Abstract:
:We analysed the CACNA1A gene, located on chromosome 19p13, in three unrelated families and one sporadic case with episodic ataxia type 2 (EA-2). In two of the families and the sporadic patient, novel truncating mutations, which disrupt the reading frame and result in a premature stop of the CACNA1A protein, were identified in exons 14, 16 and 26. In the remaining family, a novel missense mutation (H253Y) was found. Of the twenty two EA-2 mutations identified thus far, including those of the present study, seventeen are truncating mutations and five are missense mutations, all resulting in an EA-2 clinical phenotype.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
van den Maagdenberg AM,Kors EE,Brunt ER,van Paesschen W,Pascual J,Ravine D,Keeling S,Vanmolkot KR,Vermeulen FL,Terwindt GM,Haan J,Frants RR,Ferrari MDdoi
10.1007/s00415-002-0860-8keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1515-9issue
11eissn
0340-5354issn
1432-1459journal_volume
249pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to identify clinical, magnetic resonance imaging (MRI) and biological markers predictive of long-term clinical response to interferon beta (IFN beta) therapy in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:Sixty-eight patients treated with IFN beta were foll...
journal_title:Journal of neurology
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abstract::Posterior leukoencephalopathy typically denotes neurotoxicity from immunosuppressive agents, malignant hypertension or eclampsia. It has not been documented in central nervous system angiitis. We present three cases associated with isolated cerebral angiitis after review of all cases of isolated CNS angiitis from 1998...
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