Abstract：
:A myasthenia gravis (MG) patient who seems to have recovered can later have recurrence of myasthenic signs. Clearly clinical remission does not always correspond to the normalization of all the factors involved in the pathogenesis of the disease. In ten patients who had apparently recovered from MG, electromyographic tests of repetitive supramaximal stimulation were performed and the anti-acetylcholine receptor (anti-AChR) antibody was assessed. In two of the ten patients all these tests were normal, thus showing lack of electromyographic myasthenic fatigability and the absence of circulating anti-AChR antibodies. Our hypothesis is that for these two subjects the risk of a recurrence of MG is lower than for the others.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Scoppetta C,Bartoccioni E,David P,Flamini G,Lo Monaco M,Scuderi F,Tonali Pdoi
10.1007/BF00313771subject
Has Abstractpub_date
1982-01-01 00:00:00pages
61-5issue
2eissn
0340-5354issn
1432-1459journal_volume
227pub_type
杂志文章abstract：:Adolescent-onset spastic ataxia is a proposed novel phenotype in compound heterozygous carriers of an intronic mutation (c.1909 + 22G > A) in the POLR3A gene. Here, we present ten new cases of POLR3A-related spastic ataxia and discuss the genetic, clinical and imaging findings. Patients belonged to six pedigrees with ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09574-9
更新日期：2020-02-01 00:00:00
abstract：:Magnetisation transfer (MT) imaging provides indirect information on tissue structure abnormalities in areas that otherwise may appear normal on conventional MRI. We determined the evolution of MT changes in normal appearing white matter (NAWM) and lesion on serial examination of 9 multiple sclerosis (MS) patients and...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1115-z
更新日期：2003-08-01 00:00:00
abstract：:A girl with rapid-onset, bulbospinal muscular atrophy and deafness is described. The patient's mother and brother showed EMG features consistent with subclinical involvement. T is bulbospinal form of spinal muscular atrophy associated with deafness described by Vialetto and van Laere closely resembles the Madras type ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314095
更新日期：1987-08-01 00:00:00
abstract：:The effect of furosemide (Lasix) therapy on a standardized experimental cerebral edema, induced in rats by applying a cooling stamp to the right side of the skull over the right coronal suture by means of a stereotactic instrument, was examined. The hemispherically separated water and electrolyte contents of the brain...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00705536
更新日期：1979-05-02 00:00:00
abstract：BACKGROUND AND PURPOSE:Current demographic changes indicate that more people will be care-dependent due to increasing life expectancy. Little is known about impact of preexisting dependency on stroke outcome after endovascular treatment (EVT). METHODS:We compared prospectively collected baseline and outcome data of pr...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10172-3
更新日期：2020-08-31 00:00:00
abstract：:We assessed the prevalence of vertebral artery (VA) stenosis or occlusion and its influence on outcome in patients with acute basilar artery occlusion (BAO). We studied 141 patients with acute BAO enrolled in the Basilar Artery International Cooperation Study (BASICS) registry of whom baseline CT angiography (CTA) of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7583-5
更新日期：2015-02-01 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-018-9066-6
更新日期：2018-12-01 00:00:00
abstract：:Diminished activity of uroporphyrinogen I-synthetase in the liver and other tissues may be regarded to be the primary genetic deficiency of acute intermittent porphyria (AIP). Increased production and renal excretion of delta-aminolevulinic acid (ALA) und porphobilinogen (PBG) are secondary phenomena. The neuropsychia...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00316572
更新日期：1977-03-21 00:00:00
abstract：:Atrial fibrillation (AF) is considered a predictor for severe stroke and poor outcome. The aim was to evaluate whether AF is associated with poor outcome in acute ischemic stroke (IS) patients treated with intravenous thrombolysis (IVT). In a retrospective study, 157 consecutive IS patients (98 males, mean age 67.3 +/...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5452-4
更新日期：2010-06-01 00:00:00
abstract：:The effects of left- and right-sided hemispheric brain infarction on variability in circadian blood pressure and cardiovascular measures were investigated in 35 patients to test for asymmetry of the sympathetic consequences of stroke. No significant differences regarding age, size of infarction or extent and frequency...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00878874
更新日期：1995-05-01 00:00:00
abstract：:Whereas the effect of interferons (IFNs) on magnetic resonance imaging (MRI) outcome measures in patients with multiple sclerosis (MS) has been convincingly shown, little work has been done to define the between-patient heterogeneity of treatment response. Our aim was to assess the distribution of the effect of IFNbet...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s00415-005-0885-x
更新日期：2005-12-01 00:00:00
abstract：:Toxoplasma encephalitis, cryptococcal meningitis, progressive multifocal leukoencephalopathy (PML), and cytomegalovirus (CMV) encephalitis are the most common opportunistic infections of the central nervous system (CNS) in HIV-infected patients. They occur at variable degrees of immunosuppression, and their diagnosis ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050341
更新日期：1999-04-01 00:00:00
abstract：:Neuropsychological deficits and the relationship to brain pathology were examined in 13 primary progressive (PP) and 12 secondary progressive (SP) multiple sclerosis patients with a similar duration of the progressive phase and comparable physical disability. A battery of neuropsychological tests to assess attention, ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/pl00007804
更新日期：2000-02-01 00:00:00
abstract：:We evaluated 49 paired cerebrospinal fluid (CSF) and serum samples of 35 patients infected with the human immunodeficiency virus type 1 (HIV-1) for laboratory evidence of cytomegalovirus (CMV) infection. The patients were grouped according to clinical criteria as probable CMV encephalitis/polyradiculomyelitis, CMV ret...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00900957
