Though, hydrops has also a relatively high prevalence in patients with vestibular schwannoma (48.2%) and in healthy temporal bones (12.5%) as well. In patients diagnosed with (definite or probable) Menière's disease, hydrops is less frequently diagnosed by magnetic resonance imaging compared to the histological confirmation (82.3% versus 99.4%). The mean prevalence of radiologically diagnosed hydrops was 31% in healthy subjects, 28.1% in patients with vestibular migraine, and 25.9% in patients with vestibular schwannoma. An interesting finding was an absolute difference in hydrops prevalence between the two diagnostic techniques (histology and radiology) of 25.2% in patients with Menière's disease and 29% in patients with vestibular schwannoma. CONCLUSIONS:Although the visualization of hydrops has a high diagnostic value in patients with definite Menière's disease, it is important to appreciate the relatively high prevalence of hydrops in healthy populations and other vestibular disorders. Endolymphatic hydrops is not a pathognomic phenomenon, and detecting hydrops should not directly indicate a diagnosis of Menière's disease. Both symptom-driven and hydrops-based classification systems have disadvantages. Therefore, it might be worth to explore features "beyond" hydrops. New analysis techniques, such as Radiomics, might play an essential role in (re)classifying vestibular disorders in the future.

journal_name

J Neurol

journal_title

Journal of neurology

authors

van der Lubbe MFJA,Vaidyanathan A,Van Rompaey V,Postma AA,Bruintjes TD,Kimenai DM,Lambin P,van Hoof M,van de Berg R

doi

10.1007/s00415-020-10278-8

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

197-211

issue

Suppl 1

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-020-10278-8

journal_volume

267

pub_type

杂志文章,评审
  • Evaluation of a new approach for semi-automatic segmentation of the cerebellum in patients with multiple sclerosis.

    abstract::Cerebellar dysfunction is an important contributor to disability in patients with multiple sclerosis (MS), however, few in vivo studies focused on cerebellar volume loss so far. This relates to technical challenges regarding the segmentation of the cerebellum. In this study, we evaluated the semi-automatic ECCET softw...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-012-6569-4

    authors: Weier K,Beck A,Magon S,Amann M,Naegelin Y,Penner IK,Thürling M,Aurich V,Derfuss T,Radue EW,Stippich C,Kappos L,Timmann D,Sprenger T

    更新日期:2012-12-01 00:00:00

  • Cognitive dysfunction in adult patients with neuromyelitis optica: a systematic review and meta-analysis.

    abstract::The objective of this study was to investigate cognitive dysfunction in 24-60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library...

    journal_title:Journal of neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00415-016-8345-3

    authors: Meng H,Xu J,Pan C,Cheng J,Hu Y,Hong Y,Shen Y,Dai H

    更新日期:2017-08-01 00:00:00

  • What is pathological with gaze shift fragmentation in Parkinson's disease?

    abstract::Oculomotor dysfunction in Parkinson's disease (PD) is mainly characterized by a fragmentation of memory-guided gaze shifts (target is reached by several hypometric saccades). Since this phenomenon can also be observed in normal subjects, we scrutinized its pathophysiological significance in PD patients. We recorded ho...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-002-0691-7

    authors: Kimmig H,Haussmann K,Mergner T,Lücking CH

    更新日期:2002-06-01 00:00:00

  • Vertebral artery stenosis in the Basilar Artery International Cooperation Study (BASICS): prevalence and outcome.

    abstract::We assessed the prevalence of vertebral artery (VA) stenosis or occlusion and its influence on outcome in patients with acute basilar artery occlusion (BAO). We studied 141 patients with acute BAO enrolled in the Basilar Artery International Cooperation Study (BASICS) registry of whom baseline CT angiography (CTA) of ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7583-5

    authors: Compter A,van der Hoeven EJ,van der Worp HB,Vos JA,Weimar C,Rueckert CM,Kappelle LJ,Algra A,Schonewille WJ,BASICS Study Group.

