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Opportunistic infections of the central nervous system during HIV-1 infection (emphasis on cytomegalovirus disease).

Abstract：

:Toxoplasma encephalitis, cryptococcal meningitis, progressive multifocal leukoencephalopathy (PML), and cytomegalovirus (CMV) encephalitis are the most common opportunistic infections of the central nervous system (CNS) in HIV-infected patients. They occur at variable degrees of immunosuppression, and their diagnosis is based on a systematic evaluation with includes, in a definite order, ongoing prophylactic therapies, extraneurological signs, neuroimaging and CSF studies, and an anti-Toxoplasma therapeutic trial. Concurrent neurological HIV-CNS disease (such as the AIDS dementia complex) is frequent. The development of reliable molecular biology techniques such as the polymerase chain reaction and their application to the CSF have made the diagnosis of virus-related opportunistic infections much easier and has limited the need for cerebral biopsy. The incidence of opportunistic infections has decreased since the introduction of recent antiretroviral therapeutic strategies.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Roullet E

doi

10.1007/s004150050341

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

237-43

issue

4

eissn

0340-5354

issn

1432-1459

journal_volume

246

pub_type

杂志文章,评审

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