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:The cerebellum is a predilection site of pathology in progressive multiple sclerosis (PMS) patients, contributing to cognitive deficits. Aim of this study was to investigate lobular cerebellar functional connectivity (FC) in PMS patients in relation to cognition. METHODS:In this cross-sectional study, resti...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8985-6
更新日期：2018-10-01 00:00:00
abstract：:A patient with haemorrhage in the right tegmentum of the pons demonstrated ipsilateral disturbance of taste on both the anterior two-thirds and posterior one-third of the tongue. The contralateral medial lemniscus was not disturbed, contrary to the early descriptions that the secondary gustatory neurons from the nucle...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313454
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a neurodegenerative disorder characterized by deposition of intraneural inclusion bodies in the brain as well as the enteric nervous system. Emerging concepts regarding the brain-gut axis have been proposed for neurological disorders. Thus, the present study investigat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09617-1
更新日期：2020-02-01 00:00:00
abstract：:Applying microarray technology to identify new diagnostic and prognostic markers in peripheral blood cells (PBC) after therapeutic intervention opens great perspectives regarding patient subclassification. Three recombinant products of the pleiotropic agent interferon beta (rIFN-beta) are available for disease modifyi...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-008-6010-1
更新日期：2008-12-01 00:00:00
abstract：:Migraine is a common and disabling nervous system disease with a significant genetic predisposition. The sex hormones play an important role in the pathogenesis of migraine. However, the conclusions of the previous genetic relation studies are conflicting. The aim of this study is to determine whether variants in gene...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8321-y
更新日期：2017-01-01 00:00:00
abstract：:The relationship between atherosclerosis and cognitive function is less well studied in Chinese populations. In addition, the results among middle-aged adults have been mixed. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cognitive function in middle-a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8234-9
更新日期：2016-10-01 00:00:00
abstract：:To analyze the in vivo biological effect of anti-interferon beta (IFN-beta) neutralizing antibodies (NABs), blood concentrations of neopterin, beta2microglobulin (Beta2-MG), mRNA-dependent myxovirusresistant protein A (MxA) and dsRNA-dependent protein kinase (PKR) were measured before (predose) and 24 hours after (pos...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-006-0332-7
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:The vegetative state, also known as the unresponsive wakefulness syndrome, is one of the worst possible outcomes of acquired brain injury and confronts rehabilitation specialists with various challenges. Emergence to (minimal) consciousness is classically considered unlikely beyond 3-6 months after non-traum...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09542-3
更新日期：2019-12-01 00:00:00
abstract：:Stiff-person syndrome (SPS) is a rare condition of progressive muscular rigidity and spasm, frequently accompanied by other autoimmune conditions, an association which has been further strengthened by the discovery of anti-GAD antibodies and the response of SPS to immunotherapies. Intravenous immunoglobulin (IVIg) is ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6015-z
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to identify clinical, magnetic resonance imaging (MRI) and biological markers predictive of long-term clinical response to interferon beta (IFN beta) therapy in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:Sixty-eight patients treated with IFN beta were foll...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-005-0979-5
更新日期：2006-03-01 00:00:00
abstract：:The concentrations of glucose, pyruvate and lactate were determined in the blood and lumbar CSF of 63 patients with neuromuscular disorders and 40 controls. The glucose/lactate and lactate/pyruvate ratios were also calculated, in addition to the cytoplasmic NADH/NAD+ (nicotinamide-adenine dinucleotide-H/nicotinamide-a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313438
更新日期：1981-01-01 00:00:00
abstract：:The use of a dopamine agonist with a long duration of action has theoretical advantages in attempting to reduce the motor fluctuations in Parkinson's disease. We report the results of a double-blind controlled study of adding cabergoline, an ergot derivative with potent long-lasting high affinity for the D2 receptor, ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00878534
更新日期：1996-01-01 00:00:00
abstract：:Two siblings with multiple intracranial haemangiomatosis are reported, each having psychomotor retardation, epilepsy and gyriform type calcification in the occipital and frontal lobes. There were haemangiomas in one autopsy case with calcification in the deep layers of the cortex and subcortical white matter. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313911
更新日期：1985-01-01 00:00:00
abstract：:Mutations in the mitofusin 2 (MFN2) gene are a major cause of primary axonal Charcot- Marie-Tooth (CMT) neuropathy. This study aims at further characterization of cerebral white matter alterations observed in patients with MFN2 mutations. Molecular genetic, magnetic resonance imaging (MRI), magnetic resonance spectros...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0847-1
更新日期：2008-07-01 00:00:00
abstract：:This review gives an overview of various neuroimmunological diseases in terms of incidence and prevalence rates, age and sex distribution, and the frequency of subtypes, if applicable. The disorders selected for review are inflammatory muscle disorders (polymyositis, dermatomyositis and inclusion body myositis), myast...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-5001-3
更新日期：2006-09-01 00:00:00
abstract：:An IgM antibody cytotoxic to normal human lymphocytes was found in 46.2% (male: 61.5%; female: 30.8%) of sera from chronic schizophrenics by means of a complement-dependent cytotoxicity test. The relationship between this antibody and the immunological manifestations of schizophrenia is discussed. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314296
更新日期：1987-06-01 00:00:00