    更新日期:2015-02-01 00:00:00

  • Recent developments in multiple system atrophy.

    abstract::Multiple system atrophy (MSA) is a rare late onset neurodegenerative disorder which presents with autonomic failure and a complicated motor syndrome including atypical parkinsonism, ataxia and pyramidal signs. MSA is a glial alpha-synucleinopathy with rapid progression and currently poor therapeutic management. This p...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-009-5173-8

    authors: Wenning GK,Stefanova N

    更新日期:2009-11-01 00:00:00

  • Post-stroke emotional incontinence after small lenticulocapsular stroke: correlation with lesion location.

    abstract::Although post-stroke emotional incontinence (EI) often occurs after lenticulocapsular strokes, what factors determine the development of EI in these patients has not been identified. I prospectively studied the development of EI in 25 patients (13 men and 12 women, mean age 58.5 years) with single, unilateral, first-e...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-002-0714-4

    authors: Kim JS

    更新日期:2002-07-01 00:00:00

  • Quantification of post-concussion symptoms 3 months after minor head injury in 100 consecutive patients.

    abstract::Post-concussion symptoms (PCS) (such as headaches, irritability, anxiety, dizziness, fatigue and impaired concentration) are frequently experienced by patients who have sustained a minor head injury (MHI). The post-concussion syndrome has been defined as a clinical state where 3 or more symptoms persist for more than ...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s004150050254

    authors: Ingebrigtsen T,Waterloo K,Marup-Jensen S,Attner E,Romner B

    更新日期:1998-09-01 00:00:00

  • Step length predicts executive dysfunction in Parkinson's disease: a 3-year prospective study.

    abstract::Cognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-018-8973-x

    authors: Amboni M,Iuppariello L,Iavarone A,Fasano A,Palladino R,Rucco R,Picillo M,Lista I,Varriale P,Vitale C,Cesarelli M,Sorrentino G,Barone P

    更新日期:2018-10-01 00:00:00

  • Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients.

    abstract::Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson's disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-na...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-011-6407-0

    authors: Erro R,Santangelo G,Picillo M,Vitale C,Amboni M,Longo K,Costagliola A,Pellecchia MT,Allocca R,De Rosa A,De Michele G,Santoro L,Barone P

    更新日期:2012-09-01 00:00:00

  • Malignant diseases among patients with multiple sclerosis.

    abstract::The frequency of malignant diseases among 1866 living and 340 deceased multiple sclerosis (MS) patients was investigated in Finland. The study revealed a low prevalence (0.64%) and mortality (0.07%) rate of cancer among MS patients. The difference between MS patients and general population was significant. The highest...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313623

    authors: Palo J,Duchesne J,Wikström J

    更新日期:1977-10-07 00:00:00

  • Neutralising antibodies to interferon beta in multiple sclerosis : expert panel report.

    abstract::Interferon beta (IFNbeta) therapy for multiple sclerosis (MS) is associated with a potential for the development of neutralising antibodies (NAbs) that negatively affect therapy. Several factors influence the development of NAbs, such as lack of complete sequence homology with the endogenous IFNbeta sequence, frequenc...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-006-0486-3

    authors: Hartung HP,Polman C,Bertolotto A,Deisenhammer F,Giovannoni G,Havrdova E,Hemmer B,Hillert J,Kappos L,Kieseier B,Killestein J,Malcus C,Comabella M,Pachner A,Schellekens H,Sellebjerg F,Selmaj K,Sorensen PS

    更新日期:2007-07-01 00:00:00

  • Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic Parkinson's disease from those with striatonigral degeneration.

    abstract::Multiple System Atrophy (MSA) and idiopathic Parkinson's disease (PD) can be difficult to distinguish. There is an ongoing debate about the diagnostic value of the growth-hormone response to clonidine (CGH-test) in PD and MSA. We investigated whether the CGH-test can identify individual patients in the early stages of...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-002-0809-y

    authors: Strijks E,van't Hof M,Sweep F,Lenders JW,Oyen WJ,Horstink MW

    更新日期:2002-09-01 00:00:00

  • Diffuse Lewy body disease in Japan.

    abstract::Thirty-seven Japanese autopsy cases with diffuse Lewy body disease (DLBD) were reviewed from a clinicopathological viewpoint. Based on the neuropathological finding of whether or not many concomitant senile plaques (SPs) and/or neurofibrillary tangles (NFTs) are present. DLBD is divided into two forms: a common form a...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00314594

    authors: Kosaka K

    更新日期:1990-06-01 00:00:00

  • Mortality prediction in critical care for acute stroke: Severity of illness-score or coma-scale?

    abstract:BACKGROUND AND PURPOSE:The use of early prognostic data provided by various scores in critically ill stroke patients remains unclear. We tested the performance of the Simplified Acute Physiology Score (SAPS) II in prediction of mortality of acute stroke patients in the NeuroCriticalCareUnit (NCCU). METHODS:During one ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0853-5

    authors: Handschu R,Haslbeck M,Hartmann A,Fellgiebel A,Kolominsky-Rabas P,Schneider D,Berrouschot J,Erbguth F,Reulbach U

    更新日期:2005-10-01 00:00:00

  • Progressive multifocal leukoencephalopathy and natalizumab.

    abstract::Natalizumab (TYSABRI(®)), a specific α4-integrin antagonist, is approved as a second-line treatment of relapsing-remitting MS (RRMS) patients who fail therapy with interferons or as first-line treatment of patients with highly active relapsing-remitting disease. Since the market introduction of natalizumab as a monoth...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-011-6116-8

    authors: Hellwig K,Gold R

    更新日期:2011-11-01 00:00:00

  • Epidemics and outbreaks of peripheral nervous system disorders: II. Toxic and nutritional causes.

    abstract::Peripheral neuropathies have various causes, both infectious and non-infectious. When we think of "epidemics", we often refer to an infectious or even post-infectious origin. Nevertheless, the history of mankind is marked by episodes of epidemics of peripheral neuropathies of non-infectious nature, either of nutrition...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10216-8

    authors: Mathis S,Soulages A,Vallat JM,Le Masson G

    更新日期:2020-09-11 00:00:00

  • Neurocognitive dysfunction in adult moyamoya disease.

    abstract::We wanted to determine the neurocognitive profile of adult patients with moyamoya disease prior to neurosurgical intervention. The experience of three United States medical centers, Columbia University, University of Illinois at Chicago, and the University of Texas Southwestern Medical Center at Dallas, were combined....

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00415-009-5424-8

    authors: Festa JR,Schwarz LR,Pliskin N,Cullum CM,Lacritz L,Charbel FT,Mathews D,Starke RM,Connolly ES,Marshall RS,Lazar RM

    更新日期:2010-05-01 00:00:00

  • Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers.

    abstract::Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectivel...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-09830-3

    authors: Gersel Stokholm M,Garrido A,Tolosa E,Serradell M,Iranzo A,Østergaard K,Borghammer P,Møller A,Parbo P,Stær K,Brooks DJ,Martí MJ,Pavese N

    更新日期:2020-08-01 00:00:00

  • Lipoic (thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P-MRS in a patient with mitochondrial cytopathy.

    abstract::A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid. Before treatment a decreased phosphocreatine (PCr) content was found in the oc...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00873552

    authors: Barbiroli B,Medori R,Tritschler HJ,Klopstock T,Seibel P,Reichmann H,Iotti S,Lodi R,Zaniol P

    更新日期:1995-07-01 00:00:00

  • [Intracranial and spinal hemorrhage in haemophilia (author's transl)].

    abstract::Among 234 hemophiliacs, 14 patients (5.9%) with intracranial and 1 patient (0.4%) with intramedullary hemorrhage were observed and examined. The average age at the time of hemorrhage was 17 years in patients with severe hemophilia and 43 years in patients with moderate hemophilia. The patients with mild hemophilia and...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313358

    authors: Mamoli B,Sonneck G,Lechner K

    更新日期:1976-01-14 00:00:00

  • Identification of the spinocerebellar ataxia type 7 mutation in Taiwan: application of PCR-based Southern blot.

    abstract::Spinocerebellar ataxia (SCA) type 7 is an autosomal dominant disorder characterized by neural loss, mainly in the cerebellum and regions of the brainstem and particularly the inferior olivary complex. This neurodegeneration disease is associated with expansion of unstable CAG repeats within the 5'-translated region of...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150070131

    authors: Hsieh M,Lin SJ,Chen JF,Lin HM,Hsiao KM,Li SY,Li C,Tsai CJ

    更新日期:2000-08-01 00:00:00

  • Korsakoff's syndrome as the initial presentation of multiple sclerosis.

    abstract::A 37-year-old man presented with an acute amnestic syndrome of Korsakoff's type and an upper brain-stem oculomotor syndrome. After a moderate improvement with steroid therapy, he developed progressive behavioural changes due to a frontal lobe syndrome, in addition to motor and visual impairment. Memory performance was...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00315338

    authors: Vighetto A,Charles N,Salzmann M,Confavreux C,Aimard G

    更新日期:1991-09-01 00:00:00

  • Relation between functional brain imaging, cognitive impairment and cognitive rehabilitation in patients with multiple sclerosis.

    abstract::Cognitive impairment belongs to the core symptoms in MS affecting quality of life, self-esteem, and social as well as occupational functioning. Due to this high impact on patients' well-being efficient treatment concepts are required. Imaging studies on cognition have shown that functional reorganisation takes place s...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-007-2013-6

    authors: Penner IK,Opwis K,Kappos L

    更新日期:2007-05-01 00:00:00

  • PEN-2 gene mutation in a familial Alzheimer's disease case.

    abstract::Genetic evidence indicates a central role of cerebral accumulation of beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD). Beside presenilin 1 and 2, three other recently discovered proteins (Aph 1, PEN 2 and nicastrin) are associated with gamma-secretase activity, the enzymatic complex generating Abe...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0799-7

    authors: Sala Frigerio C,Piscopo P,Calabrese E,Crestini A,Malvezzi Campeggi L,Civita di Fava R,Fogliarino S,Albani D,Marcon G,Cherchi R,Piras R,Forloni G,Confaloni A

    更新日期:2005-09-01 00:00:00

  • Neurological complications in liver transplantation.

    abstract::To define the incidence and type of neurological complications and associated factors, we reviewed 41 consecutive patients who had 45 procedures for liver transplantation. Encephalopathy occurred after 28 procedures (62%) with immediate onset and no significant recovery before death or re-transplantation in 11 (24%), ...

    journal_title:Journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s004150170023

    authors: Ghaus N,Bohlega S,Rezeig M

    更新日期:2001-12-01 00:00:00

  • Idiopathic dystonia: neuropharmacological study.

    abstract::A total of 15 patients affected by idiopathic dystonia (7 with generalized and 8 with focal or segmental dystonia) were subjected to therapy with bromocriptine at low doses, pimozide and trihexyphenidyl. The symptoms were evaluated by giving a progressive score in relation to the intensity of the dystonic symptom to e...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313391

    authors: Girotti F,Scigliano G,Nardocci N,Angelini L,Broggi G,Giovannini P,Caraceni T

    更新日期:1982-01-01 00:00:00

  • Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures.

    abstract::The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assesse...

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00415-017-8618-5

    authors: Villanueva V,Holtkamp M,Delanty N,Rodriguez-Uranga J,McMurray R,Santagueda P

    更新日期:2017-11-01 00:00:00

  • Comparison of monoclonal gammopathy of undetermined significance-associated neuropathy and chronic inflammatory demyelinating polyneuropathy patients.

    abstract:OBJECTIVES:There are varying reports on whether monoclonal gammopathy of undetermined significance-associated neuropathy (MGUSN) patients are distinguishable from those with chronic inflammatory demyelinating polyneuropathy (CIDP) and whether specific MGUSN subclasses are associated with specific clinical phenotypes. ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7357-0

    authors: Alkhawajah NM,Dunnigan SK,Bril V

    更新日期:2014-08-01 00:00:00

  • Experimental porta-caval anastomosis and motor nerve conduction velocity in the rat.

    abstract::The influence of portal-systemic shunting on maximal motor nerve conduction velocity (MCV) was analyzed in rats with portacaval shunts. At 3 and 8 weeks after the shunting there was a marked but transient fall in MCV. This was not prevented by colectomy. At 16 weeks the MCV had almost normalized, despite sustained por...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00313181

    authors: Hindfelt B,Holmin T

    更新日期:1980-01-01 00:00:00

  • Thalamic aphasia. A conceptional critique.

    abstract::Four patients with aphasia due to small circumscribed thalamic lesions are presented. A review of the literature on thalamic aphasia revealed 16 similar cases. While the general consensus that only left-sided thalmic lesions are associated with aphasia is confirmed, analysis of the sites of the thalamic infarctions an...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/BF00314212

    authors: Bruyn RP

    更新日期:1989-01-01 00:00:00